NONHSAT018635

PAUPAR, a vertebrate-conserved and central nervous system-expressed lncRNA transcribed from a locus upstream of the gene encoding the PAX6 transcription factor, acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein.

Annotated Information

Name

PAUPAR:PAX6 upstream antisense RNA（HGNC nomenclature)

Function

Paupar acts in a transcript-dependent manner both locally, to regulate Pax6, as well as distally by binding and regulating genes on multiple chromosomes, in part through physical association with PAX6 protein.

Paupar binding sites are enriched near promoters and can function as transcriptional regulatory elements whose activity is modulated by Paupar transcript levels.

Paupar can function in trans at transcriptional regulatory elements distinct from its site of synthesis to control large-scale transcriptional programmes.

Expression

qPCR Primers are as follows,

qPCR Primers	Forward	Reverse
Paupar	accatcacccctgcaatagttc	agcagcctttgagccatctc
Pax6	caccgccctcaccaacac	tgcataggcaggttgtttgc
GAPDH	tgtgtccgtcgtggatctga	cctgcttcaccaccttcttga
Idh1	agaaaatgtggaagagccctaacg	tgccagctcgatctaccacaaaat
TBP	tcagttctggaaaaatggtgtg	tgctgctagtctggattgttct
Pax6OS1	gctgagatctgtggctgaaagg	agtccccaggcttgtctaagg
Malat1	cgtttgaaggcatgagttg	tgcctcccaagtgctaggat
Tubb3	gcgcatcagcgtatactacaa	ttccaagtccaccagaatgg

Evolutionary

Conservation and expression of Paupar.

Paupar transcripts are known from dog, as well as from more distantly related vertebrates, frog and zebrafish. Paupar is unusual in exhibiting higher degrees of sequence and transcriptional conservation than most lncRNA loci

Labs working on this lncRNA

• MRC Functional Genomics Unit, University of Oxford, Oxford UK.

