Difference between revisions of "DINOL"
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| − | <ref name="ref1"> | + | <ref name="ref1">Schmitt, A.M., et al., An inducible long noncoding RNA amplifies DNA damage signaling. Nat Genet, 2016. 48(11): p. 1370-1376. |
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Revision as of 08:32, 13 November 2017
Contents
Annotated Information
p53 is a DINO-binding protein[1]
Germline disruption of mouse Dino impairs the p53-dependent, DNA damage-induced apoptosis[1]
Approved Symbol
DINOL (damage induced long noncoding RNA)
Synonyms
DINO
Chromosome
6p21.2
RefSeq(supplied by NCBI)
NG_009364
pubmed IDs
27668660
Characteristic
DINO is a 951-base RNA transcribed divergently from CDKN1A.[1] DINO occupancies at p53 binding elements in 7 of 10 p53-target genes examined, including CDKN1A, GADD45A, and DDB2.[1]
Function
DINO encodes a p53-dependent DNA damage-induced transcript.[1] DINO stabilizes p53 and enhances regulation of its target genes.[1] Loss of DINO abrogates DNA damage-induced gene regulation and cell cycle arrest.[1]
Labs working on this lncRNA
- Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA.
- Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
