Difference between revisions of "HTT-AS"
Chunlei Yu (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== HTT-AS ===Approved Name=== HTT antisense RNA (head to head) ===Previous Symbols=== HTT-AS1 ===Synonyms=== HTTAS ===Chromosome==...") |
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===Approved Name=== | ===Approved Name=== | ||
HTT antisense RNA (head to head) | HTT antisense RNA (head to head) | ||
| + | [[File: HTT-AS.jpg|right|thumb|400px|'''HTTAS_v1 expression.(A and B) Relative expression level of HTTAS_v1 in multiple human tissues and brain regions. (C) Genomic region 5′ to the HTTAS_v1 transcription start site. (D) HTTAS_v1 promoter activity in HEK293 cells. (E) Promoter activity is increased by a short repeat, but is reduced by repeat expansion.''' <ref name="ref1" />.]] | ||
===Previous Symbols=== | ===Previous Symbols=== | ||
HTT-AS1 | HTT-AS1 | ||
| Line 12: | Line 13: | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
NR_045414 | NR_045414 | ||
| − | |||
| − | |||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000251075 | ENSG00000251075 | ||
===pubmed IDs=== | ===pubmed IDs=== | ||
21672921, 23756188 | 21672921, 23756188 | ||
| + | ===Disease=== | ||
| + | * Huntington’s disease (HD) | ||
| + | |||
| + | ===Characteristics=== | ||
| + | HTTAS is 5'capped, poly (A) tailed and contains three exons, alternatively spliced into HTT-AS1 (exons 1 and 3) and HTT-AS2 (exons 2 and 3)<ref name="ref1" />. | ||
| + | |||
| + | ===Expression=== | ||
| + | HTT-AS1 is expressed in multiple tissues types, with brain and heart expression 2-fold higher than muscle or kidney while is reduced in HD brains.<ref name="ref1" />. | ||
| + | |||
| + | ===Function=== | ||
| + | In cell systems, overexpression of HTT-AS1 specifically reduces endogenous HTT transcript levels, while siRNA knockdown of HTT-AS1 increases HTT transcript levels <ref name="ref1" />. | ||
| + | HTT-AS1 negatively regulates HTT expression, and this effect is dependent on repeat length of HTT-AS1 <ref name="ref1" />. | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Psychiatry, Division of Neurobiology, Laboratory of Genetic Neurobiology <ref name="ref1" />. | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1">Daniel W. Chung, Dobrila D. Rudnicki, Lan Yu, and Russell L. Margolis(2011) A natural antisense transcript at the Huntington’s | ||
| + | disease repeat locus regulates HTT expression. Human Molecular Genetics,Vol. 20, No. 17 3467–3477.</ref>(1) | ||
| + | </references> | ||
| + | |||
===Sequence=== | ===Sequence=== | ||
>gi|354623064|ref|NR_045414.1| Homo sapiens HTT antisense RNA (head to head) (HTT-AS), antisense RNA | >gi|354623064|ref|NR_045414.1| Homo sapiens HTT antisense RNA (head to head) (HTT-AS), antisense RNA | ||
