SSTR5-AS1

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SSTR5-AS1 is a top candidate implicated in the development of neuroendocrine prostate cancer (NEPC). This lncRNA robustly distinguishes NEPC from prostate adenocarcinoma (AD).

Annotated Information

Name

SSTR5-AS1: SSTR5 antisense RNA 1 (HGNC nomenclature).

Characteristics

SSTR5-AS1 is an antisense transcript of SSTR5, which is a member of the superfamily of somatostatin receptors. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signalling, as well as inhibiting the release of many hormones and other secretory proteins [1].

Function

SSTR5-AS1 has not been functionally characterized, but its sense form SSTR5 has and is a biomarker for neuroendocrine tumours [1].

Regulation

KDM4B and TADA3 are mRNAs that are predicted to hybridize and form joint structures independently with SSTR5-AS1 and LINC00514, respectively [1]. KDM4B can interact with N-Myc where it has been shown to regulate and epigenetically activate this oncogene in neuroblastoma [1] . N-Myc has been seen to drive the progression of NEPC [1].

Diseases

  • Neuroendocrine prostate cancer (NEPC) [1]

Expression

SSTR5-AS1 is among the highest expressed lncRNAs among a subset of lncRNAs that differentiate NEPC from AD [1]. The expression of two NEtD/NEPC lncRNA transcripts (SSTR5-AS1 and LINC00514) was able to separate patients more likely to develop metastatic disease from those that did not [1].

Experiment Forward primer Reverse primer
qRT-PCR 5'-AGCCCCTCATCTTGGCTAAT- 3' 5'-TGCAAACATTTCAGCCTCAC- 3' [1]

Labs working on this lncRNA

  • Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. [1]
  • GenomeDx Biosciences Inc., Vancouver, BC, Canada. [1]
  • Department of Computer Science, Simon Fraser University, Burnaby, BC, Canada. [1]
  • Department of Experimental Therapeutics, BC Cancer Agency, Vancouver, BC, Canada. [1]
  • Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA. [1]
  • Department of Urology, Mayo Clinic College of Medicine, Rochester, MN, USA. [1]
  • Department of Pathology and Laboratory Medicine, Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY, USA. [1]
  • Department of Computer Science, Indiana University, Bloomington, IN, USA. [1]
  • Department of Medicine, Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY, USA. [1]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Ramnarine VR, Alshalalfa M, Mo F, Nabavi N, Erho N, Takhar M, Shukin R, Brahmbhatt S, Gawronski A, Kobelev M, Nouri M. The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. GigaScience. 2018, 7(6).

Sequence

>gi|146336|ref|NR_027242.1| Homo sapiens SSTR5 antisense RNA 1 (SSTR5-AS1), long non-coding RNA

