Difference between revisions of "AATBC"

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−
 
  
 
==Annotated Information==
 
==Annotated Information==
 
===Approved Symbol===
 
===Approved Symbol===
−
''AATBC''
+
''AATBC'': apoptosis associated transcript in bladder cancer
−
 
 
−
===Approved Name===
 
−
apoptosis associated transcript in bladder cancer
 
−
 
 
−
===Previous Symbols===
 
  
 
===Synonyms===
 
===Synonyms===
 +
[[File: LincRNAs are dysregulated in bladder cancer.jpg|right|thumb|400px|'''LincRNAs are dysregulated in bladder cancer.''' <ref name="ref1" />.]]
 +
"apoptosis-associated transcript in bladder cancer"
  
 
===Chromosome===
 
===Chromosome===
Line 17: Line 13:
 
===RefSeq ID===
 
===RefSeq ID===
 
NR_026961
 
NR_026961
−
 
−
===OMIM ID===
 
  
 
===Ensembl ID===
 
===Ensembl ID===
 
ENSG00000215458
 
ENSG00000215458
  
−
===pubmed IDs===
+
===Characterisitcs===  
−
25473900
+
AATBC is a transcript of 4622bp and localizes in human chromosome 21q22.3, 8465bp downstream of RRP1 gene and 38902bp upstream of CSTB gene. <ref name="ref1" />
 +
 
 +
===Functions===
 +
[[File: The involvement of JNK and NRF2 pathway in apoptosis induced by AATBC knockdown.jpg|right|thumb|400px|'''The involvement of JNK and NRF2 pathway in apoptosis induced by ''AATBC'' knockdown.'''<ref name="ref1" />]]
 +
 
 +
[[File: AATBC knockdown attenuated bladder cancer cell proliferation.jpg|right|thumb|400px|''' ''AATB'' knockdown attenuated bladder cancer cell proliferation'''.<ref name="ref1" />]]
 +
 
 +
The pro-apoptotic effect of AATBC knockdown in bladder cancer may achieved through activation of JNK signaling and suppression of NRF2. Its overexpression hiders the apoptosis of tumor cells and increases the number of tumor cells, thereby promoting tumor growth, which partially explain AATBC may serve as a potential oncogene in bladder cancer.<ref name="ref1" />
 +
 
 +
AATBC exhibits potentially pro-proliferative and anti-apoptotic functions in bladder cancer. The most possible mechanisms underlying these functions include disregulation in the cell cycle, activity of the intrinsic apoptosis that involved in JNK and NRF2 signaling pathway. AATBC might play a critical role in promoting the tumorigenesis and progression of bladder cancer through the regulation of proliferation and apoptosis.<ref name="ref1" />
 +
 
 +
AATBC knockdown inhibits tumor growth in NOD/SCID mice.<ref name="ref1" />
 +
 
 +
===Diseases===
 +
AATBC could be a potential therapeutic target and molecular biomarker for bladder cancer. <ref name="ref1" />
 +
 
 +
===Expression===
 +
AATBC was overexpressed in bladder cancer tissues and cancer cell lines. <ref name="ref1" />
 +
 
 +
AATBC expression was positively correlated with tumor grade and pT stage of bladder cancer.<ref name="ref1" />
 +
 
 +
{| class='wikitable' style="text-align:center"
 +
|-
 +
! | Experiment
 +
! | Primer
 +
! | Forward primer
 +
! | Reverse primer
 +
|-
 +
| rowspan="1"|RT-PCR
 +
| | AATBC
 +
| | 5'-AAGGCCGGTTATCAACGT-3'
 +
| | 5'-GCCAGTCCCTCACTGCTCT-3'<ref name="ref1" />
 +
|-
 +
| rowspan="3"|Knockdown
 +
| | AATBC  si#1
 +
| | 5'-CCAUGCACGGAUCUGACUUTT-3'
 +
| | 5'-AAGUCAGAUCCGUGCAUGGTT-3' <ref name="ref1" />
 +
|-
 +
| | AATBC  si#2
 +
| | 5'-CGGUCAUAUUUGAGCAUGATT-3'
 +
| | 5'-UCAUGCUCAAAUAUGACCGTT-3' <ref name="ref1" />
 +
|-
 +
| | AATBC  negative control siRNA
 +
| | 5'-UUCUCCGAACGUGUCACGUTT-3'
 +
| | 5'-ACGUGACACGUUCGGAGAATT-3' <ref name="ref1" />
 +
|}
 +
 