<dnaseq>AGCAAGGCCGCTGACAGCGCAGCGCCCCACCCGGGCGAAGGCGCGGGGCTCAACGGAGAGGGGACGGGGCGTGGTGAGACTGTAATGGGCAATGAACATGAACTATTCAGGGGAAGATTGTTAAATGAAAGAATCTCACTGGGCGGGGAGCTAAGCATGACACCTGGCCACCTGCCTGTGCCTGTCCTGCCGAGAAGAGAGAAGAGGCCTTGAAAGCAGCCAGAGGGGGTGCACACCAGCCTGGGCAGGGGGCAGTAAGCGGGAGCAGCCCCGACCCGAGACCAGCAGCCCCTCTCTTCACCTCCAAGCCGGAGCGTGGCCTCATCCCTCCCAGGTGACTCTCTTCCCAGAAATGGTGCTGTCTCAAGAAGCCCCCTCTCTCCAAGCATCTGCCAGGCCGTTTGAGCTGCCAGGAGTCTTTGTCCTGCCCCACCAGCTCTGTCTCATCTAGATGGGGCCTTCTGTCCAGTGCTACTGAACAGAATGTTCTGCATGCCTGGCCAGTGCAGAGACCTCCTTGCACCCCTGCTCCAAGGCTGGCTCTGCCACTGACAGATAGACTGACATTTGCACTGTTCTGAGCCCCTGGGGGTGCAGTATGCAGAGCTAGGCCATCTCTGTCGTCCTACAAGAACCAGGCAGCCCTGAGCAAGGCTTTTAACATGCAAGGTGTACTCCACTAGTCTTAAGATATCTTGAGCCACTGTCTTGCTGCTCCCAACTCCCAAGCCACGCTGACT</dnaseq> | <dnaseq>AGCAAGGCCGCTGACAGCGCAGCGCCCCACCCGGGCGAAGGCGCGGGGCTCAACGGAGAGGGGACGGGGCGTGGTGAGACTGTAATGGGCAATGAACATGAACTATTCAGGGGAAGATTGTTAAATGAAAGAATCTCACTGGGCGGGGAGCTAAGCATGACACCTGGCCACCTGCCTGTGCCTGTCCTGCCGAGAAGAGAGAAGAGGCCTTGAAAGCAGCCAGAGGGGGTGCACACCAGCCTGGGCAGGGGGCAGTAAGCGGGAGCAGCCCCGACCCGAGACCAGCAGCCCCTCTCTTCACCTCCAAGCCGGAGCGTGGCCTCATCCCTCCCAGGTGACTCTCTTCCCAGAAATGGTGCTGTCTCAAGAAGCCCCCTCTCTCCAAGCATCTGCCAGGCCGTTTGAGCTGCCAGGAGTCTTTGTCCTGCCCCACCAGCTCTGTCTCATCTAGATGGGGCCTTCTGTCCAGTGCTACTGAACAGAATGTTCTGCATGCCTGGCCAGTGCAGAGACCTCCTTGCACCCCTGCTCCAAGGCTGGCTCTGCCACTGACAGATAGACTGACATTTGCACTGTTCTGAGCCCCTGGGGGTGCAGTATGCAGAGCTAGGCCATCTCTGTCGTCCTACAAGAACCAGGCAGCCCTGAGCAAGGCTTTTAACATGCAAGGTGTACTCCACTAGTCTTAAGATATCTTGAGCCACTGTCTTGCTGCTCCCAACTCCCAAGCCACGCTGACT</dnaseq> | ||
Latest revision as of 02:07, 27 September 2016
Contents
Annotated Information
Approved Symbol
HTT-AS
Approved Name
HTT antisense RNA (head to head)
HTTAS_v1 expression.(A and B) Relative expression level of HTTAS_v1 in multiple human tissues and brain regions. (C) Genomic region 5′ to the HTTAS_v1 transcription start site. (D) HTTAS_v1 promoter activity in HEK293 cells. (E) Promoter activity is increased by a short repeat, but is reduced by repeat expansion. [1].
Previous Symbols
HTT-AS1
Synonyms
HTTAS
Chromosome
4p16.3
RefSeq ID
NR_045414
Ensembl ID
ENSG00000251075
pubmed IDs
21672921, 23756188
Disease
- Huntington’s disease (HD)
Characteristics
HTTAS is 5'capped, poly (A) tailed and contains three exons, alternatively spliced into HTT-AS1 (exons 1 and 3) and HTT-AS2 (exons 2 and 3)[1].
Expression
HTT-AS1 is expressed in multiple tissues types, with brain and heart expression 2-fold higher than muscle or kidney while is reduced in HD brains.[1].
Function
In cell systems, overexpression of HTT-AS1 specifically reduces endogenous HTT transcript levels, while siRNA knockdown of HTT-AS1 increases HTT transcript levels [1]. HTT-AS1 negatively regulates HTT expression, and this effect is dependent on repeat length of HTT-AS1 [1].
