Difference between revisions of "ENST00000430058.1"
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
PTCSC2:papillary thyroid carcinoma susceptibility candidate 2 (non-protein coding)(HGNC nomenclature) | PTCSC2:papillary thyroid carcinoma susceptibility candidate 2 (non-protein coding)(HGNC nomenclature) | ||
| + | |||
| + | ===Disease=== | ||
| + | [[File: PTCSC2.jpg|down|thumb|250px|'''Figure: Gene expression analysis of PTCSC2 in PTC tumors.''' <ref name="ref1" />.]] | ||
| + | thyroid carcinoma | ||
| + | |||
| + | ===PubmedID=== | ||
| + | 25303483 | ||
===Characteristics=== | ===Characteristics=== | ||
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===Regulation=== | ===Regulation=== | ||
| − | + | PTCSC2 is involved in the regulation and interaction of coding and noncoding genes<ref name="ref1" />. | |
| + | The cells transfected with the PTCSC2-c construct showed a strong RT-PCR band in the presence of reverse transcriptase, but not in the absence of reverse transcriptase.<ref name="ref1" />. | ||
===Expression=== | ===Expression=== | ||
| − | + | Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of noncoding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer <ref name="ref1" />. | |
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Latest revision as of 10:34, 30 June 2016
PTCSC2,shorted for papillary thyroid carcinoma susceptibility candidate 2, may functions in papillary thyroid cancer.
Contents
Annotated Information
Name
PTCSC2:papillary thyroid carcinoma susceptibility candidate 2 (non-protein coding)(HGNC nomenclature)
Disease
thyroid carcinoma
PubmedID
25303483
Characteristics
PTCSC2, a 1635 bp long intergenic noncoding RNA gene and locus in 9q22.33,named papillary thyroid cancer susceptibility candidate 2 (PTCSC2)[1].
Function
PTCSC2 plays an important role in the predisposition to PTC(papillary thyroid cancer)[1].
Regulation
PTCSC2 is involved in the regulation and interaction of coding and noncoding genes[1]. The cells transfected with the PTCSC2-c construct showed a strong RT-PCR band in the presence of reverse transcriptase, but not in the absence of reverse transcriptase.[1].
Expression
Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of noncoding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer [1].
Labs working on this lncRNA
- Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics[1].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 He H, Li W, Liyanarachchi S, Jendrzejewski J, Srinivas M, Davuluri RV, et al. Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2[J]. The Journal of clinical endocrinology and metabolism. 2015,100(1):E164-72.
Basic Information
| Transcript ID |
ENST00000430058.1 |
| Source |
Gencode19 |
| Same with |
lnc-C9orf156-3:1,NONHSAT133533,PTCSC2 |
| Classification |
intergenic |
| Length |
204 nt |
| Genomic location |
chr9-:100568217..100572290 |
| Exon number |
2 |
| Exons |
100568217..100568306,100572177..100572290 |
| Genome context |
|
| Sequence |
000001 TGTCCTGGGG GAATAATTAT GTTCCCTGTC TTGGGAGCCT TTCTTCAGGG AGCTTGATGG TTCCAACCCA CCCAGGAGCC 000080
000081 TGGGACATCT GTGCCCCTGG GCAATCCCCT GCAGTTTCCT GATTCCAAGA TGAGGGGGTA GAATCCGAAG ATCTCCAAGG 000160 000161 CCTTGATGAG TGCTACCAGT CTGCAAATTC CCAAGCCAAG TTCT |
