Difference between revisions of "NONHSAT011777"
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| − | > | + | >ref| AK022045.1| Homo sapiens psoriasis associated non-protein coding RNA induced by stress (PRINS), long non-coding RNA |
<dnaseq>GGCCTTTTTTTTTTTTTTTTTCAAATGCCCCTTTCATTATGAAACTCTTTTTTAACTTTTAATTTAAGTTCAGGGGTATGTGTGCAGATTTGTTACATAGGTAAACTTGTGTCATGGGGCTTTGTTGTACAGGTTGTTTCATCACCCAGGTATTATTTTATTTTCATTTTAGTTTTTTAAATTTCTTTTTAGAGGCGGGGTCTCACTGTGTTTTGCCCAGGCTGGTCTCGAACTCCTCCTGGTCTCAAGCAATCCTCTCGCCTCTGCCTCCCCAAGTGTTGGGATTATAGGCATGAGCTACTGCACTCAGCCCACCATTTGTTTTAAAAAGGGTGGATCCTATTTGTATAAAAAGCCATGTGCATTTTCTGTGTACTTGTCTACACATTAATTTCCAGGCTGGGCGTGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGGGAGGCAGATCATGAGGTTAGGAGATCGAAACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCAGGGTGTTGTGGCGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGTGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCCCTCCAGCCTGGACAACAGAGTGAGGCTCCGTCTTAAAGGAAAAAAATTTCTGGAATGATGTCCAATAAATCAGAGAGAGGGACTAGAAGACTAATGAGGACAGAAGCTTTTATTCTTAACACCTATATTTTGCTACCATTTATATTGTCATCATATGCATATAACATTTTAACATTTAAAAACTAGTTTAAACAGAAATGGTTGCCCTGGAATGTGGCCTGTGTTCTTTCAAGGGAGGCCAGCAGTTTCTACAGTGGCTGAGATGGTACCTTCATCTCACACACCTACGCAGGCGTGCATTTGTGCTTTGATGTGGTTGTCCCTTGAAGAAGGAAGCAGTTCTCTTTTTCTTTTTTCCCTTTTCCATTATAGGATCAGTCACTTCTTGGGGCATTAGTAGTCTCATTTCCAGTGGCATCTTCCCTTGGCAAAAGGAATCCCAGATAGGACCTCATCTTTCTAAACAAATGCTGTTTTGGGTCCTAACCATCCCATGTTTGCTTTGAATATGTTTAAGTTGCCTGGAATTATCAACAAAAGAATTAAATTTATTGTAGGTCAGGGCATCTTTTGACTCATTGTATAAAACATTCACTTTAAATGTATACCGAAATGTCCTTTAGGCTGGGATTACAGGCATGAGCCATGACACCCGGCCTGTAATTTTCTTTAAAGACTGCCACTGGGTGGAACCCACTGGGCCCAGTGAGAACTACGGAAAAGAGACCCATTCTTGCCCTCATTGTTAGTGTCCACATCCGGATTTACCTAAACCCCACCCAGGTGGCATTTGCATAGTAATGAAAAACCGGTATTTTCTAGCTGTGAATCACACTTCAAATCCTGAGCGGCTGACTGTCAGGGGTGCGTCAGGCCTGCTTGCTGGGAGAATGGACGAGCTGGTTGTGGAGCGGGCGGGTCCCGCCACCCGTGGGCTCAGCACTGGACTGCTCCCAGAACATTAAAGGTCTGGCTGATGTTCCATGCCACATCTGGACATGAAGACCCATGTCTGCCCTTCTGTAGAAGGGCCAAAGAAGAAAGGAGGCATCACATGTTTCTGCTGTGGGGGGCCCTTCCGAGCAGCAGACAGGAGCAAGGTACAGGAGTGGCCTGATTCTGGGGTTTCCCTGCCCCCCCTGGGGTCCCTAAACTGCTGTGTGATATGTTTCTAACTATCTGGACAGCTCACCCAAGAGTCAGTTGTTCCCAGTCGCTTCTTGCTGAGGATAAGCCAAAAGAGGGCCGGGGGCCAATCTGGTTTCTTTCAAGTGAAATTATGCTTCTCAAGCAGAGAATGATTGCCCACAGCAGTTAAACCTTGTTTAATGGTAATTAAATTGCTTTTCTTCACTTTGAAAAATCTCTTAATTTTCTGTACAAAGGCAGGAAGCATTTTTCTTTGATTCTACAGGATGTTTCTAAGTATGGTGTAATCAGTTCATCTTACCTTGCCGGGCTCTGAAAGAATGAGTGTGTGGGATCAGATTTAGAAATGCCTCAAAGGTTAGAAAGCCGAGTGCTGCCGATTAACTCAAGCTCAGATGACC</dnaseq> | <dnaseq>GGCCTTTTTTTTTTTTTTTTTCAAATGCCCCTTTCATTATGAAACTCTTTTTTAACTTTTAATTTAAGTTCAGGGGTATGTGTGCAGATTTGTTACATAGGTAAACTTGTGTCATGGGGCTTTGTTGTACAGGTTGTTTCATCACCCAGGTATTATTTTATTTTCATTTTAGTTTTTTAAATTTCTTTTTAGAGGCGGGGTCTCACTGTGTTTTGCCCAGGCTGGTCTCGAACTCCTCCTGGTCTCAAGCAATCCTCTCGCCTCTGCCTCCCCAAGTGTTGGGATTATAGGCATGAGCTACTGCACTCAGCCCACCATTTGTTTTAAAAAGGGTGGATCCTATTTGTATAAAAAGCCATGTGCATTTTCTGTGTACTTGTCTACACATTAATTTCCAGGCTGGGCGTGGTGGCTCACGCTTGTAATCCCAGCACTTTGGGAGGCCAAGGGGAGGCAGATCATGAGGTTAGGAGATCGAAACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCAGGGTGTTGTGGCGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGTGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCCCTCCAGCCTGGACAACAGAGTGAGGCTCCGTCTTAAAGGAAAAAAATTTCTGGAATGATGTCCAATAAATCAGAGAGAGGGACTAGAAGACTAATGAGGACAGAAGCTTTTATTCTTAACACCTATATTTTGCTACCATTTATATTGTCATCATATGCATATAACATTTTAACATTTAAAAACTAGTTTAAACAGAAATGGTTGCCCTGGAATGTGGCCTGTGTTCTTTCAAGGGAGGCCAGCAGTTTCTACAGTGGCTGAGATGGTACCTTCATCTCACACACCTACGCAGGCGTGCATTTGTGCTTTGATGTGGTTGTCCCTTGAAGAAGGAAGCAGTTCTCTTTTTCTTTTTTCCCTTTTCCATTATAGGATCAGTCACTTCTTGGGGCATTAGTAGTCTCATTTCCAGTGGCATCTTCCCTTGGCAAAAGGAATCCCAGATAGGACCTCATCTTTCTAAACAAATGCTGTTTTGGGTCCTAACCATCCCATGTTTGCTTTGAATATGTTTAAGTTGCCTGGAATTATCAACAAAAGAATTAAATTTATTGTAGGTCAGGGCATCTTTTGACTCATTGTATAAAACATTCACTTTAAATGTATACCGAAATGTCCTTTAGGCTGGGATTACAGGCATGAGCCATGACACCCGGCCTGTAATTTTCTTTAAAGACTGCCACTGGGTGGAACCCACTGGGCCCAGTGAGAACTACGGAAAAGAGACCCATTCTTGCCCTCATTGTTAGTGTCCACATCCGGATTTACCTAAACCCCACCCAGGTGGCATTTGCATAGTAATGAAAAACCGGTATTTTCTAGCTGTGAATCACACTTCAAATCCTGAGCGGCTGACTGTCAGGGGTGCGTCAGGCCTGCTTGCTGGGAGAATGGACGAGCTGGTTGTGGAGCGGGCGGGTCCCGCCACCCGTGGGCTCAGCACTGGACTGCTCCCAGAACATTAAAGGTCTGGCTGATGTTCCATGCCACATCTGGACATGAAGACCCATGTCTGCCCTTCTGTAGAAGGGCCAAAGAAGAAAGGAGGCATCACATGTTTCTGCTGTGGGGGGCCCTTCCGAGCAGCAGACAGGAGCAAGGTACAGGAGTGGCCTGATTCTGGGGTTTCCCTGCCCCCCCTGGGGTCCCTAAACTGCTGTGTGATATGTTTCTAACTATCTGGACAGCTCACCCAAGAGTCAGTTGTTCCCAGTCGCTTCTTGCTGAGGATAAGCCAAAAGAGGGCCGGGGGCCAATCTGGTTTCTTTCAAGTGAAATTATGCTTCTCAAGCAGAGAATGATTGCCCACAGCAGTTAAACCTTGTTTAATGGTAATTAAATTGCTTTTCTTCACTTTGAAAAATCTCTTAATTTTCTGTACAAAGGCAGGAAGCATTTTTCTTTGATTCTACAGGATGTTTCTAAGTATGGTGTAATCAGTTCATCTTACCTTGCCGGGCTCTGAAAGAATGAGTGTGTGGGATCAGATTTAGAAATGCCTCAAAGGTTAGAAAGCCGAGTGCTGCCGATTAACTCAAGCTCAGATGACC</dnaseq> | ||
Latest revision as of 06:56, 15 November 2018
PRINS Psoriasis associated non-protein coding RNA induced by stress is involved in psoriasis susceptibility, plays a role in cellular stress response and regulation of apoptosis [1].
Contents
Annotated Information
Name
PRINS: Psoriasis associated non-protein coding RNA induced by stress (HGNC).
Characteristics
Structure of the full-length PRINS transcript in HaCaT keratinocytes [2]
