Difference between revisions of "DSCR4"
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DSCR4:Down syndrome critical region 4 | DSCR4:Down syndrome critical region 4 | ||
| − | DCRB:Down syndrome Critical | + | DCRB:Down syndrome Critical Region gene B<ref name="ref1" /> |
===Characteristics=== | ===Characteristics=== | ||
| − | DCRB (Down syndrome Critical | + | DCRB (Down syndrome Critical Region gene B) consists of three exons of 1095 bp in total and encodes a large open reading frame of 118 amino acid residues. The amino acids sequence of DCRB showed no significant homology to any known protein. <ref name="ref1" /> |
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DCRB gene locates on DCR <ref name="ref1" /> | DCRB gene locates on DCR <ref name="ref1" /> | ||
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| + | ===Disease=== | ||
| + | *Down syndrome<ref name="ref1" /> | ||
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| − | |||
===Expression=== | ===Expression=== | ||
Northern blot analysis shows that DCRB is mainly expressed in the placenta, in which a major 1.1-kb band and a minor 2.0-kb band are detected. Minor bands of 1.4 kb and 2.2 kb are also detected in adult heart and skeletal muscle.<ref name="ref1" /> | Northern blot analysis shows that DCRB is mainly expressed in the placenta, in which a major 1.1-kb band and a minor 2.0-kb band are detected. Minor bands of 1.4 kb and 2.2 kb are also detected in adult heart and skeletal muscle.<ref name="ref1" /> | ||
| Line 44: | Line 40: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Nakamura A, Hattori M, Sakaki Y. A novel gene isolated from human placenta located in Down syndrome critical region on chromosome 21. DNA Res. 1997 Oct31;4(5):321-4.</ref> |
| − | Nakamura A, Hattori M, Sakaki Y. A novel gene isolated from human placenta | ||
| − | located in Down syndrome critical region on chromosome 21. DNA Res. 1997 | ||
| − | |||
| − | </ref> | ||
</references> | </references> | ||
Latest revision as of 03:17, 14 August 2017
Contents
Annotated Information
Name
DSCR4:Down syndrome critical region 4
DCRB:Down syndrome Critical Region gene B[1]
Characteristics
DCRB (Down syndrome Critical Region gene B) consists of three exons of 1095 bp in total and encodes a large open reading frame of 118 amino acid residues. The amino acids sequence of DCRB showed no significant homology to any known protein. [1]
DCRB gene locates on DCR [1]
Disease
- Down syndrome[1]
Expression
Northern blot analysis shows that DCRB is mainly expressed in the placenta, in which a major 1.1-kb band and a minor 2.0-kb band are detected. Minor bands of 1.4 kb and 2.2 kb are also detected in adult heart and skeletal muscle.[1]
Sequence
>NM_005867.3 Homo sapiens Down syndrome critical region 4 (DSCR4), mRNA