 +
===Labs working on this lncRNA===
 +
* Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China <ref name="ref1" />
 +
 
 +
===references===
 +
<references>
 +
<ref name="ref1">Zhao F, Lin T, He W, Han J, Zhu D, Hu K, et al. Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer[J]. Oncotarget. 2015,6(2):1064-78.</ref>(1)
 +
</references>
 +
 
 
===Sequence===
 
===Sequence===
 
<dnaseq>AAGGAAGGAGGGTGACTGCAGAGACCGGCCCTGGGCAGCGGTACCAGGGGCACAGGGAGCCTGGCCCGGCCCATTGTCACTGGAATTCATGCCATGCAGACTTCTACATCAAAGGGAAACAAGGTCAGGAGGGCCGAGGGGTCCACGGCACTCCGCACCCACGGGGCCAGGCTGGCACAACGCCCCAACGCTGCAATCCTGGGAAGAGTCACACGCGCCCTCCCGGGACCCACGTGACCATCAAGGGAGTGTGGAGGACACATCCCTCGGGGGTGACGCCCCTGCAGATGGAGTTTCCCCATCTGTGCCACCCTTGCAAGGCCTGGGAAAGGCTGCGGGGCCAGGCGGCACCGGGCAAGCTGAGTGCCAGGTGGTGGTTGCAACACACCGGGCAAATCTGAAACCATGGGACGGACGAGCTGCACCCCTGGGAAAGAGAACAGAGGAAGGCCGGTTATCAACGTCCTCCTGTGCCTCAGTTTCCAGAAACAAGCCAGACTCAGTGCCTCAGGGAGACCCCGTGTGGCCTCCGGAGAGCACGGGACCCGCCCTTTGTGCAGGTGAGGAAACTGAACCCCAGAGCAGTGAGGGACTGGCCTGGGGACCCTGGGCTCAGCCCTGGGCGCCTTCCCTCTGCCCATCTCAGACGGGCACAGCCAGCACCGCCTCACCCCAACGCGCCTCCAGACTGGCCCTCCAGGGGCCCCCAGGCACAATCCTCTCACTTTCTTCCTCAAGCCCCTGCCTTCCCCCTTCGCACTGTGACCCAGGGGCTGCTAGCAGCTGGGCTGGGCTCCAAAGCTTGAAGCTGCTTCTCCAGGTCTCTTTCCAGGGGGCGGCGGATGGCTGCTCACTCAGGGACGCCAACACCAACAGGAAGGGACCCATGCACGGATCTGACTTCCCTCCCAGGCTCTGCCTTCACTCAATGTCCCTGTGGGGCAGCTGGGGCTCCCGGCCGCCCTCCCCTGCCCACAGCCGTGAGGTTGCTTCCTAGGGTTCTGTTTTCCCCACAGTCGGAACTGAGGTGCTGGGAGGCTCCAGAAGAGGGATGGGGTGGAGCAAGTGGCCTGGAGCCCCCCAGGGCAGACCCCAAAGAGAAGGGTCAGAAGTGCCCTCTGGGGCCTGGGCAGCTGGGGGGAGCCCACAAGCCTGAGACCCTGTGGGAGGGAAGCGCCCCCACCCCGTGGTAAGAAAGGGGCTGGTAGAGGCTCCTATGTGGCTCCCTCTGTCCCCTCCCGACCTCTGGCCAGGCTTGGGATAATCCCTGAGTGGACACAGGCGCCACGATGGGGTCTCGGGGGTGAGGGCTGAGGAGGCTGAGCCTCCAAGGACCCCAGGGTGCCTGTTCCCACTGCACACCCACCAGGGCACAGGGTAGGGATAGTGCCAGGAGGGCCACAGCTGCAGGGTCCATCCCAGGCCGTGGTACACAGGTAGAGGTGGGTGCCAGCCTTCGTGAAGCACCTGCAGAAGCTCCACTCAGGGAGAGAACGAGGCACTCGCCCAAACAGATCCTGGGTCACACGGGGCAGCAAGAGAGGGTGGAGCAAGTGGCCTGGAGCAAAGGGTTGGAGGCCCCGGGGCGGCGCGTTCTCCCCCAAGCCCATTCCAGGGCCATGGGCACCCCCCAGAGGCAGCTGGTGGGACTGCAGCCATGCAGGTCCTAGAGGGCAGGTGACAGGGGACGTGACAGAAGGGGACAAAGGGCCGGCAACATCCCTGGGGGAGGCACAGAGAGGGCCAGACTGCCCTCGGTGGACTGCGGAACCCAGAACCCAACGGCCAATCCTCCCCCTACTCCTCACCCACAGTAAGGGGCCAGGGCTCCATGCAATGAGAACCCACGGGTGATGCCACACGGGGGAGAAGCCACGCGGGGGAGAGGCCATGCAGGGGAGAGGTTACAAGGGGGAGAGGCTGCGGGGTGAGAGGTCACATGGGGCAGAGGCCACGCGGGGGAGAGGCCACGCAGGGGAGAGGTCACATGGGGGAGGCCACGCAGGGGAGAGGTCACATGGGGGAGAGGCCACACAAGGGAGAGGCCATGCAGGGGAGAGGTCACAATGGGGAGAGGCCGCAGGGGGGAGAGGTCACATGGGGCAGAGGCCACGCGGGGGAGAGGCCACGCAGGGGAGAGGTCACATGGGGGAGGACACGCAGGGGAGAGGTCACAAGGGGGAGAGGCCGCAGGGGGAGAGGTCACATGGGGGAGAGGCTACACAGGGGAGAGGCCGCACGCTGGGGAGATGGTCCCTGCGGGAAGACTCCGAGGCAGTCTCCTGCAGCTCCTTCCGGCGAATCCGGTTCAGGAAGTAAAACCAGCCCTGTGTAGAGGTAAGTGATGCTTGTGGGGATAATCTCCGAGCAGCTCACCGCGGCGCTGGCCATTGCCGTTCTCTTCACGGTAGAAGAGTCCATTTGGGGAAAAGGTCCCCATCAGAGATGGAGATGTTCCCTTTCAGACTCCAGGCTATGGCTGTGGGGCCGGCTCCCTACCACGTGGGCTGGGGGCTGGGCACATGCATGCCCACTCCTGGGCCCTCTTCCTGGTAGGCCACAGCACCACACACACTGCAAACCAGGCCTCTTCTTCATCCACCACCACCGTCCAGGCCTCAACATCACCGCGTGGGGTCTTGTGCCCTCTGGGGGAACTTCCGGGCTAATGAGGGGGGACAGTCCCCATTACCGGTCTATCTTTATAAGGCAGTATATGCAACAGTGGAAGTTCTGTGAGACATGTTCCAACCCCGGGGCTGCTGGCAGAACTGTCCCCAAACCCACCCTCGATCCCACGGCCAGGAAGTGGGTCCAAAATTGCCTGGCCAGGTCACACCCCTGCGTGAACCGCCCCACAACACCCAGGGCGCTGCCTGACTTGCCGTCCACCTCTCAGCCCCTCCCCTCACCCCTGCCGCAGCTGCAGGGCCTACCCTCGCCGGGGGCTGCTCCCTGCTTACCTCCCTCGCCCGTGCAATGCCTCTACTTCCCGCAAGGCCTACCGGGAGATGTTACAGGTCACGGTCATATTTGAGCATGAGAAGCTCACGCAGAGAACATTCTGGCTGAGGGAGAGGTCTTGGGGTTCAAGGCTGTTTCTTGGCTCTGCTCAGCCATGCCAGGCAGGAAAATGGGCACCTCTAGTGACCCAGGCTGGCTGAGAGCCTGCAGGGAAGAGCCTTTGGAACGTGAGCCACTGTGGGCTGGCAGGACTGCAACTGGCGTCTCCATCTACTGGTACCGAGGCGAGGAGGAAAAAGCAGGGGGGCCCGGAGACGGCCCCTCTAAGTCTGTAACTCCAGAGCTGCTGCTCAGTCCCCAGAACGTCACCTCCGAGCAGAGCCTGTGACAACTGTCAACTGTGAAGCTGTGGCGTGGGTTGCTACTGAAGCTCTGAAGTCAGCGAGGACACAGCATGTTTGTTCTAGACCGTTTGGCTGCGGGAGGAAGCTGTACATGCACACACTCGCCTCACCACCCTGCGAGTCCACAGGCCCCTCCCCGGAGTCACCTCCAGGTAAAGGGGGCCCTGCGTCGGGACTTGCTCTCTGGGGCGCTGAGATGCTCTACAATGAGCTGTGCTGCAGTGCACGGCCGCCCGACTGTGCACCCGCAACGGGGAACTGAACGCTGCATGAAGTACATCTCCAAGTTGTTCTTTAAGAAGGCTTAGGGTCCCTGGAAGACCCTCGCCCACACCCAGCGTGGAGCGTTGTTGCTCACGTGGCCACACCTCTCGGGATGGCCGTGGGTCTCCGTGATGGGCAGGCGAGTGGAACCACAGGTGCTTCCCGTCCTGGTCACAAAGTCAGAGTGGCTGGGCCAAGTGTCCTGAGAAGAGTCACCTCCTGGGATCCCATCA</dnaseq>
 
