Difference between revisions of "LUARIS"
Jiabao Cao (talk | contribs) |
Jiabao Cao (talk | contribs) (→Name) |
||
| Line 4: | Line 4: | ||
LUARIS:lncRNA upregulator of antiviral response interferon signaling | LUARIS:lncRNA upregulator of antiviral response interferon signaling | ||
| − | + | LncRNA#32<ref name="ref1" /> | |
| + | |||
===Characteristics=== | ===Characteristics=== | ||
Human lncRNA#32 (LOC100506895) is located on chromosome 7p13 and overlaps with the antisense strand of the HECW1 coding gene located within introns 21 and 22 and exon 22. And lncRNA#32 transcript is 2,946 nt in length.<ref name="ref1" /> | Human lncRNA#32 (LOC100506895) is located on chromosome 7p13 and overlaps with the antisense strand of the HECW1 coding gene located within introns 21 and 22 and exon 22. And lncRNA#32 transcript is 2,946 nt in length.<ref name="ref1" /> | ||
Revision as of 08:38, 14 December 2017
Contents
Annotated Information
Name
LUARIS:lncRNA upregulator of antiviral response interferon signaling
LncRNA#32[1]
Characteristics
Human lncRNA#32 (LOC100506895) is located on chromosome 7p13 and overlaps with the antisense strand of the HECW1 coding gene located within introns 21 and 22 and exon 22. And lncRNA#32 transcript is 2,946 nt in length.[1]
Function
LncRNA#32 has a critical role in ISG expression. The targeted depletion of lncRNA#32 leads to a reduction in the mRNA levels of several ISGs, including 2′-5′-Oligoadenylate Synthetase Like (OASL), Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2), interferon gamma-induced protein 10 (IP-10), apolipoprotein B mRNA editing enzyme catalytic polypeptide 3A (APOBEC3A), and apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3G), and results in a significant increase in the replication of encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), and HCV, all of which are human pathogens. In contrast, the overexpression of lncRNA#32 increases ISG mRNA levels.[1]
Regulation
LncRNA#32 is stabilized by heterogeneous nuclear ribonucleoprotein U (hnRNPU) and functions through interactions with activating transcription factor 2 (ATF2). [1]
Expression
RT-qPCR experiment shows that expression of lncRNA#32 is expressed at variable levels in a wide variety of tissues.[1]
Sequence
>NR_038276.1 Homo sapiens lncRNA upregulator of antiviral response interferon signaling (LUARIS), long non-coding RNA
000081 TCTATCTAAG CTTTTCCCTC TGACTCAGTC CAGGAGGCAA CTGTCTTGGG AAGCAAATGA TAACAGCATC TGGGAGATTC 000160
000161 TCTTCTGGAT GGACTAGCAG GGAATCAGGA CATGAACTCA GTGGACTAAC TGCACCGAGA CTCACCTGGT CATTACTTGA 000240
000241 AGGTCATTAC TTAAACCTCC ATGAATCTCC TGATGAACTC CCTCAGAAGG TGGAAGGAGC ACCTGACACC GACCCGAGAT 000320
000321 CAGCAGCAGC TACGCCCACG CTGTGGGCAG TTAAGAGGCA GCCAGTGGTA CCAGTCGTGA GCGATCAGAT TTGAGGACTC 000400
000401 AGGATTCTGG TTTCCTGAGT GTCATGGACC TGCGGGCTGC AGAAATGACA GCGACAGGTC TTCAGGCAGG TGCCACAGCA 000480
000481 CCCACACACT GCCAGCATTT TGTGCAAAAT ACCCAAAGCC ACATCACCAG ATCTGGGCTC TCCTAGCTTC CCTTTGCTAA 000560
000561 AATGCTGGCC AAAGAGCTTA ACGAGCCACT CAGGGGCACA AGATAGGTGA AACCTGCATG TTTTGTTTGT TAAACTATTT 000640
