Difference between revisions of "WWOX-AS1"

From LncRNAWiki
Jump to: navigation, search
(→‎Function)
Line 4: Line 4:
 
WWOX-AS1:WWOX antisense RNA 1
 
WWOX-AS1:WWOX antisense RNA 1
  
−
RP11-190D6.2<ref name="ref1" />
+
RP11-190D6.2 <ref name="ref1" />
 +
 
 
===Characteristics===
 
===Characteristics===
−
Based on the data from USCS database website, lncRNA RP11-190D6.2 is the antisense transcript of protein-coding gene WW domain-containing oxidoreductase (WWOX).  <ref name="ref1" />
+
LncRNA RP11-190D6.2 is the antisense transcript of protein-coding gene WWOX (WW domain-containing oxidoreductase) <ref name="ref1" />.
  
 
===Function===
 
===Function===
 
[[File:HO8910-pm.png|right|thumb|400px|'''cell proliferative, migratory, and invasive properties were repressed by pcDna-rP11-190D6.2 in h08910-PM cells'''<ref name="ref1" />.]]
 
[[File:HO8910-pm.png|right|thumb|400px|'''cell proliferative, migratory, and invasive properties were repressed by pcDna-rP11-190D6.2 in h08910-PM cells'''<ref name="ref1" />.]]
−
RP11-190D6.2 overexpression results in the increase of WWOX expression, whereas its knockdown leads to the decrease of WWOX expression.         In addition, the RP11-190D6.2 overexpression and knockdown experiments reveals that RP11-190D6.2 overexpression inhibits proliferation, migration, and invasion abilities in HO8910-PM cells, whereas RP11-190D6.2 knockdown in HEY-A8 cells has the opposite effect<ref name="ref1" />
+
RP11-190D6.2 may play a pivotal role in the regulation of tumor metastasis <ref name="ref1" />. RP11-190D6.2 expression is positively correlated with WWOX expression (R=0.45519, P<0.00777), and WWOX is linked with poor prognosis in numerous cancers, including epithelial ovarian cancer (EOC) <ref name="ref1" />. RP11-190D6.2 overexpression inhibits proliferation, migration, and invasion abilities in HO8910-PM cells, whereas RP11-190D6.2 knockdown in HEY-A8 cells shows the opposite effect <ref name="ref1" />.
  
 
===Regulation===
 
===Regulation===
−
RP11-190D6.2 is restored by 5-aza-2′-deoxycytidine treatment in Epithelial ovarian cancer(EOC).<ref name="ref1" />  
+
RP11-190D6.2 is restored by 5-aza-2′-deoxycytidine treatment in Epithelial ovarian cancer <ref name="ref1" />.
 +
 
===Diseases===
 
===Diseases===
−
Epithelial ovarian cancer (EOC).<ref name="ref1" />
+
Epithelial ovarian cancer (EOC) <ref name="ref1" />
 
   
 
   
 
===Expression===
 
===Expression===
 
[[File:RP11-190D6.2.png|right|thumb|400px|'''relative expression in 33 eOc tissue samples were examined by real-time Pcr and normalized to  
 
[[File:RP11-190D6.2.png|right|thumb|400px|'''relative expression in 33 eOc tissue samples were examined by real-time Pcr and normalized to  
 
β-actin expression'''<ref name="ref1" />.]]
 
β-actin expression'''<ref name="ref1" />.]]
−
Compared with the matched nontumor tissues, the expression level of RP11-190D6.2 in tumor tissues is markedly decreased. Meanwhile, the expression of RP11-190D6.2 is remarkably downregulated in tumors with higher Federation of Gynecology and Obstetrics stage (III/IV) compared with tumors with lower FIGO stage(I/II). In addition, the RP11-190D6.2 expression is positively correlated with WWOX expression(R=0.45519,
+
Compared with the matched non-tumor tissues, the expression level of RP11-190D6.2 in tumor tissues is markedly decreased. Meanwhile, the expression of RP11-190D6.2 is remarkably downregulated in tumors with higher Federation of Gynecology and Obstetrics stage (III/IV) compared with tumors with lower FIGO stage(I/II) <ref name="ref1" />.
−
P<0.00777).<ref name="ref1" />  
 
  
 
===Sequence===
 
===Sequence===

Revision as of 03:06, 31 August 2017

Annotated Information

Name

WWOX-AS1:WWOX antisense RNA 1

RP11-190D6.2 [1]

Characteristics

LncRNA RP11-190D6.2 is the antisense transcript of protein-coding gene WWOX (WW domain-containing oxidoreductase) [1].