000001 CAGTCACGGG CCAGCCTTTC CCTTAAGGAT GTCTGAGAGC TGGTCTCCTC ACTCTTTTCT TCCGCCTATT AAACTTTCCG 000080
000081 CTTCTTAACT CACCCATGTG TGTCCATGTC GTTAATCATC TTGACGAGAG ATGATGAACC CCGGATATTT ACCCCAGACA 000160
000161 GTGATGCCGC TTCACCAGCA TTGCACTCTA CTTCCCCGCT TCCTGATCCT GCCTCAGCTT CTCCTCTCCA CAGAGAAGAA 000240
000241 AAAATTCTGC CTAAAGTCTG CAACATCGTT TCCTGCCTGA GTTTCAGCCT GCCAGCTTCT CCTACGGATT CTGGACTTGC 000320
000321 CAGCCCCACA ATCATAACCA GAGAGGGGCA GCAATTTTGG GCAAAATGTC TGATTTGGAA ATACCAACTT TACCTCCATG 000400
000401 GGCTCCACAA GAAATCAGAT GGGAGAAGGG ACAAGCAGAT AAGCGCAAGC CCATCAACCT GAAGGCATAA ACCACATCCA 000480
000481 GCCACCTCCT TCTGATCAGC AGCAAAGCTG ACGTTTTGAT CTCCATCTGT CTGATTCTTG TGTCTACTTC TCAGTTTACA 000560
000561 ACTCCAGTGG GAAAGAAAGA GCTTTATTTA CAGACCCATA AAAATCCCAT CAGTGTCGTC CCCTGCTGAG AGGCCATGTG 000640
000641 AGACCATATG GAAAAACAAC AGCCATAATG GCAGCATGGC AGTGGAAGGG TTTGTCTTGT GCCCAGGCCT TGCGGTCATG 000720
000721 CAAGTTTCTT GTGGATCCTG TTGGGACCAG CCACTCACCA AGGCTGAGTA GGTCCACAAA TAATGGGGAC TTTCTACCAG 000800
000801 ACTCACAGAG AACTGCTGGG TTTTTGGGAA GGGTGTGCGT GTCTTTGGGG CATGCAAGTT GGGGTTATAG TGGAGACCCA 000880
000881 GAGGATGAGA AAACTTCTCT GCCTCAGCAG AAGAGTGGCA GCTGAGAGAG AGGCAAGAAA CTCGCACCCA CTGTGGACTG 000960
000961 GGGCAGAGAG ATTTTGAGGA GAATGAAATC CAGAAACTCT GTGTGGTATT AGTTTGTATC CAGAGGGTGA CCCTCTTCTC 001040
001041 AAGGAAATGG GTGTCATCAA TTTTCTACAC TATTAAAGAT ATAAAGTTCT TGGCATTAAA AAAAAAAAAA AAAA
000081 CTTCTTAACT CACCCATGTG TGTCCATGTC GTTAATCATC TTGACGAGAG ATGATGAACC CCGGATATTT ACCCCAGACA 000160
000161 GTGATGCCGC TTCACCAGCA TTGCACTCTA CTTCCCCGCT TCCTGATCCT GCCTCAGCTT CTCCTCTCCA CAGAGAAGAA 000240
000241 AAAATTCTGC CTAAAGTCTG CAACATCGTT TCCTGCCTGA GTTTCAGCCT GCCAGCTTCT CCTACGGATT CTGGACTTGC 000320
000321 CAGCCCCACA ATCATAACCA GAGAGGGGCA GCAATTTTGG GCAAAATGTC TGATTTGGAA ATACCAACTT TACCTCCATG 000400
000401 GGCTCCACAA GAAATCAGAT GGGAGAAGGG ACAAGCAGAT AAGCGCAAGC CCATCAACCT GAAGGCATAA ACCACATCCA 000480
000481 GCCACCTCCT TCTGATCAGC AGCAAAGCTG ACGTTTTGAT CTCCATCTGT CTGATTCTTG TGTCTACTTC TCAGTTTACA 000560
000561 ACTCCAGTGG GAAAGAAAGA GCTTTATTTA CAGACCCATA AAAATCCCAT CAGTGTCGTC CCCTGCTGAG AGGCCATGTG 000640
000641 AGACCATATG GAAAAACAAC AGCCATAATG GCAGCATGGC AGTGGAAGGG TTTGTCTTGT GCCCAGGCCT TGCGGTCATG 000720
000721 CAAGTTTCTT GTGGATCCTG TTGGGACCAG CCACTCACCA AGGCTGAGTA GGTCCACAAA TAATGGGGAC TTTCTACCAG 000800
000801 ACTCACAGAG AACTGCTGGG TTTTTGGGAA GGGTGTGCGT GTCTTTGGGG CATGCAAGTT GGGGTTATAG TGGAGACCCA 000880
000881 GAGGATGAGA AAACTTCTCT GCCTCAGCAG AAGAGTGGCA GCTGAGAGAG AGGCAAGAAA CTCGCACCCA CTGTGGACTG 000960
000961 GGGCAGAGAG ATTTTGAGGA GAATGAAATC CAGAAACTCT GTGTGGTATT AGTTTGTATC CAGAGGGTGA CCCTCTTCTC 001040
001041 AAGGAAATGG GTGTCATCAA TTTTCTACAC TATTAAAGAT ATAAAGTTCT TGGCATTAAA AAAAAAAAAA AAAA
Labs working on this lncRNA
- Human Genome Center, The Institute of Medical Science, University of Tokyo, J^-6-l Shirokanedai, Minato-ku, Tokyo 108[1]
