Difference between revisions of "PTENP1"
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===Function=== | ===Function=== | ||
[[File:PTENP1.jpg|right|thumb|400px|'''Functions of long non-coding RNA ''PTENP1'''''<ref name="ref4" />]] | [[File:PTENP1.jpg|right|thumb|400px|'''Functions of long non-coding RNA ''PTENP1'''''<ref name="ref4" />]] | ||
| + | ''PTENP1'' regulate the expresssion of tumor supressor gene ''PTEN'' <ref name="ref1" /><ref name="ref2" />. | ||
PTENP1 3'UTR can increase PTEN expression by binding to microRNAs that downregulate PTEN expression. Thus, PTENP1 plays an important role in cancer biology, restricting cell proliferation by acting as a microRNA decoy for the tumor suppressor PTEN <ref name="ref1" />. | PTENP1 3'UTR can increase PTEN expression by binding to microRNAs that downregulate PTEN expression. Thus, PTENP1 plays an important role in cancer biology, restricting cell proliferation by acting as a microRNA decoy for the tumor suppressor PTEN <ref name="ref1" />. | ||
Revision as of 06:04, 17 November 2018
PTENP1, phosphatase and tensin homolog pseudogene 1 is a tumor suppressor gene and undergoes genomic deletion in human melanoma.
Contents
Annotated Information
Name
PTENP1: Phosphatase and tensin homolog pseudogene 1 (HGNC nomenclature) LINC00586[1]
Characteristics
PTENP1 is 3932 bp long non-coding RNA, located on human chromosome 9p13.3 (HGNC). PTENP1 is highly homologous to PTEN, with only 18 mismatches throughout the coding sequence [1].
Function
Functions of long non-coding RNA PTENP1[2]
PTENP1 regulate the expresssion of tumor supressor gene PTEN [1][3]. PTENP1 3'UTR can increase PTEN expression by binding to microRNAs that downregulate PTEN expression. Thus, PTENP1 plays an important role in cancer biology, restricting cell proliferation by acting as a microRNA decoy for the tumor suppressor PTEN [1].
The overexpressed PTENP1 repressed the oncogenic PI3K/AKT pathway and elicited pro-death autophagy via sequestering miR-17, miR19b and miR-20a in vitro, and inhibited the hepatocellular carcinoma (HCC) tumor growth in vivo, which was accompanied by enhanced apoptosis, autophagy and dampened angiogenesis/neovasculature maturation [3].
PTENP1 along with two other lncRNA CUDR, and LSINCT-5 was identified as a potential diagnostic marker for gastric cancer (GC) that distinguished between early-stage GC patients and healthy subjects [4].
Regulation
Histone acetylation is a key factor in controlling lncRNA BANCR expression [1].
Diseases
Expression
PTENP1 is downregulated in hepatocellular carcinoma (HCC) cells [3].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| PCR | 59-GAGGAGCCGTCAAATCCAGAG-39 | 59-TCGTCAATGTGTGAGGTTCC-39[1] |
| Real time PCR | 59-TCAGAACATGGCATACACCAA-39 | 59-TGATGACGTCCGATTTTTCA-39[1] |
Labs working on this lncRNA
- Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.[3]
- Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan.[3]
- Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.[3]
- Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.[3]
- Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.[4]
- Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.[4]
- Institute of Pathology, Fudan University, Shanghai, China.[4]
- Fudan University Shanghai Cancer Center-Institut MeRieux Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.[4]
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ & Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumor biology[J]. Nature. 2010, 465(7301):1033-1038.
- ↑ Martens-Uzunova ES, Bottcher R, Croce CM, Jenster G, Visakorpi T & Calin GA. Long noncoding RNA in prostate, bladder, and kidney cancer[J]. Eur Urol. 2014, 65(6):1140-1151.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Chen CL, Tseng YW, Wu JC, Chen GY, Lin KC, Hwang SM et al. Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation[J]. Biomaterials. 2015, 44:71-81.
