Difference between revisions of "Lnc-CHRAC1-2:1"
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| − | + | A novel lncRNA that is transcriptionally regulated by E2Fs, and restricts apoptosis induced by E2F1, as well as by DNA damage. | |
==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| + | [[File:ERIC restricts E2F1-mediated apoptosis.jpg|right|thumb|300px|'''ERIC restricts E2F1-mediated apoptosis'''<ref name="ref1" />]] | ||
''ERICD'':E2F1-regulated inhibitor of cell death(HGNC nomenclature) | ''ERICD'':E2F1-regulated inhibitor of cell death(HGNC nomenclature) | ||
LINC01130, "long intergenic non-protein coding RNA 1130, ERIC, TCONS_00014875<ref name="ref1" /> | LINC01130, "long intergenic non-protein coding RNA 1130, ERIC, TCONS_00014875<ref name="ref1" /> | ||
| + | |||
===Function=== | ===Function=== | ||
| − | [[File:ERIC | + | [[File:Endogenous E2F1 regulates expression of ERIC.jpg|right|thumb|300px|'''Endogenous E2F1 regulates expression of ERIC.'''<ref name="ref1" />]] |
| − | + | ERIC levels were increased following DNA damage by the chemotherapeutic drug Etoposide, and inhibition of ERIC expression enhanced Etoposide -induced apoptosis which prevents E2F1-induced apoptosis from occurring at the “wrong” time <ref name="ref1" />. | |
| − | ERIC levels were increased following DNA damage by the chemotherapeutic drug Etoposide, and inhibition of ERIC expression enhanced Etoposide -induced apoptosis<ref name="ref1" />. | ||
===Regulation=== | ===Regulation=== | ||
| − | + | ERIC is transcriptionally regulated by E2Fs, and restricts apoptosis induced by E2F1, as well as by DNA damage.<ref name="ref1" />. | |
| − | |||
| − | |||
===Expression=== | ===Expression=== | ||
Expression of ERIC was cell cycle regulated and peaked in G1 in an E2F1-dependent manner. Inhibition of ERIC expression increased E2F1-mediated apoptosis, suggesting that E2F1 and ERIC constitute a negative feedback loop that modulates E2F1 activity<ref name="ref1" />. | Expression of ERIC was cell cycle regulated and peaked in G1 in an E2F1-dependent manner. Inhibition of ERIC expression increased E2F1-mediated apoptosis, suggesting that E2F1 and ERIC constitute a negative feedback loop that modulates E2F1 activity<ref name="ref1" />. | ||
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{|class='wikitable' style="text-align:center" | {|class='wikitable' style="text-align:center" | ||
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===Disease=== | ===Disease=== | ||
Retinoblastoma<ref name="ref1" /> | Retinoblastoma<ref name="ref1" /> | ||
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Latest revision as of 12:24, 30 June 2016
A novel lncRNA that is transcriptionally regulated by E2Fs, and restricts apoptosis induced by E2F1, as well as by DNA damage.
Contents
Annotated Information
Name
ERIC restricts E2F1-mediated apoptosis[1]
ERICD:E2F1-regulated inhibitor of cell death(HGNC nomenclature)
LINC01130, "long intergenic non-protein coding RNA 1130, ERIC, TCONS_00014875[1]
Function
Endogenous E2F1 regulates expression of ERIC.[1]
ERIC levels were increased following DNA damage by the chemotherapeutic drug Etoposide, and inhibition of ERIC expression enhanced Etoposide -induced apoptosis which prevents E2F1-induced apoptosis from occurring at the “wrong” time [1].
Regulation
ERIC is transcriptionally regulated by E2Fs, and restricts apoptosis induced by E2F1, as well as by DNA damage.[1].
Expression
Expression of ERIC was cell cycle regulated and peaked in G1 in an E2F1-dependent manner. Inhibition of ERIC expression increased E2F1-mediated apoptosis, suggesting that E2F1 and ERIC constitute a negative feedback loop that modulates E2F1 activity[1].
