Difference between revisions of "ENST00000579368.1"

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Please input one-sentence summary here.
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''GACAT2'',gastric cancer associated transcript 2 (non-protein coding),was significantly decreased in gastric cancer tissues and cell lines which may be a biomarker for prognosis.
  
 
==Annotated Information==
 
==Annotated Information==
 
===Transcriptomic Nomeclature===
 
===Transcriptomic Nomeclature===
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Please input transcriptomic nomeclature information here.
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''GACAT2'',gastric cancer associated transcript 2 (HGNC nomenclature)
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HMlincRNA717<ref name="ref1" />
  
 
===Function===
 
===Function===
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GACAT2 was significantly decreased in dysplasia. In addition, It is also a dysregulative molecule underlying gastric precancerous lesions that suggested that it may play crucial roles during cancer occurrence and progression<ref name="ref1" />.
  
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===Regulation===
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===Diseases===
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Gastric cancar<ref name="ref1" />.
  
 
===Expression===
 
===Expression===
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[[File:GACAT2 expression levels in gastric cancer tissues and adjacent normal tissues.gif|right|thumb|400px|'''GACAT2 expression levels in gastric cancer tissues and adjacent normal tissues'''<ref name="ref1" />]]
  
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===Allelic Information and Variation===
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GACAT2 expression was significantly decreased in gastric cancer tissues and cell lines. The downregulation expression of GACAT2 was associated with cancer distal metastasis, venous invasion, and PNI<ref name="ref1" />.
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Please input allelic information and variation information here.
 
  
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===Evolution===
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The sequences of the PCR primers for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and HMlincRNA717 were as follows:
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You can also add sub-section(s) at will.
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{| class='wikitable' stytle="text-align:center"
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|-
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! | Primer
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! | Sense Primer
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! | Antisense Primer
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|-
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| rowspan="1"| GAPDH
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| |5'-ACCCACTCCTCCACCTTTGAC-3'
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| |5'-TGTTGCTGTAGCCAAATTCGTT-3'<ref name="ref1" />
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|-
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| rowspan="1"| GACAT2
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| | 5'-TGGATGCTTACAAAGGACTGG-3'
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| | 5'-CTGCAATTACGGAAAGAGCTG-3'<ref name="ref1" />
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|}
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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Department of Biochemistry and Molecular Biology and Zhejiang Provincial KeyLaboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, 315211, China<ref name="ref1" />.
  
 
==References==
 
==References==
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Please input cited references here.
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<references>
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<ref name="ref1">Shao Y, Chen H, Jiang X, Chen S, Li P, Ye M, et al. Low expression of lncRNA-HMlincRNA717 in human gastric cancer and its clinical significances[J]. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014,35(10):9591-5.</ref>(1)
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</references>
  
 
{{basic|
 
{{basic|
 
tID = ENST00000579368.1|
 
tID = ENST00000579368.1|
 
source = Gencode19|
 
source = Gencode19|
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same = lnc-PPP4R1-7:1,NONHSAT057182|
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same = lnc-PPP4R1-7:1,NONHSAT057182,''GACAT2'',HMlincRNA717|
 
classification = intergenic|
 
classification = intergenic|
 
length = 818 nt|
 
length = 818 nt|
Line 42: Line 57:
 
sequence = <dnaseq>ACAATAAATAAAACAGTTGGTGTCAATACAACTCCCCTTATTTTCTCTCAAGTCACCTGGATCGTCCTGACCCCGGGAACCCCGTCTGCAGCACCAGGCCCCCTCCGTGGAGAAAAGATGGAGCCGGATTAAGCACCCAGTGCTAAGGCGACTAAGACGCCACTGCCCGCAGGCCCTGCCGGAAAATACTCAGAGAGTGCAGCAGGCGCCGCGATTCCTTAGAAAGTGCTGGCGTGGCCTCTCCTGACACAGAAAGCCGGCTCCTGGATGCTTACAAAGGACTGGCCCGCGCAACACCGTTGCTCCTCAACCCGGGCCACACTCCAAGGACCTCTACTGAGCTTCAGCTTGCTCACCGAAAACGGCGCGGCCCCCTCTACCCGGGATGTCGGAGCCCAGGAGACCCTGAGAGCCCCCAGCTCTTTCCGTAATTGCAGGAGAAGGGGCAAGCGGGTCCGTAGCCGGGGGCCCTCCAGTGGCATTATCCTGAACCGCCACGCCCGCACGTGGCCCGGCTAGAGCTCCCTGGCGAAGGATCACCTGTTCCTACAGTGACAACTGGACCTGGCCCGAACCCCTGGCATCTGGCAACATTATTACCTGTCGAAACAGAAGTAGAGATTTGAAATAGAGGATGCCTGTTCCCATTTCCTCCTGCTGTCTGGAAGGAAGTCTGGCTTTCCAGCCCAACTCTAAGCTCATCTTTACATACAAAATAAGGGTATGTTTACATGGAAAGCAAAAATAGAACCATGGATTTACAGAAGGTTCCATAGCAGCAAATAACAGTGCTTATGAAATAAACATTTTAAATATTA</dnaseq>|
 
