Difference between revisions of "LINC01844"
(Created page with "==Annotated Information== ===Approved Symbol=== LINC01844 ===Approved Name=== long intergenic non-protein coding RNA 1844 ===Previous Symbols=== _ ===Synonyms=== LOC101926975 ...") |
|||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Annotated Information== | ==Annotated Information== | ||
| + | [[File:Expression of LOC101926975 in HSCR.png|right|thumb|500px|'''LINC01844 is significantly downregulated in HSCR tissues compared control samples'''.<ref name="ref1" />]] | ||
| + | [[File:Function of LOC101926975 in vitro.jpg|right|thumb|400px|'''(A) LINC01844 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LINC01844 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration.'''.<ref name="ref1" />]] | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | LINC01844 | + | LINC01844 （long intergenic non-protein coding RNA 1844） |
| − | |||
| − | |||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
LOC101926975 | LOC101926975 | ||
| Line 12: | Line 10: | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
NR_110558 | NR_110558 | ||
| − | === | + | ===Characteristics=== |
| − | + | LINC01844 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.<ref name="ref1" /> | |
| − | === | + | ===Expression=== |
| − | + | Compared with the control tissues, the expression of LINC01844 is down-regulated in hirschsprung disease (HSCR) tissues.<ref name="ref1" /> | |
| − | === | + | {| class='wikitable' style="text-align:center" |
| − | + | |- | |
| + | ! | Experiment | ||
| + | ! | Forward primer | ||
| + | ! | Reverse primer | ||
| + | |- | ||
| + | | rowspan="1"|qRT-PCR | ||
| + | | | 5'-AACCCAGTGTTCAAAACCCCA- 3' | ||
| + | | | 5'-GCAGGGGAAAATACCAGGGAA- 3'<ref name="ref1" /> | ||
| + | |} | ||
| + | ===Function=== | ||
| + | SiRNA experiment shows that LINC01844 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.<ref name="ref1" /> | ||
| + | The expression correlation analysis shows LINC01844 regulate the expression of FGF1.<ref name="ref1" /> | ||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. | ||
| + | * State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Shen, Z., et al., Downregulated Expression of Long Non-Coding RNA LOC101926975 Impairs both Cell Proliferation and Cell Cycle and Its Clinical Implication in Hirschsprung Disease Patients. Int J Med Sci, 2016. 13(4): p. 292-7. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 02:11, 23 October 2017
Contents
Annotated Information
LINC01844 is significantly downregulated in HSCR tissues compared control samples.[1]
(A) LINC01844 was effectively knocked down in SK-N-BE(2) cells. Downregulation of LINC01844 suppressed cell proliferation (B)and caused cell cycle arrest (C)without impact on cell apoptosis (D)or cell migration..[1]
Approved Symbol
LINC01844 （long intergenic non-protein coding RNA 1844）
Synonyms
LOC101926975
Chromosome
5q31.3
RefSeq ID
NR_110558
Characteristics
LINC01844 locates on chromosome 5 (142745600-142760993) and it is near the gene FGF1.[1]
Expression
Compared with the control tissues, the expression of LINC01844 is down-regulated in hirschsprung disease (HSCR) tissues.[1]
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-AACCCAGTGTTCAAAACCCCA- 3' | 5'-GCAGGGGAAAATACCAGGGAA- 3'[1] |
Function
SiRNA experiment shows that LINC01844 knockdown inhibits cell proliferation and blocks the G0/G1 to S phase transition.[1] The expression correlation analysis shows LINC01844 regulate the expression of FGF1.[1]
Labs working on this lncRNA
- Department of Pediatric Surgery, Nanjing Children's Hospital Affiliated Nanjing Medical University, Nanjing 210008; 2. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
- State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, China; 3. Key Laboratory of Modern Toxicology (Nanjing Medical University), Ministry of Education, China.
