Difference between revisions of "NONHSAT008995"

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Please input one-sentence summary here.
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''BLACAT1'',also named ''linc-UBC1'' (Up-regulated in bladder cancer 1), which regulates histone modification status of target genes by physically associating with PRC2 complex.  
  
 
==Annotated Information==
 
==Annotated Information==
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===Transcriptomic Nomeclature===
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===Transcriptomic Nomenclature===
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Please input transcriptomic nomeclature information here.
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''BLACAT1'':bladder cancer associated transcript 1(non-protein coding)(HGNC nomenclature)
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linc-UBC1, LINC00912, "long intergenic non-protein coding RNA 912", "long intergenic noncoding RNA up-regulated in bladder cancer"<ref name="ref1" />
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===Cellular Localization===
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Nucleus<ref name="ref1" />.
  
 
===Function===
 
===Function===
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[[File:''linc-UBC1'' physically associates with PRC2 components EZH2 and SUZ12.jpg|right|thumb|300px|'''linc-UBC1 physically associates with PRC2 components EZH2 and SUZ12. '''<ref name="ref1" />]]
  
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===Regulation===
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''Linc-UBC1'' physically associates with PRC2 complex and regulates histone modification status of target genes, which serves as a negative prognostic factor for lymph node metastasis and survival in bladder cancer patients.<ref name="ref1" />.
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===Diseases===
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* Bladder cancer
  
 
===Expression===
 
===Expression===
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''BLACAT1''  is frequently overexpressed in bladder cancer tissues compared with normal adjacent tissues<ref name="ref1" />.
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===Allelic Information and Variation===
 
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===Evolution===
 
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You can also add sub-section(s) at will.
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{| class='wikitable' style="text-align:center"
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|-
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! | Primers for qRT-PCR
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! | Forward
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! | Reverse
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|-
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| rowspan="1"|''linc-UBC1'' (lincRNA:chr1:205404014-205407007)
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| | 5’-CCTGCTTGGAAACTAATGACC-3’
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| | 5’-AGGCTCAACTTCCCAGACTCA-3'<ref name="ref1" />
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|-
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| rowspan="1"|lincRNA:chr10:4692376-4720283
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| | 5'-CGAGATGGAGCAAAGGATAAACG-3'
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| | 5'-TCAGGGCCAGGAGGTGACTGGA-3'<ref name="ref1" />
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|-
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| rowspan="1"|lincRNA:chr18:37236595-37243620
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| | 5'-GTTACCCTTGCCCTTTGGATG-3'
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| | 5'-GCCTTGTAGGCCCTCACAGAC-3'<ref name="ref1" />
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|-
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| rowspan="1"|lincRNA:chr4:15669186-15683175
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| | 5'-GGCCAGGACGCTGGTTCAT-3'
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| | 5'-TCGGGAGGTTGTGGGAGGA-3'<ref name="ref1" />
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|-
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| rowspan="1"|GAPDAH
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| |5’-GAAGGTGAAGGTCGGAGTC-3’
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| |5’-GAAGATGGTGATGGGATTTC-3’<ref name="ref1" />
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|-
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| rowspan="1"|EZH2
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| |5'-AATCAGAGTACATGCGACTGAGA-3'
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| |5'-GCTGTATCCTTCGCTGTTTCC-3'<ref name="ref1" />
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|-
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| rowspan="1"|SUZ12
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| |5'-TTGCAGCTTACGTTTACTGGTT-3'
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| |5'-GGAACTTGCCTTATTGGACAACT-3'<ref name="ref1" />
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|}
  
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
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* Department of Urology, Sun Yat-sen Memorial Hospital, 107th Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong province, PR China. <ref name="ref1" />.
  
 
==References==
 
==References==
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<references>
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<ref name="ref1"> He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, et al. linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer[J]. Biochimica et biophysica acta. 2013,1832(10):1528-37.
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</ref>(1)
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</references>
  
