TP73-AS1

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Annotated Information

Name

Approved symbol: TP73-AS1

Approved name: TP73 antisense RNA 1

HGNC ID: HGNC:29052

Ensembl ID: ENSG00000227372

Previous names: KIAA0495

Alias symbols: PDAM

Alias names: p53-dependent apoptosis modulator

RefSeq ID: NR_033708

LncBook ID: HSALNT0289273

Chromosome

1p36.32

Characteristics

High lncRNA-TP73-AS1 expression in HCC was correlated with poorer prognosis[1]

TP73-AS1, transcribed from chromosome 1p36[1].

Expression

TP73-AS1 expression was significantly higher in HCC tissues compared to mixed normal tissues[1].

Regulation

Please input regulation information here.

Function

The_correlation_of_TP73-AS1_with_miR-200a,_HMGB1_and_RAGE_in_HCC_tissues[1].

TP73-AS1 and HMGB1 could bind to miR-200a; TP73-AS1 competed with HMGB1 for miR-200a binding. TP73-AS1 inhibited miR-200a to promote HCC cell proliferation through HMGB1/RAGE pathway[1].

Disease

HCC[1]

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Department of Surgery, University of Pittsburgh, Pittsburgh, 15260, USA.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.

Sequence

>gi|297747264|ref|NR_033708.1| Homo sapiens TP73 antisense RNA 1 (TP73-AS1), transcript variant 4, long non-coding RNA