| siRNA | Sequences |
|---|---|
| ERIC | si#1: AAGCCAGCCTGTGGCTACCTCCTTT[1] |
| si#2: CCCGTGGCATCGGCTGTCTGCATAT[1] | |
| SiE2F1 | si#1- CUGAGGAGUUCAUCAGCCU[1] |
| si#2- CAGAGCAGAUGGUUAUGGU[1] | |
| SiE2F3 | si#1- GCCUUAAAGACCAAACUGU[1] |
| si#2- CAUAUCAAGAUAUUCGAAA[1] |
Disease
Retinoblastoma[1]
Labs working on this lncRNA
The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat Gan 52900, Israel
References
Basic Information
| Transcript ID |
lnc-CHRAC1-2:1 |
| Source |
LNCipedia2.1 |
| Same with |
NONHSAT129383,ERICD,LINC01130, "long intergenic non-protein coding RNA 1130, ERIC, TCONS_00014875 |
| Classification |
intergenic |
| Length |
1745 nt |
| Genomic location |
chr8+:141646243..141648531 |
| Exon number |
2 |
| Exons |
141646243..141647585,141648130..141648531 |
| Genome context |
|
| Sequence |
000001 CGGAGGTCGG GAAGCTCCCT CCCAGCCCGG AGCTTGAACT TGAACGCGGC CGGCCGCTCG CGCAGGACCA CACCGCCACC 000080
000081 TCCCGGCGCG GCCCCAGAAC CCAGATAATC CGTTTAAAGC ACTGAGAAAA TCTAAGAAGT TTTTAGTAAA CTGTAGCTGG 000160 000161 TATCAGGGAT CAGATCAGCG GACACGCCCA TTCCAGCAGT CAGGGGCCTG CTCGGACCGT CGTGCACCTC CGAGCGTTTC 000240 000241 TGTCCGGTCC CTCTGGGTCC GTCTGGTTTT CGGAGGCTTT CCTGGAAAAG CCAGCCTGTG GCTACCTCCT TTCTCCCCTA 000320 000321 AGTGATGGAG GATTAGAAGG CAGAGGTTGA CCCACAATCT AAAGTGCCTG GTCGCCTTTT CCCAGATTTC CCGGAGCATT 000400 000401 CCTTCACCCC GTGGCATCGG CTGTCTGCAT ATGGGTGCAA GGCCCTGTTC CGGGCGGAGA ATAAACAGGA GTTCTGACTG 000480 000481 ACAGGAGCTC CGCAGCCAGC AGGGTGGTCA CTAGTTCTCT GCAGTCTCGG AGGACAGCCC TGAAGAAGGG CAGGAGAACC 000560 000561 AGCACTTCCT CCGAAAACTC AAAAGGACAT CAGTCTTCAC CAAGTTGCCG ATACAAAACG TGCTCCTGAA ATGTGTAGTA 000640 000641 ATGAACACCA GGAAACCTGG GTAGGAGTGT GCATGGCATT CTTCATCACC GCTTGGACTG CATGGCACTG AATACCCACG 000720 000721 GAGAGCAGGA TGGAGAAACA GTGTGCTCAT ATTCACAGGA TGGAATCTAG CCATTCACAA AAATTCCAAA ACAGGCAAAA 000800 000801 TTAAACTGCA TTCTTTAGGG AAGCATCATT AAGTAGTAAA TAATTGACAG AAGGGCAAGA AGGTGCTTAC TCTAAGTGTC 000880 000881 AGAATGGTGG ATACAGCTGG GGGTGAGAGG GCTGTGACCA CAGCAGGGCC CCTGGGGGAT TTGGGGGTGC CAGGCCTGTT 000960 000961 CCTTCCTGCA ATGGTGCCCT TTGGCAGCCA TCCCTTAAAC TGCACTTTTA CTTTATATGC TTTTCTGTAC CTTTACTGTA 001040 001041 GTATTTCACG GAAATTTTTA AATAATCATG AATGTTACCA CTTTCCTATT TATGAACCAT GCAACCTCAT CAATCTTCCC 001120 001121 AGTTCGCAGA TGCCCACCCT CTCTCTCTGC CCCTGTCTCC TTCACATATC CCCAAAACTC GTTTTGGCCC GAAATCCCTG 001200 001201 AGGCCCAACT GCCCTGCTGT CAGCGACTGC ACGCCTCAGC AAAGGCCCAG AAGGCTCTGT CATCACTGGC TGCCCTCAGC 001280 001281 CCGCCTTCAG CTCCTTTGAG CGCTGTGTTG GGGAACTTTG TTGCAAGGAT TTCGTTCCAG AAGGATCCTG ATGCTTTGAT 001360 001361 AAGACCGTGG GCTCTAATCA CAGCCAGGGA CATTTGCAGC AGCCTGGCCT GCAGCTCTGC ACACTGGGTG CACTCAGTCT 001440 001441 AAAGCACCAG CTCCCCATGA GAGAGAAAGA AGGGGTGAGG GGAAGTACAG AGAAAGCTCC TGAGGCCACA GGGCTGACAA 001520 001521 AGCCCTCGGC TTTGGGGGCA CTTTGTTTCT TCAAGACTAA AATGCAGGCA ATGGAATAAA TCATTTGTTC CTAAAACATG 001600 001601 TTCTGCACAT GATTAAAGCA GCTTTGGGAA GTCAAGTAAA TTGGGAAGCA CTGGATCAAA CAATGATAAA TAAGTTTATT 001680 001681 GTCTGCAGGC CTTCTCAGAG CCTGTAGCAA GGTGAGAAGA ATCATGCTTC TACAAAGAGG AAGGA |