Basic Information

Transcript ID	NONHSAT018635
Source	NONCODE4.0
Same with	PAUPAR,
Classification	antisense
Length	17909 nt
Genomic location	chr11+:31840694..31858602
Exon number	1
Exons	31840694..31858602
Genome context
Sequence	000001 TGCGCGCCTT GATCCGGGCG GCGGCTAAGG GAGAGCCGAG CACAGATGGC GCCGAGGCGG AGGTCTAGTG ATTCCCGCTC 000080 000081 CCGCCCCTGG CACACCTGGA CAGGTGCCGG GCCTCGCAAC CGGCCAGGAG GCAGCTCCAG GCAGCCCGTC TGCCCACTCC 000160 000161 TCTTAGCCCG GACAGCTCCT AGCTGGACTT GATTTTTTGT CTTGCTCAGC CCGTCGAGGA CTGGAGGGCA GAgtaggggt 000240 000241 gggagtgggg gtaggggtag aggtgggggt ggcggtgaag gtggggAGGA GAATGGGAGC TTTGGCTGAG AAGTTTCCGC 000320 000321 AGGATGTTCT TACTTATTTA CAAACATTCT CCAAACTTTC TTTCTTCTTC CTAACGCCCT GGGCATCCTG TGTTAAGGCC 000400 000401 TAGGAGCGCC CACCTCCCAC TGGCCACTCT AGTCTGGGCC TAGACCTTAC CATGGTCCTG TCGCCCTGCT CGGCTGGGAA 000480 000481 GGGATGCTAA GAGAGGCATT TGTTCTGGTT TCCCTGTCGC CGTCGGCCAT CTCCAGTGAC CTAGTTTCTT GGTAAGCCCC 000560 000561 TAGCTCCCCT CCAGGACCTG GCCCAGCCTC CAGCCTCAGA TGTCCTGAGG TCTCCCAGAC TCCGCCGTCC GCCTTGGCGT 000640 000641 GTGGGCTGCG GATAGGCCTC GGACCTGTGT AGGCCTTCCT AGCTGGCCAG TTTCTGTCCG GGTCTCGCTC CCCACACTGT 000720 000721 ACCAACCCTA GGCCGCCGAG AGGGCTGTTA TGGGCTTGTT TGGAGTCCAG GCCATTAAGT GTGCGCAAAT CCCTGCAACC 000800 000801 CAGCAGGGTG CTCGAGAGCG ACTCTGGAAA CGCCACGGCC CCCGCCTGCT TATCTGCCTG TCAATAAAGG GCGCGTTCGG 000880 000881 GCTGCGCGGG AGCGCCGGTG GTGCAGGCGA GGCCCGAACT AGGCCCTTCC GAGCTCCGGG CCAACGCACG AGCCGCTCTC 000960 000961 CATTTGTCCC GGGCAAGGAG GCTGGGAGGG AGGGAGCCGG CTCTGGGGTC GCCGAGGGAG AAGGTGCGGG TTTAGCCGCT 001040 001041 GCCTCAGCTG GATTCTTGGA GAAGCGCTCG ACCTCGGAGC ACTCTGGAGA CCCTACCAGA AATCTAGTGC TGGGGGCTCC 001120 001121 TCTCCGCGCC TGCCACCAGC CTTGGAGGAA GCTGGGCAGG GCCCCGTGTG GTGCCCAGCC TACGAGGTCC CACCTCGCCT 001200 001201 CTCCCTGGCA GAGGCATCCT CTCTAGGCCA CACTGGCTCG CATTGCGGGA AGAAGGGCAC CGCGGGCGGC CCGGGGGCAT 001280 001281 CATCGACGAC TCGTAGAGCC CCAAATGCCG AGTGCTACCT GAGGCAGGCT GTAGCTGGGG TGAAAAGGAC CGGAAGCGGG 001360 001361 AAAGAAACCT CTTTTCTTTC AGGCCTCCCT TCAGCCCGGG GTAGCACAGA CTGCAAATTT CCGACACCTA GGGCAGCTCC 001440 001441 AGGCTCTGAT TCTCCACCGC ACAGTGAGCG AGCTCGGCAG CCGCCCAGTC TGCGTAGGCT CCCAGGCCAG CCCCGGCCCC 001520 001521 AGAGCTTCCC CATCAGCCAG CAGAGGCTGG GTGGAGAGCC TGGATGGGCG TGAGAGGCCT TGAAGTAGGG GAAGTAGTGG 001600 001601 AGAGAGAGAA AGATAGAGAA ATCGGCTCTT GGCTTGAACT GTTGTTCTTG TCGAAGGTAT GTTTTCCCCT CCCGGCCTCT 001680 001681 GTCGCTTTTC CTCTCTCCCC TTAACTACTT TATGCAAATA AAGCCGCTTC CAGACTGGAG GAGCCCCTAC CGCTGGATCT 001760 001761 GTGCTACCAG GTGGGTGGGA ATTGATTTAG TATTTGCCTT TTTATTGAGA ATAGGCACTG AGTCTCCCAC CAATTATAAA 001840 001841 ATAAAAATGG ATTTTCCTCT TAAAATTTAA TTTTACTCAA TCTGGAAGAT AATGCATCCT GTTAATTTCT ACAATATTTT 001920 001921 TAAAAAAGGA TTCCAGGGTG AGCGCTAACT TATAAAATGG TTTAATAAAG CTTTTCCATA TACAAATTAA TAGGAGAGGA 002000 002001 AAAAGCCCCT AAATAATTGA TTTAAAATAC TGTGTATTAT TTGAGTGTCA TTTCAAATAG CTGTACAAGC CAGTAATCAA 002080 002081 TATATCATCT AAGGAATCTA ATTTACTGGG CAGTACGTGT GGCTCTTGCT CTTCCTTCCC TCTCCACTTC CTCCCCTTTA 002160 002161 AACAGAAAAC TTGTTTTAAC AAGATTTTTA TTTTAAATCA AAATTGAAGG AAAGTTTTGT GAATTCGAGC GTCAAAAAGG 002240 002241 GGACTATTTA GCAAAGATAA TATTTGCCAT