Difference between revisions of "SOX2-OT"
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==Annotated Information== | ==Annotated Information== | ||
| − | [[File:Genomic organization of Sox2ot locus in mouse.jpg|right|thumb| | + | [[File:Genomic organization of Sox2ot locus in mouse.jpg|right|thumb|300px|'''Genomic organization of Sox2ot locus in mouse.'''<ref name="ref1" />]] |
| − | [[File:SOX2-OT dynamic expression in mouse adult neurogenesis.jpg|right|thumb| | + | [[File:SOX2-OT dynamic expression in mouse adult neurogenesis.jpg|right|thumb|300px|'''SOX2-OT dynamic expression in mouse adult neurogenesis.'''<ref name="ref1" />]] |
| − | [[File:Expression of Sox2ot orthologs in different vertebrate species.jpg|right|thumb| | + | [[File:Expression of Sox2ot orthologs in different vertebrate species.jpg|right|thumb|300px|'''Expression of Sox2ot orthologs in different vertebrate species.'''<ref name="ref1" />]] |
===Approved Symbol=== | ===Approved Symbol=== | ||
SOX2-OT (SOX2 overlapping transcript) | SOX2-OT (SOX2 overlapping transcript) | ||
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Esophageal squamous cell cancer, Alzheimer's disease,Neurodevelopmental syndromes associated with the SOX2 locus | Esophageal squamous cell cancer, Alzheimer's disease,Neurodevelopmental syndromes associated with the SOX2 locus | ||
===Characteristics=== | ===Characteristics=== | ||
| − | + | SOX2-OT is originally reported as a spliced ncRNA mapping to human chromosome 3q26.3-q27, with an intron overlapping the SOX2 gene in the same transcriptional orientation.<ref name="ref1" /> | |
| − | + | SOX2-OT is transcribed by RNA polymerase II (RNAP II), and therefore represents a putative “mRNA-like” ncRNA.<ref name="ref1" /> | |
===Expression=== | ===Expression=== | ||
SOX2-OT is dynamically expressed in different developmental processes.<ref name="ref1" /> | SOX2-OT is dynamically expressed in different developmental processes.<ref name="ref1" /> | ||
Latest revision as of 15:32, 8 December 2017
Contents
Annotated Information
Genomic organization of Sox2ot locus in mouse.[1]
SOX2-OT dynamic expression in mouse adult neurogenesis.[1]
Expression of Sox2ot orthologs in different vertebrate species.[1]
Approved Symbol
SOX2-OT (SOX2 overlapping transcript)
Previous Symbols
SOX2OT
Synonyms
DKFZp761J1324, NCRNA00043
Chromosome
3q26.33
RefSeq ID
NR_004053
OMIM ID
616338
Ensembl ID
ENSG00000242808
Disease
Esophageal squamous cell cancer, Alzheimer's disease,Neurodevelopmental syndromes associated with the SOX2 locus
Characteristics
SOX2-OT is originally reported as a spliced ncRNA mapping to human chromosome 3q26.3-q27, with an intron overlapping the SOX2 gene in the same transcriptional orientation.[1] SOX2-OT is transcribed by RNA polymerase II (RNAP II), and therefore represents a putative “mRNA-like” ncRNA.[1]
Expression
SOX2-OT is dynamically expressed in different developmental processes.[1] SOX2-OT is expressed in pluripotent ES cells and is initially down-regulated upon EB differentiation.[1] SOX2-OT is highly enriched in the human brain and its expression is spatially regulated.[1]
Function
The expression profiles of SOX2-OT, as well as its evolutionarily preserved genomic association with Sox2, suggest that it has conserved functions in vertebrate development, and that it may participate in the regulation of Sox2 or related processes.[1]
Labs working on this lncRNA
- ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia,QLD 4072, Australia.