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Dong L, Qi P, Xu MD, Ni SJ, Huang D, Xu QH et al. Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls[J]. Int J Cancer. 2015, 137(5):1128-1135.
Sequence
>gi|11191|ref|NR_023917.1| Homo sapiens phosphatase and tensin homolog pseudogene 1 (PTENP1), long non-coding RNA
000001 AGATGAGAGA CAGAGACGGC GGCGGCGGCG GCGGCCCGGC CCGGCCCGGC CTGAAGCCCC TCTCAGCAAC CCGTGAGCAT 000080
000081 CCGCGGGGGC GGCGCCGGCA GCGGCGGCGT TTCTCGCTTC TTCTTCGTCT TTTCTAACTG TGCAGCCTCT TCCTCGGCTT 000160
000161 CTCCTGAAAG GGAAGGTGGA AGCCGTGGGC TTGGGCGGGA GCCGGCTGAG GCGCGGCGGC GGCGGCACCT CCCCCTCCTG 000240
000241 GAGCGGGGGG AGAAGCGGCG GCGGCGGCGC CCCCGGTGGC CCCGGCGGCT GCAGCTCCAG GGAGGGGGTC TGAGTCGCCT 000320
000321 GTCACCATTT CCAGGGCTGG GAACGCCGGA GAGTTGGTCT CTCCCCTTCT ACTGCCTCCA ACACGGCGGC GGCGGCGGCG 000400
000401 GCGGCGGCGG CACATGGAGG GACCCGGGCC GGTTTTAAAC CTCTCGTCCG CCGCCGCCGC ACCCCCCGTG GCCCGGGCTC 000480
000481 CGGAGGCCGC TGGAGGAGGC AGCCGTTCGG AGGATTATTC GTCTTCTCCC CATTCCGCTG CCGCCGCTGC CAGGCCTCTG 000560
000561 GCTGCTGAGG AGAAGCAGGC CCAGTAGCTG CCACCATCCA GCAGCTGCTG CCGCAGCCAT TACCCGGCTG CGGTCCAGAG 000640
000641 CCAAGCAGCG GCTGAGCGAG GGGCATCAGC TACCGCCAAG TCCAGAGCCA TTTCCATCCT GCAGAGCCCC GCCACCAGCA 000720
000721 GCTTCTGCCA TCTCTCTCCT CCTTTTTCTT CAGCCACAGG CTCCCAGACA GGACAGCCAT CATCAAAGAG ATCGTTAGCA 000800
000801 GAAACAAAAG GAGATATCAA GAGGATGGAT TCGACTTAGA CTTGACCTAT ATTTATCTAA ACATTATTGC TATGGGATTT 000880
000881 CCTGCAGAAA GACTTGAAGG CGTATACAGG AACAATATTG ATGATGTAGT AAGGTTTTTG GATTCAAAGC ATAAAAACCA 000960
000961 TTACAAGATA CACAATCTTT GTGCTGAAAG ACATTATGAC ACCGCCAAAT CTAATTACAG AGTTGCGCAA TATCCTTTTG 001040
001041 AAGACCATAA CCCACCACAG CTAGAACTTA TCAAACCCTT TTGTGAAGAT CTTGACCAAT GGCTAAGTGA AGATGACAAT 001120
001121 CATGTTGCAG CAATTCACTG TAAAGCTGGA AAGGGACGAA CTGGTATAAT GATTTATGCA TATTTATTAC ATCGGGGCAA 001200
001201 ATTTTTAAAG GCACAAGAGG CCCTAGATTT CTATGGGGAA GTAAGGACCA GAGACAAAAA GGGAGTAACT ATTCCCAGTC 001280
001281 AGAGGCGCTA TGTGTATTAC TATAGCTACC TGGTAAAGAA TCATGTGGAT TATAGACCAG TGGCACTGTT GTTTCACAAG 001360