CTCTTCACCC CGGTCTCAAG GATTGCATAA TGGCATGATT ATGTGCAATT 002320 002321 CTGTGTTTTC TCTGCTATTA ATTTATTTTC CTGCTCTCAT TTAAATAACT ACTTTACTTT TTTCTCTCTT CTATTTTGCC 002400 002401 ACACCATAAA AAGTTTTCCC GGACCTCTGT GGAAAATCTC CAATCCTTCC AGTTAGCTTT GTCacaaaca aacaaacaaa 002480 002481 caaaaaacaa acaaacaaac aaaacaaaac aaaaaacTCT ACAACAATCA ATTTGAGAAA ACTCTGCTTT TTCTTTCCTT 002560 002561 TTAAACATTT TCATATTAAG TCAGTTTGTG GCACCATGTT TGATTTCTTT CTCTCCCTTG TCCGGGTAGA GATGGAGACA 002640 002641 TTAGCTGAAT TCCCTGGGGG TGATTGGATG CAATTCACTG AAAGTAGACA GGCACGTCCT GGATGTTAGA AATTCACTTT 002720 002721 TTCTCAACGT GACAAGGCCG GCTTCGATCT ACAATTGTAT TTGAATGGGC AATGAGCGGA AAGATCTCTC ATCATTAAGC 002800 002801 TTGCTTCTAC TTTAGCAAAA TAAGGAGAGC CTTCATTTGC ACACAAATGC TCATAAAACT CGGATTCCCT GCAACCCTTT 002880 002881 AATAAAAAAG GATTGCTGCA TAATTTAAAT TGGAGGCCAG GGGAAGGCTG AGAGAGGGAG ATGAGGGGGT TTCAACTGAG 002960 002961 TCCCCTCCCT TCCCCCAAAA GGTCCATGTG ATCGAGTTGA CTTTTTTACT TTAAATCTTA AATAAGATGT GAGTTGTAAC 003040 003041 AAGAGGATTG GCACTTACTC CGTGACCCTT ATAATTGGAT TAAATATAGA CTGAGACGTA CAAAAACACA CCAAGATTGA 003120 003121 CACCTGCCAA CTGGACTTCC TTATGATTGA TTGTGATGCT TCGTGCTGGC AACAATAATG AAATAAATTG TACGGATAAA 003200 003201 ACAGCACATT TGTCATTTCC GTGCCATGAG TGAGGAAGTC AACGAGTTAG GCAAGCTGTT AGCTGACAGG CGCGAGCGGG 003280 003281 AGGCAAGCTA AAGAGATAAA TAAGGATTCC AGGCATTGAC AGGACAAATT ATAACTTGTC ACAACCTTTT TAAATTCAGA 003360 003361 AGTTTTCAAT TAACATATAT ATTGCTGTTA CATATAAGAT AAGGGGGCAC TGACGTAAAC ACGCGTGGGG TGCAGGGACC 003440 003441 CCCCCCCCCA GTGCCAAGGG TTTGGGCATC CGGGCTTGGG CATCCAGGCC TCTCTGGCTC TGTTCTCCCA TTCTGGCAAG 003520 003521 CCGGAGGGCA CCCAGGTTTG CATGGCCAGC CTGTAGGCCC GGGGCTCCGT AAGGTGGGTG AGAGTGTGAT AGGCTAAGTG 003600 003601 CAGCTGCTTC TTTTGCTAGG AGCCCCAGTT CACAGGTCCA GCACCCTTTC TTCATGGAAG CAAAGCTCCC AGATCAAGGG 003680 003681 AGAGGCTGGG CGAGGCCTGG GCCCAGGTCT GGAAGGACAA GTCCTGCTCT GTCTCCTGGA GTCCTATGTA AGGAGTAAGA 003760 003761 GATAGAGGGC AGAGGCTCCC CCTTTTGCGC TCCAATGTCT TGCCCTCATA GGAAAATCTG AGCTGCTGGA CACAACATAT 003840 003841 CAACAATGGC CACATCCTGT GGGCAGGCCT AGGCCACTGA AACCTGGTGT GGCCTGAGGC TGCTCCTGAG CTCTCAACTC 003920 003921 CTTCTCTGAC TCACCGGCCC AGTGCCGCCA AGGAACCGGT CCTGTGTCCT ACCTAGGAAG AGCTGCTTTT CCCTCCTCAG 004000 004001 ACTTTGTTTC TGGTACAGTT CCCAGGGCTC TTCCTTGACC CATGGGTAGG AACGAGTTTG CCAGTGGGTC CTTGATAACC 004080 004081 TGAGGCCATT CACCTAGAGC AAGTGAGATT TTCAGAGGAG CAAAGCGCTG GAGTCACCCT GTGAGGCTGC AAGTTAGGGG 004160 004161 AAGCCATGAG ATTTCTGGGG AAGTCTAGGT GTTGTGACTG TGACTGGGGA CTGCTGTGGG TGAGGTTTGA AGAGTGTGGA 004240 004241 GGGACTGTAA ACTCTGCAAC CATCTTCACC CCAAAGGAGG CTGGCTTTTT GGTTTTAAAG CTAACCCCTA TCCTAAAGCA 004320 004321 GAATCTAGAC TTGCAGGGCC TCTCTGAACT CAGGTCCCAG CCTCCCCGCA AAGTCCAGCT GGAAAGGAAA GTTTGGGCGG 004400 004401 GAAGCGAGCG TCCCCGGGTC TGAGGCTGCT GGGTGGAAAG CTGGCCTAGG AGGGCGAGTA GGGAGCAAAA TAGGGCCTGG 004480 004481 TCCTTGCGGG GCCGGGGAGC TAGAGGCCGC AGGAAGCTGG GAGGGCCCTT TCCAGGCAGG CAGGGCAGCC TCCTGGCGCG 004560 004561 GCCCAAGGCG CGAGGCAGCC GCTGGCTAGG GAGGTCCAGT CTCCTGCAGG CCAGGGAGGG CTTCCTCTGG GTGCAGCCGT 004640 004641 CTCCCTCCGC TCCTCAGCTT GGCTACTTGG TGCTCGGACC CCGCATCCTA GTCCTCGTCC TTGTGGGACA GAGGCCAACC 004720 