000001 GTTGTTGCGG GATCTCACAG GCTTTAAACC GCGGCGCCGC GGCGCCCGGG TGTGGATCCC TAGATGGGAG CCGGGGATGG 000080
000081 GCCGGGTGCC TGGTGGGTGG CAGTCGGGGC TGACGGCGGC GGCACTTTGC CGCCTCAGGC CCTGGACACC TTCACCCCGC 000160
000161 CGCCTGCCCA GGCGGGCCGG CCCTGCCCGT CCACCGGCCG CCGAGAGTCC CCGGCCTTGG GTCCCCGGGG CCGCTGACTG 000240
000241 GCCTCGGTCA CCTCCCGGGG AAGGCTCCCG CGCCTCCATC TGCCCCCGCA GGAAGGGACC CTCTTCTCGC CCGCGAGGCT 000320
000321 TCTCCGGGTG GGATCGTCCT GGCCCCCAGC CCTAAGGGAT CCGCCCCCTC CGAGCATCCG CCGCCCCTCG GAGACCACTC 000400
000401 CAGCTCGGAC GGACCCACTC CAGCCCCCGC TGCACGCGGA AGCGCTCATC CTCCCCGCCT GCCCCGTTCC CTCCCCCTTC 000480
000481 TCCTGTGGGA CAACCAGGGA CCGCAGCTCC CCGCTCCCCA GGTGTGGGGG CTCCGACACG AACGCCTCTG CTCGCAGGGC 000560
000561 GGTGAGCGCA GATCCCACGG GTCCCTCGGT CGGGGGTCGA GGCTGCTTCC GTTTCCATCC CGGACCCGAC AATGGGCGGG 000640
000641 AAAAAGAAGG CTTTACACGA CTACGCGGCG GAGTTCACCG ACCTGGTGGT GAAGCACCTG ATTGAGCACA GTGACTCTGG 000720
000721 GGACACGTCT GTGGTGGAGA CCCTTTACTG CAGGGCCTGC GAGCTGCCCG TGCGCGTGCG GAGGGACCGC ATCCTGGAAC 000800
000801 ACCTGTCCTC GGGCAGGCAG CACGGCCTGC GGACGCCCAT TCTCATGTAA ATGTCAGTGC CAACGCTGGT GTTTCAGGAG 000880
000881 TCATCCCAGC GGGCTGCGGG CTATTTTAGG ATTCTCTGCC CTGCAAACGT TTCCAAAGTA CGTGGACAGG CCGCCTGATG 000960
000961 ACACTACGTT TACGGGATCT GCTAGTGGCT TGCCTACTTA GGGAGTAAAC CCTGTGAAGT CTCGCAGTTT TGTTAAAGTG 001040
001041 TGCGTGGCCA CCTGAATGCT GCCTTATCAC AAGCCAGATA CATACTGGTC TGTAGGGTAA CTCCCCACTG TTGATCCTCT 001120
001121 GAGATGATTG TGGACTGGGT GCTGTGAGTC CTGCCACTTT GTTTAAGTGA ATGTGTCTTT TGTCCAGCTC AGCCGCCTCG 001200
001201 GATCTCGCTG CCACCAGCCT TACTGCACAC CCGTGCCACC CGCCCTTGCC CCGTCAGCCT CAGCCTCAGC TCATTCTCTC 001280
001281 AGGCAGTCCC AGCATTGGCA CGGTACCTCC TCCCGCTGTG GGCCACACGT CTCTGCTCCC TGTCAACCCT CCTGCCATCA 001360
001361 GCACCACCAC CAGCGACTTG TCTGCCCGGG AGGATGCAAC ACCATCTGCC TCCACCGGCC ACCTTTCAGT GTTTCCTGCT 001440
001441 TTCCAAGTAA AGATACCAGC AGTGCCCTCA GAGCAGACCA GCCAGAGTTT TTCTGAAGCC TCCCACAGGG TGCTCCCCGG 001520
001521 AGGAGGCCCG AGATGCTCTC GTGACTTTGG AGCCGGGGTG GCTGGCCACC TTGGCCTGGG CATCTTTGGG GTGGGCTTCG 001600
001601 GGAGCCCGGC ACTGCTGCAG AGTGTGGTGG ATGAGAACAG CTGCTGCTTG CTGTACGTGG TGGAGGACCA GCTGTGTGAT 001680
001681 GTGGAGCAAG CCTTCAGAGC TGAGCATTTG GGCCAACACC AGAGTGGTTC GGGAACAGGA TGCAGACATT GTCCTCAACG 001760
001761 ACCAGCGGCA CTTTGATCCG GTTTTCCAGT TCTTGCACAA GCAAGTTTGT GTCAGCCACG CCCTGGGGAG GATCCACTGG 001840
001841 ATCACCGCCG TCACTGCCTG TTCCCGGCGG CCTCTCCGGC TTCCCTAAAG AGAGCAGCTT CCCTCGAGAC CAGAAGCCAG 001920
001921 AGCTCACCCT CCCTTGTGTC CAGGTGGGAC TTTCTACAAC GCTGCTGTGC ACGACGTGGA TGCCGTATGC ATGTTGCTGG 002000
002001 GGGAAGCCAC TCCGGACACT GTGTTTTCTC TGGGACATGT CTTCTGCCCA GATATGGCCG CCTTAAAAGA TGCAGATGCT 002080
002081 GTTGTGATCA GCATGAAGTT TCCCTGTGAG GCCGTGGTTA GCGTGGACAT CAGCCAGCAC TGCACAGACA GCTGCGACCA 002160
002161 GGACGTCAGC CAGCACTGCA CAGACAGCTG CGACCAGAGA CTGGAGATGG AGTCTTGCCC TGTCACCCAG GCTGGAGTGC 002240
002241 AATGGTGCGA TCTCGGCTCA CTGCAACCTC CGTCTCCCAG GTTCAAGCGA TTCTTCTGCC TCAGCCTTCT GAGTAGCTGG 002320
002321 GATTACACGC GTGTGCCACC ACGCTCGGCT AATTTTTGTA TTTTTAGTAG AGATGGGATT TCACCATGTT GGCCAGGCTG 002400
002401 GTCTCGAACT ACTGACCTCG TGATCCACCT GCCATGGCCT CCCAAAGTGC TGGGATTACA GGCGTGAGCC ACCATGCTCG 002480
002481 GCCTAAAAAA CAATTTTCTT GAAGAATCCG ATTTTGTGCA TAGTAATGAC ACAGCACCAT TCCTGAGAAA TAGGAAATAT 002560
002561 ATGTGTGTGG TATGAAAAGC CCATATTCTG TTCTTGTCAC CTGAATCTAG GCTTCCTCTT TGGATGTGAA CGCGGGAATG 002640
002641 AACAGTGGCT GTTTTCCACC CAAAGGGGCG TGGAGACCTT TTGGAAACGG GCTTTCTCCT TTCCATTTTG CAGCCGGGGG 002720
002721 CGGGTGGAAA CCTTCCTTCG AAGGGTAGTG CCTTGGGGAG CAGCAGACCT GCTCTGAGTC CAGCTTAGCT TTCCAAAATT 002800
002801 CTGTGTGGAA CTTACTGGAG ATGTTTTTAT ATATTTGAAA ATAATGGCCT GTATTTCTCA CGCTATACTT AAAAAAAATA 002880
002881 ACTAACCTTT TAAACAAAGA TATTCAAACT CACCCTTGTG CTGAAAGCAC TCACATTTCT GTGTTCATTC CTGAAAGGGC 002960
002961 GTTTTAGAGT CCCCGTTTCT ACGTTCTATG TGGCACCCTC TTGCCGAGGG AACATCCAGA ATCCCTCCAC TTCCTGTCTA 003040
003041 GTTTGAGGCC TCAACACCTT CATGATCCAG AGTCCTGCGG CTATGAGGGG GTGGGCCCAC CACCGCCCAG CCCTCCTTGG 003120
003121 TGGACGTGGG GACAGGTAGG AGCCTAGGGA AAGGGGTGGG CGGGCTCTGG TGTGACGGCG TGAGCGCTAG CCAGGAAGAT 003200
003201 GGGGCCAGGG CTTGGCATGG CACCTCACCT GTGGGGGAAC TCGGCGGAGC TTCCTGGCGG CATCTCCCCC TCTTGCCTTG 003280
003281 GTCCTTTCTA TCTTT