PRINS is ~3.6 kb long noncoding RNA and located at human Chromosome 10p12.1 (HGNC) [2].PRINS contains two Alu elements, as well as also contains a heatshock element that displays approximately 70% similarity to G8, a cytoplasmic noncoding RNA in Tetrahymena thermophila, that is responsible for developing thermotolerance [2].
Function
siRNA knock-down shows that PRINS is required for cell viability after serum starvation and also alters cell morphology and gene expression [2][3].
Elevated PRINS expression in the epidermis is suggested to contribute to psoriasis susceptibility by disrupting the signal transduction events mediating the genes involved in apoptosis regulation such as G1P3 [2][4]. In keratinocytes PRINS regulates the expression of the G1P3 gene, an anti-apoptotic protein that is overexpressed in psoriasis [3].
PRINS is essential for the survival of keratinocytes under stress conditions [4].
Expression
PRINS is expressed in various human tissues with great variability in the level of expression. Interestingly, the level of expression differed to a great extent in different organs. The lowest level of PRINS RNA was detected in cardiac muscle, whereas the highest level was seen in veins. The level of expression was 18-fold higher in veins than in cardiac muscle [2].
PRINS is overexpressed in psoriatic epidermis. Regulated by the proliferation and differentiation state of keratinocytes [2]. Several stress signals such as ultraviolet-B (UV-B) irradiation, viral infection (herpes simplex virus), and translational inhibition increased the RNA level of PRINS as well as HaCaT keratinocyte cell treatment with microbial agents such as bacteria peptidoglycan, lipopolysaccharide (LPS) and wall extract [2][4].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| RT-PCR | 5-GCATCTTCCCTTGGCAAA-3' | 5-GCCTAAAGGACATTTCGGTAT-3'[4] |
Regulation
PRINS is regulated by the proliferation and differentiation state of keratinocytes [2].
Disease
- Psoriasis
Labs working on this lncRNA
- Department of Pathology, University of Szeged, Szeged, Hungary. [2]
- Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary. [2]
- Department of Dermatology and Allergology, University of Szeged, Szeged, Koranyi fasor 6, 6720, Hungary. [2][4]
- Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, Szeged 6720, Hungary. [4]
References
- ↑ Hombach S & Kretz M. The non‐coding skin: Exploring the roles of long non‐coding RNA s in epidermal homeostasis and disease[J]. Bioessays. 2013, 35(12):1093-1100.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Sonkoly E, Bata-Csorgo Z, Pivarcsi A, Polyanka H, Kenderessy-Szabo A, Molnar G et al. Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS[J]. Journal of Biological Chemistry. 2005, 280(25):24159-24167.
