Difference between revisions of "LAMP5-AS1"
Chunlei Yu (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== LAMP5-AS1 ===Approved Name=== LAMP5 antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosome=== 20p12.2 ===RefSe...") |
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===Approved Name=== | ===Approved Name=== | ||
LAMP5 antisense RNA 1 | LAMP5 antisense RNA 1 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===Chromosome=== | ===Chromosome=== | ||
20p12.2 | 20p12.2 | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
NR_109957 | NR_109957 | ||
| − | |||
| − | |||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000225988 | ENSG00000225988 | ||
===pubmed IDs=== | ===pubmed IDs=== | ||
24488769 | 24488769 | ||
| + | ===Disease=== | ||
| + | * acute lymphoblastic leukemia<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | LAMP5-AS1-001(LAMP5's natural antisense-lncRNA/ENST00000443469),is found to be highly expressed and correlated with its adjacent gene, LAMP5, a lysosomal-associated membrane protein that is upregulated in non-activated human plasmacytoid dendritic cells and may be involved in endocytosis.<ref name="ref1" /> | ||
| + | |||
| + | ===Regulation=== | ||
| + | LAMP5-AS1-001 is epigenetically regulated by H3K79 methylation.<ref name="ref1" /> | ||
| + | |||
| + | ===Function=== | ||
| + | LAMP5-AS1-001 might play significant roles in MLL-r leukemia.<ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou 510275, China. <ref name="ref1" /> | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1">Fang K, Han BW, Chen ZH, Lin KY, Zeng CW, Li XJ, et al. A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target[J]. Human molecular genetics. 2014,23(12):3278-88.</ref>(1) | ||
| + | </references> | ||
| + | |||
===Sequence=== | ===Sequence=== | ||
>gi|568599893|ref|NR_109957.1| Homo sapiens LAMP5 antisense RNA 1 (LAMP5-AS1), long non-coding RNA | >gi|568599893|ref|NR_109957.1| Homo sapiens LAMP5 antisense RNA 1 (LAMP5-AS1), long non-coding RNA | ||
