NONHSAT130775

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Annotated Information

Name

PTENP1: PTEN Pseudogene 1

Characteristics

Processed pseudogene of PTEN tumour suppressor gene at 9p13.3. ~3.9kb. Predominately polyA- (Johnsson (2013)). PTENP1 "coding sequence" quite similar to PTEN but has lost start codon, while 3'UTR is ~1kb shorter than PTEN. Part of the PTENP1 3'UTR sequence is highly conserved compared to PTEN (~95%) with seed matches to the same miRNAs.

Function

Competing endogenous RNA (ceRNA). PTENP1, through its 3'UTR, acts as a decoy for miRNAs that target PTEN. PTNEP1 functions as a tumour suppressor gene. Overexpression of the PTENP1 3'UTR lead to an increased level of PTEN and cellular growth inhibition, an effect dependent on the presence of mature miRNAs, supporting PTENP1's role as a miRNA decoy. While knockdown of PTENP1 lead to a decrease in PTEN levels and faster cell growth. PTENP1 asRNA beta isoform forms an RNA-RNA interaction with PTENP1 sense and stabilizes it. This interaction promotes the function of PTENP1 sense as a positive regulator of PTEN mRNA levels, potentially by allowing the export of PTENP1 sense to the cytoplasm (Johnsson (2013)). The PTENP1 locus was lost in a subset of colon cancers and a relationship was reported between PTENP1 copy number and PTEN expression level.

Expression

Expressed in a very wide variety of human tissues and in prostate cancer. Good correlation between PTENP1 and PTEN levels. Inhibition of endogenous miRNAs with seed matches to PTEN and PTENP1 leads to an increase in PTENP1 expression, validating it is targeted by miRNAs known to repress PTEN.

Conservation

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Misc

Cells are very sensitive to levels of PTEN, with even subtle changes influencing cancer susceptibility (Alimonti (2010)). A wider role for pseudogenes as miRNA decoys/ sponges has been proposed.