- ↑ 3.0 3.1 Szegedi K, Sonkoly E, Nagy N, Németh IB, Bata‐Csörgő Z, Kemény L et al. The anti‐apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non‐coding RNA, PRINS[J]. Experimental dermatology. 2010, 19(3):269-278.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Bari L, Bacsa S, Sonkoly E, Bata-Csörgő Z, Kemény L, Dobozy A et al. Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells[J]. Archives of dermatological research. 2011, 303(10):745-752.
sequence
>ref| AK022045.1| Homo sapiens psoriasis associated non-protein coding RNA induced by stress (PRINS), long non-coding RNA
000001 GGCCTTTTTT TTTTTTTTTT TCAAATGCCC CTTTCATTAT GAAACTCTTT TTTAACTTTT AATTTAAGTT CAGGGGTATG 000080
000081 TGTGCAGATT TGTTACATAG GTAAACTTGT GTCATGGGGC TTTGTTGTAC AGGTTGTTTC ATCACCCAGG TATTATTTTA 000160
000161 TTTTCATTTT AGTTTTTTAA ATTTCTTTTT AGAGGCGGGG TCTCACTGTG TTTTGCCCAG GCTGGTCTCG AACTCCTCCT 000240
000241 GGTCTCAAGC AATCCTCTCG CCTCTGCCTC CCCAAGTGTT GGGATTATAG GCATGAGCTA CTGCACTCAG CCCACCATTT 000320
000321 GTTTTAAAAA GGGTGGATCC TATTTGTATA AAAAGCCATG TGCATTTTCT GTGTACTTGT CTACACATTA ATTTCCAGGC 000400
000401 TGGGCGTGGT GGCTCACGCT TGTAATCCCA GCACTTTGGG AGGCCAAGGG GAGGCAGATC ATGAGGTTAG GAGATCGAAA 000480
000481 CCATCCTGGC TAACACGGTG AAACCCCGTC TCTACTAAAA ATACAAAAAC AAAATTAGCA GGGTGTTGTG GCGGGCGCCT 000560
000561 GTAGTCCCAG CTACTCAGGA GGCTGAGGCA GGAGAATGGC ATGAACCCGG GAGGTGGAGC TTGCAGTGAG CTGAGATTGC 000640
000641 GCCACTGCCC TCCAGCCTGG ACAACAGAGT GAGGCTCCGT CTTAAAGGAA AAAAATTTCT GGAATGATGT CCAATAAATC 000720
000721 AGAGAGAGGG ACTAGAAGAC TAATGAGGAC AGAAGCTTTT ATTCTTAACA CCTATATTTT GCTACCATTT ATATTGTCAT 000800
000801 CATATGCATA TAACATTTTA ACATTTAAAA ACTAGTTTAA ACAGAAATGG TTGCCCTGGA ATGTGGCCTG TGTTCTTTCA 000880
000881 AGGGAGGCCA GCAGTTTCTA CAGTGGCTGA GATGGTACCT TCATCTCACA CACCTACGCA GGCGTGCATT TGTGCTTTGA 000960
000961 TGTGGTTGTC CCTTGAAGAA GGAAGCAGTT CTCTTTTTCT TTTTTCCCTT TTCCATTATA GGATCAGTCA CTTCTTGGGG 001040
001041 CATTAGTAGT CTCATTTCCA GTGGCATCTT CCCTTGGCAA AAGGAATCCC AGATAGGACC TCATCTTTCT AAACAAATGC 001120
001121 TGTTTTGGGT CCTAACCATC CCATGTTTGC TTTGAATATG TTTAAGTTGC CTGGAATTAT CAACAAAAGA ATTAAATTTA 001200
001201 TTGTAGGTCA GGGCATCTTT TGACTCATTG TATAAAACAT TCACTTTAAA TGTATACCGA AATGTCCTTT AGGCTGGGAT 001280