<dnaseq>AAGGAAGGAGGGTGACTGCAGAGACCGGCCCTGGGCAGCGGTACCAGGGGCACAGGGAGCCTGGCCCGGCCCATTGTCACTGGAATTCATGCCATGCAGACTTCTACATCAAAGGGAAACAAGGTCAGGAGGGCCGAGGGGTCCACGGCACTCCGCACCCACGGGGCCAGGCTGGCACAACGCCCCAACGCTGCAATCCTGGGAAGAGTCACACGCGCCCTCCCGGGACCCACGTGACCATCAAGGGAGTGTGGAGGACACATCCCTCGGGGGTGACGCCCCTGCAGATGGAGTTTCCCCATCTGTGCCACCCTTGCAAGGCCTGGGAAAGGCTGCGGGGCCAGGCGGCACCGGGCAAGCTGAGTGCCAGGTGGTGGTTGCAACACACCGGGCAAATCTGAAACCATGGGACGGACGAGCTGCACCCCTGGGAAAGAGAACAGAGGAAGGCCGGTTATCAACGTCCTCCTGTGCCTCAGTTTCCAGAAACAAGCCAGACTCAGTGCCTCAGGGAGACCCCGTGTGGCCTCCGGAGAGCACGGGACCCGCCCTTTGTGCAGGTGAGGAAACTGAACCCCAGAGCAGTGAGGGACTGGCCTGGGGACCCTGGGCTCAGCCCTGGGCGCCTTCCCTCTGCCCATCTCAGACGGGCACAGCCAGCACCGCCTCACCCCAACGCGCCTCCAGACTGGCCCTCCAGGGGCCCCCAGGCACAATCCTCTCACTTTCTTCCTCAAGCCCCTGCCTTCCCCCTTCGCACTGTGACCCAGGGGCTGCTAGCAGCTGGGCTGGGCTCCAAAGCTTGAAGCTGCTTCTCCAGGTCTCTTTCCAGGGGGCGGCGGATGGCTGCTCACTCAGGGACGCCAACACCAACAGGAAGGGACCCATGCACGGATCTGACTTCCCTCCCAGGCTCTGCCTTCACTCAATGTCCCTGTGGGGCAGCTGGGGCTCCCGGCCGCCCTCCCCTGCCCACAGCCGTGAGGTTGCTTCCTAGGGTTCTGTTTTCCCCACAGTCGGAACTGAGGTGCTGGGAGGCTCCAGAAGAGGGATGGGGTGGAGCAAGTGGCCTGGAGCCCCCCAGGGCAGACCCCAAAGAGAAGGGTCAGAAGTGCCCTCTGGGGCCTGGGCAGCTGGGGGGAGCCCACAAGCCTGAGACCCTGTGGGAGGGAAGCGCCCCCACCCCGTGGTAAGAAAGGGGCTGGTAGAGGCTCCTATGTGGCTCCCTCTGTCCCCTCCCGACCTCTGGCCAGGCTTGGGATAATCCCTGAGTGGACACAGGCGCCACGATGGGGTCTCGGGGGTGAGGGCTGAGGAGGCTGAGCCTCCAAGGACCCCAGGGTGCCTGTTCCCACTGCACACCCACCAGGGCACAGGGTAGGGATAGTGCCAGGAGGGCCACAGCTGCAGGGTCCATCCCAGGCCGTGGTACACAGGTAGAGGTGGGTGCCAGCCTTCGTGAAGCACCTGCAGAAGCTCCACTCAGGGAGAGAACGAGGCACTCGCCCAAACAGATCCTGGGTCACACGGGGCAGCAAGAGAGGGTGGAGCAAGTGGCCTGGAGCAAAGGGTTGGAGGCCCCGGGGCGGCGCGTTCTCCCCCAAGCCCATTCCAGGGCCATGGGCACCCCCCAGAGGCAGCTGGTGGGACTGCAGCCATGCAGGTCCTAGAGGGCAGGTGACAGGGGACGTGACAGAAGGGGACAAAGGGCCGGCAACATCCCTGGGGGAGGCACAGAGAGGGCCAGACTGCCCTCGGTGGACTGCGGAACCCAGAACCCAACGGCCAATCCTCCCCCTACTCCTCACCCACAGTAAGGGGCCAGGGCTCCATGCAATGAGAACCCACGGGTGATGCCACACGGGGGAGAAGCCACGCGGGGGAGAGGCCATGCAGGGGAGAGGTTACAAGGGGGAGAGGCTGCGGGGTGAGAGGTCACATGGGGCAGAGGCCACGCGGGGGAGAGGCCACGCAGGGGAGAGGTCACATGGGGGAGGCCACGCAGGGGAGAGGTCACATGGGGGAGAGGCCACACAAGGGAGAGGCCATGCAGGGGAGAGGTCACAATGGGGAGAGGCCGCAGGGGGGAGAGGTCACATGGGGCAGAGGCCACGCGGGGGAGAGGCCACGCAGGGGAGAGGTCACATGGGGGAGGACACGCAGGGGAGAGGTCACAAGGGGGAGAGGCCGCAGGGGGAGAGGTCACATGGGGGAGAGGCTACACAGGGGAGAGGCCGCACGCTGGGGAGATGGTCCCTGCGGGAAGACTCCGAGGCAGTCTCCTGCAGCTCCTTCCGGCGAATCCGGTTCAGGAAGTAAAACCAGCCCTGTGTAGAGGTAAGTGATGCTTGTGGGGATAATCTCCGAGCAGCTCACCGCGGCGCTGGCCATTGCCGTTCTCTTCACGGTAGAAGAGTCCATTTGGGGAAAAGGTCCCCATCAGAGATGGAGATGTTCCCTTTCAGACTCCAGGCTATGGCTGTGGGGCCGGCTCCCTACCACGTGGGCTGGGGGCTGGGCACATGCATGCCCACTCCTGGGCCCTCTTCCTGGTAGGCCACAGCACCACACACACTGCAAACCAGGCCTCTTCTTCATCCACCACCACCGTCCAGGCCTCAACATCACCGCGTGGGGTCTTGTGCCCTCTGGGGGAACTTCCGGGCTAATGAGGGGGGACAGTCCCCATTACCGGTCTATCTTTATAAGGCAGTATATGCAACAGTGGAAGTTCTGTGAGACATGTTCCAACCCCGGGGCTGCTGGCAGAACTGTCCCCAAACCCACCCTCGATCCCACGGCCAGGAAGTGGGTCCAAAATTGCCTGGCCAGGTCACACCCCTGCGTGAACCGCCCCACAACACCCAGGGCGCTGCCTGACTTGCCGTCCACCTCTCAGCCCCTCCCCTCACCCCTGCCGCAGCTGCAGGGCCTACCCTCGCCGGGGGCTGCTCCCTGCTTACCTCCCTCGCCCGTGCAATGCCTCTACTTCCCGCAAGGCCTACCGGGAGATGTTACAGGTCACGGTCATATTTGAGCATGAGAAGCTCACGCAGAGAACATTCTGGCTGAGGGAGAGGTCTTGGGGTTCAAGGCTGTTTCTTGGCTCTGCTCAGCCATGCCAGGCAGGAAAATGGGCACCTCTAGTGACCCAGGCTGGCTGAGAGCCTGCAGGGAAGAGCCTTTGGAACGTGAGCCACTGTGGGCTGGCAGGACTGCAACTGGCGTCTCCATCTACTGGTACCGAGGCGAGGAGGAAAAAGCAGGGGGGCCCGGAGACGGCCCCTCTAAGTCTGTAACTCCAGAGCTGCTGCTCAGTCCCCAGAACGTCACCTCCGAGCAGAGCCTGTGACAACTGTCAACTGTGAAGCTGTGGCGTGGGTTGCTACTGAAGCTCTGAAGTCAGCGAGGACACAGCATGTTTGTTCTAGACCGTTTGGCTGCGGGAGGAAGCTGTACATGCACACACTCGCCTCACCACCCTGCGAGTCCACAGGCCCCTCCCCGGAGTCACCTCCAGGTAAAGGGGGCCCTGCGTCGGGACTTGCTCTCTGGGGCGCTGAGATGCTCTACAATGAGCTGTGCTGCAGTGCACGGCCGCCCGACTGTGCACCCGCAACGGGGAACTGAACGCTGCATGAAGTACATCTCCAAGTTGTTCTTTAAGAAGGCTTAGGGTCCCTGGAAGACCCTCGCCCACACCCAGCGTGGAGCGTTGTTGCTCACGTGGCCACACCTCTCGGGATGGCCGTGGGTCTCCGTGATGGGCAGGCGAGTGGAACCACAGGTGCTTCCCGTCCTGGTCACAAAGTCAGAGTGGCTGGGCCAAGTGTCCTGAGAAGAGTCACCTCCTGGGATCCCATCA</dnaseq>

