Difference between revisions of "NONHSAT076558"
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| − | + | GPR1-AS is a novel imprinted gene that is expressed from a paternal allele in the human placenta | |
==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | + | [[File:Relative expression of GPR1AS and Zdbf2linc in multiple human and mouse tissues (qRT-PCR).jpg|right|thumb|300px|'''Relative expression of GPR1AS and Zdbf2linc in multiple human and mouse tissues (qRT-PCR)'''<ref name="ref1" />]] | |
| + | GPR1-AS:GPR1 antisense RNA (HGNC nomenclature) | ||
| + | |||
| + | "G protein-coupled receptor 1 antisense RNA", GPR1AS<ref name="ref1" /> | ||
===Function=== | ===Function=== | ||
| − | + | Epigenetic regulation mechanisms in the imprinted GPR1-GPR1AS-ZDBF2 region were well-conserved betweenhuman and mouse genomes without the high sequence conservation of the intergenic lncRNAs. LncRNAs with highly conserved epigenetic and transcriptional regulation across species arose by divergent evolution from a common ancestor, if they do not have identical exon structures.<ref name="ref1" /> | |
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| − | |||
| − | |||
===Expression=== | ===Expression=== | ||
| − | + | GPR1AS/Zdbf2linc is exclusively expressed in human/mouse placenta with paternal-allele-specific expression and maternal-allele-specific promoter methylation (GPR1/Gpr1 DMR)<ref name="ref1" />. | |
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| − | + | GPR1AS/Zdbf2linc is rarely expressed throughout post-gastrulation development and into somatic tissues due to bi-allelic hypermethylation at their transcription start sites<ref name="ref1" />. | |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| − | + | Department of BioScience; Tokyo University of Agriculture; Tokyo, Japan<ref name="ref1" />. | |
==References== | ==References== | ||
| − | + | <references> | |
| + | <ref name="ref1">Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, et al. Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc[J]. Epigenetics : official journal of the DNA Methylation Society. 2013,8(6):635-45.</ref>(1) | ||
| + | </references> | ||
{{basic| | {{basic| | ||
tID = NONHSAT076558| | tID = NONHSAT076558| | ||
source = NONCODE4.0| | source = NONCODE4.0| | ||
| − | same = ,| | + | same = GPR1-AS,GPR1AS,"G protein-coupled receptor 1 antisense RNA"| |
| − | classification = | + | classification = antisense| |
length = 1343 nt| | length = 1343 nt| | ||
location = chr2+:207128708..207130050| | location = chr2+:207128708..207130050| | ||
| Line 42: | Line 38: | ||
sequence = <dnaseq>ACTCCAGCCTGGGCAACAAGAGTGAAACTCTGCCTCGGAGGGAAAAAAAAAAAAAAAGAATTGAAAGAATGAAAACCTGTCCTCAATGTGCCTGAATAAATGCTTGTTCAGACACTGGATGTGAAGTCCGATTCTCCACTGGATACCCAAACTGCAGGAGGTAGGTGGTTCCCATCTGGACCCGAGTTGCCTACCAGACCATTGTCAGAAACACAGCTGGACGTGAGTTAAAGTGGTGAAAAAACAGATTTTATTCAGTAACTACTGAAAGTAGGGAAGGAGCTGAGCTTATTCCGATTTCGGCAGAGGTGATTTGGGTGTTTTAAAGAAAGAATGAGGGAGACGGGAATAAAGGAGCTCCGAAGTGTCGGGGAAGTGAAAAAGTGCAAAGGGGAGCTTCCGGATAGCGAAGCACGTGGAGGTTCCTGGAGGGTGTCCTCCCAGAGAGGACGTGGAACCTTCCCGCTCCCACCGCGCACTTGCCCTGTGTATCTCTTCCCTTTGGCTGTTCATCTACATACGTGGTAGTTTCCTTTATAGTAAACTAATAAACGGAAATTTGCAGCAGCTGTGAAAAACTTCAATTTTCTGAATCCACTTTTGATTTTTAGTGGCGATTGCTTAAATGCCTCAGTTTTAAGTATCATAACGAAAGGAAAGCATACGATTCCTATATTAATGAATCGGAAGTACCTTTTGCAGTTTTTGTTTTGCTTTTTCAGACAAGGTCTTATTCTGTCATCCAGGCTGGAGTGCATTGGTGGGAACACAGCTCACTACCTACTCAGCCTCCTGAGCTCAAGCGATCCTCCCACCTCAGCCTCTCAAGTGGCTAGGACCACAGGCACCCACGCACTACACCGCCTAACTAATGTTTTGTTTTATATTATATTATTTTATTTTATAGAGACAGAGGTCTCACCATGTCGACCAGGCTAGTTTTGAACTCCTGGCCTCAAGCAATCCTCCTCCCACCTCAGCCTCCCAAAGTGCTAAAATGATAGGTGTGAGCCACTGCACCCGGTGATTTTGCAGTTTTTGGAAACCACAAGTTTGATTTCGGTGTGAATATTTTGGAAGAATCTATGAAACAAATGCACTTCATCTGATTTCTCAGTAATGTTGATGATAGATTTACTTCTGAACCTCTTGGACGTGTGTATGTTAGAAGTTCTCCACCCAATTGATACGGAATTAAATAGCTGTGAAATTACTGTAAGAAGAACCGAAGCAACGTTGGAAATTTGGTAACTAATGCCACGTTGGAAGCTATTCATGCCAATGTAGCATTGCTTCATACAGGTACTTCCAGATCTAATTGAATACATCCAGTGGGAAATTTC</dnaseq>| | sequence = <dnaseq>ACTCCAGCCTGGGCAACAAGAGTGAAACTCTGCCTCGGAGGGAAAAAAAAAAAAAAAGAATTGAAAGAATGAAAACCTGTCCTCAATGTGCCTGAATAAATGCTTGTTCAGACACTGGATGTGAAGTCCGATTCTCCACTGGATACCCAAACTGCAGGAGGTAGGTGGTTCCCATCTGGACCCGAGTTGCCTACCAGACCATTGTCAGAAACACAGCTGGACGTGAGTTAAAGTGGTGAAAAAACAGATTTTATTCAGTAACTACTGAAAGTAGGGAAGGAGCTGAGCTTATTCCGATTTCGGCAGAGGTGATTTGGGTGTTTTAAAGAAAGAATGAGGGAGACGGGAATAAAGGAGCTCCGAAGTGTCGGGGAAGTGAAAAAGTGCAAAGGGGAGCTTCCGGATAGCGAAGCACGTGGAGGTTCCTGGAGGGTGTCCTCCCAGAGAGGACGTGGAACCTTCCCGCTCCCACCGCGCACTTGCCCTGTGTATCTCTTCCCTTTGGCTGTTCATCTACATACGTGGTAGTTTCCTTTATAGTAAACTAATAAACGGAAATTTGCAGCAGCTGTGAAAAACTTCAATTTTCTGAATCCACTTTTGATTTTTAGTGGCGATTGCTTAAATGCCTCAGTTTTAAGTATCATAACGAAAGGAAAGCATACGATTCCTATATTAATGAATCGGAAGTACCTTTTGCAGTTTTTGTTTTGCTTTTTCAGACAAGGTCTTATTCTGTCATCCAGGCTGGAGTGCATTGGTGGGAACACAGCTCACTACCTACTCAGCCTCCTGAGCTCAAGCGATCCTCCCACCTCAGCCTCTCAAGTGGCTAGGACCACAGGCACCCACGCACTACACCGCCTAACTAATGTTTTGTTTTATATTATATTATTTTATTTTATAGAGACAGAGGTCTCACCATGTCGACCAGGCTAGTTTTGAACTCCTGGCCTCAAGCAATCCTCCTCCCACCTCAGCCTCCCAAAGTGCTAAAATGATAGGTGTGAGCCACTGCACCCGGTGATTTTGCAGTTTTTGGAAACCACAAGTTTGATTTCGGTGTGAATATTTTGGAAGAATCTATGAAACAAATGCACTTCATCTGATTTCTCAGTAATGTTGATGATAGATTTACTTCTGAACCTCTTGGACGTGTGTATGTTAGAAGTTCTCCACCCAATTGATACGGAATTAAATAGCTGTGAAATTACTGTAAGAAGAACCGAAGCAACGTTGGAAATTTGGTAACTAATGCCACGTTGGAAGCTATTCATGCCAATGTAGCATTGCTTCATACAGGTACTTCCAGATCTAATTGAATACATCCAGTGGGAAATTTC</dnaseq>| | ||
}} | }} | ||
| − | [[Category: | + | [[Category:Antisense]][[Category:NONHSAG030342]][[Category:Transcripts]][[Category:Transcripts]] |
Latest revision as of 11:51, 30 June 2016
GPR1-AS is a novel imprinted gene that is expressed from a paternal allele in the human placenta
Contents
Annotated Information
Name
.jpg)
Relative expression of GPR1AS and Zdbf2linc in multiple human and mouse tissues (qRT-PCR)[1]
GPR1-AS:GPR1 antisense RNA (HGNC nomenclature)
"G protein-coupled receptor 1 antisense RNA", GPR1AS[1]
Function
Epigenetic regulation mechanisms in the imprinted GPR1-GPR1AS-ZDBF2 region were well-conserved betweenhuman and mouse genomes without the high sequence conservation of the intergenic lncRNAs. LncRNAs with highly conserved epigenetic and transcriptional regulation across species arose by divergent evolution from a common ancestor, if they do not have identical exon structures.[1]
Expression
GPR1AS/Zdbf2linc is exclusively expressed in human/mouse placenta with paternal-allele-specific expression and maternal-allele-specific promoter methylation (GPR1/Gpr1 DMR)[1].