References
Sequence
>gi|449020153|ref|NR_004053.3| Homo sapiens SOX2 overlapping transcript (SOX2-OT), transcript variant 4, long non-coding RNA
000001 AAAAATGTTG AATATCAACA ATGGGTTTCA GTGCTGTATT GTTGAGTTTT GTATGAACTA ATCTAGCTTC TCTAAAAAAA 000080
000081 AAAAAAAAAA AAAAAAAAAG AAAGAAAAGA AAGAAAGAAA AGAAAGAAAG AAAGAAAAAA AAAGAAAAGA AAAAAAAGAG 000160
000161 AACCACAGCT TTGGACAAAA GTCTATAGCC AGTGCATTTG AAAACTCCCC TTGCACCAGG GCTGACTGTA GCTGGGGGAA 000240
000241 GACATTTTAC TCATTTGCTC TTTCCTTTCA TACAGTCAGC TGGTCCCTCT TCTCAGGTGT AGATCACCTA TTATAATTTT 000320
000321 ACCTAATTTT GATACTCTGA TAAGGAAAGT CCCAGGACTT ATCAGCTGGG ATAGGCCTCA CTTACAAGAC AGCTCTGTTC 000400
000401 AGTATTTGGA AGAAAGCCTG ACAGGTTTCT TCGGAAAAGT GGCCATCCAT GGAATGAATG AAATGTTCTC TTTCTATTCC 000480
000481 AGGGATTGCA GTGGCAAAGC TAGGCTAGGT CTTGGAGGCT GGTGTAAGGC GATGTGGGTG AAGGCAGGAG GCTGATGGAA 000560
000561 AGACTGGGGG GAAGAAAAGC CGAAATGGAT TCACGGTGCC TTGGATGAAG GACGAGAGGG GAACTGCAAG CTCCTTCAAC 000640
000641 TGGTTCTGTC CGGTGAGAAG TGATCAAGCT TGGGCTGACA AGAGGCTCAG GGAGCCCTCA CGTTCTTTCG CTTTTTTACC 000720
000721 TGCCAATCAA ACTGCTACAA GACAACACCC TGATCTGGCA TGGACATCGC GGGTCCAAGC CTGTAGCCCC AAATCGGATA 000800
000801 ATCTCTGCAG CTGATAACAA GCAAAAGAGA AGCCAGGCAA CAGCCATATT AAAGAAGAAA ACAATCAACT CTGAGATCCA 000880
000881 ACTTAGAAAT AATGTTTCAT TCAAGATAAG GCTCGTGGCT TAGGAGATTG TGACCTGGCT TGCATCATTC TAAGACTTCT 000960
000961 ATCGTCTGTT TTCAAAACCC AAGGAGGACC TCCTTTTCTG TGTGATAGTT CCTCATGCTT TGCCAGCCAC TGGGTCTTTA 001040
001041 AGGAAGCTTG CCAAGAGTTC CCGGCTGGGA AGGACAGTTC GAGTTCATCA TAGACAATGA GCTGGCACCA CAGTTTAAGT 001120
001121 GACTCACCAA CCTGGTTGCC CACTTCAAAA TGTCAAGAAC CACACTATCT AATTGAAAGA ACTGTGTTTT AGCAAAGTGT 001200
001201 AATTGGATCG CCTGGCAAGA TCATCTCAAA CTATGTCTCT GACCTTGCCT TTCAGTGGCT ATTTTGAGCA CAAGAGGAGA 001280
001281 AAGGAAATGA TTCCTGAATT ATATCTTGTT TTTAAAAATT AAGATTAATT AATACTTGGT TTTATGTTCA TTCCATTGTA 001360
001361 GGAACTTAGT GATTATTACA AAACAGTCAA AATAGGTCAT AGCAAAATGA ACGTTTAAGA TTAGGTTAAA ACATTCCTCT 001440
001441 GAAATTTTAG TATTCACTTT TGAAGTGTCA ATTACTATAT TTCTGTAATT TCTCATTTTT TTCTTGGCTT AGAGTCAAGA 001520
001521 TGAAAAATGA TATTTGAATC AAAGACATTG TTTTGTTATA TAGCCACTCC TTTCTAAAAT GCAAATCCAC CCTCCCCTCA 001600
