Difference between revisions of "Lnc-APBA1-3:1"

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Please input one-sentence summary here.
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BANCR, BRAF activated non-coding RNA,a 693-bp transcript on chromosome 9, actively functions as a regulator of EMT during non-small cell lung cancer(NSCLC) metastasis.
  
 
==Annotated Information==
 
==Annotated Information==
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===Transcriptomic Nomeclature===
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===Transcriptomic Nomenclature===
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''BANCTR'':  BRAF-activated non-protein coding RNA (HGNC nomenclature)
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LINC00586<ref name="ref1" />
  
 
===Function===
 
===Function===
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[[File:BANCR overexpression suppresses NSCLC cell invasion and metastasis by affecting EMT.jpg|right|thumb|400px|'''BANCR overexpression suppresses NSCLC cell invasion and metastasis by affecting EMT'''<ref name="ref1" />]]
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BANCR inhibits migration and invasion of NSCLC cells and induces apoptosis, which possibly also affected EMT<ref name="ref1" />.
  
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Downregulation of BANCR may be a negative prognostic factor for NSCLC patients, and indicative of poor survival rates and a higher risk for cancer metastasis<ref name="ref1" />.
 
===Regulation===
 
===Regulation===
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Histone acetylation is a key factor in controlling lncRNA BANCR expression<ref name="ref1" />.
  
 
===Expression===
 
===Expression===
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[[File: ''BANCR'' expression was downregulated and correlated with poor prognosis of NSCLC.jpg|right|thumb|400px|'''''BANCR'' expression was downregulated and correlated with poor prognosis of NSCLC''' <ref name="ref1" />.]]
  
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===Allelic Information and Variation===
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BANCR is overexpressed in melanoma cells and crucial for melanoma cell migration. Specifically, BANCR expression was significantly lower at the later stages of tumor development, and in tumors that had undergone extensive metastasis<ref name="ref1" />.  
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Please input allelic information and variation information here.
 
  
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===Evolution===
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{| class='wikitable' style="text-align:center"
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|-
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! | Primer
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! | Sequence(5'-3')
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|-
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| rowspan="1"|BANCR F
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| | ACAGGACTCCATGGCAAACG<ref name="ref1" />
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|-
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| rowspan="1"|BANCR R
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| | ATGAAGAAAGCCTGGTGCAGT<ref name="ref1" />
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|-
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| rowspan="1"|si-BANCR
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| | GGAAAUAGACUGCAGCACCAATT<ref name="ref1" />
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|}
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===Diseases===
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* Non-small cell lung cancer(NSCLC)<ref name="ref1" />
  
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==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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* Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People's Republic of China.  <ref name="ref1" />.
  
 
==References==
 
==References==
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Please input cited references here.
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<references>
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<ref name="ref1"> Sun M, Liu XH, Wang KM, Nie FQ, Kong R, Yang JS, et al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition[J]. Molecular cancer. 2014,13:68.
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</ref>(1)
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</references>
  
 
{{basic|
 
{{basic|
 
tID = lnc-APBA1-3:1|
 
tID = lnc-APBA1-3:1|
 
source = LNCipedia2.1|
 
source = LNCipedia2.1|
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same = NONHSAT131775|
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same = NONHSAT131775,BANCR,LINC00586|
 
classification = intergenic|
 
classification = intergenic|
 
length = 722 nt|
 
length = 722 nt|

Revision as of 03:39, 9 April 2015

BANCR, BRAF activated non-coding RNA,a 693-bp transcript on chromosome 9, actively functions as a regulator of EMT during non-small cell lung cancer(NSCLC) metastasis.

Annotated Information

Transcriptomic Nomenclature

BANCTR: BRAF-activated non-protein coding RNA (HGNC nomenclature) LINC00586[1]

Function

BANCR overexpression suppresses NSCLC cell invasion and metastasis by affecting EMT[1]

BANCR inhibits migration and invasion of NSCLC cells and induces apoptosis, which possibly also affected EMT[1].

Downregulation of BANCR may be a negative prognostic factor for NSCLC patients, and indicative of poor survival rates and a higher risk for cancer metastasis[1].

Regulation

Histone acetylation is a key factor in controlling lncRNA BANCR expression[1].

Expression

BANCR expression was downregulated and correlated with poor prognosis of NSCLC [1].

BANCR is overexpressed in melanoma cells and crucial for melanoma cell migration. Specifically, BANCR expression was significantly lower at the later stages of tumor development, and in tumors that had undergone extensive metastasis[1].

Primer Sequence(5'-3')
BANCR F ACAGGACTCCATGGCAAACG[1]
BANCR R ATGAAGAAAGCCTGGTGCAGT[1]
si-BANCR GGAAAUAGACUGCAGCACCAATT[1]

Diseases

  • Non-small cell lung cancer(NSCLC)[1]


Labs working on this lncRNA

  • Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing 210029, People's Republic of China. [1].

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Sun M, Liu XH, Wang KM, Nie FQ, Kong R, Yang JS, et al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition[J]. Molecular cancer. 2014,13:68.

Basic Information

Transcript ID

lnc-APBA1-3:1

Source

LNCipedia2.1

Same with

NONHSAT131775,BANCR,LINC00586

Classification

intergenic

Length

722 nt

Genomic location

chr9-:71911594..71922016

Exon number

4

Exons

71911594..71911783,71919852..71919993,71921064..71921206,71921770..71922016

Genome context

Sequence
000001 GAACAGCCCA TGCTGCTGCT CTGCCTATGG AGTAGCCATT CTTTATTCCC TTACTTTCTT AATAAACTCG CTTTCACTTT 000080
000081 ATGGATTCAA CTGTAATTCT TTCTTGTGTG AGATCCAAGA ACCTTCTTGT AGGGTCTGGA TTGGGACCCT TTTCTGGTAA 000160
000161 CATCTTCCTG GTGACCATGA AGGGACAATA CTGAAGAGAC CCCTGACCCT AAGGAAATAG ACTGCAGCAC CAATGGGCCA 000240
000241 ACTTTGGGGC GATCATCTTG CCCAGAAACA TCATGTTGAA ACTCTTGGTC AGAGGTTGGA TGAAAGCTGA CAGGGTCCAT 000320
000321 CCAGGAGCAA GTTTGAGCCT TGCCAGTTCC ATTTTGGGTG CTGAGTGGAG TGGCGACTAT AGCAAACCTG TGATCTCTGG 000400
000401 CTGCTGCTCA GAAGAAACAA GAGGGAGGGA TGAATAATGT AAAACTCTGG ATCAATATTC TAATTCTGAG CCTCTATTGG 000480
000481 AATCAGCTAG CAACCACATA TCAGCTTGGT TTCAACAGTT TCCCAGTTCA TGCTGCTGAG AAGTTCAGAG TCAAACCTGA 000560
000561 ATCTCACCTC TGCAAAGAGC ACAGGACTCC ATGGCAAACG TTGTATATAC GCAAGTCATC CCTGGCACCA CATTGATTTA 000640
000641 CTGCACCAGG CTTTCTTCAT TGTGATGATG TTCTCTCTCT TTTCTAAAAA AAAAATAAAA ATAAAATTTA AAAAATCCTG 000720
000721 TT
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