Difference between revisions of "COL1A2-AS1"
Guangyu Wang (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== COL1A2-AS1 ===Approved Name=== COL1A2 antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== "TCONS_00013888, lncRNA8975-1" ==...") |
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | COL1A2-AS1 | + | COL1A2-AS1:COL1A2 antisense RNA 1 |
| − | === | + | |
| − | COL1A2 antisense | + | LncRNA8975-1<ref name="ref1" /> |
| − | + | ===Characteristics=== | |
| − | + | LncRNA8975-1(TCONS_00013888 in UCSC hg38; also named NONHSAT122029 in NONCODEv4) is an lncRNA located upstream of the COL1A2 gene on chromosome 7(UCSC hg38, chr7:94278999-94392179, ChIPBase named it lncRNA8975-1). In addition, lncRNA8975-1 is a transcript of 352 nucleotides and comprises 5 exons(NONHSAT122029 in NONCODEv4) based on bioinformatics analyses. LncRNA8975-1 contains no overlapping sequence with the transcripts from its neighbouring gene COL1A2 and is a natural antisense lncRNA. <ref name="ref1" /> | |
| − | === | + | |
| − | " | + | ===Function=== |
| − | === | + | [[File:LncRNA8975-1 fun.jpg|right|thumb|400px|'''Effects of knocking down or overexpressing lncRNA8975-1 on collagen synthesis and α-SMA in HSFs'''<ref name="ref1" />.]] |
| − | + | Dysregulation of lncRNA8975-1 can affect collagen and α-SMA expression in fibroblasts. Further more, knockdown of lncRNA8975-1 significantly increases cell proliferation, whereas overexpression of lncRNA8975-1 inhibits HSF(hypertrophic scar fibroblasts) cell proliferation.<ref name="ref1" /> | |
| − | === | + | |
| − | + | ===Expression=== | |
| − | == | + | [[File:LncRNA8975-1 expre.jpg|right|thumb|400px|'''Expression of ''lncRNA8975-1'' in hypertrophic scar tissues and fibroblasts''' <ref name="ref1" />.]] |
| − | + | The expression of lncRNA8975-1 is significantly overexpressed in hypertrophic scar tissues compared to normal skin tissues. Furthermore, lncRNA8975-1 expression in hypertrophic scar fibroblasts (HSF) is higher than in normal skin fibroblasts (NSF). <ref name="ref1" /> | |
| − | + | ||
| − | + | ==Labs working on this lncRNA== | |
| − | + | *State key Laboratory of Reproductive Medicine, Department of Plastic&Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China. | |
| − | + | ==References== | |
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Li J, Chen L, Cao C, Yan H, Zhou B, Gao Y, Li Q, Li J. The Long Non-Coding RNA | ||
| + | LncRNA8975-1 is Upregulated in Hypertrophic Scar Fibroblasts and Controls | ||
| + | Collagen Expression. Cell Physiol Biochem. 2016;40(1-2):326-334. | ||
| + | </ref> | ||
| + | </references> | ||
Latest revision as of 07:23, 25 October 2017
Contents
Annotated Information
Name
COL1A2-AS1:COL1A2 antisense RNA 1
LncRNA8975-1[1]
Characteristics
LncRNA8975-1(TCONS_00013888 in UCSC hg38; also named NONHSAT122029 in NONCODEv4) is an lncRNA located upstream of the COL1A2 gene on chromosome 7(UCSC hg38, chr7:94278999-94392179, ChIPBase named it lncRNA8975-1). In addition, lncRNA8975-1 is a transcript of 352 nucleotides and comprises 5 exons(NONHSAT122029 in NONCODEv4) based on bioinformatics analyses. LncRNA8975-1 contains no overlapping sequence with the transcripts from its neighbouring gene COL1A2 and is a natural antisense lncRNA. [1]
Function
Dysregulation of lncRNA8975-1 can affect collagen and α-SMA expression in fibroblasts. Further more, knockdown of lncRNA8975-1 significantly increases cell proliferation, whereas overexpression of lncRNA8975-1 inhibits HSF(hypertrophic scar fibroblasts) cell proliferation.[1]
Expression
The expression of lncRNA8975-1 is significantly overexpressed in hypertrophic scar tissues compared to normal skin tissues. Furthermore, lncRNA8975-1 expression in hypertrophic scar fibroblasts (HSF) is higher than in normal skin fibroblasts (NSF). [1]
Labs working on this lncRNA
- State key Laboratory of Reproductive Medicine, Department of Plastic&Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing, China.