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT130775
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	3932 nt
Genomic location	chr9-:33673502..33677497
Exon number	1
Exons	33673502..33677497
Genome context
Sequence	000001 AGATGAGAGA CAGAGACGGC GGCGGCGGCG GCGGCCCGGC CCGGCCCGGC CTGAAGCCCC TCTCAGCAAC CCGTGAGCAT 000080 000081 CCGCGGGGGC GGCGCCGGCA GCGGCGGCGT TTCTCGCTTC TTCTTCGTCT TTTCTAACTG TGCAGCCTCT TCCTCGGCTT 000160 000161 CTCCTGAAAG GGAAGGTGGA AGCCGTGGGC TTGGGCGGGA GCCGGCTGAG GCGCGGCGGC GGCGGCACCT CCCCCTCCTG 000240 000241 GAGCGGGGGG AGAAGCGGCG GCGGCGGCGC CCCCGGTGGC CCCGGCGGCT GCAGCTCCAG GGAGGGGGTC TGAGTCGCCT 000320 000321 GTCACCATTT CCAGGGCTGG GAACGCCGGA GAGTTGGTCT CTCCCCTTCT ACTGCCTCCA ACACGGCGGC GGCGGCGGCG 000400 000401 GCGGCGGCGG CACATGGAGG GACCCGGGCC GGTTTTAAAC CTCTCGTCCG CCGCCGCCGC ACCCCCCGTG GCCCGGGCTC 000480 000481 CGGAGGCCGC TGGAGGAGGC AGCCGTTCGG AGGATTATTC GTCTTCTCCC CATTCCGCTG CCGCCGCTGC CAGGCCTCTG 000560 000561 GCTGCTGAGG AGAAGCAGGC CCAGTAGCTG CCACCATCCA GCAGCTGCTG CCGCAGCCAT TACCCGGCTG CGGTCCAGAG 000640 000641 CCAAGCAGCG GCTGAGCGAG GGGCATCAGC TACCGCCAAG TCCAGAGCCA TTTCCATCCT GCAGAGCCCC GCCACCAGCA 000720 000721 GCTTCTGCCA TCTCTCTCCT CCTTTTTCTT CAGCCACAGG CTCCCAGACA GGACAGCCAT CATCAAAGAG ATCGTTAGCA 000800 000801 GAAACAAAAG GAGATATCAA GAGGATGGAT TCGACTTAGA CTTGACCTAT ATTTATCTAA ACATTATTGC TATGGGATTT 000880 000881 CCTGCAGAAA GACTTGAAGG CGTATACAGG AACAATATTG ATGATGTAGT AAGGTTTTTG GATTCAAAGC ATAAAAACCA 000960 000961 TTACAAGATA CACAATCTTT GTGCTGAAAG ACATTATGAC ACCGCCAAAT CTAATTACAG AGTTGCGCAA TATCCTTTTG 001040 001041 AAGACCATAA CCCACCACAG CTAGAACTTA TCAAACCCTT TTGTGAAGAT CTTGACCAAT GGCTAAGTGA AGATGACAAT 001120 001121 CATGTTGCAG CAATTCACTG TAAAGCTGGA AAGGGACGAA CTGGTATAAT GATTTATGCA TATTTATTAC ATCGGGGCAA 001200 001201 ATTTTTAAAG GCACAAGAGG CCCTAGATTT CTATGGGGAA GTAAGGACCA GAGACAAAAA GGGAGTAACT ATTCCCAGTC 001280 001281 AGAGGCGCTA TGTGTATTAC TATAGCTACC TGGTAAAGAA TCATGTGGAT TATAGACCAG TGGCACTGTT GTTTCACAAG 001360 001361 ATGATGTTTG AAACTATTCC AATGTTCAGT GGCGGAACTT GCAATCCTCA GTTTGTGGTC TGCCAGCTAA AGGTGAAGAT 001440 001441 GTATTCCTCC AATTCAGGAC CCACACGATG GGAGGACAAG TTCATGTATT TTGAGTTCCC TCAGCCGTTA CCTGTGTGTG 001520 001521 GTGATATCAA AGTAGAGTTC TTCCACAAAC AGAACAAGAT GCTAAAAAAG GACAAAATGT TTCACTTTTG GGTAAATACA 001600 001601 TTCTTCATAC CAGGACCAGA GGAAACCTCA GAAAAAGTAG AAAATGGAAG TCTATGTGAT CAAGAAATTG ATAGCATTTG 001680 001681 CAGTATAGAG CGTGCAGATA ATGACAAGGA GTATCTAGTA CTTACTTTAA CAAAAAATGA TCTTGACAAA GCAAATAAAG 001760 001761 ACAAAGCCAA CCGATACTTT TCTCCAAATT TTAAGGTGAA GCTGTACTTC ACAAAAACAG TAGAGGAGCC GTCAAATCCA 001840 001841 GAGGCTAGCA GTTCAACTTC TGTAACACCA GATGTTAGTG ACAATGAACC TGATCATTAT