Difference between revisions of "NONHSAT023851"

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==Annotated Information==
 
==Annotated Information==
 +
===Name===
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PR antisense transcripts
 +
 +
===Characteristics===
 +
Found several antisense transcripts which initiate in the progesterone receptor (PR) promoter region. AT1 and AT3 were unspliced. AT2-T47D and AT2-MCF7 were spliced with seven exons and transcribed over a 70kb region. AT2 isoforms initiated between the PR A and B start sites, had different (cell line specific) start sites but were otherwise identical. AT2-T47D ~1.35kb. AT2-MCF7 ~1.5kb.
 +
 +
===Expression===
 +
Expression identified in human breast cancer cell lines (MCF7 and T47D). AT2 isoforms were the most highly expressed antisense transcripts. AT2 isoforms could be detected in the nucleus.
 +
 +
===Function===
 +
All function characterisation was on the AT2 isoforms. PR antisense transcripts act as a scaffold for other RNAs and proteins to bind, allowing them to regulate transcription of the progesterone receptor. Different small RNAs targeted at PR antisense transcripts can activate or repress PR transcription. A PR antisense transcript was necessary for activating PR transcription via a small RNA. PR antisense transcripts could associate with small RNAs, Argonaute proteins and hnRNP-k to bring about regulation of the PR protein coding gene.
 +
 
===Transcriptomic Nomeclature===
 
===Transcriptomic Nomeclature===
 
Please input transcriptomic nomeclature information here.
 
Please input transcriptomic nomeclature information here.
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===Function===
 
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Please input function information here.
 
  
 
===Regulation===
 
===Regulation===
 
Please input regulation information here.
 
Please input regulation information here.
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===Expression===
 
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===Allelic Information and Variation===
 
===Allelic Information and Variation===
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==References==
 
==References==
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Please input cited references here.
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[http://www.lncrnadb.org/prantisensetranscripts/ Annotation originally sourced from lncRNAdb.]
  
 
{{basic|
 
{{basic|
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sequence = <dnaseq>TGGACTCCCCTTTTCTCCTCCCCCGTCTCCAGGAGGAGGGAAAAGGGAAGGAGGAGGGGGTTTCGGGAATATAGGGGCAGAGGGAGGAGAAAGTGGGTGTTGAATGTGGCTGGACCGGAGGGATCTCCACCTCCTGGGTCGGGGGCGGGGGAGGGCGGCGCTGGTCAGCTCCTGCCCTTGGCCTCCATCCTGTCGTCAGGGGAACTGTGGCTGTCGTTTGTCCCAGCGAGCGGCAAGTGGGGAGCGCAAGAAAAAGTAGTAATTGTTAGGAGATCTCGTCTCCTAACTCGGGGAGTTCTCCAAGAGAGTTCTCCAACTTCTGTCCGAGGACTGGAGACGCAGAGTACTCACAAGTCCGGCACTTGAGTGGCTGCGGCTGCGACGGCAATTTAGTGACACGCGGCTCCTTTATCTCCCGACTTTTTCTCTGGCATCAAACTCGTGCATGCTGTGAAGCTCTCAGTCCCTCGCTGAGTTCCACTGCCCCCTCACTAAAACCCTGGGGCTAGTCGGACCTCTCGGTACAGCCCATTCCCAGGAAGGGTCGGACTTCTGCTGGCTCCGTACTGCGGGCGACAGTCATCTCCGAAGATCTCAGATCCCAGTAGTGCGGGAGCACTAGCCGCCTCGGGTTGTAGATTTCACTCAAATGACAAGTGAAGCTAGTTCTCATTGAGAATGCCACCCACACGCACAAATACAACAAGGCTTACCCCGATTAGGACAGTGTGGACTCCAGACAGTTTTAACAAGCCTCCTCTCTAGGGGCCCGCCCAAAGCCCCTCCCTACCCCAATTACCGGACCTCAAGGTCTAGCTGTGCTAATGACTCATAGTTTATTCACCATGTATAAAGAATGCAGAAGACTCCAGAAGGTGGGGGAGCCACTAGAGGATTCCATCCAGGACACCACATTTAATTGTTATGATGTCTTGTGCTCCTCTTGGCTGTGAGAGTTTCTCAGATTTTCCTTGTATTTGATGACCTTGACAGTCCTTAGGAGTACTGAGATGGGGGTTTCACGATATTGCCCAGGCTGGTCCCAAACTCCTGGCCTCAAGCTATCCTCCTGCCTTGACGTTCGAAAGCACTAGATTTTCCTTCTGTCCTGCCGCCATGTGAAGAAAATGTGTTTGCTTCCCCTTCCCCGTGATTGTATTTTCCTGCAGCCTCCCCAGCCAAGCTGAACTGCAATGAGGAAGCAATAAAGGACTTGAGCAAGAGAACGATGTATATAGGCCATTGTTTTGGAAGATTCATCCAAATTCATGTGCAAGTAGATTGGAGGAAGGAAGTATCAACAAAAAAAGGCCAATTATGAGACCATTGCAATACTATATGATGAGAGCATCAGAGCAATAACCAAGGTTTATAGATACCAAGTGAGGAATCTGGGATTAAAGTCAGTTATTTCATTGGAAAGGCTGTTTTCAGTTTTTTCACTGGAAAAGTTGTCATCCTGTGTCTTTTTATAGTACATATATTCAGTAATAAAACTTTATTTTCCTTTTCAAAAAAAAAAAAAAAAAAAA</dnaseq>|
 
