Difference between revisions of "LIF-AS1"

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==Annotated Information==
 
==Annotated Information==
===Approved Symbol===
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===Name===
LIF-AS1
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LIF-AS1:LIF antisense RNA 1
===Approved Name===
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LIF antisense RNA 1
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ENST00000447565 <ref name="ref1" />
===Previous Symbols===
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_
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===Characteristics===
===Synonyms===
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ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA <ref name="ref1" />.
Lnc-LIF-AS
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===Chromosome===
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===Function===
22q12.2
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Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs <ref name="ref1" />.
===RefSeq ID===
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_
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===Regulation===
===OMIM ID===
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The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability <ref name="ref1" />.
_
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===RefSeq(supplied by NCBI)===
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===Expression===
_
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ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs <ref name="ref1" />.
===pubmed IDs===
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28391028
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===Diseases===
===Disease===
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Cervical squamous cancers <ref name="ref1" />
Cervical squamous cancers
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 +
==Labs working on this lncRNA==
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*Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
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==References==
 +
<references>
 +
<ref name="ref1">
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Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B,
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Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical
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squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017
 +
Aug;96:114-122.
 +
</ref>
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</references>

Latest revision as of 03:16, 30 August 2017

Annotated Information

Name

LIF-AS1:LIF antisense RNA 1

ENST00000447565 [1]

Characteristics

ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA [1].

Function

Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs [1].

Regulation

The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability [1].

Expression

ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs [1].

Diseases

Cervical squamous cancers [1]

Labs working on this lncRNA

  • Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.