NONHSAT024776

Same as ENST00000531381.1

MIR100HG, the human miR-99a/100 ~ 125b cluster host gene, locating in the nuclear cell compartment, plays a role in the regulation of erythro-megakaryocytic development.

Annotated Information

Name

Approved symbol: MIR100HG

Approved name: mir-100-let-7a-2-mir-125b-1 cluster host gene

HGNC ID: HGNC:39522

Previous names: mir-100-let-7a-2 cluster host gene (non-protein coding); mir-100-let-7a-2 cluster host gene;

Alias symbols: AGD1; lncRNA-N2; linc-NeD125

Alias names: "adipogenesis down-regulated transcript 1", AGD1, "lncRNA neuronal 2", lncRNA-N2^[1]

RefSeq ID: NR_024430

LncBook ID: HSALNT0289173

Characteristics

MIR100HG was localized in the nucleus and their expression correlated with the corresponding miRNA clusters^[1].

It was contained in BH3-like motif ,which was associated with the single nucleotide polymorphism (SNP) rs577948, a susceptibility locus for high myopia in Japanese subjects^[2].

Cellular Localization

MIR100HG was localized in the nucleus^[1].

Regulation

TGF-β increases MIR100HG transcription through SMAD2/3 TFs^[3].

Function

Knockdown of MIR100HG impaired cell viability and replating-efficiency of AMKL（acute megakaryoblastic leukemia） cells,which implys MIR100HG may contributes to the maintenance of leukemic growth^[1].

Diseases

myeloid leukemia
Pancreatic ductal adenocarcinoma (PDAC)^[3]

Labs working on this lncRNA

Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany^[1]

School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China^[2]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D, Klusmann JH. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia[J]. Molecular cancer. 2014,13:171.
↑ ^2.0 ^2.1 Zhao F, Bai J, Chen W, Xue A, Li C, Yan Z, et al. Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population[J]. Molecular vision. 2010,16:1920-7.
↑ ^3.0 ^3.1 Ottaviani S, Stebbing J, Frampton AE, et al. TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression[J]. Nat Commun, 2018, 9: 1845.

