Difference between revisions of "TRPM2-AS"
| Line 1: | Line 1: | ||
==Annotated Information== | ==Annotated Information== | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | TRPM2-AS | + | TRPM2-AS (TRPM2 antisense RNA) |
| − | |||
| − | TRPM2 antisense RNA | ||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
TRPM2-AS1 | TRPM2-AS1 | ||
| Line 16: | Line 12: | ||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000230061 | ENSG00000230061 | ||
| − | === | + | [[File: Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21.jpg|right|thumb|400px|'''Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21.''' <ref name="ref1" />.]] |
| − | + | [[File: Expression analysis of TRPM2-AS.png|right|thumb|400px|'''Expression analysis of TRPM2-AS.''' <ref name="ref1" />.]] | |
| + | |||
| + | ===Characteristics=== | ||
| + | TRPM2-AS is antisense with respect to TRPM2, an ion channel capable of conferring cell death upon oxidative stress.<ref name="ref1" /> | ||
| + | |||
| + | ===Regulation=== | ||
| + | The CpG island could be involved in the transcriptional regulation of TRPM2-AS,specifically,the methylation status of the CpG island contributes negatively to the expression level of both TRPM2-AS.<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | TRPM2-AS transcripts is up-regulated in melanoma, and their activation is consistent with the methylation status of the shared CpG island.<ref name="ref1" /> | ||
| + | Tumor samples displayed higher levels of TRPM2-AS and TRPM2-TE transcripts with respect to their matched normal tissue. <ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * DIBIT-San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. <ref name="ref1" /> | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1">Orfanelli U, Wenke AK, Doglioni C, Russo V, Bosserhoff AK, Lavorgna G.Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res. 2008 Nov;18(11):1128-40. doi: 10.1038/cr.2008.296. | ||
| + | </ref>(1) | ||
| + | </references> | ||
| + | |||
===Sequence=== | ===Sequence=== | ||
>gi|568786345|ref|NR_109964.1| Homo sapiens TRPM2 antisense RNA (TRPM2-AS), long non-coding RNA | >gi|568786345|ref|NR_109964.1| Homo sapiens TRPM2 antisense RNA (TRPM2-AS), long non-coding RNA | ||
