Difference between revisions of "MAPT-AS1"

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(Created page with "==Annotated Information== ===Approved Symbol=== MAPT-AS1 ===Approved Name=== MAPT antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosome=== 17q21.31 ===RefSeq...")
 
 
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==Annotated Information==
 
==Annotated Information==
 
===Approved Symbol===
 
===Approved Symbol===
MAPT-AS1
+
MAPT-AS1 (MAPT antisense RNA 1)
===Approved Name===
 
MAPT antisense RNA 1
 
===Previous Symbols===
 
_
 
===Synonyms===
 
_
 
 
===Chromosome===
 
===Chromosome===
 
17q21.31
 
17q21.31
===RefSeq ID===
+
[[File: Effect of MAPT-AS1 over- and knock-down expression on MAPT expression in HEK293 and SK-N-MC cells.jpg|right|thumb|400px|'''Effect of MAPT-AS1 over- and knock-down expression on MAPT expression in HEK293 and SK-N-MC cells.''' <ref name="ref2" />.]]
NR_024559
 
===OMIM ID===
 
_
 
 
===RefSeq(supplied by NCBI)===
 
===RefSeq(supplied by NCBI)===
 
NR_024559
 
NR_024559
===pubmed IDs===
+
===Characteristics===
27336847
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MAPT-AS1 is an 840 bp lncRNA transcribed from the anti-sense strand of the MAPT promoter region.<ref name="ref1" />
 +
===Expression===
 +
The siRNA s237111 can knock-down the expression of MAPT-AS1.The sequence of the s237111 siRNA is described in the table below.<ref name="ref2" />
 +
{| class='wikitable' style="text-align:center"
 +
|-
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! | sense
 +
! | antisense
 +
|-
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| | 5’-CCACUUCAUGGAUAAGUAAtt-3’
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| | 5’-UUACUUAUCCAUGAAGUGGgt-3’<ref name="ref2" />
 +
|}
 +
===Function===
 +
MAPT-AS1 has an inhibitory effect on the expression of a major neurodegenerative gene, MAPT. MAPT-AS1 may serve as a sensitive biomarker of disease state in Parkinson’s disease, as well as a potential therapeutic target for inhibiting the expression of MAPT. <ref name="ref2" />
 +
==Labs working on this lncRNA==
 +
* Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.<ref name="ref1" />
 +
* Neuroscience Research Australia, Randwick, NSW, Australia.<ref name="ref2" />
 +
* School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.<ref name="ref2" />
 +
==References==
 +
<references>
 +
<ref name="ref1"> Speir, M.L., et al., The UCSC Genome Browser database: 2016 update. Nucleic Acids Res, 2016. 44(D1): p. D717-25.
 +
</ref>(1)
 +
<ref name="ref2">Coupland, K.G., et al., Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease. PLoS One, 2016. 11(6): p. e0157924.
 +
</references>

Latest revision as of 14:55, 22 October 2017

Annotated Information

Approved Symbol

MAPT-AS1 (MAPT antisense RNA 1)

Chromosome

17q21.31

Effect of MAPT-AS1 over- and knock-down expression on MAPT expression in HEK293 and SK-N-MC cells. [1].

RefSeq(supplied by NCBI)

NR_024559

Characteristics

MAPT-AS1 is an 840 bp lncRNA transcribed from the anti-sense strand of the MAPT promoter region.[2]

Expression

The siRNA s237111 can knock-down the expression of MAPT-AS1.The sequence of the s237111 siRNA is described in the table below.[1]

sense antisense
5’-CCACUUCAUGGAUAAGUAAtt-3’ 5’-UUACUUAUCCAUGAAGUGGgt-3’[1]

Function

MAPT-AS1 has an inhibitory effect on the expression of a major neurodegenerative gene, MAPT. MAPT-AS1 may serve as a sensitive biomarker of disease state in Parkinson’s disease, as well as a potential therapeutic target for inhibiting the expression of MAPT. [1]

Labs working on this lncRNA

  • Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.[2]
  • Neuroscience Research Australia, Randwick, NSW, Australia.[1]
  • School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Cite error: Invalid <ref> tag; no text was provided for refs named ref2
  2. 2.0 2.1 Speir, M.L., et al., The UCSC Genome Browser database: 2016 update. Nucleic Acids Res, 2016. 44(D1): p. D717-25.