001601 CCAATGCTTT ATTCTTTGTG CGCGCACACA CACACACACA CACACACACA CACACACACA CACACAGACA TACACAGAAC 001680
001681 CAGCACCCAA ATGGTAGAGG AGGTCCTTCC AAGACTTCTA GGACCTGGAT CATGTAAGCA GTAGATGAGA AAATGAAGTA 001760
001761 AGAGATATAG AGTAATAACA ATAAAAGTCA ATGATTTCAT TTTACAAAAA AGTCATTGTG TAGTACTCAG ATATTTTTAA 001840
001841 GAGCAAGTAT TATTATGACT AAAGTATATT ATACTTCTAA ATTATTATGA TTCTCATCTA ATTTCAAGCC ACACATAGGC 001920
001921 GCCATTTGAA AGCATTTTGT GTTACAACCT ATCAACAAAA ATCAACTAAT AGTTTTATAA CGTGCATAGG TTTACCCCAT 002000
002001 GGGGAATTAA AATTTTTATC TGCAAGTATT TCTGTTGTTG TGAGACTTTA GGACAAGACA ACATTTGGTG TTAACATAGA 002080
002081 AGAATATTCT ATGGCTTTTT TAGCTTTAAA GTTCATTACT CTAAAATAAA GTACACGTGG TATTTTTTTC TTCCTAGTGT 002160
002161 TCTCTTATTA TATGTAGAGT ATTTTCGGTT GTTGTTTTTA ACGTATACAT TATTTTTATT AAGTCATTTC ATAAAAGATA 002240
002241 AGATATATAC TAATAGACCC TTGGTTTTCT CCTAATTTAA TTATTTCAAG TCAAGCAAAA TTGGGCAATT TTCTTTCAGG 002320
002321 AAAAAAAAAA TATTGAGCAT GATTTTGAGG TAAAACTGAT TATTTACAGC ATCTTTTCTC TAATAGGCTA ACATTTATGA 002400
002401 TGGATCTTAT TTCAAAGTTG ATTATTCTCA AAGAAAAGTG GAGATATTAG AATTTCCGAG TAAATTGCAT TGTTTTAAAA 002480
002481 AGTACTTTAA TGCATTGTTC ACATTGTTGC CAGCTATTGA CCAAAAAAGA GAAGAAGAAA AAAGAAATAA AAAAAGCAGT 002560
002561 ATCTGCTCCA AACGTCAAGT TTTGCAGTTT GAAAGACTTG TACATTATAA TTGTTTTTTT CTTTTTTGGA AAGCAGTAGT 002640
002641 AATTAATACC AAAGGCATAG ACAATTTAGG GCCATAACCT CCCTTCCCCC CTCTCCACCT TTTTTTTTTT TTTTTTTTTT 002720
002721 TTTTAACTTT AACCATGATA GGCATCTCTG CAAGGTAGGT TTTAACATAT TTTTTTCCTA ATTTTTTTCC CTCCATTCAG 002800
002801 TAAGAAGGAT AAGCTTTTAG AGTACCCAGT CACCGTGGTA ACTGCCAAAA AAATTCTCCT GAAGTTTGAA GAGGTCAGCT 002880
002881 AGCAGGGTCA ACAACCCTGG CCTCTCTCTG AGCTCGGTCT AGCATGCCCC AGCCTGCGGT TGGAGTGTCA GGCCAGATCT 002960
002961 GACCCTGGGA GGTGGACCAT TCTGGCTCTG ATATAAATTT TTCGAGTCAG TTCATGGCCT GGACTCTCCA GGTGGCCTCC 003040
003041 AAAATCGATT TTGACCCCCT GACCCTGTCT CACGGAGGCA TAGCATCCAC CCTAAGTAAG GATTTAGCCA GGAATGACAG 003120
003121 CTTTCCACTG AGTGTTATTG GGGACAGTAT AAACAGTTTG GAAAGCAAGT AAGGAGGTGT GAGGGCTAGC AATCATTAAA 003200
003201 AGCACATTAA AAAACAATTT TTAAAAATCT TTATTAGAGA AAGTTGTAAA TGCATATCTG TTACAGAATT CCTGTGATTT 003280
003281 GTAGAGTTTT CTAGTCAGTT TTGAATATAA ATAGGTCACA TATCTTTATC TTTTTGCATA CTTTGTTACA AATATGCAAA 003360