<dnaseq>CTCCACCTCCCCGAGCCCAAATGGCCATGCAGGTCGAACACCAGCTCTGAAGTGGGCAGGGCCCCCAGGGAGGACAGCCACGGGAGCTCAGGCAGCGTCCCCGCCGGCACCTGCCTCTTTGTGCAGCGGCAGTCAGGGCCCTCGGCAATGAGCTGAACTCGCAGTGCGGTTACGAGGGCAAATATGCTCCTTGAGGGCCGGCGAAACTCAGCAGCCCGAGGAAGGCTACTGATGTGCATTTCATAGCCGGCTGCGAATTTAGGAAAACAGACTTTGCTTCTCGTCACTCAGCCTACGTGACCAGGTTCAGACACAGTCTGCAGCCGCCCGCCTCGCACCCCCACTCTGCAGTGCGGTATGTGGGGAGCTCAGGGCACAGCAGGCCAGGCCTCCCCGTGGACGTCCAGGAACCAGAACCAAACTGCCCAGGGCCCCAGAGGGGAAGATGTCTCAGCAGACGGACAGCCGAGGCTCACATGGCAAGCTCTGGCAGCCTGTCGGTCCCAGGAGAGAGGGGGAGATGGCAGACGGGAAAAGAAGCCACCTGCTGGGATGCTGAGACTCGCTTGCAGGAGCTTTTGGAACTGGCTGAGGTCACAGCTGGAACCACTGTGGCCAGCTGGAGTCTGCACAGCCCGAGTTTCCACCCCAGGGTCCCAGTAACTCCGCCCAAATGTGCACACGAGACCTATGAGGAGACATAACTTTCCAGAACCCCCTTTTCTTCCACCAGCCACTTACTCATCCAAGAACCCACCCCCGAACCTTCCCTAATAGAAACACTGCATTAAAGCCAGCGCGGGGAGACAGACGTGAACTGCGCCCCTGTCTCCTTGTGGGTTGGCCTAGAATAAAAGCTTTTCTTTTCTCAAAAA</dnaseq> | <dnaseq>CTCCACCTCCCCGAGCCCAAATGGCCATGCAGGTCGAACACCAGCTCTGAAGTGGGCAGGGCCCCCAGGGAGGACAGCCACGGGAGCTCAGGCAGCGTCCCCGCCGGCACCTGCCTCTTTGTGCAGCGGCAGTCAGGGCCCTCGGCAATGAGCTGAACTCGCAGTGCGGTTACGAGGGCAAATATGCTCCTTGAGGGCCGGCGAAACTCAGCAGCCCGAGGAAGGCTACTGATGTGCATTTCATAGCCGGCTGCGAATTTAGGAAAACAGACTTTGCTTCTCGTCACTCAGCCTACGTGACCAGGTTCAGACACAGTCTGCAGCCGCCCGCCTCGCACCCCCACTCTGCAGTGCGGTATGTGGGGAGCTCAGGGCACAGCAGGCCAGGCCTCCCCGTGGACGTCCAGGAACCAGAACCAAACTGCCCAGGGCCCCAGAGGGGAAGATGTCTCAGCAGACGGACAGCCGAGGCTCACATGGCAAGCTCTGGCAGCCTGTCGGTCCCAGGAGAGAGGGGGAGATGGCAGACGGGAAAAGAAGCCACCTGCTGGGATGCTGAGACTCGCTTGCAGGAGCTTTTGGAACTGGCTGAGGTCACAGCTGGAACCACTGTGGCCAGCTGGAGTCTGCACAGCCCGAGTTTCCACCCCAGGGTCCCAGTAACTCCGCCCAAATGTGCACACGAGACCTATGAGGAGACATAACTTTCCAGAACCCCCTTTTCTTCCACCAGCCACTTACTCATCCAAGAACCCACCCCCGAACCTTCCCTAATAGAAACACTGCATTAAAGCCAGCGCGGGGAGACAGACGTGAACTGCGCCCCTGTCTCCTTGTGGGTTGGCCTAGAATAAAAGCTTTTCTTTTCTCAAAAA</dnaseq> | ||
Revision as of 15:06, 8 December 2017
Contents
Annotated Information
Approved Symbol
TRPM2-AS (TRPM2 antisense RNA)
Synonyms
TRPM2-AS1
Chromosome
21q22.3
RefSeq ID
NR_109964
Disease
cancer
Ensembl ID
ENSG00000230061
Identification of an antisense transcript and related molecules within the human TRPM2 gene on chromosome 21. [1].
Expression analysis of TRPM2-AS. [1].