004721 TTGCTGTCGA GGCCCCAATA TGTCACCACA AACACTCCCA GAACAAGAGC ATCAACCCCA AGCTCCAGAA CTTCTGGTCT 004800 004801 TAGCCTACTG GAGCCTGCCA CCAAATTAAA CACCGCGAAG GCTTTGAATC CCTGCAAAGA CGGAGCCTGG AAGAAAGGGA 004880 004881 GGGAGGAAAA GGGAGGAAAA AAAACAAGTT ACATGGAATT AGTTGGAAGC GGGCGCATTC CCCAGCGACC GCAGCCATTA 004960 004961 ACATTATAAT CTCAAACGCC ATTTTTTATG TAACACTATT GTTAGTAAAT CAACTCCTCA GGTCCTCAGA GACGCTGACC 005040 005041 CCTGGCAATT CAGTGAAAGT GTAATTATCT CCCCGAATCT TGGACAGATT TAAGAGATTA CATTTCAACT AAATCTATAT 005120 005121 CAATGCTAAT TCCCTCTCTC CCCCCAGCCT GCAGGTGCTA GGCACGGGAA ATGGCGTCAG GCCCCAGCAG AACGCTTCAC 005200 005201 AAAGAGGAGA GGGCTAGCTG TGTACAGGGC CAAAAGAAAT GAAGCCCCAC ATAAAATTAC ACCTTTTTTT TTTTGCTACA 005280 005281 AAACCTGGTT CTTATATAGC AAAGTTAAAC AAAGCAGCTA TGCTAAATTA GCGTTACATA AAGGCGAGTT TAATGCTCGG 005360 005361 TTACAGTCAA CTGGTGTATC TCTGATGGCT AATTGTCTAT CAAAATTAAA GAGAAAAGAA CAAATGATTC GTTATAAGAA 005440 005441 GGTGTTAAAA GCCTCAACAA AAGGACATTT CACAAATATA ATATCGGCAG CTCCCGGATT GCCTGCGGGG TTGTTCAGGC 005520 005521 CCCGGGCCTG CACAGCTATG AGAAGTGGGG TGCAGGGTGC TATTTGCCCA GCAAAAGCTC ATTTCCTCCC AAATGAGTAT 005600 005601 AATGAAAACC CGAGAGGCGA TATTAGTGTA AAGATCGGGA TTAGTCCAAA TAGGAGCCGC GGACTTGGGC TTCAAAGGCG 005680 005681 ACCCCTACTC TTTTTGCCCA GTCTGGGGGC GGAGGGCGCT CGAAGGGATA CTTCAAGGAC ACCACATCCA ACTTGTCGCA 005760 005761 GCCCCACGTT CAGGCACAGG AGGGAGCGAA CATTGGGCAG AGGGTAATTT CAACAAAGGA CGGCAGGCTC CGGGGATCCC 005840 005841 GGCTTTTCCC TGAGTTCTCT GGGTTGGAAG GAGAGGGTCC GGGCTCTGTC GGAGGAGTGG GTACAGCCCA GCACATGCTT 005920 005921 TTCTGACGCG CAGCGCTGGC CTGGGGAGTG GGTGCAGCTG CTGCAGCCAG CCCCCACCCC GCCCCAGGCT GGGAAGGACG 006000 006001 CAGAGTATAA TACGACGGCC CCCTTCCCCA AGGGGACACT AGATCCAGAG CTCCAGGCAT ATTTGTTGTT CAAAGTTAAT 006080 006081 TATACCTGAA AGCAACCAAA ATGCGCACGC CAGGCCCACG GAGGCCGATT GCCGACCAGC GTAGCCGGCC CGCAGCGCCA 006160 006161 GAGAAGCCGC TCACTCCGGC GGAGTCTCTG CAAGAGAATC TGAGGCTGGG GAATAAAAGC CGAAACTAAA TCAGGCAGCA 006240 006241 AGAGTAACAA ACCATCTGGA AAATGGACCC ACGGAGCCGC AAGAATGTAC TTTTTTTTTT TATCCTTGAC AACTTGTGTC 006320 006321 CTAAAGAAAG TGTATTGAAG ATAATTGAAA TGATTACAAT TCATTGCTGC CTGACTTTGA ATATGAACAG TCACATAATG 006400 006401 ACATCCCCGC CACACAACAA CAGTTTAATT TCCATTATCC GACTTCGGGA TCCTAGCGCC AGCCGCCGGG GCAACGTGGC 006480 006481 GCTAATGCAG AAATCTTGGC TCCTGCCTGC ATTATTCATT TCGGGGACGT GGGGATGGGA TAGGAGTGGA GAGTGGGTTT 006560 006561 CTTCCCCTCC CCCGAACTTA TTCTGAAAAT CCCGGGGACC AATGGACACC GAGGAACCGA AAGCCGAGAG AATAGCTGTC 006640 006641 AAGGGGCCAC TTTGACCGAC GGGGCTGCGG TCGACGGCGC TCCCCGGCTG TCTTTTTGTC CCAGGGGTTC CCAGGCCCGC 006720 006721 AGGGCTAGGA TCCCCCAGCT CCCACCCTAG TCAGTCCCAG TCAGGGAGGA CCTAGGCCAG GGCCTCCTCC CAAGGCTGTC 006800 006801 ATCTGGCGGG GCAAACGCTC TTCTCTCATT CCTTCGTCTC CCTTCCAGCC CTCGCATCCT TTCCTTCTTT CTGCTTCAGA 006880 006881 GCTCTCAGGC TCGCGTGCAG GGCGGGATGG GCCCGGATCG GGGGCCCCTT CGCAGATTTG AAAGTTGCCT CGGCCTTGAT 006960 006961 CTTCTCCCAG CCTCCCTGCT GGGGACTCAC CCCCACATCC CGCTACCCCC CGGGGAAAAG CGAAGAAAGC CAGAGTCTCT 007040 007041 TTGCACGGCG GGGACGCTGG CGCTCACCTC TGGGCGCGGC CTCGGTGGAG CCTCAGGGCC AGGGCGGGGT GTGGCGGGGT 007120 007121 GTGGCCCGGT GGGGTGAGGG AGGGACCCGG GGTGCAAGCC AGGCCAAGGC CTCCTCAGTG