Latest revision as of 08:00, 1 July 2016

Annotated Information

Approved Symbol

AATBC: apoptosis associated transcript in bladder cancer

Synonyms

LincRNAs are dysregulated in bladder cancer. [1].

"apoptosis-associated transcript in bladder cancer"

Chromosome

21q22.3

RefSeq ID

NR_026961

Ensembl ID

ENSG00000215458

Characterisitcs

AATBC is a transcript of 4622bp and localizes in human chromosome 21q22.3, 8465bp downstream of RRP1 gene and 38902bp upstream of CSTB gene. [1]

Functions

The involvement of JNK and NRF2 pathway in apoptosis induced by AATBC knockdown.[1]
AATB knockdown attenuated bladder cancer cell proliferation.[1]

The pro-apoptotic effect of AATBC knockdown in bladder cancer may achieved through activation of JNK signaling and suppression of NRF2. Its overexpression hiders the apoptosis of tumor cells and increases the number of tumor cells, thereby promoting tumor growth, which partially explain AATBC may serve as a potential oncogene in bladder cancer.[1]

AATBC exhibits potentially pro-proliferative and anti-apoptotic functions in bladder cancer. The most possible mechanisms underlying these functions include disregulation in the cell cycle, activity of the intrinsic apoptosis that involved in JNK and NRF2 signaling pathway. AATBC might play a critical role in promoting the tumorigenesis and progression of bladder cancer through the regulation of proliferation and apoptosis.[1]

AATBC knockdown inhibits tumor growth in NOD/SCID mice.[1]

Diseases

AATBC could be a potential therapeutic target and molecular biomarker for bladder cancer. [1]

Expression

AATBC was overexpressed in bladder cancer tissues and cancer cell lines. [1]

AATBC expression was positively correlated with tumor grade and pT stage of bladder cancer.[1]

Experiment Primer Forward primer Reverse primer
RT-PCR AATBC 5'-AAGGCCGGTTATCAACGT-3' 5'-GCCAGTCCCTCACTGCTCT-3'[1]
Knockdown AATBC si#1 5'-CCAUGCACGGAUCUGACUUTT-3' 5'-AAGUCAGAUCCGUGCAUGGTT-3' [1]
AATBC si#2 5'-CGGUCAUAUUUGAGCAUGATT-3' 5'-UCAUGCUCAAAUAUGACCGTT-3' [1]
AATBC negative control siRNA 5'-UUCUCCGAACGUGUCACGUTT-3' 5'-ACGUGACACGUUCGGAGAATT-3' [1]

Labs working on this lncRNA

  • Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China [1]

references

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Zhao F, Lin T, He W, Han J, Zhu D, Hu K, et al. Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer[J]. Oncotarget. 2015,6(2):1064-78.