sequence = <dnaseq>TGGACTCCCCTTTTCTCCTCCCCCGTCTCCAGGAGGAGGGAAAAGGGAAGGAGGAGGGGGTTTCGGGAATATAGGGGCAGAGGGAGGAGAAAGTGGGTGTTGAATGTGGCTGGACCGGAGGGATCTCCACCTCCTGGGTCGGGGGCGGGGGAGGGCGGCGCTGGTCAGCTCCTGCCCTTGGCCTCCATCCTGTCGTCAGGGGAACTGTGGCTGTCGTTTGTCCCAGCGAGCGGCAAGTGGGGAGCGCAAGAAAAAGTAGTAATTGTTAGGAGATCTCGTCTCCTAACTCGGGGAGTTCTCCAAGAGAGTTCTCCAACTTCTGTCCGAGGACTGGAGACGCAGAGTACTCACAAGTCCGGCACTTGAGTGGCTGCGGCTGCGACGGCAATTTAGTGACACGCGGCTCCTTTATCTCCCGACTTTTTCTCTGGCATCAAACTCGTGCATGCTGTGAAGCTCTCAGTCCCTCGCTGAGTTCCACTGCCCCCTCACTAAAACCCTGGGGCTAGTCGGACCTCTCGGTACAGCCCATTCCCAGGAAGGGTCGGACTTCTGCTGGCTCCGTACTGCGGGCGACAGTCATCTCCGAAGATCTCAGATCCCAGTAGTGCGGGAGCACTAGCCGCCTCGGGTTGTAGATTTCACTCAAATGACAAGTGAAGCTAGTTCTCATTGAGAATGCCACCCACACGCACAAATACAACAAGGCTTACCCCGATTAGGACAGTGTGGACTCCAGACAGTTTTAACAAGCCTCCTCTCTAGGGGCCCGCCCAAAGCCCCTCCCTACCCCAATTACCGGACCTCAAGGTCTAGCTGTGCTAATGACTCATAGTTTATTCACCATGTATAAAGAATGCAGAAGACTCCAGAAGGTGGGGGAGCCACTAGAGGATTCCATCCAGGACACCACATTTAATTGTTATGATGTCTTGTGCTCCTCTTGGCTGTGAGAGTTTCTCAGATTTTCCTTGTATTTGATGACCTTGACAGTCCTTAGGAGTACTGAGATGGGGGTTTCACGATATTGCCCAGGCTGGTCCCAAACTCCTGGCCTCAAGCTATCCTCCTGCCTTGACGTTCGAAAGCACTAGATTTTCCTTCTGTCCTGCCGCCATGTGAAGAAAATGTGTTTGCTTCCCCTTCCCCGTGATTGTATTTTCCTGCAGCCTCCCCAGCCAAGCTGAACTGCAATGAGGAAGCAATAAAGGACTTGAGCAAGAGAACGATGTATATAGGCCATTGTTTTGGAAGATTCATCCAAATTCATGTGCAAGTAGATTGGAGGAAGGAAGTATCAACAAAAAAAGGCCAATTATGAGACCATTGCAATACTATATGATGAGAGCATCAGAGCAATAACCAAGGTTTATAGATACCAAGTGAGGAATCTGGGATTAAAGTCAGTTATTTCATTGGAAAGGCTGTTTTCAGTTTTTTCACTGGAAAAGTTGTCATCCTGTGTCTTTTTATAGTACATATATTCAGTAATAAAACTTTATTTTCCTTTTCAAAAAAAAAAAAAAAAAAAA</dnaseq>|
 