001281 TACAGGCATG AGCCATGACA CCCGGCCTGT AATTTTCTTT AAAGACTGCC ACTGGGTGGA ACCCACTGGG CCCAGTGAGA 001360
001361 ACTACGGAAA AGAGACCCAT TCTTGCCCTC ATTGTTAGTG TCCACATCCG GATTTACCTA AACCCCACCC AGGTGGCATT 001440
001441 TGCATAGTAA TGAAAAACCG GTATTTTCTA GCTGTGAATC ACACTTCAAA TCCTGAGCGG CTGACTGTCA GGGGTGCGTC 001520
001521 AGGCCTGCTT GCTGGGAGAA TGGACGAGCT GGTTGTGGAG CGGGCGGGTC CCGCCACCCG TGGGCTCAGC ACTGGACTGC 001600
001601 TCCCAGAACA TTAAAGGTCT GGCTGATGTT CCATGCCACA TCTGGACATG AAGACCCATG TCTGCCCTTC TGTAGAAGGG 001680
001681 CCAAAGAAGA AAGGAGGCAT CACATGTTTC TGCTGTGGGG GGCCCTTCCG AGCAGCAGAC AGGAGCAAGG TACAGGAGTG 001760
001761 GCCTGATTCT GGGGTTTCCC TGCCCCCCCT GGGGTCCCTA AACTGCTGTG TGATATGTTT CTAACTATCT GGACAGCTCA 001840
001841 CCCAAGAGTC AGTTGTTCCC AGTCGCTTCT TGCTGAGGAT AAGCCAAAAG AGGGCCGGGG GCCAATCTGG TTTCTTTCAA 001920
001921 GTGAAATTAT GCTTCTCAAG CAGAGAATGA TTGCCCACAG CAGTTAAACC TTGTTTAATG GTAATTAAAT TGCTTTTCTT 002000
002001 CACTTTGAAA AATCTCTTAA TTTTCTGTAC AAAGGCAGGA AGCATTTTTC TTTGATTCTA CAGGATGTTT CTAAGTATGG 002080
002081 TGTAATCAGT TCATCTTACC TTGCCGGGCT CTGAAAGAAT GAGTGTGTGG GATCAGATTT AGAAATGCCT CAAAGGTTAG 002160
002161 AAAGCCGAGT GCTGCCGATT AACTCAAGCT CAGATGACC
000081 TGTGCAGATT TGTTACATAG GTAAACTTGT GTCATGGGGC TTTGTTGTAC AGGTTGTTTC ATCACCCAGG TATTATTTTA 000160
000161 TTTTCATTTT AGTTTTTTAA ATTTCTTTTT AGAGGCGGGG TCTCACTGTG TTTTGCCCAG GCTGGTCTCG AACTCCTCCT 000240
000241 GGTCTCAAGC AATCCTCTCG CCTCTGCCTC CCCAAGTGTT GGGATTATAG GCATGAGCTA CTGCACTCAG CCCACCATTT 000320
000321 GTTTTAAAAA GGGTGGATCC TATTTGTATA AAAAGCCATG TGCATTTTCT GTGTACTTGT CTACACATTA ATTTCCAGGC 000400
000401 TGGGCGTGGT GGCTCACGCT TGTAATCCCA GCACTTTGGG AGGCCAAGGG GAGGCAGATC ATGAGGTTAG GAGATCGAAA 000480
000481 CCATCCTGGC TAACACGGTG AAACCCCGTC TCTACTAAAA ATACAAAAAC AAAATTAGCA GGGTGTTGTG GCGGGCGCCT 000560
000561 GTAGTCCCAG CTACTCAGGA GGCTGAGGCA GGAGAATGGC ATGAACCCGG GAGGTGGAGC TTGCAGTGAG CTGAGATTGC 000640
000641 GCCACTGCCC TCCAGCCTGG ACAACAGAGT GAGGCTCCGT CTTAAAGGAA AAAAATTTCT GGAATGATGT CCAATAAATC 000720
000721 AGAGAGAGGG ACTAGAAGAC TAATGAGGAC AGAAGCTTTT ATTCTTAACA CCTATATTTT GCTACCATTT ATATTGTCAT 000800
000801 CATATGCATA TAACATTTTA ACATTTAAAA ACTAGTTTAA ACAGAAATGG TTGCCCTGGA ATGTGGCCTG TGTTCTTTCA 000880
000881 AGGGAGGCCA GCAGTTTCTA CAGTGGCTGA GATGGTACCT TCATCTCACA CACCTACGCA GGCGTGCATT TGTGCTTTGA 000960