<dnaseq>AAGCTAATTGACTTTACTTTGCCGGCTCTGTTCTCTGCAAAGAGTGCCCGTCCTCTCTCCCAGTCGCCAAATCGCTACTCACGGAACAACATCAGGAGAACTCGAAGTCTGTCGATGCTGGGGACCCCTCTTCCTTGGAGATCCATACTCGCAGTGCCCCGAATGAGGCCGGCTGTGCTGCTGCAGAGGCCGCCAGAGAGGGAATCCCTCAAAGTCGCCGCTGGAGTGGGCCGGGGAAGTGTGCGCTGCTCAGGACACATGGCCCGTGGTCTGTGGTGTTACCTTTGGATGGCGCGGCGGTAGGTGGGCCTGGTTGCTCATGGCTCAGTATCCCTGGGCTGGCCCGCGCGCCCGCTGCGGACTCCAGACTTGACGGCTTCTGCCCGCGGGAAGGAAGATGCATTCTACTGTTGGGCGCCTCGCTGCCTGCACCTCTGGCTCGCGATGTCCTCAACCTGGGAAAGACGTCGGCGCTTTGCACCCGAGTTGGGCTCCTTGGCACATTCGAGCAGCTGCTCTGGAGAAACAGCAGGATCTACGGAAGTTTGTACCCACCGCCTCGCCTGCAGCCTCGGGAGTCTCAACCCAAGCCGGCCCGGCCTTGTAGCCCAGAGCAGCAAAGCCACAGCAGGCAACGCGAGCTAACGCGGGTCGCGCGGAGGTCGGGAGCCCAGGCGGCGGAGGCGGCGGCGGCGCAGTTATTCCCGGGTGACTCTGGGGACTCGTGCAGATGGGGGACGCCTCCGGCCACGCACTTGGAGCCAGCTGCAGCTCCCGGGAGCCTGGCACTGATGGATCGTCTCATTTCCCAACTTGATGGGCCGGAACCTGGGATAGCTGTGCCTGCAGGGAGAGGCAAGACGAAGAAAGTCGTGCATCCCCTGGGAGGGAGAGGCTGCTTGTCCCTGTCCTGACACCCCACCCCATGGCTCAGGCTGGAGTCAGAGGGAATGAGAAGAGTGGGAAGCCAGAGGCTGAGCTTGGCTTCCTAGAATCTTCCTCCATCTCAAGAAGTGGAACTCCAACTCCGCTCCAAGGCCTACCTCCTTAGCTGGGTCTTGGAGATCACTGAACGGATCTCAAACCTGGGATCTTAAAGAATCCCAAATCTGGGTGCACCTCAGCAGAATACGTTCTCCCAGACCAGTCTGTCAGGAAAGCCCCAGCTCTCTAGCTGGCCAGGAAACACCACATGGTTCGGGACATCTGACAAAGTGCCGTCCAAAATCCAAAGTGTGGTTCTGAGACCAGTAGCATCACTGTCCCTTGGAGACTGCAGGATTGCAGGCCTCATCCAGCCCTACTGCATCGGAACGTGCATCTGAGAGATATCCAAGGACTGTGTACAGTCTGGTTGGAGAAGCCCTTGCCCAATTTACAGAACCTGAGTTTAGCCATTGACAACCTGTTCAACCCTGTTCCTCCCAGCCTCCTCTTCATCACCTGTCAAGTGGGAGCTGTTTTGGAGGTCCTGGGGGGCTCTTATGCACTCCTGAGTGCATTCAGACCAATGGAATCAGAATCTCTGGTTTGCTGGAGCCTAGGCAGGAGTGTGTGTTTTGGGTGTCTCCAGGTGATTTTAATGGCAGCCAGGAATGACTAGTGTAGAAATACCCACTTTACAGATTAGTTAGATTAGCTAATCTGTCTAGCCTGGGCAAGACAATATGTGCAGTGTTAAGCCCACTGCTCTCTGTAGCCTGATTCATTCTGTAGCCTGACATTCTGTAGCCTGAGTCATTCTGACTCCAGCAAGTATGGCCTTGAACCATACTTAATTAGCCAAGTATGGCTAATCAGCTTCGCTGTGCCTCGGTTTCCTTACCCACAAAATGAAGTTGATAATAGTGCCCACCACAAAGGGTGTTTGTGAGGATTTAGAATCAAATGTTTAAAATCAAATTCAATAAATATTAGTTTATGAGGTC</dnaseq> | <dnaseq>AAGCTAATTGACTTTACTTTGCCGGCTCTGTTCTCTGCAAAGAGTGCCCGTCCTCTCTCCCAGTCGCCAAATCGCTACTCACGGAACAACATCAGGAGAACTCGAAGTCTGTCGATGCTGGGGACCCCTCTTCCTTGGAGATCCATACTCGCAGTGCCCCGAATGAGGCCGGCTGTGCTGCTGCAGAGGCCGCCAGAGAGGGAATCCCTCAAAGTCGCCGCTGGAGTGGGCCGGGGAAGTGTGCGCTGCTCAGGACACATGGCCCGTGGTCTGTGGTGTTACCTTTGGATGGCGCGGCGGTAGGTGGGCCTGGTTGCTCATGGCTCAGTATCCCTGGGCTGGCCCGCGCGCCCGCTGCGGACTCCAGACTTGACGGCTTCTGCCCGCGGGAAGGAAGATGCATTCTACTGTTGGGCGCCTCGCTGCCTGCACCTCTGGCTCGCGATGTCCTCAACCTGGGAAAGACGTCGGCGCTTTGCACCCGAGTTGGGCTCCTTGGCACATTCGAGCAGCTGCTCTGGAGAAACAGCAGGATCTACGGAAGTTTGTACCCACCGCCTCGCCTGCAGCCTCGGGAGTCTCAACCCAAGCCGGCCCGGCCTTGTAGCCCAGAGCAGCAAAGCCACAGCAGGCAACGCGAGCTAACGCGGGTCGCGCGGAGGTCGGGAGCCCAGGCGGCGGAGGCGGCGGCGGCGCAGTTATTCCCGGGTGACTCTGGGGACTCGTGCAGATGGGGGACGCCTCCGGCCACGCACTTGGAGCCAGCTGCAGCTCCCGGGAGCCTGGCACTGATGGATCGTCTCATTTCCCAACTTGATGGGCCGGAACCTGGGATAGCTGTGCCTGCAGGGAGAGGCAAGACGAAGAAAGTCGTGCATCCCCTGGGAGGGAGAGGCTGCTTGTCCCTGTCCTGACACCCCACCCCATGGCTCAGGCTGGAGTCAGAGGGAATGAGAAGAGTGGGAAGCCAGAGGCTGAGCTTGGCTTCCTAGAATCTTCCTCCATCTCAAGAAGTGGAACTCCAACTCCGCTCCAAGGCCTACCTCCTTAGCTGGGTCTTGGAGATCACTGAACGGATCTCAAACCTGGGATCTTAAAGAATCCCAAATCTGGGTGCACCTCAGCAGAATACGTTCTCCCAGACCAGTCTGTCAGGAAAGCCCCAGCTCTCTAGCTGGCCAGGAAACACCACATGGTTCGGGACATCTGACAAAGTGCCGTCCAAAATCCAAAGTGTGGTTCTGAGACCAGTAGCATCACTGTCCCTTGGAGACTGCAGGATTGCAGGCCTCATCCAGCCCTACTGCATCGGAACGTGCATCTGAGAGATATCCAAGGACTGTGTACAGTCTGGTTGGAGAAGCCCTTGCCCAATTTACAGAACCTGAGTTTAGCCATTGACAACCTGTTCAACCCTGTTCCTCCCAGCCTCCTCTTCATCACCTGTCAAGTGGGAGCTGTTTTGGAGGTCCTGGGGGGCTCTTATGCACTCCTGAGTGCATTCAGACCAATGGAATCAGAATCTCTGGTTTGCTGGAGCCTAGGCAGGAGTGTGTGTTTTGGGTGTCTCCAGGTGATTTTAATGGCAGCCAGGAATGACTAGTGTAGAAATACCCACTTTACAGATTAGTTAGATTAGCTAATCTGTCTAGCCTGGGCAAGACAATATGTGCAGTGTTAAGCCCACTGCTCTCTGTAGCCTGATTCATTCTGTAGCCTGACATTCTGTAGCCTGAGTCATTCTGACTCCAGCAAGTATGGCCTTGAACCATACTTAATTAGCCAAGTATGGCTAATCAGCTTCGCTGTGCCTCGGTTTCCTTACCCACAAAATGAAGTTGATAATAGTGCCCACCACAAAGGGTGTTTGTGAGGATTTAGAATCAAATGTTTAAAATCAAATTCAATAAATATTAGTTTATGAGGTC</dnaseq> | ||
Latest revision as of 05:40, 23 October 2016
Contents
Annotated Information
Approved Symbol
LAMP5-AS1
Approved Name
LAMP5 antisense RNA 1
Chromosome
20p12.2
RefSeq ID
NR_109957
Ensembl ID
ENSG00000225988
pubmed IDs
24488769
Disease
- acute lymphoblastic leukemia[1]
Expression
LAMP5-AS1-001(LAMP5's natural antisense-lncRNA/ENST00000443469),is found to be highly expressed and correlated with its adjacent gene, LAMP5, a lysosomal-associated membrane protein that is upregulated in non-activated human plasmacytoid dendritic cells and may be involved in endocytosis.[1]
Regulation
LAMP5-AS1-001 is epigenetically regulated by H3K79 methylation.[1]
Function
LAMP5-AS1-001 might play significant roles in MLL-r leukemia.[1]
Labs working on this lncRNA
- Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, School of Life Science, Sun Yat-sen University, Guangzhou 510275, China. [1]
References
Sequence
>gi|568599893|ref|NR_109957.1| Homo sapiens LAMP5 antisense RNA 1 (LAMP5-AS1), long non-coding RNA
000001 AAGCTAATTG ACTTTACTTT GCCGGCTCTG TTCTCTGCAA AGAGTGCCCG TCCTCTCTCC CAGTCGCCAA ATCGCTACTC 000080
