NBAT1

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Annotated Information

Approved Symbol

NBAT1

Approved Name

neuroblastoma associated transcript 1

Previous Symbols

CASC14

Synonyms

NBAT-1

Chromosome

6p22.3

RefSeq ID

NR_034143

OMIM ID

616206

Disease

Fighting Neuroblastomas ;breast cancer

Ensembl ID

ENSG00000260455

pubmed IDs

25859549, 26378045

Characteristics

lncRNA LOC729177 (known as neuroblastoma associated transcript1 or NBAT1; formerly referred to as NBAT-1) that maps to a neuroblastoma hotspot on the 6p22 region [1].

Cellular Localization

The lncRNA NBAT1 maps to a neuroblastoma hotspot on the 6p22 region.[1].

Function

Figure: Model explaining functional role of NBAT1 during neuroblastoma pathogenesis. [1].

NBAT1 expression can be used as an independent prognostic marker for prediction of event-free survival in neuroblastoma patients [1].

The role of NBAT1 as an effective tumor suppressor of neurobastomas complements its very important functions during neural lineage differentiation [1].

Regulation

NBAT1 regulates biological processes that are highly critical for tumor development, such as cell proliferation and invasion by associating with PRC2 member, EZH2 [1].

Diseases

  • neuroblastoma

Expression

NBAT1 expression analysis in large datasets of 591 tumors showed that low expression is associated with poor clinical outcomes [1].

A higher level of NBAT1 in low-risk tumors controls neuroblastoma progression and promotes neural differentiation. On the contrary, the hypermethylated NBAT1 promoter and the G/G genotype at the disease associated SNP in high-risk neuroblastomas results in decreased expression of NBAT1, leading to highly proliferative and invasive neuroblastoma cells with an impaired ability to differentiation [1].

Sequence

>gi|300797090|ref|NR_034143.1| Homo sapiens neuroblastoma associated transcript 1 (NBAT1), long non-coding RNA

000001 CTAGAATGAG AATGCACAGC AAGCGGCAGA CAATCACCCG GCATTCGGCA TCTCTTTCTT TTCACGCGCT CCCTCGCTCC 000080
000081 GCCTTTCTCC AGCTCTGCCT TCTCAGGCAG ATACATCAGA TACCTTGTTT ATCCATCTTC AGCTCCACTC TGAGGGCGCA 000160
000161 GACGCACGAT TCCGGGATCG GGTGCACCAC GGCGAAGCCC AGGCGGGAGA CGGCAGGAGC AGCTCAGATG AAGAAACTGA 000240
000241 AACCCACAGA GATGAAGTAA CATCCTCAAG ATCAAAAGGT AACAAACGAT TGAGGCAGGA TTTGGATATT GCTCTACATG 000320
000321 ACGGGAAAGC CTGTGCTCTT GGAATTACAG TCATAGTACA ACAGATCAAG TTCAAAGCAT CATCTAAGTC AAGGAAAACC 000400
000401 AGTAAAGAGG TTTGGAGAGA CAAACAGGGT CAACTCCAGG CATTTGGGTC AGCAGAAACG GCACGATTGA GCAGCACTGT 000480
000481 GACTATAGGA TCATGGATCA GAGGCTGCTT CCTCTTTGGT TCTGGGCATC AGCCTCATGT CCACTCAAAG TAAGTGGCCC 000560
000561 CTCTGATTGG AATCGGAGGT GCCTGGGTCA TCTCACAGAG CCAAACAAAT ACAATTAGCT ATTGCAAAGC CTTTTGGGAA 000640
000641 TTATTCCCAG TGTAAATAAA CACATAACCA TATAGCAAGA GCCTTGATAA AGTCCAAAAA CATGCAAACT TGGAGTATCT 000720
000721 AAGAGAAAAG ACCACAATGT AAATGAAAAA CCAAATAAAC TCGGGCAAAC CATAGGATAG GGCCCTGTCT GTGATGGCCT 000800
000801 GCATATGATG AGCCATAGAA AAAGGATGGT GAATTCTGGA TAATAAGAAA TGTCAATGAG ATGCAAGAAC CACCTGTTTT 000880
000881 ATGTAAAGCT CCAAATAACC AGATCACAGT GGACAGCCAC TCAAATAATG CCTTCATAAT ACAGAGTATT ATTGAGAATA 000960
000961 ACTCAGTTCA CAGAGAGCTT AAGGCAGCCA ATATTTGATA GCCTGTCAGA AAAAAACAGA ACAGTAATTA TAGAAAAGAA 001040
001041 TCATATCCTC GGAAAAACAA AAATTAATCA AACTAAGTTT GTAAAGTCTA TCTTACAGAC ACATTGTCTG GACTGGTCCT 001120
001121 CTCAAAAATA CTGTTTTTTT TTAATGCCAA TTTGTTTAGT TAATGATTTT TGTCTTATTA CTTCAAAACT GGAAATATCC 001200
001201 TATGACTCAT AATATCTTAC AACCTTTCTA CTTTCTTAAA GAATCTCAAG TTTATAATCA CAGGGGATCG GATTATTTTT 001280
001281 CAAAAATTAA ATGGTGATGT AATGATTTCT GTGTCTATTG TAGAAAAGTC AACCTTATTA CAGCTGCAAC AATGGCATTA 001360
001361 AGAAATATGA GTAATTCCAA TCAACTTGAG ATAATGTCTA ATCAAACACA AATACAACTG GTAAATTTCA TTAAATAGCA 001440
001441 TGGAGATTAA ATTAAAACAC TATTATGTAA TAAAAACCTT TAGTGGTACT AAAATTTTAG AATAGTTCAG ATATACAGAA 001520
001521 AAATTTCAAA GATACACAGA GTTCCCATTT TTTTCCTATT ACTAACCTCT CATATTTGTC ACAACTAATG AATATTCAAT 001600
001601 AGAGTATTAT TAACTAAAGC CTATACATTT ATTTAGATTT CCTTAGTTTT TAGCTAACAT TCTTTTTCTT TGTTCCAGGA 001680
001681 TCCCATCCGG GCCACCACAT TGAATTTATT TGTCATTTTA GGTACCTCTT GGCTGTGAGT TTCTTAGACT TTCCTTGTTT 001760
001761 TTGGTGACCC TGACAGTTTG AGGGAGTACT AGTCAGTCAG TTATTTTTGC AGAATGCCCT AAATTTGAGT TTGGCTGATG 001840
001841 TTTTTCTTAG GGTTTGACTG GGGTTATGGG TTTTGGGGAG GAAGACCACA GAGGTGAAGT ACCATTCTCA CCAAATTATA 001920
001921 TTAAAGGTAC ATACCATCAG CATGCCTTAT ACTATTGATG TGAACTTTGA TTGCCTGGCT GTGGTAGTGT TTGTCATGTT 002000
002001 TCTTCACTGT AAAGTTACTC TTCTCATCAC CCACTTTTCT GTACTGTACT CTTTGGAAGA AAGTCACTAT ATGCATCCCA 002080
002081 AATTTAAGGA GTGGGAAGTT ATGCTCCACC CATTTGTAAG CAGAAAATCT ACATAATTTG TTTGGCATTC TTCTGCATAG 002160
002161 GAAAAT