Difference between revisions of "HOXC-AS1"
(Created page with "==Annotated Information== ===Approved Symbol=== HOXC-AS1 ===Approved Name=== HOXC cluster antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== _ ===Chromosome=== 12q13.13 =...") |
|||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | HOXC-AS1 | + | HOXC-AS1 (HOXC cluster antisense RNA 1) |
| − | |||
| − | HOXC cluster antisense RNA 1 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===Chromosome=== | ===Chromosome=== | ||
12q13.13 | 12q13.13 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===RefSeq(supplied by NCBI)=== | ===RefSeq(supplied by NCBI)=== | ||
NR_047504 | NR_047504 | ||
| − | === | + | [[File:Expression of lncRNA HOXC-AS1 and HOXC6 in normal tissues and atherosclerotic plaques.gif|right|thumb|400px|'''Expression of lncRNA HOXC-AS1 and HOXC6 in normal tissues and atherosclerotic plaques.'''<ref name="ref1" />]] |
| − | + | ===Characteristics=== | |
| + | lncRNA HOXC-AS1 is located on chromosome 12 and its transcription position is nearby.<ref name="ref1" /> | ||
| + | ===Expression=== | ||
| + | Compared to normal renal arterial intima, HOXC-AS1 is downregulated in carotid atherosclerosis.<ref name="ref1" /> | ||
| + | Ox-LDL can suppress the expression of lncRNA HOXC-AS1 and HOXC6 in THP-1 macrophages.<ref name="ref1" /> | ||
| + | {| class='wikitable' style="text-align:center" | ||
| + | |- | ||
| + | ! | Experiment | ||
| + | ! | Forward primer | ||
| + | ! | Reverse primer | ||
| + | |- | ||
| + | | rowspan="1"|qRT-PCR | ||
| + | | | 5′-CTGCGACACTTCCCCACC-3′ | ||
| + | | | 5′-CTACTT GCCCACGACCGA-3′<ref name="ref1" /> | ||
| + | |} | ||
| + | |||
| + | ===Function=== | ||
| + | Overexpression of HOXC-AS1 promotes expression of HOXC6 at mRNA and protein levels. | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China . | ||
| + | * Department of Anesthesiology, Nanfang Hospital, Southern Medical University , Guangzhou, China . | ||
| + | * Department of Vascular Surgery, Nanfang Hospital, Southern Medical University , Guangzhou, China . | ||
| + | * Department of Cardiology, Nanfang Hospital, Southern Medical University , Guangzhou, China . | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Huang, C., et al., Long Noncoding RNA HOXC-AS1 Suppresses Ox-LDL-Induced Cholesterol Accumulation Through Promoting HOXC6 Expression in THP-1 Macrophages. DNA Cell Biol, 2016. 35(11): p. 722-729. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 02:35, 28 October 2017
Contents
Annotated Information
Approved Symbol
HOXC-AS1 (HOXC cluster antisense RNA 1)
Chromosome
12q13.13
RefSeq(supplied by NCBI)
NR_047504
Expression of lncRNA HOXC-AS1 and HOXC6 in normal tissues and atherosclerotic plaques.[1]
Characteristics
lncRNA HOXC-AS1 is located on chromosome 12 and its transcription position is nearby.[1]
Expression
Compared to normal renal arterial intima, HOXC-AS1 is downregulated in carotid atherosclerosis.[1] Ox-LDL can suppress the expression of lncRNA HOXC-AS1 and HOXC6 in THP-1 macrophages.[1]
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5′-CTGCGACACTTCCCCACC-3′ | 5′-CTACTT GCCCACGACCGA-3′[1] |
Function
Overexpression of HOXC-AS1 promotes expression of HOXC6 at mRNA and protein levels.
Labs working on this lncRNA
- Laboratory Medicine Center, Nanfang Hospital, Southern Medical University , Guangzhou, China .
- Department of Anesthesiology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
- Department of Vascular Surgery, Nanfang Hospital, Southern Medical University , Guangzhou, China .
- Department of Cardiology, Nanfang Hospital, Southern Medical University , Guangzhou, China .
