Difference between revisions of "NONHSAT033821"
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| − | + | BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma. | |
==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
DLEU2,deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature) | DLEU2,deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature) | ||
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===Function=== | ===Function=== | ||
DLEU2 are strong candidates as tumor suppressor involved in B-CLL leukemogenesis<ref name="ref1" /> | DLEU2 are strong candidates as tumor suppressor involved in B-CLL leukemogenesis<ref name="ref1" /> | ||
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===Expression=== | ===Expression=== | ||
| − | + | [[File: BCMSUN.jpg|right|thumb|400px|'''Expression analysis of the BCMSUNL gene''' <ref name="ref1" />.]] | |
| + | As expected, in patients with bi-allelic loss of 13q14.3, BCMSUN expression was reduced markedly.<ref name="ref1" /> | ||
| + | Residual amounts of BCMSUN expression likely represent gene expression in non-tumor cells, which were present in the range of 2% to 15% in the tumor specimens.<ref name="ref1" /> | ||
===Allelic Information and Variation=== | ===Allelic Information and Variation=== | ||
| − | + | Apart from the distinct 3′end(74 bp),BCMSUNL shares 90.3% homology with the sequence of BCMSUN. Due to the lack of introns, the BCMSUNL transcript cannot be spliced, whereas RT-PCR with appropriately selected primers detected BCMSUN transcripts lacking exons 2 and 6, as reported previously,indicating the existence of respective splicing variants.<ref name="ref1" /> | |
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==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| − | * Abteilung "Organisation komplexer Genome", Deutsches Krebsforschungszentrum, Heidelberg, Germany<ref name=" | + | * Abteilung "Organisation komplexer Genome", Deutsches Krebsforschungszentrum, Heidelberg, Germany<ref name="ref1" /> |
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1">Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Dohner H, et al. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like[J]. International journal of cancer Journal international du cancer. 2000,88(5):692-7.</ | + | <ref name="ref1">Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Dohner H, et al. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like[J]. International journal of cancer Journal international du cancer. 2000,88(5):692-7.</ref>(1) |
</references> | </references> | ||
Latest revision as of 12:45, 30 June 2016
BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma.
Contents
Annotated Information
Name
DLEU2,deleted in lymphocytic leukemia 2 (non-protein coding)(HGNC nomenclature)
LEU2, LINC00022, "long intergenic non-protein coding RNA 22", "mir-15a-16-1 cluster host gene (non-protein coding)", MIR15AHG, NCRNA00022, "non-protein coding RNA 22", TRIM13OS[1]
Function
DLEU2 are strong candidates as tumor suppressor involved in B-CLL leukemogenesis[1]
Expression
Expression analysis of the BCMSUNL gene [1].
As expected, in patients with bi-allelic loss of 13q14.3, BCMSUN expression was reduced markedly.[1] Residual amounts of BCMSUN expression likely represent gene expression in non-tumor cells, which were present in the range of 2% to 15% in the tumor specimens.[1]
Allelic Information and Variation
Apart from the distinct 3′end(74 bp),BCMSUNL shares 90.3% homology with the sequence of BCMSUN. Due to the lack of introns, the BCMSUNL transcript cannot be spliced, whereas RT-PCR with appropriately selected primers detected BCMSUN transcripts lacking exons 2 and 6, as reported previously,indicating the existence of respective splicing variants.[1]
Labs working on this lncRNA
- Abteilung "Organisation komplexer Genome", Deutsches Krebsforschungszentrum, Heidelberg, Germany[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Mertens D, Wolf S, Bullinger L, Ohl S, Schaffner C, Dohner H, et al. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like[J]. International journal of cancer Journal international du cancer. 2000,88(5):692-7.