 
{{basic|
 
{{basic|
 
tID = NONHSAT008995|
 
tID = NONHSAT008995|
 
source = NONCODE4.0|
 
source = NONCODE4.0|
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same = ,|
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same =''BLACAT1'',''Linc-UBC1''|
 
classification = intergenic|
 
classification = intergenic|
 
length = 2616 nt|
 
length = 2616 nt|
Line 42: Line 79:
 
sequence = <dnaseq>GTGCGCCCCGTGCTAACCCATTGAAGAATAATTATTTTTCTCCACTGGAAGCTACAGCAGAGAATCGGACAAGGAGGGAAGAAAGAGATTGGTgagggggagagagagagaaagagagagagagaCACAAAGGAAGTGAGTGCAAGAGGAGCCGGCTTAGCATCTAAACTcatcaccaccaccaccaccacaaccaccTGCAGATAGATGCTCAAGTGATTCTAGAAGAGATCTCAAGGACTGGCGCTCTGCTCCAGTTATGTAACCCATGGGCTTCCCTTTGCACAGCTCCTCATGTGCTCATCTCCATGCTGATCAAACCACCCCACCTCATTCCTTGCCTTCTGCAAGGGGAAGTGCCTCAGGCTGGAGTTTGTCCTGTCTACAGACTGAATATGCATTTTGCCCAGTGGCTGGAGATGTGCTGGTGGTGGAATGTGCTGGTGATTGTTTCTGGATGGAGAGCCACAGCCCCCCAGTGTTCTGCCATGACTGACTCCTGACCTTGGCAAATTGCCTCCTCTCTCCCAGCCTCCTCCATAACAGGTGGCGATGAGTCCCATTTCCTCCCTACCTCACAGGAAGGCACGCATTATAAAGGGCACACTTATCAGATGTGCCCAGATGTGGCTGGAACTTTTGGAGACAGATACTTGGTTCACAACTGCAAAGGTGGGCTTTCACCAGAGAAGAAAATCTCTGGGCTGCTGAGTTCAGTGGGCTCCTTGCAGGCTGGTCCAGGAAGTCTGGTGTTCCTCCTGAAGGTGGCTGCTATGTCCAGCAGGTGATCAAGCTGACAGTACCACAAGAACCAAGAAACAGAATCTGTTCCCAAGGAATGAATGTTCTATCTCTCTGACCCAAAAGCAAGAGCAAGAGAGAGCTGTCACCATCATCACCCTGCTCCCAACACAAACACAGCCCCCCAAGTCCATATTGCTGACAAGGGTATCTGCCTTGTCAGGGTGAATCCTCTGGACCCCAGGCCATCCCTGGAGTGGTCAGTGCCCACTGTGCCGGGGTTATTGTGGCCAGTCCGCCTGGGTTCGCTTCTCTAAATTTCCATGGGATAGGAACTATAGATCATGAAGAAGAAACAGGAACCTTGACTCTTCACGGAGGAGCCCAGGAGGTCAGAACCATCCACCAGGAGGGTGAGCGGTAGCTGCCCAGGGCATCCCTGGAGGAAGTCGTCATACTGAGGAAGAAATTGCCAAAGCCAAGAGCTCCCAGACCTGGGCAGCTCAGGAGCTGACAGAAACCACCCCCCAGGTCTGGAGTTCAAGGGTTTTCCTCGTGGGCTGCTGGTCTGTCTCTTTCCCTTCTGGGGCAGCCGTCTCTCCTCCTTCAGCTCATTCCCGTGTTCCATCTGAGGGGCGGGAGGAAGGCAGGAGGGGGAGATGGCAGGACCCAGACAGATCCTCAGGACTCTCCCAGCCTCTGTTGCCATGGCAACACTGCTATTTTTATCCCGTTGTTCATGATGCTCAAAGCTCTAACTTTCTCTGTTCCAGAGAGGCCAGGCTGGTTTCTGCCCTCATCCTTTAACACAGCATCTTCTCCCAGAGGCCTGAGGATGGGAAAAAGTGATGGAGAAAAGGGGAACCCCTAAGGTCACCCCTCAGCCAGGGGGAACTGTTTAACAGGGGTTTGTCTCTGCCCTTTTGAGCCTTTGGTTTTCTACCTGGCTCAGGCACCCAGGTTTATGTTTTCTAGATCAAAACTCTGCATGGTCTCCCTGAGAGACTGGAAAAGAGCTGCCAATCAGGATGGATTTTTTCCTACACAGGTATGACACTGCAGCCACTTCCCTTCTTGGGAAAATTAAACTTCATTCTGAAGAATGTCCTGTTGGTGGTATAAGCCAACCCCTGCCCTCCTAAAAGGGGATAGATAATTAAATTTGGTTAATTAGCAATCAGATTCACTGGGGAATTGAAACCAGTACTTCCCTTTCTTCTGTCCCTCCACCAAAGAACCGGAACAAATGGCTTCATGTCTTTGTCCAGTCTTTCTGCCTAAAGCAAAATAGCATATATTCTCCAGGCTGAAAAGTAGATTCCTCCTCACCCCTACTCAAGATGGCCACATTTCAATCCAGGCTCTTGAAGACAGGGTCTAATGAAAGGATTTCTGTTCTTTCTCTGTCTGTTCCCTCTGGCCCAGCTTCTAGTCCTCTCCTTATGTCCCCACCTCCATGGCAGTGGCAAGAGACCCCTGAGAGTCAATGGTGCTAACGTTCCCCACCTATATACCCCTATGTAGTTTATCGAGATTTGAACCCAGCACCTGGGTGGCTGTGTTGGGCGGATACATTTCACGTCCTCAAGACCACAACCCTGGCGACAGGTCTGGATTAATTCTGTAAAGTAGCAATCTATATCATGCTAAACTCCTGCACTGAGGTTCTTCCTCGGCTGAACTGACTCGTGGATGGTTAAGTTTCCTGGGGTGGCTGGAACCCATTTACTAAGCCTCTAATTGGTTTCATTTTGGCTCAAGTTGCATGGTTTCCCGAATCTATGCACCTGGAGTAAGCACTTTTCTGGTTGCCACTGAAAAGCATGCCGGCAAACGCTGCTCTGTTAATTGCTGTAATAAACAGACTTTATTATA</dnaseq>|
 