AGATATTCTG ACACCACTGA 001920 001921 CTCTGATCCA GAGAATGAAC CTTTTGATGA AGATCAGCAT ACACAAATTA CAAAAGTCTG AATTTTTTTT TATCAAGAGG 002000 002001 GATAAAACAC CATGAAAACA AACTTGAATA AACTGAAAAG GGACCTTTTT TTTTAATGGC AATAGGACAT TGTGTCAGAT 002080 002081 TACCAGTTAT AGAAACAATT CTCTTTTCGT GACCAATCTT GTTTTACCCT ATACATCCAC AGGGTTTTGA CACTTGTTGT 002160 002161 CCAGTTGAAA AAAGGTTGTG TAGCTGTGTC ATGTATATAC CTTTTTGTGT CAAAAGGACA TTTAAAATTC AATTAGGATT 002240 002241 AATAAAGATG GCACTTTCCC ATTTTATTCC AGTTTTATAA AAAGTGGAGA CAGACTGGTG TGTATACGTA GGAATTTTTT 002320 002321 CCTTTTGTGT TCTGTCACCA ACTGAAGTGG CTAAAGAGCT TTGTGATATA CTGGTTCACA TCATACCCCT TTGCACTTGT 002400 002401 GGCAACAGAT AAGTTTGCAG TTAGCTAAGA GAAGTTTCTG AAGGGTTTTG CTGCATTCTT GCATGTATTT GGGTTAGGGG 002480 002481 AATGGAGGGA ATGCTCAGAA AGGAAATAAT TTTATGCTGG ACTCTGGACC ATATACCATC TCCAGCTATT TACACACACC 002560 002561 TTTCTTTAGC ATGCTACAGT TATTAATCTG GACATTCGAG GAATTGGCTG CTGTCACTGC TTGTTGTTTT CGCATTTTTT 002640 002641 TAAAAGCATA TTGGTGCTAG AAAAGGCAGC TAAAGGAAGT GAATCTGTAT TGGGGTACAG GAATGAACCT TCTGCAACAT 002720 002721 CTTAAGATCC ACAAATGAAG GGATATAAAA ATAATGTCAT AGATAAGAAA CACAGCAACA ATGACTTAAC CATATAAATG 002800 002801 TGGAGGCTAT CAACAAAGAA TGGGCTTGAA ACATTATAAA AATTGACAAT GATTTGTTAA ATATGTTTTC TTAATTGTAA 002880 002881 CGACTTCTCC ATCTCCTGTG TAATCAAGGC CAGTGCTGAA AGTCAGATGC TATTAGTACC TACATCAGTC AACAACTTAC 002960 002961 ACTTATTTTA CTAGTTTTCA ATCATATACC TGCTGTGAAT GCTTCATGTG CTGCCTGCAA GCTTCTTTTT TCTCATTAAA 003040 003041 TATAAAATAT TTTGTAATGC TAAAAAAAAA AAAAAGAACA TAGAAGACAA ACATCAGAAA TAAACCCATC CACTATGGTT 003120 003121 AACTCATTTT TGAATATGGT GTAAAGTCAG TTTAATGATG AAATAATATT ATTTTCAACA AATAGTACAG AAATTAAACT 003200 003201 ATGCAAAAAT ACTATTAATA ATGATGTTGG ATCATTACCT CACACCATAC CCCCAAATTA ACTCAGAACA TGGCATACAC 003280 003281 CAAATATAAG AGCAAAAACT ATGAAATTTC TAGAAGAAGA CAGAAAAAAA ATTATGACTT TGGCTTAGTT GTTTCTTAGA 003360 003361 AGTAACAGGA AAAGCATAAT TCATAAAAGA TAAATTGAAA AATCGGACGT CATCAAAATA AAAAATGGTT TATCTTCAAA 003440 003441 GTCACCTGTT AAGAAAATGA GAAGACAAAT CATAAAGCAG GGAGAAATTT TTGAAAGTCA TGTATCTGAT AAGGGACAGT 003520 003521 TAAAACTAAA TAAAAACACA AACCATCCAA TTAAAATGAA TAAAGGGTTC GAATAGGTAT GTCATCAGAG ATCATATAGG 003600 003601 AATAACCAAT AAGCAAACAA AAGATGTTCA ATATCATTAG TTATTAGAGA AACAAAATTT AAAAACCACA ATGAGATGAC 003680 003681 ACTACACATT TGCCAGAATG ATGATTATTA AAAAAGACCA AGTATTGGAG AGGATGTGAA AAAACTGGAA CCTCACACAT 003760 003761 TGACGATAGA AATGTAAAAT GAAATAGCCA ATTCAGAAAA CATTTTACAA GTTTTCTTTG TTTTTGTTTT TAATTTATTA 003840 003841 TACCCTTACC CTATGACTCA GTAATTCCAC TTCTAGATAC CTACCAAATA AAATTAAAGT TTATAACTTC ACAAAGAAAA 003920 003921 AAAAAAAAAA AA

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