Difference between revisions of "LINC01844"

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===Function===
 
===Function===
SiRNA experiment show that LOC101926975 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.<ref name="ref1" />
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SiRNA experiment shows that LOC101926975 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.<ref name="ref1" />
 
The expression correlation analysis shows LOC101926975 regulate the expression of FGF1.<ref name="ref1" />
 
The expression correlation analysis shows LOC101926975 regulate the expression of FGF1.<ref name="ref1" />
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==

Revision as of 13:32, 22 October 2017

Annotated Information

LOC101926975 is significantly downregulated in HSCR tissues compared control samples.[1]
(A) LOC101926975 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LOC101926975 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration..[1]

Approved Symbol

LINC01844

Approved Name

long intergenic non-protein coding RNA 1844

Synonyms

LOC101926975

Chromosome

5q31.3

RefSeq ID

NR_110558

Characteristics

LOC101926975 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.[1]

Expression

Compared with the control tissues, the expression of LOC101926975 is down-regulated in hirschsprung disease (HSCR) tissues.[1]

Experiment Forward primer Reverse primer
qRT-PCR 5'-AACCCAGTGTTCAAAACCCCA- 3' 5'-GCAGGGGAAAATACCAGGGAA- 3'[1]

Function

SiRNA experiment shows that LOC101926975 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.[1] The expression correlation analysis shows LOC101926975 regulate the expression of FGF1.[1]

Labs working on this lncRNA

  • Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
  • State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Shen, Z., et al., Downregulated Expression of Long Non-Coding RNA LOC101926975 Impairs both Cell Proliferation and Cell Cycle and Its Clinical Implication in Hirschsprung Disease Patients. Int J Med Sci, 2016. 13(4): p. 292-7.