SAP30-DT
SAP30-DT can mediated by derepressing of PDK4 through competitively binding to miR-15b-5p.[1]
Contents
Annotated Information
Name
Approved symbol:SAP30-DT Approved name:SAP30 divergent transcript HGNC ID:54424 Alias symbol:ENST00000608794 RefSeq ID:XR_939462
Characteristics
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Function
LncRNA SAP30-DT in dexamethasone induced steatosis.[1]
Regulation
SAP30-DT is expressed at higher levels in dexamethasone treated HepG2 cell, and SAP30-DT can bind and be regulated by miR-15b-5p. [1]
Expression
Ectopic expression of SAP30-DT enhanced steatosis and the protein expression of PDK4 which is a critical gene in lipid metabolism and also is a target of miR-15b-5p. [1]
Diseases
Steatosis[1]
Labs working on this lncRNA
- Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China.[1]
- Laboratory Center, The Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, Fujian, China.[1]
- Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China. [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Liu F, Chen Q, Chen F, Wang J, Gong R, He B. The lncRNA ENST00000608794 acts as a competing endogenous RNA to regulate PDK4 expression by sponging miR-15b-5p in dexamethasone induced steatosis. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1449-1457. doi: 10.1016/j.bbalip.2019.07.003. Epub 2019 Jul 19.