sequence = <dnaseq>ACAATAAATAAAACAGTTGGTGTCAATACAACTCCCCTTATTTTCTCTCAAGTCACCTGGATCGTCCTGACCCCGGGAACCCCGTCTGCAGCACCAGGCCCCCTCCGTGGAGAAAAGATGGAGCCGGATTAAGCACCCAGTGCTAAGGCGACTAAGACGCCACTGCCCGCAGGCCCTGCCGGAAAATACTCAGAGAGTGCAGCAGGCGCCGCGATTCCTTAGAAAGTGCTGGCGTGGCCTCTCCTGACACAGAAAGCCGGCTCCTGGATGCTTACAAAGGACTGGCCCGCGCAACACCGTTGCTCCTCAACCCGGGCCACACTCCAAGGACCTCTACTGAGCTTCAGCTTGCTCACCGAAAACGGCGCGGCCCCCTCTACCCGGGATGTCGGAGCCCAGGAGACCCTGAGAGCCCCCAGCTCTTTCCGTAATTGCAGGAGAAGGGGCAAGCGGGTCCGTAGCCGGGGGCCCTCCAGTGGCATTATCCTGAACCGCCACGCCCGCACGTGGCCCGGCTAGAGCTCCCTGGCGAAGGATCACCTGTTCCTACAGTGACAACTGGACCTGGCCCGAACCCCTGGCATCTGGCAACATTATTACCTGTCGAAACAGAAGTAGAGATTTGAAATAGAGGATGCCTGTTCCCATTTCCTCCTGCTGTCTGGAAGGAAGTCTGGCTTTCCAGCCCAACTCTAAGCTCATCTTTACATACAAAATAAGGGTATGTTTACATGGAAAGCAAAAATAGAACCATGGATTTACAGAAGGTTCCATAGCAGCAAATAACAGTGCTTATGAAATAAACATTTTAAATATTA</dnaseq>|
 
}}
 
}}
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[[Category:Intergenic]][[Category:lnc-PPP4R1-7]]
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[[Category:Intergenic]][[Category:lnc-PPP4R1-7]][[Category:NONHSAG023313]][[Category:ENSG00000265962.1]][[Category:Transcripts]][[Category:Transcripts]]

Latest revision as of 09:51, 5 April 2015

GACAT2,gastric cancer associated transcript 2 (non-protein coding),was significantly decreased in gastric cancer tissues and cell lines which may be a biomarker for prognosis.

Annotated Information

Transcriptomic Nomeclature

GACAT2,gastric cancer associated transcript 2 (HGNC nomenclature)

HMlincRNA717[1]

Function

GACAT2 was significantly decreased in dysplasia. In addition, It is also a dysregulative molecule underlying gastric precancerous lesions that suggested that it may play crucial roles during cancer occurrence and progression[1].

Diseases

Gastric cancar[1].

Expression

GACAT2 expression levels in gastric cancer tissues and adjacent normal tissues[1]

GACAT2 expression was significantly decreased in gastric cancer tissues and cell lines. The downregulation expression of GACAT2 was associated with cancer distal metastasis, venous invasion, and PNI[1].

The sequences of the PCR primers for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and HMlincRNA717 were as follows:

Primer Sense Primer Antisense Primer
GAPDH 5'-ACCCACTCCTCCACCTTTGAC-3' 5'-TGTTGCTGTAGCCAAATTCGTT-3'[1]
GACAT2 5'-TGGATGCTTACAAAGGACTGG-3' 5'-CTGCAATTACGGAAAGAGCTG-3'[1]

Labs working on this lncRNA

Department of Biochemistry and Molecular Biology and Zhejiang Provincial KeyLaboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, 315211, China[1].

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Shao Y, Chen H, Jiang X, Chen S, Li P, Ye M, et al. Low expression of lncRNA-HMlincRNA717 in human gastric cancer and its clinical significances[J]. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014,35(10):9591-5.

Basic Information

Transcript ID

ENST00000579368.1

Source

Gencode19

Same with

lnc-PPP4R1-7:1,NONHSAT057182,GACAT2,HMlincRNA717

Classification

intergenic

Length

818 nt

Genomic location

chr18-:8695854..8707619

Exon number

2

Exons

8695854..8696119,8707068..8707619

Genome context

Sequence
000001 ACAATAAATA AAACAGTTGG TGTCAATACA ACTCCCCTTA TTTTCTCTCA AGTCACCTGG ATCGTCCTGA CCCCGGGAAC 000080
000081 CCCGTCTGCA GCACCAGGCC CCCTCCGTGG AGAAAAGATG GAGCCGGATT AAGCACCCAG TGCTAAGGCG ACTAAGACGC 000160
000161 CACTGCCCGC AGGCCCTGCC GGAAAATACT CAGAGAGTGC AGCAGGCGCC GCGATTCCTT AGAAAGTGCT GGCGTGGCCT 000240
000241 CTCCTGACAC AGAAAGCCGG CTCCTGGATG CTTACAAAGG ACTGGCCCGC GCAACACCGT TGCTCCTCAA CCCGGGCCAC 000320
000321 ACTCCAAGGA CCTCTACTGA GCTTCAGCTT GCTCACCGAA AACGGCGCGG CCCCCTCTAC CCGGGATGTC GGAGCCCAGG 000400
000401 AGACCCTGAG AGCCCCCAGC TCTTTCCGTA ATTGCAGGAG AAGGGGCAAG CGGGTCCGTA GCCGGGGGCC CTCCAGTGGC 000480
000481 ATTATCCTGA ACCGCCACGC CCGCACGTGG CCCGGCTAGA GCTCCCTGGC GAAGGATCAC CTGTTCCTAC AGTGACAACT 000560
000561 GGACCTGGCC CGAACCCCTG GCATCTGGCA ACATTATTAC CTGTCGAAAC AGAAGTAGAG ATTTGAAATA GAGGATGCCT 000640
000641 GTTCCCATTT CCTCCTGCTG TCTGGAAGGA AGTCTGGCTT TCCAGCCCAA CTCTAAGCTC ATCTTTACAT ACAAAATAAG 000720
000721 GGTATGTTTA CATGGAAAGC AAAAATAGAA CCATGGATTT ACAGAAGGTT CCATAGCAGC AAATAACAGT GCTTATGAAA 000800
000801 TAAACATTTT AAATATTA
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