Basic Information
| Transcript ID |
NONHSAT033821 |
| Source |
NONCODE4.0 |
| Same with |
DLEU2 ,LEU2 |
| Classification |
intergenic |
| Length |
2440 nt |
| Genomic location |
chr13+:50656307..51102670 |
| Exon number |
6 |
| Exons |
50656307..50656693,50730963..50732212,51007549..51007686,51066787..51066897,51102002..51102200,51102316..51102670 |
| Genome context |
|
| Sequence |
000001 GCACATGCGC AGAATCATCG TGGTGCACGG CTCTCCCTTT GCTTCTTCGG TTGCAGTCCT CTTGCTTCTT GCGCGTGCGT 000080
000081 GTAGCGCTTT TGCAAAGCCG CGGAGGTGAA GTGAACTTAG AGGTTGTGGG GCCGAGGGGT CGTCTTATAG CTACCAGCCC 000160 000161 ACAGGCATTT AGTCTACGTT GGAGGTAAAC AAATACGGGT CCTGCTTAGG AGAAAAGAAA AACGTCTTAC AGCCAGTGTC 000240 000241 TAAACTCCAA ACAACGGAAT GTATCAATGA GACCTTGTAT ATGGATACAC GTGCATTTAA AACCGCCCTG CCGGCttgta 000320 000321 gagcttttgc cgttctccag cgctttacag gggttatcgc acttaagcct cggaacaact ttaccagATT CAGCTGGCTA 000400 000401 CCCCACTTGG CTACAGAGTA CTAAAGAAGA GACTGAACTT GATCCTGCTG CCCTTGCATA CACAACACTC CCATTGACGC 000480 000481 TAGTGAAGAC TTAAGCGCAT GAAAGGATTC CAGGATCAAA AGGTTAGCTC TATGGGGAGC TGTGTCTGGC TCAAGCAATC 000560 000561 CATTTTTTTC TATTGACAGT GAAAACGTTT TATAGTTCTT TTTCAAAGTT TTCCCAAACT TTTACAATAA CAGGCAACTT 000640 000641 GTGAAAAAGT GAGAAGGCAT CTAATTGAAC TATATCCAGA GGAGATCATG GCAGAGACCA ACAGGAAGAA AAACATTTCC 000720 000721 AAACCACAGC GATATTGGTC AAATCAATTG TATTTGAAGA ATAAAGCATT TGAGGCGTCG GCTGAGAAAA ATTTTCATTA 000800 000801 TGAAACTTGG TTGGACTATG AAGCAGAATG TGAGATAAAA TAAAACACAG AGCTCATGAG TTTTTATCTT TGTCTGCTAA 000880 000881 TGACTTATGC TAGCAGGATT ATACTTTTTT TTTGCATTTT ATGAGATGTA TGAACTAGGA AGAAAATACA TGCTATATCT 000960 000961 AAATGGATTA GACGTGCAGA TTCTTAACTA ACATTTAATT CATTGCTAGT AAAACAAATG CCTTAAAACA TTTAAAAAAG 001040 001041 TGAAATTATC TTAAGGAGAT AATTAACAAG CAGAGTAGAA TAGCATTTTT GAAGAAAGTG TAATATGGTT CTACACTGGC 001120 001121 ATTTTCTGCA TTTATTGAAG ATACTTAGTC TATCCAACAA TTCACTCATT CATTCTTTCA tgaaaccctg tctctactaa 001200 001201 aaatacaaaa aaaaattagc tgggcacggg ggtaggccct tgtagtccca gctactcggg aggctgaggc aggagaatgg 001280 001281 cgtgaacccg ggaggcagag cttgtagtga accaagatcg cgtcactgca ctccagccta ggtgacagag cgagactccg 001360 001361 tctcaaaaca acaacaacaa caacaacaac aacaacaaca acaacaaATT TCTTTGTGCA CTTACTATAT GCCCAATGCT 001440 001441 AATCTAATAG TTTTACAAGA CCTCAATTGA ACAAGTGTCT GAGGAAATGG ATTGCATCTA ATAAAGCAAG ACACACCAAC 001520 001521 TGTGGATGGG TGGTGTGTCT AGAGTATTTT GCATTCCTAA ATCACTCTTC TGGAGAAAAT TTGTATCAAT AATTTTGTCT 001600 001601 AGCTTCACCT GGAGTTACAC ATTTTGATTG GTAAGTGttg ctctggctat atcaaataaa agtgtcaaga gtgagcatcc 001680 001681 ttgccttgtg ctgaatcaca aaggaatacc tttcagtttt tctccattga ttatgatagc agtgggcttt tcacagtggg 001760 001761 ctttactgtg ttgagGTACC CTAATGACAA GTTCACCCCA GTGTTTTCTG AGGAGTCTAC CTGGAAATGA GAACCATCTG 001840 001841 TCCTTCCTAT AGTAGTTCTT CTCAGAATGC CGACTCTATG CTAATGGAGG AGGTCTGATG GCCGGGAGGA CAGGAAGAAG 001920 001921 GAACCCACAA TGAAGCAAAA GTTGCGTTTA ACTCTGTCCT CACCATTCCT CTCCTGGACC TGTCCTAAAC TGGAAGCTGG 002000 002001 GGGAGGATGG AGTGCTGGAA TGCTGCAGAA GTCTCATGGG AGGGCGCCTG GTGTTCACCA CATGTGTACA CTGTTGCACG 002080 002081 ACCAGATGGA AATTTGAATG CTGGGGCTCA GTGGAACACC TGAAGGAAGC TGGTGAGGCA GATGTCCCGC TATGCCTTCC 002160 002161 AAGTGTCATG CAACCAGTTC ATGCCTGTCA GCATCTCTGC CGGTGGACTC TGTGAGTCAG CAAATCTACA GAGCAGAGAG 002240 002241 CCACAAGTGG GGACAGATGT GGTCAAATGC CATTTAAATC AGTGATTCTC AACCCAGGAG TTGTCATGGC ACTGGCCTTG 002320 002321 AGTGAGCTGG ACCAAGGGAA GTGGTAGAAT TCCCCATGAA GGACCAAGTG AGCAGATAGA AGTTTCTCCA TTTTAACTTT 002400 002401 TTCTGAGTCA ATTTAAAAAA CACCTAGTGC CTTTTTCTGT |
