Difference between revisions of "LINC01186"

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==Annotated Information==
 
==Annotated Information==
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===Approved Symbol===
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===Name===
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LINC01186
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LINC01186:long intergenic non-protein coding RNA 1186
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===Approved Name===
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long intergenic non-protein coding RNA 1186
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===Characteristics===
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===Previous Symbols===
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LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X.<ref name="ref1" />
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_
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===Synonyms===
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===Cellular Localization===
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_
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Comparison on the nuclear and cytosolic fractions of A549 cells shows that the LINC01186 transcript is mainly located in the nucleus irrespective of TGF-β1 treatment.<ref name="ref1" />
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===Chromosome===
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Xp11.3
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===Function===
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===RefSeq ID===
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The bioinformatics analysis suggest that LINC01186 is associated with TGF-β and might participatein EMT process. In addition, knocking-down LINC01186 promots cell migration and invasion, whereas, LINC01186 overexpression prevents cell metastasis.<ref name="ref1" />
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NR_110388
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===Regulation===
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===OMIM ID===
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LINC01186 is regulated by SMAD3 and inhibits EMT.<ref name="ref1" />
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_
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===Expression===
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===RefSeq(supplied by NCBI)===
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The expression of LINC01186 is significantly decreased in A549 cells treated with TGF-β1. Furthermore, LINC01186 is stably down-regulated in lung cancer tissues compared with normal tissues in TCGA data sets and another published lung cancer datasets.<ref name="ref1" />
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NR_110388
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===Diseases===
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===pubmed IDs===
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Lung cancer <ref name="ref1" />
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28119085
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===Sequence===
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===Disease===
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>NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA
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Lung cancer
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<dnaseq>AGGCTAACAGAAACCCAGCCCTGCCCACTGGGTGAAACTGCAAGTCGAGAGCGTGGGAAACCAGCAAGTT
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GAGAGAGGATCCAGAAGTAACCCCTTCTAAAACGGGAAAGATGCCTTCCGAAAGCACTTGGCCCTAAAGA
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GAAAACACTAGGAGGATGGGAACCAGGGACAGAGAAGCTACTTGCTCTGCAGCTGTTTGGGCCAGTATGT
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TCCCTAATCTTGATGGCCATCCTGGGCTTATTTTCCTGAGAGTCTCTAAGTGACTCACTGCATCACGTAA
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AACTAAGAAAAAGGATGTCCTGAATTTTCCTGCTTAGAGAGCTTGTTTTTCTTTCCTGTTGCATCAAAGG
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GGTCTGTTAAACTTTCTAAAAGTACTAATCTGACCTGATATCTGAAGTAACAGATAGGAATTTGGGCTCT
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TTAAATGGAGCCCTTCCCCCATACCTGCATCTCATTGAAGAGGCTGAACTTCAAAACAAAATCATGTTGG
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AGAATTAAGTCTCGTTCCCAGATTTAATTTCTTATTTTTATATTGTTGCATAAGAAATCTACTCTATAAG
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GCATCTATTTTCAAATTTGGAAAATCTTATTTTAAGTTCATTTATTTAAAGACCAACAAACAAAAACACC
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AAATTCACTAGCCCAGGTCTTTATG</dnaseq>
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==Labs working on this lncRNA==
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*Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
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==References==
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<references>
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<ref name="ref1">
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Hao Y, Yang X, Zhang D, Luo J, Chen R. Long noncoding RNA LINC01186, regulated
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by TGF-β/SMAD3, inhibits migration and invasion through
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Epithelial-Mesenchymal-Transition in lung cancer. Gene. 2017 Apr 15;608:1-12.
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</ref>
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</references>

Revision as of 14:15, 2 September 2017

Annotated Information

Name

LINC01186:long intergenic non-protein coding RNA 1186

Characteristics

LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X.[1]

Cellular Localization

Comparison on the nuclear and cytosolic fractions of A549 cells shows that the LINC01186 transcript is mainly located in the nucleus irrespective of TGF-β1 treatment.[1]

Function

The bioinformatics analysis suggest that LINC01186 is associated with TGF-β and might participatein EMT process. In addition, knocking-down LINC01186 promots cell migration and invasion, whereas, LINC01186 overexpression prevents cell metastasis.[1]

Regulation

LINC01186 is regulated by SMAD3 and inhibits EMT.[1]

Expression

The expression of LINC01186 is significantly decreased in A549 cells treated with TGF-β1. Furthermore, LINC01186 is stably down-regulated in lung cancer tissues compared with normal tissues in TCGA data sets and another published lung cancer datasets.[1]

Diseases

Lung cancer [1]

Sequence

>NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA

000001 AGGCTAACAG AAACCCAGCC CTGCCCACTG GGTGAAACTG CAAGTCGAGA GCGTGGGAAA CCAGCAAGTT GAGAGAGGAT 000080
000081 CCAGAAGTAA CCCCTTCTAA AACGGGAAAG ATGCCTTCCG AAAGCACTTG GCCCTAAAGA GAAAACACTA GGAGGATGGG 000160
000161 AACCAGGGAC AGAGAAGCTA CTTGCTCTGC AGCTGTTTGG GCCAGTATGT TCCCTAATCT TGATGGCCAT CCTGGGCTTA 000240
000241 TTTTCCTGAG AGTCTCTAAG TGACTCACTG CATCACGTAA AACTAAGAAA AAGGATGTCC TGAATTTTCC TGCTTAGAGA 000320
000321 GCTTGTTTTT CTTTCCTGTT GCATCAAAGG GGTCTGTTAA ACTTTCTAAA AGTACTAATC TGACCTGATA TCTGAAGTAA 000400
000401 CAGATAGGAA TTTGGGCTCT TTAAATGGAG CCCTTCCCCC ATACCTGCAT CTCATTGAAG AGGCTGAACT TCAAAACAAA 000480
000481 ATCATGTTGG AGAATTAAGT CTCGTTCCCA GATTTAATTT CTTATTTTTA TATTGTTGCA TAAGAAATCT ACTCTATAAG 000560
000561 GCATCTATTT TCAAATTTGG AAAATCTTAT TTTAAGTTCA TTTATTTAAA GACCAACAAA CAAAAACACC AAATTCACTA 000640
000641 GCCCAGGTCT TTATG

Labs working on this lncRNA

  • Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Hao Y, Yang X, Zhang D, Luo J, Chen R. Long noncoding RNA LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer. Gene. 2017 Apr 15;608:1-12.
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