Difference between revisions of "FOXD2-AS1"
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==Annotated Information== | ==Annotated Information== | ||
| + | [[File: LncRNA FOXD2-AS was highly expressed in NSCLC tumors.jpg|right|thumb|400px|'''LncRNA FOXD2-AS was highly expressed in NSCLC tumors''' <ref name="ref1" />.]] | ||
| + | [[File: FOXD2-AS1 regulates Wnt-catenin signaling in NSCLC cells.jpg|right|thumb|400px|'''FOXD2-AS1 regulates Wnt-catenin signaling in NSCLC cells''' <ref name="ref1" />.]] | ||
| + | |||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | FOXD2-AS1 | + | FOXD2-AS1 (FOXD2 antisense RNA 1 (head to head)) |
| − | |||
| − | FOXD2 antisense RNA 1 (head to head) | ||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
MGC12982 | MGC12982 | ||
===Chromosome=== | ===Chromosome=== | ||
1p33 | 1p33 | ||
| − | |||
| − | |||
| − | |||
| − | |||
===RefSeq(supplied by NCBI)=== | ===RefSeq(supplied by NCBI)=== | ||
NR_026878 | NR_026878 | ||
| − | === | + | ===Disease=== |
| − | + | Lung cancer | |
| + | ===Function=== | ||
| + | Loss- and gain-function assays suggested that FOXD2-AS1 remarkably modulates the tumorigenesis of NSCLC through Wnt/β-catenin signaling.<ref name="ref1" /> | ||
| + | FOXD2-AS1 overexpression promotes NSCLC progression.<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | Compared with the adjacent tissues,lncRNA FOXD2-AS1 had significantly high expression in NSCLC tissues.<ref name="ref1" />.To be specific, high expression of lncRNA FOXD2-AS1 was shown in 23 cases of 45 (53.3%), in which unchanged was revealed in 10 cases (22%) and down-regulation in 12 cases (24%) <ref name="ref1" /> | ||
| + | |||
| + | {| class='wikitable' style="text-align:center" | ||
| + | |- | ||
| + | ! | Experiment | ||
| + | ! | Forward primer | ||
| + | ! | Reverse primer | ||
| + | |- | ||
| + | | rowspan="1"|qRT-PCR | ||
| + | | | 5'-TGGACCTAGCTGCAGCTCCA- 3' | ||
| + | | | 5'-AGTTGAAGGTGCACACACTG- 3'<ref name="ref1" /> | ||
| + | |} | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, China. Electronic address: wchqba@163.com. | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Rong, L., R. Zhao, and J. Lu, Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt/beta-catenin signaling. Biochem Biophys Res Commun, 2017. 484(3): p. 586-591. | ||
| + | </ref>(1) | ||
| + | </references> | ||
Latest revision as of 11:31, 19 November 2017
Contents
Annotated Information
LncRNA FOXD2-AS was highly expressed in NSCLC tumors [1].
FOXD2-AS1 regulates Wnt-catenin signaling in NSCLC cells [1].
Approved Symbol
FOXD2-AS1 (FOXD2 antisense RNA 1 (head to head))
Synonyms
MGC12982
Chromosome
1p33
RefSeq(supplied by NCBI)
NR_026878
Disease
Lung cancer
Function
Loss- and gain-function assays suggested that FOXD2-AS1 remarkably modulates the tumorigenesis of NSCLC through Wnt/β-catenin signaling.[1] FOXD2-AS1 overexpression promotes NSCLC progression.[1]
Expression
Compared with the adjacent tissues,lncRNA FOXD2-AS1 had significantly high expression in NSCLC tissues.[1].To be specific, high expression of lncRNA FOXD2-AS1 was shown in 23 cases of 45 (53.3%), in which unchanged was revealed in 10 cases (22%) and down-regulation in 12 cases (24%) [1]
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-TGGACCTAGCTGCAGCTCCA- 3' | 5'-AGTTGAAGGTGCACACACTG- 3'[1] |
Labs working on this lncRNA
- Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, China. Electronic address: wchqba@163.com.