Sequence

000001 AAGGAAGGAG GGTGACTGCA GAGACCGGCC CTGGGCAGCG GTACCAGGGG CACAGGGAGC CTGGCCCGGC CCATTGTCAC 000080
000081 TGGAATTCAT GCCATGCAGA CTTCTACATC AAAGGGAAAC AAGGTCAGGA GGGCCGAGGG GTCCACGGCA CTCCGCACCC 000160
000161 ACGGGGCCAG GCTGGCACAA CGCCCCAACG CTGCAATCCT GGGAAGAGTC ACACGCGCCC TCCCGGGACC CACGTGACCA 000240
000241 TCAAGGGAGT GTGGAGGACA CATCCCTCGG GGGTGACGCC CCTGCAGATG GAGTTTCCCC ATCTGTGCCA CCCTTGCAAG 000320
000321 GCCTGGGAAA GGCTGCGGGG CCAGGCGGCA CCGGGCAAGC TGAGTGCCAG GTGGTGGTTG CAACACACCG GGCAAATCTG 000400
000401 AAACCATGGG ACGGACGAGC TGCACCCCTG GGAAAGAGAA CAGAGGAAGG CCGGTTATCA ACGTCCTCCT GTGCCTCAGT 000480
000481 TTCCAGAAAC AAGCCAGACT CAGTGCCTCA GGGAGACCCC GTGTGGCCTC CGGAGAGCAC GGGACCCGCC CTTTGTGCAG 000560
000561 GTGAGGAAAC TGAACCCCAG AGCAGTGAGG GACTGGCCTG GGGACCCTGG GCTCAGCCCT GGGCGCCTTC CCTCTGCCCA 000640
000641 TCTCAGACGG GCACAGCCAG CACCGCCTCA CCCCAACGCG CCTCCAGACT GGCCCTCCAG GGGCCCCCAG GCACAATCCT 000720
000721 CTCACTTTCT TCCTCAAGCC CCTGCCTTCC CCCTTCGCAC TGTGACCCAG GGGCTGCTAG CAGCTGGGCT GGGCTCCAAA 000800
000801 GCTTGAAGCT GCTTCTCCAG GTCTCTTTCC AGGGGGCGGC GGATGGCTGC TCACTCAGGG ACGCCAACAC CAACAGGAAG 000880
000881 GGACCCATGC ACGGATCTGA CTTCCCTCCC AGGCTCTGCC TTCACTCAAT GTCCCTGTGG GGCAGCTGGG GCTCCCGGCC 000960
000961 GCCCTCCCCT GCCCACAGCC GTGAGGTTGC TTCCTAGGGT TCTGTTTTCC CCACAGTCGG AACTGAGGTG CTGGGAGGCT 001040
001041 CCAGAAGAGG GATGGGGTGG AGCAAGTGGC CTGGAGCCCC CCAGGGCAGA CCCCAAAGAG AAGGGTCAGA AGTGCCCTCT 001120
001121 GGGGCCTGGG CAGCTGGGGG GAGCCCACAA GCCTGAGACC CTGTGGGAGG GAAGCGCCCC CACCCCGTGG TAAGAAAGGG 001200
001201 GCTGGTAGAG GCTCCTATGT GGCTCCCTCT GTCCCCTCCC GACCTCTGGC CAGGCTTGGG ATAATCCCTG AGTGGACACA 001280
001281 GGCGCCACGA TGGGGTCTCG GGGGTGAGGG CTGAGGAGGC TGAGCCTCCA AGGACCCCAG GGTGCCTGTT CCCACTGCAC 001360
001361 ACCCACCAGG GCACAGGGTA GGGATAGTGC CAGGAGGGCC ACAGCTGCAG GGTCCATCCC AGGCCGTGGT ACACAGGTAG 001440
001441 AGGTGGGTGC CAGCCTTCGT GAAGCACCTG CAGAAGCTCC ACTCAGGGAG AGAACGAGGC ACTCGCCCAA ACAGATCCTG 001520
001521 GGTCACACGG GGCAGCAAGA GAGGGTGGAG CAAGTGGCCT GGAGCAAAGG GTTGGAGGCC CCGGGGCGGC GCGTTCTCCC 001600