CGCAGGCGCC GTTCGGGCCC 007200 007201 GCCGCCCCCT CCCAAGGCGT GGGGTCCCGG GGACAGACCC CGAGCCCCTC TCTGCGCAAC TACCGCCTCT AAAAAAAAGA 007280 007281 CCATCTGGTA ATTGTCTTTC TTTAGATCTT CCCTTAATTA TGCTTTTAAT TAAAGATGGT TCAAGGCACC GGACCACATG 007360 007361 AAGGGCAGTA ATTACAAATT ACATTACAAA CCCGACAGAC GTAGCAGGAT CTGCTGGGAA AAAGGTACCG GAATAAAAAT 007440 007441 TTGACTAAAG TTTGGGATAA ATTAATCGGT GGCTTGAAGA ACAGTAGCAC ATTTCTGATT ATGTAGGCTC CAGCCAGGAT 007520 007521 TTAAGTTTTG TGTCATGATT GTTTTCATAT TTCTTTGACA TCTATTGATT TGGAGGCAGC TGCAAGCCTT TGTCACAGGA 007600 007601 GAGAAGAGCA GTCACAATAT ATTAGCTTGA TGGCATAACT CGAACCGGAG AAGCGAGGGG AGCCTGAGTG ACTGGGGCGC 007680 007681 ACATGACCCC CCTCCTGGGG CCTTTGGGCT CAACCCTTAC TTTTAACTTG TTCTAACAGG AATAATGGAG TAGTACTACT 007760 007761 AATGCATGGT CAGAAGGGGC TTTTCTGTCT AGAACGCAGG CGGCGGGAGT TGCACCGCCA CAGCCCGGGA GACCAAAGAG 007840 007841 TCTCCACTCC CCGCTCCCGG CGCCTCCTCG CCGACCGGAG CCCCGAGCCC AGTGAGCCCA GCCGGTCCCA CGTCGAGAGG 007920 007921 CGCTGGGTTG GGAGAAGTTC TGCTGGTCGT GGGCTCGGCC CCCAGGCGCC AGGCCGAGTG CCCACCTCGG CTTCTTTAGG 008000 008001 GGGCCTACAG CGGGCAGCCG AGCGGCTGGC GGACCCGGAG CTTGGGAGGC GACCGCCAGG CTGGTGCCCG GCCTGACCCG 008080 008081 GCGTTcgcgg ccgcccgctc gcccgccgcg ggccgggAGC GTACAGGAGT GTGACGCAGA TTGTGAAAAC AGAAGGGAGG 008160 008161 GAGTTGGGTC ATTTCCTTCG CTAATCATCG CCCCCTCCTG CTCCTCCTCC CCACCCCCAT CCCATCCTCG CCGCCACCCA 008240 008241 GCCTCGAACT CTCTTCCTTG CCAGAGTCTG CCTCACTTTG AGCCAGTGGC TGCACTTTAT GGAGAAAATA TATGTGCCCA 008320 008321 TCACTCACCC ATCTATTTGC AGCGTCCATG GAGCGCCTCG GGGAACACGC ATGGACAATT AAACACACCC ACTTACGGCG 008400 008401 GGATGATGAG GCTTTCTGTT AACCACATGT GTTCAGAAAT GGATACAGCC CTAATTTTGA CACGGAATGC AGCTAATGCA 008480 008481 CCTTGCTATA GATGTACGTC CGTTGGAAAA GTGTGTGATG GGCACCTGAT CTACACCAAG AGAACAGGGC TGTCTGCAGA 008560 008561 AGACCCAGCG GCCTGACACC TTTTCTTGTT GCCGGGGAAG GAAAGTTTTT CTTTTGATTT GTCCTCTCAC GATTTTTCCC 008640 008641 TTTTCCTTTG CATTACAGTT TCAGAGAGGA ATGTAAATAT TTTGACTAGA CCTCTGCAGG GGCCTTTTAA ACACCAGGCA 008720 008721 CAATCATCTG TGGAATACTG TAGTTCATAC TTTCAAAACT TGGGTGTTAA AGAGTCTGTC TTGCTGAGGA AACCCATAGA 008800 008801 ACTAGTGGCG ACCTTTCAAC TCCCTATTTG TGTGATGAAA TGAAGTATGC CCTAGTGATT GTCGAATTTT AAGGACTTGT 008880 008881 TCTGTCACTG CTACTTTCCG ATCGTTTGCA GGGAAGAAAA ATCAATCAAA CAGACCTTTG ATGGGGTTGT GGCAAGGTCA 008960 008961 CATTTCACTG TGCTCCAGGC TTACCTCTTC TTAACGCCCC TCCCTGCTGT GGAGCGTGTG CAGGTAGTAT GCAAAACTCT 009040 009041 AGAAATAATA TTTGAAAAAA TTAACACCTT GTTTATCTCT TCTGTGTATT TGATATAGGG GTTTCTTTCT TTTCCTGTTT 009120 009121 TGGTGTTTAA TACAAGGCTG ATATATTGGA ACAGAATGCA GACTTCAAAG AAACTAAAAT TAGGAGGCAA ATAGCGTCAA 009200 009201 GGTTTCCTCG GTTTCTGTAT GTAGTACAAA TAGTATAGCG TCTTTTCATC CAAAAAGAAG CAAAAATTGC CAGGAGGCAT 009280 009281 AAAGCATCTC TGAATATCCG TTTTTTTTAA AGAAACAAAC ATTTCCCAAA TATTGATGTA CGCATGGTTT TATAGTCTGA 009360 009361 AAATATTTCT AGGCACAAAT ATGGCATACA AACATTCGTT TCAACTCTGT CGTTGTTGTT AAAATGACAG TAAATTATAG 009440 009441 TTTATTTTAA GATACCTCCC TGTTAATGTC AGTTGAGGTT ATTTTAGGGC CTGGATGCTC TAGGAAGACC ACCTAAAATG 009520 009521 TGTTTATTTC TCTGCCCAAT TCACCTATAG TGTAAGGAGC attttatttt attttatttt attttatttt attttattat 009600 009601 actttaagtt ttagggtaca