sequence = <dnaseq>GTGCGCCCCGTGCTAACCCATTGAAGAATAATTATTTTTCTCCACTGGAAGCTACAGCAGAGAATCGGACAAGGAGGGAAGAAAGAGATTGGTgagggggagagagagagaaagagagagagagaCACAAAGGAAGTGAGTGCAAGAGGAGCCGGCTTAGCATCTAAACTcatcaccaccaccaccaccacaaccaccTGCAGATAGATGCTCAAGTGATTCTAGAAGAGATCTCAAGGACTGGCGCTCTGCTCCAGTTATGTAACCCATGGGCTTCCCTTTGCACAGCTCCTCATGTGCTCATCTCCATGCTGATCAAACCACCCCACCTCATTCCTTGCCTTCTGCAAGGGGAAGTGCCTCAGGCTGGAGTTTGTCCTGTCTACAGACTGAATATGCATTTTGCCCAGTGGCTGGAGATGTGCTGGTGGTGGAATGTGCTGGTGATTGTTTCTGGATGGAGAGCCACAGCCCCCCAGTGTTCTGCCATGACTGACTCCTGACCTTGGCAAATTGCCTCCTCTCTCCCAGCCTCCTCCATAACAGGTGGCGATGAGTCCCATTTCCTCCCTACCTCACAGGAAGGCACGCATTATAAAGGGCACACTTATCAGATGTGCCCAGATGTGGCTGGAACTTTTGGAGACAGATACTTGGTTCACAACTGCAAAGGTGGGCTTTCACCAGAGAAGAAAATCTCTGGGCTGCTGAGTTCAGTGGGCTCCTTGCAGGCTGGTCCAGGAAGTCTGGTGTTCCTCCTGAAGGTGGCTGCTATGTCCAGCAGGTGATCAAGCTGACAGTACCACAAGAACCAAGAAACAGAATCTGTTCCCAAGGAATGAATGTTCTATCTCTCTGACCCAAAAGCAAGAGCAAGAGAGAGCTGTCACCATCATCACCCTGCTCCCAACACAAACACAGCCCCCCAAGTCCATATTGCTGACAAGGGTATCTGCCTTGTCAGGGTGAATCCTCTGGACCCCAGGCCATCCCTGGAGTGGTCAGTGCCCACTGTGCCGGGGTTATTGTGGCCAGTCCGCCTGGGTTCGCTTCTCTAAATTTCCATGGGATAGGAACTATAGATCATGAAGAAGAAACAGGAACCTTGACTCTTCACGGAGGAGCCCAGGAGGTCAGAACCATCCACCAGGAGGGTGAGCGGTAGCTGCCCAGGGCATCCCTGGAGGAAGTCGTCATACTGAGGAAGAAATTGCCAAAGCCAAGAGCTCCCAGACCTGGGCAGCTCAGGAGCTGACAGAAACCACCCCCCAGGTCTGGAGTTCAAGGGTTTTCCTCGTGGGCTGCTGGTCTGTCTCTTTCCCTTCTGGGGCAGCCGTCTCTCCTCCTTCAGCTCATTCCCGTGTTCCATCTGAGGGGCGGGAGGAAGGCAGGAGGGGGAGATGGCAGGACCCAGACAGATCCTCAGGACTCTCCCAGCCTCTGTTGCCATGGCAACACTGCTATTTTTATCCCGTTGTTCATGATGCTCAAAGCTCTAACTTTCTCTGTTCCAGAGAGGCCAGGCTGGTTTCTGCCCTCATCCTTTAACACAGCATCTTCTCCCAGAGGCCTGAGGATGGGAAAAAGTGATGGAGAAAAGGGGAACCCCTAAGGTCACCCCTCAGCCAGGGGGAACTGTTTAACAGGGGTTTGTCTCTGCCCTTTTGAGCCTTTGGTTTTCTACCTGGCTCAGGCACCCAGGTTTATGTTTTCTAGATCAAAACTCTGCATGGTCTCCCTGAGAGACTGGAAAAGAGCTGCCAATCAGGATGGATTTTTTCCTACACAGGTATGACACTGCAGCCACTTCCCTTCTTGGGAAAATTAAACTTCATTCTGAAGAATGTCCTGTTGGTGGTATAAGCCAACCCCTGCCCTCCTAAAAGGGGATAGATAATTAAATTTGGTTAATTAGCAATCAGATTCACTGGGGAATTGAAACCAGTACTTCCCTTTCTTCTGTCCCTCCACCAAAGAACCGGAACAAATGGCTTCATGTCTTTGTCCAGTCTTTCTGCCTAAAGCAAAATAGCATATATTCTCCAGGCTGAAAAGTAGATTCCTCCTCACCCCTACTCAAGATGGCCACATTTCAATCCAGGCTCTTGAAGACAGGGTCTAATGAAAGGATTTCTGTTCTTTCTCTGTCTGTTCCCTCTGGCCCAGCTTCTAGTCCTCTCCTTATGTCCCCACCTCCATGGCAGTGGCAAGAGACCCCTGAGAGTCAATGGTGCTAACGTTCCCCACCTATATACCCCTATGTAGTTTATCGAGATTTGAACCCAGCACCTGGGTGGCTGTGTTGGGCGGATACATTTCACGTCCTCAAGACCACAACCCTGGCGACAGGTCTGGATTAATTCTGTAAAGTAGCAATCTATATCATGCTAAACTCCTGCACTGAGGTTCTTCCTCGGCTGAACTGACTCGTGGATGGTTAAGTTTCCTGGGGTGGCTGGAACCCATTTACTAAGCCTCTAATTGGTTTCATTTTGGCTCAAGTTGCATGGTTTCCCGAATCTATGCACCTGGAGTAAGCACTTTTCTGGTTGCCACTGAAAAGCATGCCGGCAAACGCTGCTCTGTTAATTGCTGTAATAAACAGACTTTATTATA</dnaseq>|
 