003361 TAAGATAGGC ATACTTGCTA CAAAATAGGT ACAGCAGGAA TGTAATATGT TCAGAAAAGG CAAACTGGTT ATTAAAACAC 003440
003441 ATTAACAGGT AAGGAGTTTC T
000081 AAAAAAAAAA AAAAAAAAAG AAAGAAAAGA AAGAAAGAAA AGAAAGAAAG AAAGAAAAAA AAAGAAAAGA AAAAAAAGAG 000160
000161 AACCACAGCT TTGGACAAAA GTCTATAGCC AGTGCATTTG AAAACTCCCC TTGCACCAGG GCTGACTGTA GCTGGGGGAA 000240
000241 GACATTTTAC TCATTTGCTC TTTCCTTTCA TACAGTCAGC TGGTCCCTCT TCTCAGGTGT AGATCACCTA TTATAATTTT 000320
000321 ACCTAATTTT GATACTCTGA TAAGGAAAGT CCCAGGACTT ATCAGCTGGG ATAGGCCTCA CTTACAAGAC AGCTCTGTTC 000400
000401 AGTATTTGGA AGAAAGCCTG ACAGGTTTCT TCGGAAAAGT GGCCATCCAT GGAATGAATG AAATGTTCTC TTTCTATTCC 000480
000481 AGGGATTGCA GTGGCAAAGC TAGGCTAGGT CTTGGAGGCT GGTGTAAGGC GATGTGGGTG AAGGCAGGAG GCTGATGGAA 000560
000561 AGACTGGGGG GAAGAAAAGC CGAAATGGAT TCACGGTGCC TTGGATGAAG GACGAGAGGG GAACTGCAAG CTCCTTCAAC 000640
000641 TGGTTCTGTC CGGTGAGAAG TGATCAAGCT TGGGCTGACA AGAGGCTCAG GGAGCCCTCA CGTTCTTTCG CTTTTTTACC 000720
000721 TGCCAATCAA ACTGCTACAA GACAACACCC TGATCTGGCA TGGACATCGC GGGTCCAAGC CTGTAGCCCC AAATCGGATA 000800
000801 ATCTCTGCAG CTGATAACAA GCAAAAGAGA AGCCAGGCAA CAGCCATATT AAAGAAGAAA ACAATCAACT CTGAGATCCA 000880
000881 ACTTAGAAAT AATGTTTCAT TCAAGATAAG GCTCGTGGCT TAGGAGATTG TGACCTGGCT TGCATCATTC TAAGACTTCT 000960
000961 ATCGTCTGTT TTCAAAACCC AAGGAGGACC TCCTTTTCTG TGTGATAGTT CCTCATGCTT TGCCAGCCAC TGGGTCTTTA 001040
001041 AGGAAGCTTG CCAAGAGTTC CCGGCTGGGA AGGACAGTTC GAGTTCATCA TAGACAATGA GCTGGCACCA CAGTTTAAGT 001120
001121 GACTCACCAA CCTGGTTGCC CACTTCAAAA TGTCAAGAAC CACACTATCT AATTGAAAGA ACTGTGTTTT AGCAAAGTGT 001200
001201 AATTGGATCG CCTGGCAAGA TCATCTCAAA CTATGTCTCT GACCTTGCCT TTCAGTGGCT ATTTTGAGCA CAAGAGGAGA 001280
001281 AAGGAAATGA TTCCTGAATT ATATCTTGTT TTTAAAAATT AAGATTAATT AATACTTGGT TTTATGTTCA TTCCATTGTA 001360
001361 GGAACTTAGT GATTATTACA AAACAGTCAA AATAGGTCAT AGCAAAATGA ACGTTTAAGA TTAGGTTAAA ACATTCCTCT 001440
001441 GAAATTTTAG TATTCACTTT TGAAGTGTCA ATTACTATAT TTCTGTAATT TCTCATTTTT TTCTTGGCTT AGAGTCAAGA 001520
001521 TGAAAAATGA TATTTGAATC AAAGACATTG TTTTGTTATA TAGCCACTCC TTTCTAAAAT GCAAATCCAC CCTCCCCTCA 001600
001601 CCAATGCTTT ATTCTTTGTG CGCGCACACA CACACACACA CACACACACA CACACACACA CACACAGACA TACACAGAAC 001680
001681 CAGCACCCAA ATGGTAGAGG AGGTCCTTCC AAGACTTCTA GGACCTGGAT CATGTAAGCA GTAGATGAGA AAATGAAGTA 001760