000081 ACGGAACAAC ATCAGGAGAA CTCGAAGTCT GTCGATGCTG GGGACCCCTC TTCCTTGGAG ATCCATACTC GCAGTGCCCC 000160
000161 GAATGAGGCC GGCTGTGCTG CTGCAGAGGC CGCCAGAGAG GGAATCCCTC AAAGTCGCCG CTGGAGTGGG CCGGGGAAGT 000240
000241 GTGCGCTGCT CAGGACACAT GGCCCGTGGT CTGTGGTGTT ACCTTTGGAT GGCGCGGCGG TAGGTGGGCC TGGTTGCTCA 000320
000321 TGGCTCAGTA TCCCTGGGCT GGCCCGCGCG CCCGCTGCGG ACTCCAGACT TGACGGCTTC TGCCCGCGGG AAGGAAGATG 000400
000401 CATTCTACTG TTGGGCGCCT CGCTGCCTGC ACCTCTGGCT CGCGATGTCC TCAACCTGGG AAAGACGTCG GCGCTTTGCA 000480
000481 CCCGAGTTGG GCTCCTTGGC ACATTCGAGC AGCTGCTCTG GAGAAACAGC AGGATCTACG GAAGTTTGTA CCCACCGCCT 000560
000561 CGCCTGCAGC CTCGGGAGTC TCAACCCAAG CCGGCCCGGC CTTGTAGCCC AGAGCAGCAA AGCCACAGCA GGCAACGCGA 000640
000641 GCTAACGCGG GTCGCGCGGA GGTCGGGAGC CCAGGCGGCG GAGGCGGCGG CGGCGCAGTT ATTCCCGGGT GACTCTGGGG 000720
000721 ACTCGTGCAG ATGGGGGACG CCTCCGGCCA CGCACTTGGA GCCAGCTGCA GCTCCCGGGA GCCTGGCACT GATGGATCGT 000800
000801 CTCATTTCCC AACTTGATGG GCCGGAACCT GGGATAGCTG TGCCTGCAGG GAGAGGCAAG ACGAAGAAAG TCGTGCATCC 000880
000881 CCTGGGAGGG AGAGGCTGCT TGTCCCTGTC CTGACACCCC ACCCCATGGC TCAGGCTGGA GTCAGAGGGA ATGAGAAGAG 000960
000961 TGGGAAGCCA GAGGCTGAGC TTGGCTTCCT AGAATCTTCC TCCATCTCAA GAAGTGGAAC TCCAACTCCG CTCCAAGGCC 001040
001041 TACCTCCTTA GCTGGGTCTT GGAGATCACT GAACGGATCT CAAACCTGGG ATCTTAAAGA ATCCCAAATC TGGGTGCACC 001120
001121 TCAGCAGAAT ACGTTCTCCC AGACCAGTCT GTCAGGAAAG CCCCAGCTCT CTAGCTGGCC AGGAAACACC ACATGGTTCG 001200
001201 GGACATCTGA CAAAGTGCCG TCCAAAATCC AAAGTGTGGT TCTGAGACCA GTAGCATCAC TGTCCCTTGG AGACTGCAGG 001280
001281 ATTGCAGGCC TCATCCAGCC CTACTGCATC GGAACGTGCA TCTGAGAGAT ATCCAAGGAC TGTGTACAGT CTGGTTGGAG 001360
001361 AAGCCCTTGC CCAATTTACA GAACCTGAGT TTAGCCATTG ACAACCTGTT CAACCCTGTT CCTCCCAGCC TCCTCTTCAT 001440
001441 CACCTGTCAA GTGGGAGCTG TTTTGGAGGT CCTGGGGGGC TCTTATGCAC TCCTGAGTGC ATTCAGACCA ATGGAATCAG 001520
001521 AATCTCTGGT TTGCTGGAGC CTAGGCAGGA GTGTGTGTTT TGGGTGTCTC CAGGTGATTT TAATGGCAGC CAGGAATGAC 001600
001601 TAGTGTAGAA ATACCCACTT TACAGATTAG TTAGATTAGC TAATCTGTCT AGCCTGGGCA AGACAATATG TGCAGTGTTA 001680
001681 AGCCCACTGC TCTCTGTAGC CTGATTCATT CTGTAGCCTG ACATTCTGTA GCCTGAGTCA TTCTGACTCC AGCAAGTATG 001760
001761 GCCTTGAACC ATACTTAATT AGCCAAGTAT GGCTAATCAG CTTCGCTGTG CCTCGGTTTC CTTACCCACA AAATGAAGTT 001840
001841 GATAATAGTG CCCACCACAA AGGGTGTTTG TGAGGATTTA GAATCAAATG TTTAAAATCA AATTCAATAA ATATTAGTTT 001920
001921 ATGAGGTC
