Difference between revisions of "LIF-AS1"
Guangyu Wang (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== LIF-AS1 ===Approved Name=== LIF antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== Lnc-LIF-AS ===Chromosome=== 22q12.2 ===...") |
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | LIF-AS1 | + | LIF-AS1:LIF antisense RNA 1 |
| − | === | + | |
| − | LIF antisense | + | ENST00000447565 <ref name="ref1" /> |
| − | === | + | |
| − | + | ===Characteristics=== | |
| − | === | + | ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA <ref name="ref1" />. |
| − | Lnc-LIF-AS | + | |
| − | === | + | ===Function=== |
| − | + | Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs <ref name="ref1" />. | |
| − | === | + | |
| − | + | ===Regulation=== | |
| − | == | + | The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability <ref name="ref1" />. |
| − | + | ||
| − | == | + | ===Expression=== |
| − | + | ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs <ref name="ref1" />. | |
| − | + | ||
| − | + | ===Diseases=== | |
| + | Cervical squamous cancers <ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | *Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, | ||
| + | Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical | ||
| + | squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 | ||
| + | Aug;96:114-122. | ||
| + | </ref> | ||
| + | </references> | ||
Latest revision as of 03:16, 30 August 2017
Contents
Annotated Information
Name
LIF-AS1:LIF antisense RNA 1
ENST00000447565 [1]
Characteristics
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA [1].
Function
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs [1].
Regulation
The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability [1].
Expression
ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs [1].
Diseases
Cervical squamous cancers [1]
Labs working on this lncRNA
- Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
