Difference between revisions of "DM1-AS"
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | DM1-AS | + | DM1-AS:DM1 locus antisense RNA |
| − | + | ===Characteristics=== | |
| − | DM1 locus antisense RNA | + | DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat. <ref name="ref1" /> |
| − | === | + | |
| − | + | ===Cellular Localization=== | |
| − | === | + | DM1-AS transcripts are present in the nucleus and in the cytoplasm.<ref name="ref1" /> |
| − | + | ||
| − | === | + | ===Expression=== |
| − | + | DM1-AS expression appears upregulated in patients, but transcript abundance remains very low in some tissues. In addition, DM1-AS expression was lowest in brain and highest in kidney, testis and muscle.<ref name="ref1" /> | |
| − | === | + | ===Diseases=== |
| − | + | Myotonic dystrophy type 1<ref name="ref1" /> | |
| − | + | ||
| − | + | ==Labs working on this lncRNA== | |
| − | == | + | * a Radboud University Medical Center , Department of Cell Biology , Nijmegen , The Netherlands. |
| − | + | ==References== | |
| − | == | + | <references> |
| − | + | <ref name="ref1"> | |
| − | = | + | Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang |
| − | + | ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy | |
| + | locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan | ||
| + | 19:1-15. | ||
| + | </ref> | ||
| + | </references> | ||
Revision as of 15:11, 2 September 2017
Contents
Annotated Information
Name
DM1-AS:DM1 locus antisense RNA
Characteristics
DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat. [1]
Cellular Localization
DM1-AS transcripts are present in the nucleus and in the cytoplasm.[1]
Expression
DM1-AS expression appears upregulated in patients, but transcript abundance remains very low in some tissues. In addition, DM1-AS expression was lowest in brain and highest in kidney, testis and muscle.[1]
Diseases
Myotonic dystrophy type 1[1]
Labs working on this lncRNA
- a Radboud University Medical Center , Department of Cell Biology , Nijmegen , The Netherlands.
