Difference between revisions of "DM1-AS"

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==Annotated Information==
 
==Annotated Information==
===Approved Symbol===
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===Name===
DM1-AS
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DM1-AS:DM1 locus antisense RNA
===Approved Name===
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DM1 locus antisense RNA
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===Characteristics===
===Previous Symbols===
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DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat <ref name="ref1" />. Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients <ref name="ref1" />.
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===Synonyms===
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===Cellular Localization===
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DM1-AS transcripts are present in both the nucleus and the cytoplasm <ref name="ref1" />.
===Chromosome===
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19q13.32
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===Expression===
===RefSeq ID===
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[[File:DM1-AS.jpg|right|thumb|400px|'''The DM1-AS transcript is a low-abundance RNA'''<ref name="ref1" />.]]
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DM1-AS expression appears upregulated in patients, but transcript abundance remains very low <ref name="ref1" />.  Comparison among different tissues shows that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle <ref name="ref1" />.
===OMIM ID===
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_
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===Diseases===
===RefSeq(supplied by NCBI)===
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Myotonic dystrophy type 1 <ref name="ref1" />
NG_009784
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===pubmed IDs===
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==Labs working on this lncRNA==
28102759
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* a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands.
===Disease===
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Myotonic dystrophy type 1
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==References==
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<references>
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<ref name="ref1">Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.</ref>
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</references>

Latest revision as of 09:26, 28 September 2017

Annotated Information

Name

DM1-AS:DM1 locus antisense RNA

Characteristics

DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat [1]. Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients [1].

Cellular Localization

DM1-AS transcripts are present in both the nucleus and the cytoplasm [1].

Expression

The DM1-AS transcript is a low-abundance RNA[1].

DM1-AS expression appears upregulated in patients, but transcript abundance remains very low [1]. Comparison among different tissues shows that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle [1].

Diseases

Myotonic dystrophy type 1 [1]

Labs working on this lncRNA

  • a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gudde AEEG, van Heeringen SJ, de Oude AI, van Kessel IDG, Estabrook J, Wang ET, Wieringa B, Wansink DG. Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat. RNA Biol. 2017 Jan 19:1-15.