000001 GGGTAAACAC GATTAGTCAT GTTTAGCTTG GCCGGGAATC ACGTTAAGCA AATTGTTTGG AAAATAAGCC AGGAGAGGAA 000080
000081 GGAGCGGCGG GCAGGTGGCC CCGGGAGCCC AGACGGACGG CTGCTGTCGA TATGGCGACA GCTGCCCTGT GGCCGCCCCT 000160
000161 GCACCCAGAT GGCGCCTGGC CTGGCCGCAG CATCCTGGAG TCTGAGGCCA GCACCTGCGT CTCCCTGAAG CCCCTCAGAG 000240
000241 CCTGCCCTGC AGTGCTGCTG CCCTCGTCTA CCAGTGGCTC AAGCCTGTCA TCCCAGCACT GTGGGAGGCC GAGGCGGGTG 000320
000321 GATCACCTGA GGACAGGAGT TCAAGACCAG CCTGGGCAAC ATGGCTATAT GGAAAGCACA GGTGTTTCTG CTTCTGGAGA 000400
000401 GGCCCCAGGA AGCTTCCAAC CGTGGTGGAA GGCGAAGCGG GAGCAGGTGT CTCACATGGC GTGAGCGGGA ACGAGAAAGA 000480
000481 CAGAGCAGGG AAACGTGCAG AGGAAATGGT TGGAGAGCGA AGTCCAGGCA CAGGGGCCAT GAGAGCCGGA CCCCACGCAG 000560
000561 CTGCAGACCT CGACCCGAAC TGCATGCGGC TGAGGACCCC CAAGCCAGGC AGACCCCGAC CCAGACCCCA CGCGGCCGCG 000640
000641 GACCCCCGAC CTCGACCCAA ACTGCATGCG GCTGAGGACC CCCAAGCCAG GCAGACGCCA ATCCAGACCC CACGCGGCCG 000720
000721 CGGACCCCAA CCCAGACAGA CCCCGACCCA CCCGTGCAGC CCCCAGCCCC AGAAGTCAAA CCCCAGCGTC CCCCAGGGCG 000800
000801 GCCCGGGCTC CCTCAGATAC AGCAGCTTCC TGAGGTGGCC TCACCTGCAA CTCCAGACCA ATCAGAGAAG GCCAAATGGG 000880
000881 CTCCCCAAGC CCAGCAGGTG GGACCCCCGA TCTAGAGAGC CCCTTCCCCG CCCCAGGCCA ACAGCCACCC TCGGGCTCCG 000960
000961 CATCAGGTCT GCCAAATGCA GGGGCGAGGG GCCGACCCCG CCACGGGAAC CAAACTCAGG AAACAGCCCA TCCAGCGTCC 001040
001041 ATCTCCATCC GGACCCGCCG CCGCGGCCGC AGGTTCACGC GCCGTTCCGC GGAGATCTCT CAGGCGCCTC CGGCCCGGCA 001120
001121 GAAACCCGCG GTTCCGATGG CAGAGGTCCT GGTGGGAATC GCACCGCCTG CCGTTCCTGC CTCCGCGGAG GATGCGCTGC 001200
001201 CCTAAACTGC CCCCGGCTCT TCATCCCCCA ACCCCCGGCA GCCTCCGACC CTCCCCCGGC CGGCGCAGCT CAGCCTTTCG 001280
001281 CAGACGCGGG GGAGCTGGAA TCCGACCACG CGCAGCCTTC TCACCGTGGT GCACGCTTCG GGCCCCCCAC GCCTTTCCCA 001360
001361 GGCTTCATCA CCCATTTCTC TCCAGCGCTG AAGGAAACCC CCCAGATGCT TCTCCACTCA CCCACCGAAG CAGGTCTCGG 001440
001441 TTGCCCCCAG CCCCGGGCCC TCCCGAGAAC ACTGCAAGCC CCCACTGGTC CCCTCCCGGC AACCCCACGG CCCATCCCCA 001520
001521 ACCTGCACTC ACCCTGTGGG GCCTCCACCC TTTGGAGGAA GGACGTGTCA AAGCTTGGAG GTGCGCGGCC TGTCTAACCT 001600
001601 CCGCCCAAGG CGCGCGGCAG GCGACAGGTC TCAGCCCGGA TCAGCGTGGT CCAAAAGGAC TTATCGTTAA AAGTGCTGGT 001680
001681 CCCAGAACCC AAGGGGAAGA CATGCTGGTT CTCTGATGAG CTGGGCCGCC TCCTCCAGGA AGCCTCCTCC TTGGAGCTCT 001760
001761 GTAGCCATCG TGGGCTTGCA AGAGTCAAAG GGCCTGGCCC ACAGCGGCGC CCGGCACTGA GCTGGACAGT GTCCTGCCCC 001840
001841 CAAAATTCAT GTCCGCCCAG AACCTCAGAA TGCAACCTTC CCTGGTAGTA GGGCTTTGCA GATGTAATTA AGGATCTGGG 001920
001921 GACGAGGTCA CCCTGGATTG AGGCTGAGTC CCAAGTCAGT CACTGGTGTT CCTCCATGAA GAGCAGAGCA GAATAGAGAC 002000
002001 AGATGCACAG AGCAGGCCCT GTGAGGACAG AGGCAGGGAC TGGAGCGTCG GCCGCAGCAG GGGCGTGGAG CCCCCAGAGC 002080
002081 TGGAAGAGGG AGGGATCCTC CCCAGGGCCT CCGGAAGGAG TGTGCTGCGT GCTGCCCACA CCGTGATTT