001361 ATGATGTTTG AAACTATTCC AATGTTCAGT GGCGGAACTT GCAATCCTCA GTTTGTGGTC TGCCAGCTAA AGGTGAAGAT 001440
001441 GTATTCCTCC AATTCAGGAC CCACACGATG GGAGGACAAG TTCATGTATT TTGAGTTCCC TCAGCCGTTA CCTGTGTGTG 001520
001521 GTGATATCAA AGTAGAGTTC TTCCACAAAC AGAACAAGAT GCTAAAAAAG GACAAAATGT TTCACTTTTG GGTAAATACA 001600
001601 TTCTTCATAC CAGGACCAGA GGAAACCTCA GAAAAAGTAG AAAATGGAAG TCTATGTGAT CAAGAAATTG ATAGCATTTG 001680
001681 CAGTATAGAG CGTGCAGATA ATGACAAGGA GTATCTAGTA CTTACTTTAA CAAAAAATGA TCTTGACAAA GCAAATAAAG 001760
001761 ACAAAGCCAA CCGATACTTT TCTCCAAATT TTAAGGTGAA GCTGTACTTC ACAAAAACAG TAGAGGAGCC GTCAAATCCA 001840
001841 GAGGCTAGCA GTTCAACTTC TGTAACACCA GATGTTAGTG ACAATGAACC TGATCATTAT AGATATTCTG ACACCACTGA 001920
001921 CTCTGATCCA GAGAATGAAC CTTTTGATGA AGATCAGCAT ACACAAATTA CAAAAGTCTG AATTTTTTTT TATCAAGAGG 002000
002001 GATAAAACAC CATGAAAACA AACTTGAATA AACTGAAAAG GGACCTTTTT TTTTAATGGC AATAGGACAT TGTGTCAGAT 002080
002081 TACCAGTTAT AGAAACAATT CTCTTTTCGT GACCAATCTT GTTTTACCCT ATACATCCAC AGGGTTTTGA CACTTGTTGT 002160
002161 CCAGTTGAAA AAAGGTTGTG TAGCTGTGTC ATGTATATAC CTTTTTGTGT CAAAAGGACA TTTAAAATTC AATTAGGATT 002240
002241 AATAAAGATG GCACTTTCCC ATTTTATTCC AGTTTTATAA AAAGTGGAGA CAGACTGGTG TGTATACGTA GGAATTTTTT 002320
002321 CCTTTTGTGT TCTGTCACCA ACTGAAGTGG CTAAAGAGCT TTGTGATATA CTGGTTCACA TCATACCCCT TTGCACTTGT 002400
002401 GGCAACAGAT AAGTTTGCAG TTAGCTAAGA GAAGTTTCTG AAGGGTTTTG CTGCATTCTT GCATGTATTT GGGTTAGGGG 002480
002481 AATGGAGGGA ATGCTCAGAA AGGAAATAAT TTTATGCTGG ACTCTGGACC ATATACCATC TCCAGCTATT TACACACACC 002560
002561 TTTCTTTAGC ATGCTACAGT TATTAATCTG GACATTCGAG GAATTGGCTG CTGTCACTGC TTGTTGTTTT CGCATTTTTT 002640
002641 TAAAAGCATA TTGGTGCTAG AAAAGGCAGC TAAAGGAAGT GAATCTGTAT TGGGGTACAG GAATGAACCT TCTGCAACAT 002720
002721 CTTAAGATCC ACAAATGAAG GGATATAAAA ATAATGTCAT AGATAAGAAA CACAGCAACA ATGACTTAAC CATATAAATG 002800
002801 TGGAGGCTAT CAACAAAGAA TGGGCTTGAA ACATTATAAA AATTGACAAT GATTTGTTAA ATATGTTTTC TTAATTGTAA 002880
002881 CGACTTCTCC ATCTCCTGTG TAATCAAGGC CAGTGCTGAA AGTCAGATGC TATTAGTACC TACATCAGTC AACAACTTAC 002960
