Difference between revisions of "DDX11-AS1"
| Line 5: | Line 5: | ||
CONCR | CONCR | ||
[[File:CONCR Is a Nuclear lncRNA Negatively Regulated by p53 and Activated by MYC.jpg|right|thumb|400px|'''CONCR Is a Nuclear lncRNA Negatively Regulated by p53 and Activated by MYC'''<ref name="ref1" />]] | [[File:CONCR Is a Nuclear lncRNA Negatively Regulated by p53 and Activated by MYC.jpg|right|thumb|400px|'''CONCR Is a Nuclear lncRNA Negatively Regulated by p53 and Activated by MYC'''<ref name="ref1" />]] | ||
| − | '' | + | [[File:CONCR Is Upregulated in Multiple Cancer Types.jpg|right|thumb|400px|'''CONCR Is Upregulated in Multiple Cancer Types'''<ref name="ref1" />]] |
===Chromosome=== | ===Chromosome=== | ||
12p11.21 | 12p11.21 | ||
| Line 13: | Line 13: | ||
27477908 | 27477908 | ||
===Characteristics=== | ===Characteristics=== | ||
| − | DDX11-AS1 is a divergent non-overlapping transcript of the protein-coding gene DDX11, which is a predominant nuclear lncRNA. | + | DDX11-AS1 is a divergent non-overlapping transcript of the protein-coding gene DDX11, which is a predominant nuclear lncRNA. ChIP-seq data from ENCODE shows that MYC is bound to DDX11-AS1 promoter region in multiple cell types. |
===Expression=== | ===Expression=== | ||
| − | + | DDX11-AS1 is expressed in a panel of different human cell lines and upregulated in multiple cancer types. <ref name="ref1" /> | |
===Regulated=== | ===Regulated=== | ||
| − | DDX11-AS1 is negatively regulated by p53 and activated by MYC. | + | DDX11-AS1 is negatively regulated by p53 and activated by MYC. <ref name="ref1" /> |
| + | ===Function=== | ||
| + | DDX11-AS1 contributes to tumor growth. <ref name="ref1" /> | ||
Revision as of 14:58, 27 October 2017
Contents
Annotated Information
Approved Symbol
DDX11-AS1 (DDX11 antisense RNA 1)
Synonyms
CONCR
CONCR Is a Nuclear lncRNA Negatively Regulated by p53 and Activated by MYC[1]
CONCR Is Upregulated in Multiple Cancer Types[1]
Chromosome
12p11.21
RefSeq(supplied by NCBI)
NR_038927
pubmed IDs
27477908
Characteristics
DDX11-AS1 is a divergent non-overlapping transcript of the protein-coding gene DDX11, which is a predominant nuclear lncRNA. ChIP-seq data from ENCODE shows that MYC is bound to DDX11-AS1 promoter region in multiple cell types.
Expression
DDX11-AS1 is expressed in a panel of different human cell lines and upregulated in multiple cancer types. [1]
Regulated
DDX11-AS1 is negatively regulated by p53 and activated by MYC. [1]