GPR1AS/Zdbf2linc is rarely expressed throughout post-gastrulation development and into somatic tissues due to bi-allelic hypermethylation at their transcription start sites[1].
Labs working on this lncRNA
Department of BioScience; Tokyo University of Agriculture; Tokyo, Japan[1].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, et al. Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc[J]. Epigenetics : official journal of the DNA Methylation Society. 2013,8(6):635-45.
Basic Information
| Transcript ID |
NONHSAT076558 |
| Source |
NONCODE4.0 |
| Same with |
GPR1-AS,GPR1AS,"G protein-coupled receptor 1 antisense RNA" |
| Classification |
antisense |
| Length |
1343 nt |
| Genomic location |
chr2+:207128708..207130050 |
| Exon number |
1 |
| Exons |
207128708..207130050 |
| Genome context |
|
| Sequence |
000001 ACTCCAGCCT GGGCAACAAG AGTGAAACTC TGCCTCGGAG GGAAAAAAAA AAAAAAAGAA TTGAAAGAAT GAAAACCTGT 000080
000081 CCTCAATGTG CCTGAATAAA TGCTTGTTCA GACACTGGAT GTGAAGTCCG ATTCTCCACT GGATACCCAA ACTGCAGGAG 000160 000161 GTAGGTGGTT CCCATCTGGA CCCGAGTTGC CTACCAGACC ATTGTCAGAA ACACAGCTGG ACGTGAGTTA AAGTGGTGAA 000240 000241 AAAACAGATT TTATTCAGTA ACTACTGAAA GTAGGGAAGG AGCTGAGCTT ATTCCGATTT CGGCAGAGGT GATTTGGGTG 000320 000321 TTTTAAAGAA AGAATGAGGG AGACGGGAAT AAAGGAGCTC CGAAGTGTCG GGGAAGTGAA AAAGTGCAAA GGGGAGCTTC 000400 000401 CGGATAGCGA AGCACGTGGA GGTTCCTGGA GGGTGTCCTC CCAGAGAGGA CGTGGAACCT TCCCGCTCCC ACCGCGCACT 000480 000481 TGCCCTGTGT ATCTCTTCCC TTTGGCTGTT CATCTACATA CGTGGTAGTT TCCTTTATAG TAAACTAATA AACGGAAATT 000560 000561 TGCAGCAGCT GTGAAAAACT TCAATTTTCT GAATCCACTT TTGATTTTTA GTGGCGATTG CTTAAATGCC TCAGTTTTAA 000640 000641 GTATCATAAC GAAAGGAAAG CATACGATTC CTATATTAAT GAATCGGAAG TACCTTTTGC AGTTTTTGTT TTGCTTTTTC 000720 000721 AGACAAGGTC TTATTCTGTC ATCCAGGCTG GAGTGCATTG GTGGGAACAC AGCTCACTAC CTACTCAGCC TCCTGAGCTC 000800 000801 AAGCGATCCT CCCACCTCAG CCTCTCAAGT GGCTAGGACC ACAGGCACCC ACGCACTACA CCGCCTAACT AATGTTTTGT 000880 000881 TTTATATTAT ATTATTTTAT TTTATAGAGA CAGAGGTCTC ACCATGTCGA CCAGGCTAGT TTTGAACTCC TGGCCTCAAG 000960 000961 CAATCCTCCT CCCACCTCAG CCTCCCAAAG TGCTAAAATG ATAGGTGTGA GCCACTGCAC CCGGTGATTT TGCAGTTTTT 001040 001041 GGAAACCACA AGTTTGATTT CGGTGTGAAT ATTTTGGAAG AATCTATGAA ACAAATGCAC TTCATCTGAT TTCTCAGTAA 001120 001121 TGTTGATGAT AGATTTACTT CTGAACCTCT TGGACGTGTG TATGTTAGAA GTTCTCCACC CAATTGATAC GGAATTAAAT 001200 001201 AGCTGTGAAA TTACTGTAAG AAGAACCGAA GCAACGTTGG AAATTTGGTA ACTAATGCCA CGTTGGAAGC TATTCATGCC 001280 001281 AATGTAGCAT TGCTTCATAC AGGTACTTCC AGATCTAATT GAATACATCC AGTGGGAAAT TTC |