Basic Information

Transcript ID	ENST00000531381.1
Source	Gencode19
Same with	lnc-BLID-1:4,NONHSAT024776,MIR100HG,AGD1, lncRNA-N2
Classification	intergenic
Length	3370 nt
Genomic location	chr11-:121959811..121972886
Exon number	2
Exons	121959811..121962448,121972155..121972886
Genome context
Sequence	000001 GAGACACACT ACAACAGGAG AGGGAGCAAG CGCGAGAGGA TATTAGAAGA GAGGCTTGTC TCCAAGATAT GGAAGGAAGT 000080 000081 GAGAAATGAC AGGGCTGCAA GCTTTGTATG TAGGAGCCCG GCAGGGCGGG GGAGCGGCGA GGAGAGCCAA GTGGATTCTC 000160 000161 AGAAAAGGGG GGAAGCCATC GAAGAGCTAA AGGTGATTAG AGGGGGATAT TGATTTCTTA TTCTGCCAGA GATTTAAGCA 000240 000241 GGCATGCGAG GAATCTGCAC CATGGTTGGC AAAAAGAGAC CCGTTGCCTC CTGTAACCAG ACACTCAGGC TTTCCAGGAG 000320 000321 CCCAGGGAGC AAGCCGAGAA GAAAGGGGGC AGTGTGGTCT AGGAAAATTC AACTTGTCGC TGATTTGTGC CTGATGCCTG 000400 000401 CTGTCCGTCA GCAGCCTCCC TTACAATCTT TTTTTCTCTC TCTCCTTTTT TTTTCCTTGC CTTCTCCTTC TTCACTGAAG 000480 000481 CCTAGGGGAG CCAGTAAAGA TTAAATGTGC TTCTCAAAGG CAGCCACTTC ATGCTGCTAT GTCGAAAGGG CCATTATTAT 000560 000561 TATTATATTT TAATGGTAAA AGAGAAAAGG AGAGAGGTTG AGCGAGCGAG AGAGAAGCTA GGTGTGATGA TGACAGACTA 000640 000641 GCTTTTCTGA GAGGAAAAGG AAAAGGGAAG GGAGAGAAAA AGGAGAGCCT CTGAGCTCAA CGGAGGATTG TGCCTGAGAA 000720 000721 GAACCCACAG AGTTGTGTTG ATGTTCCTTT CAGCTGGTCC TATAGTACCC CTCCTCAGGA ATGTCTCCCC AGTGCAAGGA 000800 000801 CAAAGACTGA AGAGACTGCT ATATTGATGG ACTCTCAAGC CAACTATGAA GTTGAAACAA AGAAAGTGAT CACCTGAAGA 000880 000881 CACCTCCTCT GCTAAGAAAC ACCCCCAAAT TGTGCAGCTT CTGCCACTAG AACTCTCAGA ACAAGAGACA ATCTTTTCAA 000960 000961 GAAACAGAAA AACTCAATAA TGACATCTAG ATTTTCATGA GCCAAGAACT TTCCCTTCCT CATGTGTATT CCTCTGTTTG 001040 001041 TACTTAAATT CATGTGACAT TCATTTTTTT CCTAGTATGG ATATGCTTAT TAATGCACTT GTTTCAAAAT CCCAAATTGC 001120 001121 ACAAATGTGT TAATATTTTA AGAAACAAAA TGAATCCTAC AAGGAGAATG ATTTTTAGCC ACACATAGGG TTGGATCTTG 001200 001201 AGAGTGACCT ACAGAATAAA AGTACTTTTA AAATAAAGTA GTCAGAGGCT ATTCAAAGGG TAAAATAATC ATAGTACCAC 001280 001281 ATTGGTCCAC TTGACACTAA CCAATCGATC ATTTTTTTTT AATCAAGAAA GCTAGATTCT ATCAGATAAA ATCACTGCTT 001360 001361 CTAAAGAGTT TAAATCTAGT TAGAAAAAGT TATAGAAATG TTTGCAAAGA TAAGTAACAG ATAGAGTCAG TAGAGGATAA 001440 001441 GATCAAAAAC AAAACCAAGC AAAAGATGAG TTCAGGGGAG TTTGCCATCA AGTTGGCAAA ACTGACTTAC TTAGGGAAGA 001520 001521 AAGTTATAAA ACAGGAAAAT ATGAGATGAA CCTTGAGTGA TGTGGAAGAT TTAGATAAAT GGAAAGGAAG GAGAAAATGG 001600 001601 AGTTCTTTAG GTGGTTGTAA TTGGAGGAGG AAATGAATAC ACACATCTTG TTGACTTAAA CCCAGACATT CAGCAGCTCT 001680 001681 CTATACATAT CTGGAAAAGA CTGCACAGTC ACCTCCTGTC TCTCACCCCA GGTATTACTT AGAATTATTA TCATATTTCC 001760 001761 CTTCCTTTAA AGTAAGTAAG GGTGATTGGT GACAATATGG AGAACTATGA TTTTTCCATT AACCTAATAA TAATTGGTAT 001840 001841 TTATTGAGTT CTGTTAAGCA TTTTACATAT TAACTCACTT AAGCCTTTCA ACAGCCTTGC AAAATAGGTA TTATTATCCC 001920 001921 CATTTTACAG GCAAGAAAAC TGAGGTTTAA GTAACTTGCC GAAGTGCCAT ATACAGGGCT CACATTCAGT ATTGCAGTTG 002000 002001 CAAAGCTCAT GATCTATAGT GCCAAGTTGC AATATTGTAG TCAATGTCAC AATTATTACC CCTTTTTATA TTCCTTGATA 002080 002081 TTTTTCCATG GCAAACAATT AGCTATTTCA TTTAATAATC ACCTAAAACT TTTCA</

[ref1-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D, Klusmann JH. LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia[J]. Molecular cancer. 2014,13:171.

[ref2-2] 2.0 ^2.1 Zhao F, Bai J, Chen W, Xue A, Li C, Yan Z, et al. Evaluation of BLID and LOC399959 as candidate genes for high myopia in the Chinese Han population[J]. Molecular vision. 2010,16:1920-7.

[ref3-3] 3.0 ^3.1 Ottaviani S, Stebbing J, Frampton AE, et al. TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression[J]. Nat Commun, 2018, 9: 1845.

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