tgtgcacaat gtgcaggttt gttacatgtg tatacttgtg ccatgttggt gtgatgcacc 009680 009681 cattaactcg tcatttagca ttaggtatat ctcctaatgc tatccctccc ctccccccat cccacaacag tccccagagt 009760 009761 gtcatgtAAG GAGCATTTTA AATAAAATAT TTTGGGCATC CTTAAGTCCT TTTTTAAAAA TCCAACATTC TACAATTGTG 009840 009841 ACAAATAGGC TGAAAAATTT TGTTTTGTTT ATACCAAATT CATTTTAATA AAGCATTTGC TGAGATTTTA ATACAACAAA 009920 009921 TGCCAACAAA ATGCATCAGA GTAGAAAAAA GAAAATATTT TCAGAATTGC CTATAATATT GCTTGTGATC CTAAATTTTT 010000 010001 TGATGCAAGG AACTTGAATT TTTCAGCTAA TATTATTCTG TTTTCTTATT CTGTGTTTCT ATTAGAACAC TCACCTATGC 010080 010081 TCTGCTTCCC TTGCTGTCTT CCCATAGCTT ATGTGTGCAC TATGAATTTC AATAAATATA AATTACTGCT TAAAAGAGTA 010160 010161 AAGAATGGCT ACTTTATGAC TCACTGTTCT CTCCTTACAA TCTGCTCAAA AATCTTTTTT ACAAATCCCA TTGTAGCTAC 010240 010241 TTCCCCTCAA TTCCACGATG AAAGTGAATG GCAAATGCCA TTCAATTTAG AGGAACTCAA GCACAGAGAA TATAAAGATG 010320 010321 TTGTTCAAAG CCTCCCTCAA ATCTATCTGT AGGCTTACAA ACAAAATGAG ACTGGAGGCA ACATCAGTAC ACATCTCCGA 010400 010401 CTCCATATGA GGTTACTTGA AGCTTTGGGG TTCACTCTGG AAACAGAAGA CATGCATCAA GGTATGTGTT CCTTAGAGAC 010480 010481 TGACAAGCAA CAGTGGACCT CAGGAGAAAT AAAACAACTC ATGCTCTCAA CTGCCTCTGA TTTGCAGACA AGGAAGAGTT 010560 010561 TTCTCTAAtt tttttttttt tttttttttt ttGCCTGCAT TACTTTTTCT GTGCTTGGTG gctaaaccag agagcagtct 010640 010641 gcaacatttt gcttttgggg atttcctgtg gctttgccac attccctgga gaaactcata aagtcctgga gtctatggag 010720 010721 ggattacaga gagccacaaa catcattctt cctctaatcc atctggggca gatacagtat tgataacaac ctttctgtta 010800 010801 cttgacagtt tcagaccatT CAGATGAGAA CAAATAATAG GAATTTGGTA GTGGAGGTGG GGAAAATAGA GGCAATTGGT 010880 010881 ATAGTCTTCT GAGTTGAAAG GACTGGTTTC CATTCCAAAA TCGTGGAAAC AAGTACAAAA TTAAACACTT TCCATTCAAT 010960 010961 TCTTTGGAAG TGATTTCTTC TGTCTTTGGT TATTGTAGTG CATTTGTGTT GGGGAATTGA TGCATTTATT TACTTTGTCC 011040 011041 CTAAGACAAG ACAGTGCTCA GTTGCTTGCA TTTTGTAGCT TCAGTTTGTT TGGCTCTCCC AGCTTGAACC TACTATGTTA 011120 011121 GGTAATAAGG AAGCCCATTT GCATTAGATA ATAAGAATCA GGGACAAGGC AGACACAATG CTGATTAAAC AAGGGCTCAT 011200 011201 ATCCCATTTT GAGAGCTCCC TGATAACCAG CGCCACAATC ACATTGGTAG GTCAAGCAAA AATCTGAAGA TAAAATCAAT 011280 011281 GTCAGTTTTC TGTCTTGGTG ACAGACAGCG ACCCACCAGA ATTATATCCA GTAAATCCTG TTATCAAGTT CCTCACTGTC 011360 011361 GTTGATGAAT TCACTTATGC TATGGGTCAG AGATTATGCT GTGGCCACCA CCTATGTGAT GATGTCTACG GCATCCCTCA 011440 011441 CTTTGACACA GACTtacaca gaacaatacg ctaacaatta tagctgtcca acttcctggt ctgctttgta aggtaagggc 011520 011521 agtgaagaca ctgggaatgt tcaagtggaa tctggGGTGT GGGGAAGACC AAACCTGCAT GAAGGAGTGG TTAGGGAAAT 011600 011601 TAACTTACTT CCCAAACTGT ATCAGGGCCA GAATCATCCC AGAAACATTT ATTTTATCTA TTGGttattt attaaataat 011680 011681 ttaaatatGA TTACTTGTCA AAATGAAAGT ACATTCATGT GGTTCAAAAT TCTGAAGTTC AGAAAATATT TTGTGAAAAT 011760 011761 TCTTCATATC CAGTCATACA GCCACCCCCT TCTTACCTAT TGAAAGCAAC CAACACTATC AGTATCTTAT GTATAGGGGA 011840 011841 GCTTTAAAAA TATGGAATTc caaggcctac ttaatgagac tctttggaga cagaggcttt gctattggtg tttaaaaaaa 011920 011921 atctttccag ataagtttgt tgATATGTGG GCACTTAAGT GATTTTTAGA CTTCTTTCAA ACACTGAGAT TTTATGGAAA 012000 012001 TATATAATGT aatactactc gtcccctacg ttcctacaat gtgtgtaaag tattttcaaa actagtatat atttttttct 012080 