002961 ACTTATTTTA CTAGTTTTCA ATCATATACC TGCTGTGAAT GCTTCATGTG CTGCCTGCAA GCTTCTTTTT TCTCATTAAA 003040
003041 TATAAAATAT TTTGTAATGC TAAAAAAAAA AAAAAGAACA TAGAAGACAA ACATCAGAAA TAAACCCATC CACTATGGTT 003120
003121 AACTCATTTT TGAATATGGT GTAAAGTCAG TTTAATGATG AAATAATATT ATTTTCAACA AATAGTACAG AAATTAAACT 003200
003201 ATGCAAAAAT ACTATTAATA ATGATGTTGG ATCATTACCT CACACCATAC CCCCAAATTA ACTCAGAACA TGGCATACAC 003280
003281 CAAATATAAG AGCAAAAACT ATGAAATTTC TAGAAGAAGA CAGAAAAAAA ATTATGACTT TGGCTTAGTT GTTTCTTAGA 003360
003361 AGTAACAGGA AAAGCATAAT TCATAAAAGA TAAATTGAAA AATCGGACGT CATCAAAATA AAAAATGGTT TATCTTCAAA 003440
003441 GTCACCTGTT AAGAAAATGA GAAGACAAAT CATAAAGCAG GGAGAAATTT TTGAAAGTCA TGTATCTGAT AAGGGACAGT 003520
003521 TAAAACTAAA TAAAAACACA AACCATCCAA TTAAAATGAA TAAAGGGTTC GAATAGGTAT GTCATCAGAG ATCATATAGG 003600
003601 AATAACCAAT AAGCAAACAA AAGATGTTCA ATATCATTAG TTATTAGAGA AACAAAATTT AAAAACCACA ATGAGATGAC 003680
003681 ACTACACATT TGCCAGAATG ATGATTATTA AAAAAGACCA AGTATTGGAG AGGATGTGAA AAAACTGGAA CCTCACACAT 003760
003761 TGACGATAGA AATGTAAAAT GAAATAGCCA ATTCAGAAAA CATTTTACAA GTTTTCTTTG TTTTTGTTTT TAATTTATTA 003840
003841 TACCCTTACC CTATGACTCA GTAATTCCAC TTCTAGATAC CTACCAAATA AAATTAAAGT TTATAACTTC ACAAAGAAAA 003920
003921 AAAAAAAAAA AA
000081 CCGCGGGGGC GGCGCCGGCA GCGGCGGCGT TTCTCGCTTC TTCTTCGTCT TTTCTAACTG TGCAGCCTCT TCCTCGGCTT 000160
000161 CTCCTGAAAG GGAAGGTGGA AGCCGTGGGC TTGGGCGGGA GCCGGCTGAG GCGCGGCGGC GGCGGCACCT CCCCCTCCTG 000240
000241 GAGCGGGGGG AGAAGCGGCG GCGGCGGCGC CCCCGGTGGC CCCGGCGGCT GCAGCTCCAG GGAGGGGGTC TGAGTCGCCT 000320
000321 GTCACCATTT CCAGGGCTGG GAACGCCGGA GAGTTGGTCT CTCCCCTTCT ACTGCCTCCA ACACGGCGGC GGCGGCGGCG 000400
000401 GCGGCGGCGG CACATGGAGG GACCCGGGCC GGTTTTAAAC CTCTCGTCCG CCGCCGCCGC ACCCCCCGTG GCCCGGGCTC 000480
000481 CGGAGGCCGC TGGAGGAGGC AGCCGTTCGG AGGATTATTC GTCTTCTCCC CATTCCGCTG CCGCCGCTGC CAGGCCTCTG 000560
000561 GCTGCTGAGG AGAAGCAGGC CCAGTAGCTG CCACCATCCA GCAGCTGCTG CCGCAGCCAT TACCCGGCTG CGGTCCAGAG 000640
000641 CCAAGCAGCG GCTGAGCGAG GGGCATCAGC TACCGCCAAG TCCAGAGCCA TTTCCATCCT GCAGAGCCCC GCCACCAGCA 000720
