Difference between revisions of "HELLPAR"
| Line 5: | Line 5: | ||
HELLP associated long non-coding RNA | HELLP associated long non-coding RNA | ||
===Synonyms=== | ===Synonyms=== | ||
| − | LINC-HELLP | + | LINC-HELLP, "long intergenic non-protein coding RNA associated with HELLP syndrome" |
===Chromosome=== | ===Chromosome=== | ||
12q23.2 | 12q23.2 | ||
| Line 18: | Line 18: | ||
===Characteristics=== | ===Characteristics=== | ||
| − | + | HELLPAR is a transcript of 205,012 bases and is localized in early placenta extravillous trophoblasts.<ref name="ref1" /> | |
===Functions=== | ===Functions=== | ||
| − | + | HELLPAR is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.<ref name="ref1" /> | |
===Expression=== | ===Expression=== | ||
| − | + | Expression can be found to be nuclear, perinuclear, and cytoplasmic, both in vitro — in the extravillous trophoblast cell line (SGHPL-5)and in vivo (i.e., first trimester placenta tissue).<ref name="ref1" /> | |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Revision as of 06:01, 19 September 2016
Contents
Annotated Information
Approved Symbol
HELLPAR
Approved Name
HELLP associated long non-coding RNA
Synonyms
LINC-HELLP, "long intergenic non-protein coding RNA associated with HELLP syndrome"
Chromosome
12q23.2
OMIM ID
614985
Ensembl ID
ENSG00000281344
pubmed IDs
23093777
Diseases
- HELLP syndrome
Characteristics
HELLPAR is a transcript of 205,012 bases and is localized in early placenta extravillous trophoblasts.[1]
Functions
HELLPAR is involved in 1 or more processes in the cell cycle, in which siRNA-mediated knockdown of the transcript leads to reduced activity of the G2/M phase of the cell cycle, while the G1/S phase shows an increase in activity.[1]
Expression
Expression can be found to be nuclear, perinuclear, and cytoplasmic, both in vitro — in the extravillous trophoblast cell line (SGHPL-5)and in vivo (i.e., first trimester placenta tissue).[1]
Labs working on this lncRNA
- Department of Clinical Chemistry and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.[1].