012081 ttttgcaacc ctgtaaaata ggtattattt tctgccccct tcccattttt cagagaatgg aaacttctga aaaactctca 012160 012161 gaagtttgga caacttgacg gaggtaactc agctagtaaa cagcagggtc aggTAGCATC Attcaaggcc atgctaggac 012240 012241 ctaagtgctt ttactttgag ctttacccca catcacatca aatgataaca tgacccgtac ttcaacataa ttatttgcta 012320 012321 taaactgttt taaaataatt ttgataaatt tgaagttcat taggaatgaa ttattcattt catttttatg attAAACTTT 012400 012401 ACTACattta tacatgacat gtaagttgag ttgcagctgg tgtgttgaca tgatgtcaac gcttttagtc atgtaaacat 012480 012481 ttatcaatgc tgactctgTG TGTGTATGTG TGtgagacag ggtgttactg tgtcgcccag gctgtagtgc agtggctgta 012560 012561 atcttggctt actgcaacct ccacttcaaa cgaccctcct acctcagcct cctgagtagc taggactaca ggcatgcacc 012640 012641 accatgcccg gctaattttt aaattttttt ttgtagagat agggtttcgc catattgccc aggctgatct tgaatttctg 012720 012721 ggctcaagcg atctgcccac cttggcctcc taaagtgctg ggattacagg agtgaacgct gcacctggcc GATGCTGACT 012800 012801 TTAAAGTTGC TGCCATTTTt ttttttttca tattttggag ctactaattt tggggataag ggcaagaatt caaatatctt 012880 012881 ttcaagcttt tgaggagctt gtaggtttta ggttctatac ttgaggtgct tgttttagtt aggttaaggc taaatttctc 012960 012961 taacaaatag ccccagaaaa aattcagtgg attaaagaga ataagagttt attttccttt catctaacag tctgaggtgt 013040 013041 atgtttcagg gtagcaggca gcttgcttta tgtagttttc cagccatcta ggattctcta tcccttaggc tattgccttt 013120 013121 atctgcatga accatagatt cctccaggtt ctggttcata agtggagaaa gtgcaggagg tgcgtccatg gtttttaggt 013200 013201 ccatggtcta ccttgaaact ggcacacatt ccttctgctc acattccttt gttcagaact tagtcacatg tccacagcaa 013280 013281 actacaagTA GAATTGGTCA ACCCATATTG ACCCAAATGC GGTGGTGACC CACATGTAGT GAAACAACCA GCAGCATTCA 013360 013361 CAACAATGCA TAATGcagct aggagactgt tacaataatc caggtagaag ctgatgatgg tagcagtggt atttgtggga 013440 013441 gataactgaa ttctggatat attttaaaga atatcctaat agattggata aggctgtgag tcaaagaaga gtcaaggatg 013520 013521 atgtccaggt tttggcctga gaaactagaa gaacagattt ctcatttata gaggtgagga agactgagga ggaaatttct 013600 013601 gtagaaaggc aaagaatttg gtgttggata tattgggtgt gagatgccta ttagaaatcc aagtaaaaat gtcatgtaag 013680 013681 agttgagcat atgagtctgg agttttaaaa ctaaacactg aataaagtca acaaggaaat caatataggc agagaagaag 013760 013761 cctaaggatc aagctttggg acatgttgat gtttagaggt ctggaagatg aagagaaatt gaggggagtc cctagaaagg 013840 013841 caggaggata accaggaaag gctggcacac aggagtccaa ttggagaaag cattttagga agcggaacat gatcaacctt 013920 013921 taaacaacta tagtgttaaa tactgtaaat aggtcatgtt ggatgagaac tgagaattga ctgttggatt tatcaatatg 014000 014001 tcatggattt ttggggaaag tgactagtag gaatagaata ttggaataaa aacataatga aaggagagaa atttgaggca 014080 014081 gcacaagtac ctataactat ttcagtgatt tttgttgcaa aggggtaagc agaaaaatgg ggcagtagtt agagatcaag 014160 014161 gttttttaaa ggttgcatga aaaaatcttc atgtttggat tctattggga aatcattcac tagagaaggt aaaattaatg 014240 014241 atgcaaggaa ggagtggaga attgtcttat cagtgtccat gagaaggcaa gaagaaatag gacctagttc acaaatggag 014320 014321 gtgttggtct acttgcaagc atggatgatc cattcacaat aatgggacaa agcagagtga acagctcaga tacagtgtag 014400 014401 caggatgtgg tgaaggtgct tgttcttttc tgattttctc aataaaattg taagtcaggt cattatttca gaagatggag 014480 014481 aaggagacac tgtgggtttg aggtgaagag ggaaattggg aaactcagct