000641 GCCACATGGC ACAAGAAAAT AACAAAAAAT AAACAAAAGG AATAACTGCA GCATCATGGT TTTGTTAAGA TGTCCCAAAG 000720
000721 CTGATCAGGG CTTCCTGTTG AAATCTAAAT GAGACTCTTC CTAGGTGGCT TACATTCAGT CAGCTGTGGC TCTGTGCAAA 000800
000801 GAAAACCAGT TTCCCTTGCT CAGAAATTTG GAGCCACTGA TAAGAGAAGA AAAGTGTGAT TCCACATGGA GGGTCATGAT 000880
000881 ACAATCTGAT CTCTGACCCC GTGGAGGTGA AGGGGCTTGT TCTGCATGCC AGGCTGAGGA CTCTCGGGAC TGAGGCATTC 000960
000961 AGAGTCGCAG CTTTAAATCA TAAGGGTTCC CTGCCCATTT CATCACAAGT CAGCAGCATC CAAAGAGTGG CGTTGAAGAA 001040
001041 AATCTCATCA CCGTGGGCTC AGTTTAGATT GCTAGTCGGC TCAGAAAGCT ACCTGCAATT GCGTTTCCAG GATGCACCAC 001120
001121 AAATACTCTC CACATGAGGG AGAACATCAG TGGATGAAAC TCAGCATGCT TAGTGCGGGG CCAAGTCCTC TAACAAAGGA 001200
001201 CACAGCGGTT AACCTGCATT TCGAGGACAG GCACTGTCAA GCCCTCATCA GGGATCCATC CAGAGAACTT TGGTAATTCT 001280
001281 TGCAAAATCC CTGTATCACA CAATTTCCTT CCTTAATGTG ATGAAGTGTA ACGGACACAT CTATAAAGCT TCTTCAGTCC 001360
001361 TGCAATGCAT AGATGAGCAG AAGGCCACAA AGCCAGGTCA TAGCACTCTC TACCATCAGA ATGGAGCCTG CCTGAATGTG 001440
001441 AGCTCAGTGA GAGGCAGATT CCATTCTTGG GCCCGTCCAC GGTGACTTGT CTGCTCTGCT CCATCATCCA CTTATTCACA 001520
001521 AGTTCTGGGG CAACAAAGGG CACGTTTTGT TTCATCTTGT GCCAAACCCT CGATGTGTAC TCACTCACTC TACCTCATCT 001600
001601 CAAGAACTTC AGGGCTGGGA GTGCATTTGG AGAGAAGGCA TGTGCAATAT CTGGAAGCCT TAGCACAGGT GGGTTATACT 001680
001681 GATGCTCTAT AGCCAAACTA TAGGAACTTG GGTTCTAAGG CCAGCAGGCC CAGGTGTCAC CCCAATGGCT CCCTTCAACA 001760
001761 GCAGCATAAA TAAGTCATGT CAGAAGAACT CACATTAGCC ATCTCCAGGA CTCATTTCCC TCTCAACAGC AGGAGCTCCT 001840
001841 GCAGTCAGAA CAGCGGTAAT TTTCAAATCA GGCATGTGGT GATGCAGCAG GAAAGTGCCT GCATCCCAGG TGTCCCAGCA 001920
001921 GCTTTCTGGA GACCTCTAAT ACCCACATCT GCACCACAAA ACTGCACAGC ATTGAGTGAT ACCAATCTTC TTATACATAT 002000
002001 AGGTAAGTGG TAATAGAATG CCTCAACAGC AGACCACCCA GGAACCAAAG ACATACTGGA TTTTCAAGTC AGAAGAATGC 002080
002081 TTAGAGATCA TCTGACCCAA TAGCCATATT TTACAGTAAG ATGCAGAAGC CAGTGTCCAC AGTGCTAAAG CCACTGGTCC 002160
002161 AAGGTGAAAG AATTTCAAAC CCATAAATAC CTCCAAGAAG CTTCCACTGG GACCCTATGA TTTTAGTAAA ATTATCAACA 002240
002241 TTCATGACCT ATGTCTACTG ATCTTAGCGT CTTCTCAGTA GGCAATTATT CTTTCTCACA TCAATTTGCA GTTGCTATAT 002320
002321 TATCAGCATC CTTGGTAAAT CCATCTTGTG TTCTGGGTGA AGACTAACAG ATTCTTCCTT CTTGGACTCT GTCATTCACT 002400
002401 CTCATCCCTC ATAACATCTG GCCACTGCTC TAAACACAGT GGCCTTTGAG AAATGCTGCT GAATTCTGAC TAAGAAAGAG 002480
002481 GAGAACTTTC AAATACAAGA AAGTGAACAT TATAGAGCTT ACCACTCAAG ATGGTTTTCT ACAAATGCGG ACATGGGGCT 002560
002561 GATCTGCACC GTGTAAGTAT CATTTGCCGA GTACTCAAAG AGTCCATAGT AAGGGTTGAA GAGCTCCTGA GACAGAAGGA 002640
002641 AGAAGAACTC CCGCGAGGGG CCACTGTAGT CCAGGCTGCA AAGAAAGCAG AGGTCCAGGA AGCTCATTCT GTGCCCGGAG 002720
002721 GTGGGGGGAC CTGTTTGCAC CCAGATTCTA GTGTGCCCTT TCAGAGTTGG GTGCTGGGGA AAGCAGAGAG CAGCCTCTGC 002800
002801 TCTTTGGAGT GAATGCCAAT GGCAGCATCA ATTTGCTGTA GAAAATGAGG ATGCAGTAAT TGGTTTGGAG ATGTTTCTTA 002880
002881 ACCAGATGTC CATGAATAAA CTCTTATGGC AGCTTTAAAA AAAAAAAAAA AAAAA
Labs working on this lncRNA
- Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Chiba 272-8516, Japan lbnishitsuji@hospk.ncgm.go.jp.