001601 CCAAGCCCAT TCCAGGGCCA TGGGCACCCC CCAGAGGCAG CTGGTGGGAC TGCAGCCATG CAGGTCCTAG AGGGCAGGTG 001680
001681 ACAGGGGACG TGACAGAAGG GGACAAAGGG CCGGCAACAT CCCTGGGGGA GGCACAGAGA GGGCCAGACT GCCCTCGGTG 001760
001761 GACTGCGGAA CCCAGAACCC AACGGCCAAT CCTCCCCCTA CTCCTCACCC ACAGTAAGGG GCCAGGGCTC CATGCAATGA 001840
001841 GAACCCACGG GTGATGCCAC ACGGGGGAGA AGCCACGCGG GGGAGAGGCC ATGCAGGGGA GAGGTTACAA GGGGGAGAGG 001920
001921 CTGCGGGGTG AGAGGTCACA TGGGGCAGAG GCCACGCGGG GGAGAGGCCA CGCAGGGGAG AGGTCACATG GGGGAGGCCA 002000
002001 CGCAGGGGAG AGGTCACATG GGGGAGAGGC CACACAAGGG AGAGGCCATG CAGGGGAGAG GTCACAATGG GGAGAGGCCG 002080
002081 CAGGGGGGAG AGGTCACATG GGGCAGAGGC CACGCGGGGG AGAGGCCACG CAGGGGAGAG GTCACATGGG GGAGGACACG 002160
002161 CAGGGGAGAG GTCACAAGGG GGAGAGGCCG CAGGGGGAGA GGTCACATGG GGGAGAGGCT ACACAGGGGA GAGGCCGCAC 002240
002241 GCTGGGGAGA TGGTCCCTGC GGGAAGACTC CGAGGCAGTC TCCTGCAGCT CCTTCCGGCG AATCCGGTTC AGGAAGTAAA 002320
002321 ACCAGCCCTG TGTAGAGGTA AGTGATGCTT GTGGGGATAA TCTCCGAGCA GCTCACCGCG GCGCTGGCCA TTGCCGTTCT 002400
002401 CTTCACGGTA GAAGAGTCCA TTTGGGGAAA AGGTCCCCAT CAGAGATGGA GATGTTCCCT TTCAGACTCC AGGCTATGGC 002480
002481 TGTGGGGCCG GCTCCCTACC ACGTGGGCTG GGGGCTGGGC ACATGCATGC CCACTCCTGG GCCCTCTTCC TGGTAGGCCA 002560
002561 CAGCACCACA CACACTGCAA ACCAGGCCTC TTCTTCATCC ACCACCACCG TCCAGGCCTC AACATCACCG CGTGGGGTCT 002640
002641 TGTGCCCTCT GGGGGAACTT CCGGGCTAAT GAGGGGGGAC AGTCCCCATT ACCGGTCTAT CTTTATAAGG CAGTATATGC 002720
002721 AACAGTGGAA GTTCTGTGAG ACATGTTCCA ACCCCGGGGC TGCTGGCAGA ACTGTCCCCA AACCCACCCT CGATCCCACG 002800
002801 GCCAGGAAGT GGGTCCAAAA TTGCCTGGCC AGGTCACACC CCTGCGTGAA CCGCCCCACA ACACCCAGGG CGCTGCCTGA 002880
002881 CTTGCCGTCC ACCTCTCAGC CCCTCCCCTC ACCCCTGCCG CAGCTGCAGG GCCTACCCTC GCCGGGGGCT GCTCCCTGCT 002960
002961 TACCTCCCTC GCCCGTGCAA TGCCTCTACT TCCCGCAAGG CCTACCGGGA GATGTTACAG GTCACGGTCA TATTTGAGCA 003040
003041 TGAGAAGCTC ACGCAGAGAA CATTCTGGCT GAGGGAGAGG TCTTGGGGTT CAAGGCTGTT TCTTGGCTCT GCTCAGCCAT 003120
003121 GCCAGGCAGG AAAATGGGCA CCTCTAGTGA CCCAGGCTGG CTGAGAGCCT GCAGGGAAGA GCCTTTGGAA CGTGAGCCAC 003200
003201 TGTGGGCTGG CAGGACTGCA ACTGGCGTCT CCATCTACTG G