Labs working on this lncRNA
- Department of Psychiatry, Division of Neurobiology, Laboratory of Genetic Neurobiology [1].
References
Sequence
>gi|354623064|ref|NR_045414.1| Homo sapiens HTT antisense RNA (head to head) (HTT-AS), antisense RNA
000001 AGCAAGGCCG CTGACAGCGC AGCGCCCCAC CCGGGCGAAG GCGCGGGGCT CAACGGAGAG GGGACGGGGC GTGGTGAGAC 000080
000081 TGTAATGGGC AATGAACATG AACTATTCAG GGGAAGATTG TTAAATGAAA GAATCTCACT GGGCGGGGAG CTAAGCATGA 000160
000161 CACCTGGCCA CCTGCCTGTG CCTGTCCTGC CGAGAAGAGA GAAGAGGCCT TGAAAGCAGC CAGAGGGGGT GCACACCAGC 000240
000241 CTGGGCAGGG GGCAGTAAGC GGGAGCAGCC CCGACCCGAG ACCAGCAGCC CCTCTCTTCA CCTCCAAGCC GGAGCGTGGC 000320
000321 CTCATCCCTC CCAGGTGACT CTCTTCCCAG AAATGGTGCT GTCTCAAGAA GCCCCCTCTC TCCAAGCATC TGCCAGGCCG 000400
000401 TTTGAGCTGC CAGGAGTCTT TGTCCTGCCC CACCAGCTCT GTCTCATCTA GATGGGGCCT TCTGTCCAGT GCTACTGAAC 000480
000481 AGAATGTTCT GCATGCCTGG CCAGTGCAGA GACCTCCTTG CACCCCTGCT CCAAGGCTGG CTCTGCCACT GACAGATAGA 000560
000561 CTGACATTTG CACTGTTCTG AGCCCCTGGG GGTGCAGTAT GCAGAGCTAG GCCATCTCTG TCGTCCTACA AGAACCAGGC 000640
000641 AGCCCTGAGC AAGGCTTTTA ACATGCAAGG TGTACTCCAC TAGTCTTAAG ATATCTTGAG CCACTGTCTT GCTGCTCCCA 000720
000721 ACTCCCAAGC CACGCTGACT
000081 TGTAATGGGC AATGAACATG AACTATTCAG GGGAAGATTG TTAAATGAAA GAATCTCACT GGGCGGGGAG CTAAGCATGA 000160
000161 CACCTGGCCA CCTGCCTGTG CCTGTCCTGC CGAGAAGAGA GAAGAGGCCT TGAAAGCAGC CAGAGGGGGT GCACACCAGC 000240
000241 CTGGGCAGGG GGCAGTAAGC GGGAGCAGCC CCGACCCGAG ACCAGCAGCC CCTCTCTTCA CCTCCAAGCC GGAGCGTGGC 000320
000321 CTCATCCCTC CCAGGTGACT CTCTTCCCAG AAATGGTGCT GTCTCAAGAA GCCCCCTCTC TCCAAGCATC TGCCAGGCCG 000400
000401 TTTGAGCTGC CAGGAGTCTT TGTCCTGCCC CACCAGCTCT GTCTCATCTA GATGGGGCCT TCTGTCCAGT GCTACTGAAC 000480
000481 AGAATGTTCT GCATGCCTGG CCAGTGCAGA GACCTCCTTG CACCCCTGCT CCAAGGCTGG CTCTGCCACT GACAGATAGA 000560
000561 CTGACATTTG CACTGTTCTG AGCCCCTGGG GGTGCAGTAT GCAGAGCTAG GCCATCTCTG TCGTCCTACA AGAACCAGGC 000640
000641 AGCCCTGAGC AAGGCTTTTA ACATGCAAGG TGTACTCCAC TAGTCTTAAG ATATCTTGAG CCACTGTCTT GCTGCTCCCA 000720
000721 ACTCCCAAGC CACGCTGACT