}}
 
}}
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[[Category:Intergenic]][[Category:NONHSAG004054]]
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[[Category:Intergenic]][[Category:NONHSAG004054]][[Category:Transcripts]]

Latest revision as of 13:22, 30 June 2016

BLACAT1,also named linc-UBC1 (Up-regulated in bladder cancer 1), which regulates histone modification status of target genes by physically associating with PRC2 complex.

Annotated Information

Transcriptomic Nomenclature

BLACAT1:bladder cancer associated transcript 1(non-protein coding)(HGNC nomenclature)

linc-UBC1, LINC00912, "long intergenic non-protein coding RNA 912", "long intergenic noncoding RNA up-regulated in bladder cancer"[1]

Cellular Localization

Nucleus[1].

Function

linc-UBC1 physically associates with PRC2 components EZH2 and SUZ12. [1]

Linc-UBC1 physically associates with PRC2 complex and regulates histone modification status of target genes, which serves as a negative prognostic factor for lymph node metastasis and survival in bladder cancer patients.[1].

Diseases

  • Bladder cancer

Expression

BLACAT1 is frequently overexpressed in bladder cancer tissues compared with normal adjacent tissues[1].

Primers for qRT-PCR Forward Reverse
linc-UBC1 (lincRNA:chr1:205404014-205407007) 5’-CCTGCTTGGAAACTAATGACC-3’ 5’-AGGCTCAACTTCCCAGACTCA-3'[1]
lincRNA:chr10:4692376-4720283 5'-CGAGATGGAGCAAAGGATAAACG-3' 5'-TCAGGGCCAGGAGGTGACTGGA-3'[1]
lincRNA:chr18:37236595-37243620 5'-GTTACCCTTGCCCTTTGGATG-3' 5'-GCCTTGTAGGCCCTCACAGAC-3'[1]
lincRNA:chr4:15669186-15683175 5'-GGCCAGGACGCTGGTTCAT-3' 5'-TCGGGAGGTTGTGGGAGGA-3'[1]
GAPDAH 5’-GAAGGTGAAGGTCGGAGTC-3’ 5’-GAAGATGGTGATGGGATTTC-3’[1]
EZH2 5'-AATCAGAGTACATGCGACTGAGA-3' 5'-GCTGTATCCTTCGCTGTTTCC-3'[1]
SUZ12 5'-TTGCAGCTTACGTTTACTGGTT-3' 5'-GGAACTTGCCTTATTGGACAACT-3'[1]