}}
 
}}
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[[Category:Antisense]]
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[[Category:Antisense]][[Category:NONHSAG009456]][[Category:Transcripts]]
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{{lncrnadb|
 
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tID = NONHSAT023851|
 
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ltID = PR antisense transcripts|
 
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ann = <tab class=wikitable sep=tab head=top>
 
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Section Description
 
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ID PR antisense transcripts
 
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Characteristics Found several antisense transcripts which initiate in the progesterone receptor (PR) promoter region. AT1 and AT3 were unspliced. AT2-T47D and AT2-MCF7 were spliced with seven exons and transcribed over a 70kb region. AT2 isoforms initiated between the PR A and B start sites, had different (cell line specific) start sites but were otherwise identical. AT2-T47D ~1.35kb. AT2-MCF7 ~1.5kb.
 
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Expression Expression identified in human breast cancer cell lines (MCF7 and T47D). AT2 isoforms were the most highly expressed antisense transcripts. AT2 isoforms could be detected in the nucleus.
 
−
Function All function characterisation was on the AT2 isoforms. PR antisense transcripts act as a scaffold for other RNAs and proteins to bind, allowing them to regulate transcription of the progesterone receptor. Different small RNAs targeted at PR antisense transcripts can activate or repress PR transcription. A PR antisense transcript was necessary for activating PR transcription via a small RNA. PR antisense transcripts could associate with small RNAs, Argonaute proteins and hnRNP-k to bring about regulation of the PR protein coding gene.
 
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Misc Accessions:. AT-1: FJ515871. AT-2-MCF7: FJ515872. AT-2-T47D: FJ515873. 
 
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Name Progesterone receptor promoter antisense transcripts
 
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</tab>|
 
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}}
 

Latest revision as of 06:07, 26 August 2015

Please input one-sentence summary here.

Annotated Information

Name

PR antisense transcripts

Characteristics

Found several antisense transcripts which initiate in the progesterone receptor (PR) promoter region. AT1 and AT3 were unspliced. AT2-T47D and AT2-MCF7 were spliced with seven exons and transcribed over a 70kb region. AT2 isoforms initiated between the PR A and B start sites, had different (cell line specific) start sites but were otherwise identical. AT2-T47D ~1.35kb. AT2-MCF7 ~1.5kb.

Expression

Expression identified in human breast cancer cell lines (MCF7 and T47D). AT2 isoforms were the most highly expressed antisense transcripts. AT2 isoforms could be detected in the nucleus.

Function

All function characterisation was on the AT2 isoforms. PR antisense transcripts act as a scaffold for other RNAs and proteins to bind, allowing them to regulate transcription of the progesterone receptor. Different small RNAs targeted at PR antisense transcripts can activate or repress PR transcription. A PR antisense transcript was necessary for activating PR transcription via a small RNA. PR antisense transcripts could associate with small RNAs, Argonaute proteins and hnRNP-k to bring about regulation of the PR protein coding gene.

Transcriptomic Nomeclature

Please input transcriptomic nomeclature information here.

Regulation

Please input regulation information here.