001761 AGAGATATAG AGTAATAACA ATAAAAGTCA ATGATTTCAT TTTACAAAAA AGTCATTGTG TAGTACTCAG ATATTTTTAA 001840
001841 GAGCAAGTAT TATTATGACT AAAGTATATT ATACTTCTAA ATTATTATGA TTCTCATCTA ATTTCAAGCC ACACATAGGC 001920
001921 GCCATTTGAA AGCATTTTGT GTTACAACCT ATCAACAAAA ATCAACTAAT AGTTTTATAA CGTGCATAGG TTTACCCCAT 002000
002001 GGGGAATTAA AATTTTTATC TGCAAGTATT TCTGTTGTTG TGAGACTTTA GGACAAGACA ACATTTGGTG TTAACATAGA 002080
002081 AGAATATTCT ATGGCTTTTT TAGCTTTAAA GTTCATTACT CTAAAATAAA GTACACGTGG TATTTTTTTC TTCCTAGTGT 002160
002161 TCTCTTATTA TATGTAGAGT ATTTTCGGTT GTTGTTTTTA ACGTATACAT TATTTTTATT AAGTCATTTC ATAAAAGATA 002240
002241 AGATATATAC TAATAGACCC TTGGTTTTCT CCTAATTTAA TTATTTCAAG TCAAGCAAAA TTGGGCAATT TTCTTTCAGG 002320
002321 AAAAAAAAAA TATTGAGCAT GATTTTGAGG TAAAACTGAT TATTTACAGC ATCTTTTCTC TAATAGGCTA ACATTTATGA 002400
002401 TGGATCTTAT TTCAAAGTTG ATTATTCTCA AAGAAAAGTG GAGATATTAG AATTTCCGAG TAAATTGCAT TGTTTTAAAA 002480
002481 AGTACTTTAA TGCATTGTTC ACATTGTTGC CAGCTATTGA CCAAAAAAGA GAAGAAGAAA AAAGAAATAA AAAAAGCAGT 002560
002561 ATCTGCTCCA AACGTCAAGT TTTGCAGTTT GAAAGACTTG TACATTATAA TTGTTTTTTT CTTTTTTGGA AAGCAGTAGT 002640
002641 AATTAATACC AAAGGCATAG ACAATTTAGG GCCATAACCT CCCTTCCCCC CTCTCCACCT TTTTTTTTTT TTTTTTTTTT 002720
002721 TTTTAACTTT AACCATGATA GGCATCTCTG CAAGGTAGGT TTTAACATAT TTTTTTCCTA ATTTTTTTCC CTCCATTCAG 002800
002801 TAAGAAGGAT AAGCTTTTAG AGTACCCAGT CACCGTGGTA ACTGCCAAAA AAATTCTCCT GAAGTTTGAA GAGGTCAGCT 002880
002881 AGCAGGGTCA ACAACCCTGG CCTCTCTCTG AGCTCGGTCT AGCATGCCCC AGCCTGCGGT TGGAGTGTCA GGCCAGATCT 002960
002961 GACCCTGGGA GGTGGACCAT TCTGGCTCTG ATATAAATTT TTCGAGTCAG TTCATGGCCT GGACTCTCCA GGTGGCCTCC 003040
003041 AAAATCGATT TTGACCCCCT GACCCTGTCT CACGGAGGCA TAGCATCCAC CCTAAGTAAG GATTTAGCCA GGAATGACAG 003120
003121 CTTTCCACTG AGTGTTATTG GGGACAGTAT AAACAGTTTG GAAAGCAAGT AAGGAGGTGT GAGGGCTAGC AATCATTAAA 003200
003201 AGCACATTAA AAAACAATTT TTAAAAATCT TTATTAGAGA AAGTTGTAAA TGCATATCTG TTACAGAATT CCTGTGATTT 003280
003281 GTAGAGTTTT CTAGTCAGTT TTGAATATAA ATAGGTCACA TATCTTTATC TTTTTGCATA CTTTGTTACA AATATGCAAA 003360
003361 TAAGATAGGC ATACTTGCTA CAAAATAGGT ACAGCAGGAA TGTAATATGT TCAGAAAAGG CAAACTGGTT ATTAAAACAC 003440
003441 ATTAACAGGT AAGGAGTTTC T