000081 ACGGAACAAC ATCAGGAGAA CTCGAAGTCT GTCGATGCTG GGGACCCCTC TTCCTTGGAG ATCCATACTC GCAGTGCCCC 000160
000161 GAATGAGGCC GGCTGTGCTG CTGCAGAGGC CGCCAGAGAG GGAATCCCTC AAAGTCGCCG CTGGAGTGGG CCGGGGAAGT 000240
000241 GTGCGCTGCT CAGGACACAT GGCCCGTGGT CTGTGGTGTT ACCTTTGGAT GGCGCGGCGG TAGGTGGGCC TGGTTGCTCA 000320
000321 TGGCTCAGTA TCCCTGGGCT GGCCCGCGCG CCCGCTGCGG ACTCCAGACT TGACGGCTTC TGCCCGCGGG AAGGAAGATG 000400
000401 CATTCTACTG TTGGGCGCCT CGCTGCCTGC ACCTCTGGCT CGCGATGTCC TCAACCTGGG AAAGACGTCG GCGCTTTGCA 000480
000481 CCCGAGTTGG GCTCCTTGGC ACATTCGAGC AGCTGCTCTG GAGAAACAGC AGGATCTACG GAAGTTTGTA CCCACCGCCT 000560
000561 CGCCTGCAGC CTCGGGAGTC TCAACCCAAG CCGGCCCGGC CTTGTAGCCC AGAGCAGCAA AGCCACAGCA GGCAACGCGA 000640
000641 GCTAACGCGG GTCGCGCGGA GGTCGGGAGC CCAGGCGGCG GAGGCGGCGG CGGCGCAGTT ATTCCCGGGT GACTCTGGGG 000720
000721 ACTCGTGCAG ATGGGGGACG CCTCCGGCCA CGCACTTGGA GCCAGCTGCA GCTCCCGGGA GCCTGGCACT GATGGATCGT 000800
000801 CTCATTTCCC AACTTGATGG GCCGGAACCT GGGATAGCTG TGCCTGCAGG GAGAGGCAAG ACGAAGAAAG TCGTGCATCC 000880
000881 CCTGGGAGGG AGAGGCTGCT TGTCCCTGTC CTGACACCCC ACCCCATGGC TCAGGCTGGA GTCAGAGGGA ATGAGAAGAG 000960
000961 TGGGAAGCCA GAGGCTGAGC TTGGCTTCCT AGAATCTTCC TCCATCTCAA GAAGTGGAAC TCCAACTCCG CTCCAAGGCC 001040
001041 TACCTCCTTA GCTGGGTCTT GGAGATCACT GAACGGATCT CAAACCTGGG ATCTTAAAGA ATCCCAAATC TGGGTGCACC 001120
001121 TCAGCAGAAT ACGTTCTCCC AGACCAGTCT GTCAGGAAAG CCCCAGCTCT CTAGCTGGCC AGGAAACACC ACATGGTTCG 001200
001201 GGACATCTGA CAAAGTGCCG TCCAAAATCC AAAGTGTGGT TCTGAGACCA GTAGCATCAC TGTCCCTTGG AGACTGCAGG 001280
001281 ATTGCAGGCC TCATCCAGCC CTACTGCATC GGAACGTGCA TCTGAGAGAT ATCCAAGGAC TGTGTACAGT CTGGTTGGAG 001360
001361 AAGCCCTTGC CCAATTTACA GAACCTGAGT TTAGCCATTG ACAACCTGTT CAACCCTGTT CCTCCCAGCC TCCTCTTCAT 001440
001441 CACCTGTCAA GTGGGAGCTG TTTTGGAGGT CCTGGGGGGC TCTTATGCAC TCCTGAGTGC ATTCAGACCA ATGGAATCAG 001520
001521 AATCTCTGGT TTGCTGGAGC CTAGGCAGGA GTGTGTGTTT TGGGTGTCTC CAGGTGATTT TAATGGCAGC CAGGAATGAC 001600
001601 TAGTGTAGAA ATACCCACTT TACAGATTAG TTAGATTAGC TAATCTGTCT AGCCTGGGCA AGACAATATG TGCAGTGTTA 001680
001681 AGCCCACTGC TCTCTGTAGC CTGATTCATT CTGTAGCCTG ACATTCTGTA GCCTGAGTCA TTCTGACTCC AGCAAGTATG 001760
001761 GCCTTGAACC ATACTTAATT AGCCAAGTAT GGCTAATCAG CTTCGCTGTG CCTCGGTTTC CTTACCCACA AAATGAAGTT 001840
001841 GATAATAGTG CCCACCACAA AGGGTGTTTG TGAGGATTTA GAATCAAATG TTTAAAATCA AATTCAATAA ATATTAGTTT 001920
001921 ATGAGGTC