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID

NONHSAT023851

Source

NONCODE4.0

Same with

,

Classification

antisense

Length

1532 nt

Genomic location

chr11+:100999808..101069641

Exon number

7

Exons

100999808..101000619,101001420..101001513,101003742..101003856,101018874..101018963,101029890..101029986,101066216..101066370,101069460..101069641

Genome context

Sequence
000001 TGGACTCCCC TTTTCTCCTC CCCCGTCTCC AGGAGGAGGG AAAAGGGAAG GAGGAGGGGG TTTCGGGAAT ATAGGGGCAG 000080
000081 AGGGAGGAGA AAGTGGGTGT TGAATGTGGC TGGACCGGAG GGATCTCCAC CTCCTGGGTC GGGGGCGGGG GAGGGCGGCG 000160
000161 CTGGTCAGCT CCTGCCCTTG GCCTCCATCC TGTCGTCAGG GGAACTGTGG CTGTCGTTTG TCCCAGCGAG CGGCAAGTGG 000240
000241 GGAGCGCAAG AAAAAGTAGT AATTGTTAGG AGATCTCGTC TCCTAACTCG GGGAGTTCTC CAAGAGAGTT CTCCAACTTC 000320
000321 TGTCCGAGGA CTGGAGACGC AGAGTACTCA CAAGTCCGGC ACTTGAGTGG CTGCGGCTGC GACGGCAATT TAGTGACACG 000400
000401 CGGCTCCTTT ATCTCCCGAC TTTTTCTCTG GCATCAAACT CGTGCATGCT GTGAAGCTCT CAGTCCCTCG CTGAGTTCCA 000480
000481 CTGCCCCCTC ACTAAAACCC TGGGGCTAGT CGGACCTCTC GGTACAGCCC ATTCCCAGGA AGGGTCGGAC TTCTGCTGGC 000560
000561 TCCGTACTGC GGGCGACAGT CATCTCCGAA GATCTCAGAT CCCAGTAGTG CGGGAGCACT AGCCGCCTCG GGTTGTAGAT 000640
000641 TTCACTCAAA TGACAAGTGA AGCTAGTTCT CATTGAGAAT GCCACCCACA CGCACAAATA CAACAAGGCT TACCCCGATT 000720
000721 AGGACAGTGT GGACTCCAGA CAGTTTTAAC AAGCCTCCTC TCTAGGGGCC CGCCCAAAGC CCCTCCCTAC CCCAATTACC 000800
000801 GGACCTCAAG GTCTAGCTGT GCTAATGACT CATAGTTTAT TCACCATGTA TAAAGAATGC AGAAGACTCC AGAAGGTGGG 000880
000881 GGAGCCACTA GAGGATTCCA TCCAGGACAC CACATTTAAT TGTTATGATG TCTTGTGCTC CTCTTGGCTG TGAGAGTTTC 000960
000961 TCAGATTTTC CTTGTATTTG ATGACCTTGA CAGTCCTTAG GAGTACTGAG ATGGGGGTTT CACGATATTG CCCAGGCTGG 001040
001041 TCCCAAACTC CTGGCCTCAA GCTATCCTCC TGCCTTGACG TTCGAAAGCA CTAGATTTTC CTTCTGTCCT GCCGCCATGT 001120
001121 GAAGAAAATG TGTTTGCTTC CCCTTCCCCG TGATTGTATT TTCCTGCAGC CTCCCCAGCC AAGCTGAACT GCAATGAGGA 001200
001201 AGCAATAAAG GACTTGAGCA AGAGAACGAT GTATATAGGC CATTGTTTTG GAAGATTCAT CCAAATTCAT GTGCAAGTAG 001280
001281 ATTGGAGGAA GGAAGTATCA ACAAAAAAAG GCCAATTATG AGACCATTGC AATACTATAT GATGAGAGCA TCAGAGCAAT 001360
001361 AACCAAGGTT TATAGATACC AAGTGAGGAA TCTGGGATTA AAGTCAGTTA TTTCATTGGA AAGGCTGTTT TCAGTTTTTT 001440
001441 CACTGGAAAA GTTGTCATCC TGTGTCTTTT TATAGTACAT ATATTCAGTA ATAAAACTTT ATTTTCCTTT TCAAAAAAAA 001520
001521 AAAAAAAAAA AA
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