000721 GCTTCTGCCA TCTCTCTCCT CCTTTTTCTT CAGCCACAGG CTCCCAGACA GGACAGCCAT CATCAAAGAG ATCGTTAGCA 000800
000801 GAAACAAAAG GAGATATCAA GAGGATGGAT TCGACTTAGA CTTGACCTAT ATTTATCTAA ACATTATTGC TATGGGATTT 000880
000881 CCTGCAGAAA GACTTGAAGG CGTATACAGG AACAATATTG ATGATGTAGT AAGGTTTTTG GATTCAAAGC ATAAAAACCA 000960
000961 TTACAAGATA CACAATCTTT GTGCTGAAAG ACATTATGAC ACCGCCAAAT CTAATTACAG AGTTGCGCAA TATCCTTTTG 001040
001041 AAGACCATAA CCCACCACAG CTAGAACTTA TCAAACCCTT TTGTGAAGAT CTTGACCAAT GGCTAAGTGA AGATGACAAT 001120
001121 CATGTTGCAG CAATTCACTG TAAAGCTGGA AAGGGACGAA CTGGTATAAT GATTTATGCA TATTTATTAC ATCGGGGCAA 001200
001201 ATTTTTAAAG GCACAAGAGG CCCTAGATTT CTATGGGGAA GTAAGGACCA GAGACAAAAA GGGAGTAACT ATTCCCAGTC 001280
001281 AGAGGCGCTA TGTGTATTAC TATAGCTACC TGGTAAAGAA TCATGTGGAT TATAGACCAG TGGCACTGTT GTTTCACAAG 001360
001361 ATGATGTTTG AAACTATTCC AATGTTCAGT GGCGGAACTT GCAATCCTCA GTTTGTGGTC TGCCAGCTAA AGGTGAAGAT 001440
001441 GTATTCCTCC AATTCAGGAC CCACACGATG GGAGGACAAG TTCATGTATT TTGAGTTCCC TCAGCCGTTA CCTGTGTGTG 001520
001521 GTGATATCAA AGTAGAGTTC TTCCACAAAC AGAACAAGAT GCTAAAAAAG GACAAAATGT TTCACTTTTG GGTAAATACA 001600
001601 TTCTTCATAC CAGGACCAGA GGAAACCTCA GAAAAAGTAG AAAATGGAAG TCTATGTGAT CAAGAAATTG ATAGCATTTG 001680
001681 CAGTATAGAG CGTGCAGATA ATGACAAGGA GTATCTAGTA CTTACTTTAA CAAAAAATGA TCTTGACAAA GCAAATAAAG 001760
001761 ACAAAGCCAA CCGATACTTT TCTCCAAATT TTAAGGTGAA GCTGTACTTC ACAAAAACAG TAGAGGAGCC GTCAAATCCA 001840
001841 GAGGCTAGCA GTTCAACTTC TGTAACACCA GATGTTAGTG ACAATGAACC TGATCATTAT AGATATTCTG ACACCACTGA 001920
001921 CTCTGATCCA GAGAATGAAC CTTTTGATGA AGATCAGCAT ACACAAATTA CAAAAGTCTG AATTTTTTTT TATCAAGAGG 002000
002001 GATAAAACAC CATGAAAACA AACTTGAATA AACTGAAAAG GGACCTTTTT TTTTAATGGC AATAGGACAT TGTGTCAGAT 002080
002081 TACCAGTTAT AGAAACAATT CTCTTTTCGT GACCAATCTT GTTTTACCCT ATACATCCAC AGGGTTTTGA CACTTGTTGT 002160
002161 CCAGTTGAAA AAAGGTTGTG TAGCTGTGTC ATGTATATAC CTTTTTGTGT CAAAAGGACA TTTAAAATTC AATTAGGATT 002240
002241 AATAAAGATG GCACTTTCCC ATTTTATTCC AGTTTTATAA AAAGTGGAGA CAGACTGGTG TGTATACGTA GGAATTTTTT 002320
