NONHSAT076153

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Annotated Information

Name

PCGEM1: Prostate-specific transcript 1

Characteristics

1603 nt, 3 exons.

Function

Over-expression leads to inhibition of apoptosis induced by doxorubicin (Fu 2006).

Expression

Prostate tissue-specific and prostate cancer-associated (Srikantan 2000). Cholesterols upregulate the expression of PCGEM1 even in androgen-insensitive prostate cancer cell lines while phytosterols reverse this effect (Ifere 2009). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation (Petrovics 2004). Low specificity as a biomarker for prostate cancer (14%) (Bialkowska-Hobrzanska 2006).

Conservation

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Misc

GWAS association with schizophrenia. PCGEM1 polymorphisms may contribute to PCa risk in Chinese men (Xue 2013)

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	NONHSAT076153
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1603 nt
Genomic location	chr2+:193614571..193641625
Exon number	3
Exons	193614571..193614754,193615515..193615598,193640304..193641625
Genome context
Sequence	000001 aaggcactct ggcacccagt tttggaactg cagttttaaa agtcataaat tgaatgaaaa tgatagcaaa ggtggaggtt 000080 000081 tttaaagagc tatttatagg tccctggaca gcatcttttt tcaattaggc agcaaccttt ttgccctatg ccgtaacctg 000160 000161 tgtctgcaac ttcctctaat tgggaaatag ttaagcagat tcatagagct gaatgataaa attgtactac gagatgcact 000240 000241 gggactcaac gtgaccttat caagtgagca ggcttggtgc atttgacact tcatgatatc agccaaagtg gaactaaaaa 000320 000321 cagctcctgg aagaggacta tgacatcatc aggttgggag tctccaggga cagcggaccc tttggaaaag gactagaaag 000400 000401 tgtgaaatct attagtcttc gatatgaaat tctctgtctc tgtaaaagca tttcatattt acaagacaca ggcctactcc 000480 000481 tagggcagca aaaagtggca acaggcaagc agagggaaaa gagatcatga ggcatttcag agtgcactgt cttttcatat 000560 000561 atttctcaat gccgtatgtt tggttttatt ttggccaagc ataacaatct gctcaagaaa aaaaaatctg gagaaaacaa 000640 000641 aggtgccttt gccaatgtta tgtttctttt tgacaagccc tgagatttct gaggggaatt cacataaatg ggatcaggtc 000720 000721 attcatttac gttgtgtgca aatatgattt aaagatacaa cctttgcaga gagcatgctt tcctaagggt aggcacgtgg 000800 000801 aggactaagg gtaaagcatt cttcaagatc agttaatcaa gaaaggtgct ctttgcattc tgaaatgccc ttgttgcaaa 000880 000881 tattggttat attgattaaa tttacactta atggaaacaa cctttaactt acagatgaac aaacccacaa aagcaaaaaa 000960 000961 tcaaaagccc tacctatgat ttcatatttt ctgtgtaact ggattaaagg attcctgctt gcttttgggc ataaatgata 001040 001041 atggaatatt tccaggtatt gtttaaaatg agggcccatc tacaaattct tagcaatact ttggataatt ctaaaattca 001120 001121 gctggacatt gtctaattgt tttttatata catctttgct agaatttcaa attttaagta tgtgaattta gttaattagc 001200 001201 tgtgctgatc aattcaaaaa cattactttc ctaaatttta gactatgaag gtcataaatt caacaaatat atctacacat 001280 001281 acaattatag attgtttttc attataatgt cttcatctta acagaattgt ctttgtgatt gtttttagaa aactgagagt 001360 001361 tttaattcat aattacttga tcaaaaaatt gtgggaacaa tccagcatta attgtatgtg attgttttta tgtacataag 001440 001441 gagtcttaag cttggtgcct tgaagtcttt tgtacttagt cccatgttta aaattactac tttatatcta aagcatttat 001520 001521 gtttttcaat tcaatttaca tgatgctaat tatggcaatt ataacaaata ttaaagattt cgaaatagaa aaaaaaaaaa 001600 001601 aaa

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