000961 TGTGGTTGTC CCTTGAAGAA GGAAGCAGTT CTCTTTTTCT TTTTTCCCTT TTCCATTATA GGATCAGTCA CTTCTTGGGG 001040
001041 CATTAGTAGT CTCATTTCCA GTGGCATCTT CCCTTGGCAA AAGGAATCCC AGATAGGACC TCATCTTTCT AAACAAATGC 001120
001121 TGTTTTGGGT CCTAACCATC CCATGTTTGC TTTGAATATG TTTAAGTTGC CTGGAATTAT CAACAAAAGA ATTAAATTTA 001200
001201 TTGTAGGTCA GGGCATCTTT TGACTCATTG TATAAAACAT TCACTTTAAA TGTATACCGA AATGTCCTTT AGGCTGGGAT 001280
001281 TACAGGCATG AGCCATGACA CCCGGCCTGT AATTTTCTTT AAAGACTGCC ACTGGGTGGA ACCCACTGGG CCCAGTGAGA 001360
001361 ACTACGGAAA AGAGACCCAT TCTTGCCCTC ATTGTTAGTG TCCACATCCG GATTTACCTA AACCCCACCC AGGTGGCATT 001440
001441 TGCATAGTAA TGAAAAACCG GTATTTTCTA GCTGTGAATC ACACTTCAAA TCCTGAGCGG CTGACTGTCA GGGGTGCGTC 001520
001521 AGGCCTGCTT GCTGGGAGAA TGGACGAGCT GGTTGTGGAG CGGGCGGGTC CCGCCACCCG TGGGCTCAGC ACTGGACTGC 001600
001601 TCCCAGAACA TTAAAGGTCT GGCTGATGTT CCATGCCACA TCTGGACATG AAGACCCATG TCTGCCCTTC TGTAGAAGGG 001680
001681 CCAAAGAAGA AAGGAGGCAT CACATGTTTC TGCTGTGGGG GGCCCTTCCG AGCAGCAGAC AGGAGCAAGG TACAGGAGTG 001760
001761 GCCTGATTCT GGGGTTTCCC TGCCCCCCCT GGGGTCCCTA AACTGCTGTG TGATATGTTT CTAACTATCT GGACAGCTCA 001840
001841 CCCAAGAGTC AGTTGTTCCC AGTCGCTTCT TGCTGAGGAT AAGCCAAAAG AGGGCCGGGG GCCAATCTGG TTTCTTTCAA 001920
001921 GTGAAATTAT GCTTCTCAAG CAGAGAATGA TTGCCCACAG CAGTTAAACC TTGTTTAATG GTAATTAAAT TGCTTTTCTT 002000
002001 CACTTTGAAA AATCTCTTAA TTTTCTGTAC AAAGGCAGGA AGCATTTTTC TTTGATTCTA CAGGATGTTT CTAAGTATGG 002080
002081 TGTAATCAGT TCATCTTACC TTGCCGGGCT CTGAAAGAAT GAGTGTGTGG GATCAGATTT AGAAATGCCT CAAAGGTTAG 002160
002161 AAAGCCGAGT GCTGCCGATT AACTCAAGCT CAGATGACC
Predicted Small Protein
| Name | NONHSAT011777_smProtein_860:1045 |
| Length | 62 |
| Molecular weight | 6886.93 |
| Aromaticity | 0.147540983607 |
| Instability index | 49.9245901639 |
| Isoelectric point | 6.37005615234 |
| Runs | 9 |
| Runs residual | 0.00527605049934 |
| Runs probability | 0.0602072660896 |
| Amino acid sequence | MWPVFFQGRPAVSTVAEMVPSSHTPTQACICALMWLSLEEGSSSLFLFSLFHYRISHFLG H |
| Secondary structure | LLEEELLLLLLEEEEEEELLLLLLHHHHHHHHHHHHLLLLLLLHHHHHHHHHHHHHHHLL L |
| PRMN | LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLHHHHHHHHHHHHHHHHHHHHHHLLLLLLLL L |
| PiMo | ooooooooooooooooooooooooooooooTTTTTTTTTTTTTTTTTTTTTTiiiiiiii i |
