LINC02602

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LINC02602 serve as an independent prognostic factor and potential therapeutic target in patients with non-small cell lung cancer (NSCLC).

Annotated Information

Name

LINC02602: Long intergenic non-protein coding RNA 2602 (HGNC nomenclature), TCONS_00001798 [1].

Characteristics

LINC02602 is 1197 bp long non-coding RNA, located on human chromosome 1q32.2 [1].

Function

LINC02602 is serve an essential role in the development and progression of non-small cell lung cancer (NSCLC) via invasion and metastasis [1].

Decreased expression of LINC02602 is negatively associated with lymph node metastasis and advanced pathological stage. LINC02602 expression may be a potential independent prognostic factor for overall survival (OS) and disease-free survival (DFS) rates, and non-small cell lung cancer (NSCLC) pathological stage [1].

Expression

LINC02602 expression was downregulated in NSCLC patients. Association between the expression of TCONS_00001798 in NSCLC tissues and clinicopathological factors. (A) Relative expression of TCONS_00001798 in NSCLC tissues (n=118) compared with adjacent non-tumor tissues (n=118). TCONS_00001798 expression was detected by reverse transcription quantitative polymerase chain reaction and normalized to GAPDH. TCONS_00001798 expression was significantly lower in patients with (B) advanced pathological stage and (C) lymph node metastasis (N1 or above). (D) TCONS_00001798 expression was not associated with tumor size, measure by diameter. All data are presented as the mean ± standard deviation. NSCLC, non-small cell lung cancer; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; n.s., not significant.[1].

LINC02602 is downregulated in non-small cell lung cancer (NSCLC) tumor tissues compared with adjacent non-tumor tissues [1].

Experiment Forward primer Reverse primer
RT-qPCR 5′-CAGAAGGCTGCCCTGTAGAA-3′ 5′-GCTTCTTCCACTCCTGCGT-3′[1]

Regulation

Please input information here

Diseases

  • Non-small cell lung cancer (NSCLC) [1]

Labs working on this lncRNA

  • Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China. [1]
  • National Clinical Research Centre for Cancer, Tianjin 300060, P.R. China. [1]
  • Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China. [1]
  • Tianjin Lung Cancer Centre, Tianjin 300060, P.R. China. [1]

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Gao LW, Zhang H, Zhang B & Wang CL. A novel long non-coding RNATCONS_00001798 is downregulated and predicts survival in patients with non-small cell lung cancer[J]. Oncol Lett. 2018, 15(4):6015-6021.

Sequence

>gi|107985257|ref|XR_001738444.1| Homo sapiens , long intergenic non-protein coding RNA 2602 (LINC02602), long non-coding RNA

000001 TGTATTTTTT AATTTTTGTT TTTGATGAAG GGCTCATGGC CGCGAAGGCC AAAATGCCTA AAACCCACAA AAGTTACAAT 000080
000081 GTAGCCCTAG GTACAAGAAC TGTGTTAAGT GCTTTATATA GTACACGTTA TATAAGTCCT CATAATGGTC CTGTTGTTCC 000160
000161 CCTCATGTAA CAGGCAAAGA AACTGAGGCT TAGAGAGGTT GAGTCACTTA CTCAAGGCCC CATCTAATGG GTTGGGGAGT 000240
000241 TGGAATTCCA GCTACCTCTT GCCTGACTCC ATAGTTCTTG TTCTTCCCCA TGGTCTGCAG AAACCTGAAG GACTTGGCGG 000320
000321 CAGGAAAAAT TTGGTGGGGA ACATGTGTCT TCTCTCTTGC CTGCTCTGAT TTCTCAGGAG CAGGACCCAG GAGGGCATCC 000400
000401 GAGCCTCTGG CAGCTGAACC TCTGCAAACA GCAGTCACAG TGCATTTCTG CAGGCTCTTG GAGCTGCTCC CTCTGCCTCG 000480
000481 GCCAGATGCG AATTTGTGGC TTTTCCTTCT TGGCTCCTTT CCCCAGGTTT TCATTCCTTT TATTCTGGGA TGGAGCTGAA 000560
000561 ATTTTTCCAA CAGGGCCCAT GGTGGACACC CAGAAGTCAG TAGGGACTCC AAAAGGAAGT TAAGGCCGGG GAAGGGGGCC 000640
000641 AGGAAGAGGG AGACCAGCCT AAAGTACACA ACACTCAATT CTTCATTACT CACATGTGGC CTGACCGCTG GTGGACTGGC 000720
000721 TCCAGGAAAA TCTGAACCCT GGGCTGAGCC TCCCCGCCGG CTGGCCAGGA CAGACCTGGA TGCCCTCCAC CCTCCAGCCA 000800
000801 AACTTATTTT TTTCATATCA TAGCTGCAGA ATATTCGGAC CCTCTAGTCC CAGCCGCCCA GTGAACTTGA GCTGTGTGAC 000880
000881 CTTGAGCAAA AGGCAAAATG TTTCTGATTT TCAGTCCCCT CATCTGGAAA AGGAGGAGGC TGTGGGACAT GATGATCTTT 000960
000961 GAAAGTCTAA TAATGAAACA AACAGAAAAC CTGTGCTTCT AAGTTGGTGA GTCTGGAAAG GCTTGGTGTA CAGTTGATGT 001040
001041 CTAGAATATA TTAACAGAAG GCTGCCCTGT AGAAGTTTTG AGTTAATGGT TTCCATCAAC GCAGGAGTGG AAGAAGCTAC 001120
001121 TGGGGATCAG GAATCAGAAG TCCTGGCTTT AAGCCCTAGC TTTAGCCCTC ACTGGAATTA CAGGAATTAC ACCCCCC