agacaatggg tgtgtgaaat aacaggagac 014560 014561 ttgtacaagg tttttgggca tctctggggc ctagtcggcc tcactggtgt atacttttct ctaggcacag ctcaggtaca 014640 014641 gagtaggctg agagttggat ttggttagga ttgggctgtt gcaaggagag acagtatgat gaagggagag aaagaggcaa 014720 014721 gggagttact tgtgtgtgca aacgggttac tccgtggaat ctaaactggg tagaaaagga cgtgaaaacc tgaggggata 014800 014801 aagaccagtg gagaagtgat aggattaaag gattttagat ttaagtgggt caatgagttg ttgaagtgat ggagtgagca 014880 014881 ggaaagatag taaatgatag ttggagagtg aaatggagat gaccgagggg tgaaattaat gtcaaagtat agcataagac 014960 014961 catgggagtg ggtggtagct ggagcaacag aggtcaagga actgaaaagc aagggcactg gaaggatcat agatattgaa 015040 015041 attctgaaga attagggcag gggccatgct ggaaggaggg atggtgagat aagagctaaa gccttgaaga atgagtggga 015120 015121 aagacctggg agcctataga cttcagctac cagtgtggga tagctggata gccaccaatg tgggatagtc tgatggcatg 015200 015201 agagtcaaag ctggaagatt ttagggagga ggaagaaaca ggtatgaaag tgccagagaa ggcaggccct gtggtttgag 015280 015281 tgacatggag agaagctacc acctgagggg gctgcagagg aacagcccag tgtcaggaag agaaagtgaa ggtccctcaa 015360 015361 agaagaggat agaggtgatt gtgctaggac agactcgagg gcacactgga gggatatagg gaCAGATTAG AGCACTTATG 015440 015441 GAATTCTATG GAATCTTGAA CCTTCCAGGT CCTGGTTCAT CTATGAATGT TGATATCTTA TGACTTCAAA TTTACTCCCT 015520 015521 CCCTCTGGGC TTCTCTCTCT TGCTTTTATA GGACAGTCCT TTCTGGTCAT TCAAATCATT TATCTGTCCT CTCTGCCATC 015600 015601 CCTCTCATGT ACCTTTCAGG TCTTCCACTT ATTCTATtcc ctccctccct ccctccctcc ctacttcctt ccctacctcc 015680 015681 ttccctccct tcttccctcc ctccttctct ctctctctct ctcacacaca cacacataca cacacacact cacaTCTATC 015760 015761 TCCGTGAACA GAACTTTGGC ATAAACTTCT GAGCGTACGG AAATAGATTT GGCTCCTTAC ATTAATAAAT AATAGTATGC 015840 015841 ATAATGAGGA AAACATTTAA ATCTAAACAA TACAGAACTT AGTAAGGTAG GAAGTCAGTT TCCCCTACTT TCATTTCAGT 015920 015921 CCTAAACACA TCCTTTTTTA AGCAGAATCC ATATAATGTT TATTATATAA CCTTCCAAAT TATTTTTAAC GCTAGACATT 016000 016001 TACGTACACA CACTTGTATA TACTCATTAA TGGAATAAAG GTTCTGGTTT TTTTTCCGGC GGAGGGTcat ttaacataga 016080 016081 ttatctttgc aagtcactgt catattattt tgtttttagc ggacacacat tatgccattg tgtgaataaa acattctgta 016160 016161 gtgatggaca tttaggttgt ttggaacttt ttctattata aataatactg tagtatactt ccctgtacat atccttgtgc 016240 016241 taaaaatttg gaagctagac tcctacaact aaagttgctg aatgttacac tgaatgtaca ttttaaaatt tggctgacac 016320 016321 tgccaaattg tcaccctccc caaatcatgt accaatttat actcccacta gcagtttatg agtgtgcttc tttccccata 016400 016401 ccctacccag taatttgCCT CCTTCTGGAG GTTTGTAAAG AAGCAATCTG TCAGACAGTG GAAGAGGCAA ATGAGAATCT 016480 016481 GTGTACACTG AATacacctg acaccttgtt gaatcccagg gttggttctg ctgatctggc tgactaagca gggggtcccc 016560 016561 cttctccccc tctctctggg ctccatgggg atcccagctg aggaacggtt gatgaggGGC ACTGGGGTGC TCGCCTTCAC 016640 016641 TTTGATTTAA AGTCTGCTTC TCAGTCCACT GCTACTCGGG GACAACATGC TCTGATGGCT GATAATATGC TCTATTTGTA 016720 016721 TTCTAGCTGG ATATAGGTAT TAGAGCCAAG TGTTTATTCA TTTCCATCAG GGGAAGTCTT CAGGCACCGG GTGCTCACCT 016800 016801 TGATCTTTAA TTTTAATCAC AAAATCAAAG CCCTGCTGTC ATTTCAAAGG CTCACTCAGA CACTAAACTT TAGAAGGTCT 016880 016881 ATTAGTCCTC ATCCCAAATG GGTAGGAGAG GTGGATGCTT CCATTACAGG GCTCCATCCC CATTGCCTTT TCCCCTGATT 016960 016961 TAAACTAAGG TGCAAAGG