002321 CCTTTTGTGT TCTGTCACCA ACTGAAGTGG CTAAAGAGCT TTGTGATATA CTGGTTCACA TCATACCCCT TTGCACTTGT 002400
002401 GGCAACAGAT AAGTTTGCAG TTAGCTAAGA GAAGTTTCTG AAGGGTTTTG CTGCATTCTT GCATGTATTT GGGTTAGGGG 002480
002481 AATGGAGGGA ATGCTCAGAA AGGAAATAAT TTTATGCTGG ACTCTGGACC ATATACCATC TCCAGCTATT TACACACACC 002560
002561 TTTCTTTAGC ATGCTACAGT TATTAATCTG GACATTCGAG GAATTGGCTG CTGTCACTGC TTGTTGTTTT CGCATTTTTT 002640
002641 TAAAAGCATA TTGGTGCTAG AAAAGGCAGC TAAAGGAAGT GAATCTGTAT TGGGGTACAG GAATGAACCT TCTGCAACAT 002720
002721 CTTAAGATCC ACAAATGAAG GGATATAAAA ATAATGTCAT AGATAAGAAA CACAGCAACA ATGACTTAAC CATATAAATG 002800
002801 TGGAGGCTAT CAACAAAGAA TGGGCTTGAA ACATTATAAA AATTGACAAT GATTTGTTAA ATATGTTTTC TTAATTGTAA 002880
002881 CGACTTCTCC ATCTCCTGTG TAATCAAGGC CAGTGCTGAA AGTCAGATGC TATTAGTACC TACATCAGTC AACAACTTAC 002960
002961 ACTTATTTTA CTAGTTTTCA ATCATATACC TGCTGTGAAT GCTTCATGTG CTGCCTGCAA GCTTCTTTTT TCTCATTAAA 003040
003041 TATAAAATAT TTTGTAATGC TAAAAAAAAA AAAAAGAACA TAGAAGACAA ACATCAGAAA TAAACCCATC CACTATGGTT 003120
003121 AACTCATTTT TGAATATGGT GTAAAGTCAG TTTAATGATG AAATAATATT ATTTTCAACA AATAGTACAG AAATTAAACT 003200
003201 ATGCAAAAAT ACTATTAATA ATGATGTTGG ATCATTACCT CACACCATAC CCCCAAATTA ACTCAGAACA TGGCATACAC 003280
003281 CAAATATAAG AGCAAAAACT ATGAAATTTC TAGAAGAAGA CAGAAAAAAA ATTATGACTT TGGCTTAGTT GTTTCTTAGA 003360
003361 AGTAACAGGA AAAGCATAAT TCATAAAAGA TAAATTGAAA AATCGGACGT CATCAAAATA AAAAATGGTT TATCTTCAAA 003440
003441 GTCACCTGTT AAGAAAATGA GAAGACAAAT CATAAAGCAG GGAGAAATTT TTGAAAGTCA TGTATCTGAT AAGGGACAGT 003520
003521 TAAAACTAAA TAAAAACACA AACCATCCAA TTAAAATGAA TAAAGGGTTC GAATAGGTAT GTCATCAGAG ATCATATAGG 003600
003601 AATAACCAAT AAGCAAACAA AAGATGTTCA ATATCATTAG TTATTAGAGA AACAAAATTT AAAAACCACA ATGAGATGAC 003680
003681 ACTACACATT TGCCAGAATG ATGATTATTA AAAAAGACCA AGTATTGGAG AGGATGTGAA AAAACTGGAA CCTCACACAT 003760
003761 TGACGATAGA AATGTAAAAT GAAATAGCCA ATTCAGAAAA CATTTTACAA GTTTTCTTTG TTTTTGTTTT TAATTTATTA 003840
003841 TACCCTTACC CTATGACTCA GTAATTCCAC TTCTAGATAC CTACCAAATA AAATTAAAGT TTATAACTTC ACAAAGAAAA 003920
003921 AAAAAAAAAA AA