Function

cell proliferative, migratory, and invasive properties were repressed by pcDna-rP11-190D6.2 in h08910-PM cells[1].

RP11-190D6.2 may play a pivotal role in the regulation of tumor metastasis [1]. RP11-190D6.2 expression is positively correlated with WWOX expression (R=0.45519, P<0.00777), and WWOX is linked with poor prognosis in numerous cancers, including epithelial ovarian cancer (EOC) [1]. RP11-190D6.2 overexpression inhibits proliferation, migration, and invasion abilities in HO8910-PM cells, whereas RP11-190D6.2 knockdown in HEY-A8 cells shows the opposite effect [1].

Regulation

RP11-190D6.2 is restored by 5-aza-2′-deoxycytidine treatment in Epithelial ovarian cancer [1].

Diseases

Epithelial ovarian cancer (EOC) [1]

Expression

relative expression in 33 eOc tissue samples were examined by real-time Pcr and normalized to β-actin expression[1].

Compared with the matched non-tumor tissues, the expression level of RP11-190D6.2 in tumor tissues is markedly decreased. Meanwhile, the expression of RP11-190D6.2 is remarkably downregulated in tumors with higher Federation of Gynecology and Obstetrics stage (III/IV) compared with tumors with lower FIGO stage(I/II) [1].

Sequence

>XR_429776.2 PREDICTED: Homo sapiens uncharacterized LOC102724047 (LOC102724047), transcript variant X2, ncRNA

000001 TAAAACTCCC TCTCAAAACA AACAAACAAA CCAAAAAAAC AAATAGCAAC AGCAACCACA ATCATCATCA CCATCAAGGC 000080
000081 TGGAACAAGG ATGAGGCAGG CAGGCTCTGA TAGCAACAGG AGGAAGCAGA CCAAGGAGGG AGAGAAAGGA AGGCAGAGAA 000160
000161 GGGGAAAAAA AAACACAAAT GATAATAATA GATGCTGACA TTTACGGAGC ACTTACTATG TGCTGGGAAC CATGCTGACG 000240
000241 GCACACCGAA TCCACTGAAC AGATCTCTTT GGGTTTTGGA ATAACAAAAA AGGGACTGTA CATGGATATT TCCAAGCTGG 000320
000321 AACCGAGGCA CTTTCTAGAC GAAGGCAGCC TTATCCCCAG GAGATGATTG AAAATGTAAG AACTATTCTG AGCCTGCAGG 000400
000401 CCATAGCCAA AGAGGACCTA CTGTTAAGTT TTCAAGACCA CCCAGAAAGA AATTTGAAGT TGGGTTTATA TCCTTAATCC 000480
000481 CTCAGTTAGA AAAAAAAGAA AAGTGAAGAA ACTGCATCTC CAAGATCCTG CTATATCAAC TTCAGTTTTT TGAAGTTAAA 000560
000561 TTTGATTTTT AAATCCCTTG GCTGATGAGA CCTGTGTGGG TTTTTTTTTG TTGTTTTTTT GTTTTGTTTT GTTTTGTTTT 000640
000641 ATCATTGTAC CTCTATTTTA AAAATAGAGA CTTGTGGTTC TTTTTCCAAA AGCAGTCCAA CAGAAAGTGA ATGGTGGTCA 000720
000721 ATGCATAATA AAATGAGAGT TACCTTTTGA

Labs working on this lncRNA

  • Department of Oncology, The Fifth Hospital of Wuhan.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Tong W, Yang L, Yu Q, Yao J, He A. A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells. Onco Targets Ther. 2017 Feb 27;10:1227-1235. doi: 10.2147/OTT.S125185. eCollection 2017.
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=WWOX-AS1&oldid=1273493"