Characteristics
TRPM2-AS is antisense with respect to TRPM2, an ion channel capable of conferring cell death upon oxidative stress.[1]
Regulation
The CpG island could be involved in the transcriptional regulation of TRPM2-AS,specifically,the methylation status of the CpG island contributes negatively to the expression level of both TRPM2-AS.[1]
Expression
TRPM2-AS transcripts is up-regulated in melanoma, and their activation is consistent with the methylation status of the shared CpG island.[1] Tumor samples displayed higher levels of TRPM2-AS and TRPM2-TE transcripts with respect to their matched normal tissue. [1]
Labs working on this lncRNA
- DIBIT-San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. [1]
References
Sequence
>gi|568786345|ref|NR_109964.1| Homo sapiens TRPM2 antisense RNA (TRPM2-AS), long non-coding RNA
000001 CTCCACCTCC CCGAGCCCAA ATGGCCATGC AGGTCGAACA CCAGCTCTGA AGTGGGCAGG GCCCCCAGGG AGGACAGCCA 000080
000081 CGGGAGCTCA GGCAGCGTCC CCGCCGGCAC CTGCCTCTTT GTGCAGCGGC AGTCAGGGCC CTCGGCAATG AGCTGAACTC 000160
000161 GCAGTGCGGT TACGAGGGCA AATATGCTCC TTGAGGGCCG GCGAAACTCA GCAGCCCGAG GAAGGCTACT GATGTGCATT 000240
000241 TCATAGCCGG CTGCGAATTT AGGAAAACAG ACTTTGCTTC TCGTCACTCA GCCTACGTGA CCAGGTTCAG ACACAGTCTG 000320
000321 CAGCCGCCCG CCTCGCACCC CCACTCTGCA GTGCGGTATG TGGGGAGCTC AGGGCACAGC AGGCCAGGCC TCCCCGTGGA 000400
000401 CGTCCAGGAA CCAGAACCAA ACTGCCCAGG GCCCCAGAGG GGAAGATGTC TCAGCAGACG GACAGCCGAG GCTCACATGG 000480
000481 CAAGCTCTGG CAGCCTGTCG GTCCCAGGAG AGAGGGGGAG ATGGCAGACG GGAAAAGAAG CCACCTGCTG GGATGCTGAG 000560
000561 ACTCGCTTGC AGGAGCTTTT GGAACTGGCT GAGGTCACAG CTGGAACCAC TGTGGCCAGC TGGAGTCTGC ACAGCCCGAG 000640
000641 TTTCCACCCC AGGGTCCCAG TAACTCCGCC CAAATGTGCA CACGAGACCT ATGAGGAGAC ATAACTTTCC AGAACCCCCT 000720
000721 TTTCTTCCAC CAGCCACTTA CTCATCCAAG AACCCACCCC CGAACCTTCC CTAATAGAAA CACTGCATTA AAGCCAGCGC 000800
000801 GGGGAGACAG ACGTGAACTG CGCCCCTGTC TCCTTGTGGG TTGGCCTAGA ATAAAAGCTT TTCTTTTCTC AAAAA
000081 CGGGAGCTCA GGCAGCGTCC CCGCCGGCAC CTGCCTCTTT GTGCAGCGGC AGTCAGGGCC CTCGGCAATG AGCTGAACTC 000160
000161 GCAGTGCGGT TACGAGGGCA AATATGCTCC TTGAGGGCCG GCGAAACTCA GCAGCCCGAG GAAGGCTACT GATGTGCATT 000240
000241 TCATAGCCGG CTGCGAATTT AGGAAAACAG ACTTTGCTTC TCGTCACTCA GCCTACGTGA CCAGGTTCAG ACACAGTCTG 000320
000321 CAGCCGCCCG CCTCGCACCC CCACTCTGCA GTGCGGTATG TGGGGAGCTC AGGGCACAGC AGGCCAGGCC TCCCCGTGGA 000400
000401 CGTCCAGGAA CCAGAACCAA ACTGCCCAGG GCCCCAGAGG GGAAGATGTC TCAGCAGACG GACAGCCGAG GCTCACATGG 000480
000481 CAAGCTCTGG CAGCCTGTCG GTCCCAGGAG AGAGGGGGAG ATGGCAGACG GGAAAAGAAG CCACCTGCTG GGATGCTGAG 000560
000561 ACTCGCTTGC AGGAGCTTTT GGAACTGGCT GAGGTCACAG CTGGAACCAC TGTGGCCAGC TGGAGTCTGC ACAGCCCGAG 000640
000641 TTTCCACCCC AGGGTCCCAG TAACTCCGCC CAAATGTGCA CACGAGACCT ATGAGGAGAC ATAACTTTCC AGAACCCCCT 000720
000721 TTTCTTCCAC CAGCCACTTA CTCATCCAAG AACCCACCCC CGAACCTTCC CTAATAGAAA CACTGCATTA AAGCCAGCGC 000800
000801 GGGGAGACAG ACGTGAACTG CGCCCCTGTC TCCTTGTGGG TTGGCCTAGA ATAAAAGCTT TTCTTTTCTC AAAAA