Labs working on this lncRNA

  • Department of Urology, Sun Yat-sen Memorial Hospital, 107th Yanjiangxi Road, Yuexiu District, Guangzhou, Guangdong province, PR China. [1].

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, et al. linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer[J]. Biochimica et biophysica acta. 2013,1832(10):1528-37.

Basic Information

Transcript ID

NONHSAT008995

Source

NONCODE4.0

Same with

BLACAT1,Linc-UBC1

Classification

intergenic

Length

2616 nt

Genomic location

chr1-:205404014..205425214

Exon number

2

Exons

205404014..205406459,205425045..205425214

Genome context

Sequence
000001 GTGCGCCCCG TGCTAACCCA TTGAAGAATA ATTATTTTTC TCCACTGGAA GCTACAGCAG AGAATCGGAC AAGGAGGGAA 000080
000081 GAAAGAGATT GGTgaggggg agagagagag aaagagagag agagaCACAA AGGAAGTGAG TGCAAGAGGA GCCGGCTTAG 000160
000161 CATCTAAACT catcaccacc accaccacca caaccaccTG CAGATAGATG CTCAAGTGAT TCTAGAAGAG ATCTCAAGGA 000240
000241 CTGGCGCTCT GCTCCAGTTA TGTAACCCAT GGGCTTCCCT TTGCACAGCT CCTCATGTGC TCATCTCCAT GCTGATCAAA 000320
000321 CCACCCCACC TCATTCCTTG CCTTCTGCAA GGGGAAGTGC CTCAGGCTGG AGTTTGTCCT GTCTACAGAC TGAATATGCA 000400
000401 TTTTGCCCAG TGGCTGGAGA TGTGCTGGTG GTGGAATGTG CTGGTGATTG TTTCTGGATG GAGAGCCACA GCCCCCCAGT 000480
000481 GTTCTGCCAT GACTGACTCC TGACCTTGGC AAATTGCCTC CTCTCTCCCA GCCTCCTCCA TAACAGGTGG CGATGAGTCC 000560
000561 CATTTCCTCC CTACCTCACA GGAAGGCACG CATTATAAAG GGCACACTTA TCAGATGTGC CCAGATGTGG CTGGAACTTT 000640
000641 TGGAGACAGA TACTTGGTTC ACAACTGCAA AGGTGGGCTT TCACCAGAGA AGAAAATCTC TGGGCTGCTG AGTTCAGTGG 000720
000721 GCTCCTTGCA GGCTGGTCCA GGAAGTCTGG TGTTCCTCCT GAAGGTGGCT GCTATGTCCA GCAGGTGATC AAGCTGACAG 000800
000801 TACCACAAGA ACCAAGAAAC AGAATCTGTT CCCAAGGAAT GAATGTTCTA TCTCTCTGAC CCAAAAGCAA GAGCAAGAGA 000880
000881 GAGCTGTCAC CATCATCACC CTGCTCCCAA CACAAACACA GCCCCCCAAG TCCATATTGC TGACAAGGGT ATCTGCCTTG 000960
000961 TCAGGGTGAA TCCTCTGGAC CCCAGGCCAT CCCTGGAGTG GTCAGTGCCC ACTGTGCCGG GGTTATTGTG GCCAGTCCGC 001040
001041 CTGGGTTCGC TTCTCTAAAT TTCCATGGGA TAGGAACTAT AGATCATGAA GAAGAAACAG GAACCTTGAC TCTTCACGGA 001120
001121 GGAGCCCAGG AGGTCAGAAC CATCCACCAG GAGGGTGAGC GGTAGCTGCC CAGGGCATCC CTGGAGGAAG TCGTCATACT 001200
001201 GAGGAAGAAA TTGCCAAAGC CAAGAGCTCC CAGACCTGGG CAGCTCAGGA GCTGACAGAA ACCACCCCCC AGGTCTGGAG 001280
001281 TTCAAGGGTT TTCCTCGTGG GCTGCTGGTC TG