Difference between revisions of "ENST00000414769.1"

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Please input one-sentence summary here.
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''MIR503HG'', a lncRNA which is likely originated at least 370 Myr ago in the tetrapod ancestor, may functions like H19 by promoting miRNA transcription, preferentially in the placenta and in an imprinted manner.
  
 
==Annotated Information==
 
==Annotated Information==
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===Transcriptomic Nomeclature===
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===Name===
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Please input transcriptomic nomeclature information here.
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MIR503HG: MIR503 host gene [https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28258 (HGNC:28258)]
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===Alias===
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"H19 X-linked co-expressed lncRNA", ''H19X'' <ref name="ref1" />
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''MGC16121'' [https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28258 (HGNC:28258)]
  
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===Function===
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===Characteristics===
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Please input function information here.
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[[File:Expression pattern for an X-linked H19 co-expressed lncRNA (H19X, identified as ENSG00000223749 in the Ensembl database), in five tetrapod species.jpg|right|thumb|400px|'''Expression pattern for an X-linked H19 co-expressed lncRNA (H19X, identified as ENSG00000223749 in the Ensembl database), in five tetrapod species.'''<ref name="ref1" />]]
  
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===Regulation===
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MIG503HG could potentially promote the transcription of between 2 and 7 miRNAs in different species, such as Human,mouse,Opossum,platyous,xenopus,. This lncRNA (that we name H19X, for H19 X-linked co-expressed lncRNA)  is ikely originated at least 370 Myr ago, in the tetrapod ancestor<ref name="ref1" />.
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Please input regulation information here.
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===Fuction===
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H19X is a neighbour of Rsx, the lncRNA that drives imprinted X-inactivation in marsupials, suggesting that H19X may itself be imprinted. These results suggest that H19X may function like H19, by promoting miRNA transcription, preferentially in the placenta and in an imprinted manner<ref name="ref1" />.  
  
 
===Expression===
 
===Expression===
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Please input expression information here.
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Expression pattern appears to have dramatically shifted during evolution, from an ancestral testes-predominant pattern to preferential expression in the chorioallantoic placenta of eutherians<ref name="ref1" />.
  
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===Allelic Information and Variation===
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===Disease===
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Please input allelic information and variation information here.
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Choriocarcinoma <ref name="ref1" />
  
 
===Evolution===
 
===Evolution===
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Expression pattern appears to have dramatically shifted during evolution, from an ancestral testes-predominant pattern to preferential expression in the chorioallantoic placenta of eutherians<ref name="ref1" />.
  
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You can also add sub-section(s) at will.
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==Labs working on this lncRNA==
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* Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland<ref name="ref1" />.
  
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==Labs working on this lncRNA==
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==Sequence==
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Please input related labs here.
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>gi|84848|ref|NR_024607.1| Homo sapiens MIR503 host gene (MIR503HG), long non-coding RNA
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<dnaseq>GAAGGTAGAAGGTGGGGTCTGCCGGACGCGTGTTCCTGCCACCAGGTGCCCGCTCCCCGCGAGGCCGGCT
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CAGGAGCAGAAGGAAGCCCGGTGCCAGCCAGCCTTCCTGAAAGACCAAGCCCGCGCCATCCGGCTTCCTC
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CAGTGGACGCCTGCAGGACCCAGGAATGTTTTTCTTGAAGGCATCCAGCATCTCCAGTTAGCAGTACTGA
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TTTTTTTTCCCCCCAACAAAGGAACACTACATCAACACTGTTGGCGGGGACCTGGACACAGAAGACTCCT
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GTTTCAAGAAAATACAATCATCTCTCAAAGGCTGTAATTTATATGCATTTTAAAACTCTAGGCATTGAAA
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ACCACCCAAGTGTCCCAAATAGAAGGGTAATATATAATCAATCACTCAGTGTAATATTATACATCCTTTA
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AAAATGTTATTGGGAAATGTTTTATGATCTGTAAGTCCAAGGAATCCTCTCCCACCATTTCTTTCCCCCC
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GCTGTTCCCCCATACCCACACTTCTTTGTTCCAATTGGCATGTAAATTTGGTTTTCCCGCCAAATGAGTC
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AGTCATGATGGGAACCTCAACTGATTTGAACAGATGTGTGTCAATGTTACTTGGAAAACTAGATGTCAAT
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AACCAGGGTCACAGAAAAAGGCAGTGGTCACAACTCTGTAAAAATGTATGCATGCACACAGACAAGAACT
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AAAGTGGAACCCCACACAGGAAAACAGTGGGCTGTACTCCAGTGCTGGGACATTGAATGACTGTATGCTG
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CTTTTGATTTCCGTTA</dnaseq>
  
 
==References==
 
==References==
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Please input cited references here.
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<references>
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<ref name="ref1"> Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, et al. The evolution of lncRNA repertoires and expression patterns in tetrapods[J]. Nature. 2014,505(7485):635-40.</ref>(1)
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</references>
  
 
{{basic|
 
{{basic|
 
tID = ENST00000414769.1|
 
tID = ENST00000414769.1|
 
source = Gencode19|
 
source = Gencode19|
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same = lnc-PLAC1-1:2|
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same = lnc-PLAC1-1:2, ''MIG403HG'', ''H19X'', ''MGC16121''|
 
classification = intergenic|
 
classification = intergenic|
 
length = 720 nt|
 
length = 720 nt|
Line 42: Line 62:
 
sequence = <dnaseq>GAAGGTAGAAGGTGGGGTCTGCCGGACGCGTGTTCCTGCCACCAGGTGCCCGCTCCCCGCGAGGCCGGCTCAGGAGCAGAAGGAAGCCCGGTGCCAGCCAGCCTTCCTGAAAGACCAAGCCCGCGCCATCCGGCTTCCTCCAGTGGACGCCTGCAGGACCCAGGAATGTTTTTCTTGAAGGCATCCAGCATCTCCAGTTAGCAGTACTGATTTTTTTTCCCCCCAACAAAGGAACACTACATCAACACTGTTGGCGGGGACCTGGACACAGAAGACTCCTGTTTCAAGAAAATACAATCATCTCTCAAAGGCTGTAATTTATATGCATTTTAAAACTCTAGGCATTGAAAACCACCCAAGTGTCCCAAATAGAAGGGTAATATATAATCAATCACTCAGTGTAATATTATACATCCTTTAAAAATGTTATTGGGAAATGTTTTATGATCTGTAAGTCCAAGGAATCCTCTCCCACCATTTCTTTCCCCCCGCTGTTCCCCCATACCCACACTTCTTTGTTCCAATTGGCATGTAAATTTGGTTTTCCCGCCAAATGAGTCAGTCATGATGGGAACCTCAACTGATTTGAACAGATGTGTGTCAATGTTACTTGGAAAACTAGATGTCAATAACCAGGGTCACAGAAAAAGGCAGTGGTCACAACTCTGTAAAAATGTATGCATGCACACAGACAAGAACTAAAGTGGAACCCCACACAGG</dnaseq>|
 
sequence = <dnaseq>GAAGGTAGAAGGTGGGGTCTGCCGGACGCGTGTTCCTGCCACCAGGTGCCCGCTCCCCGCGAGGCCGGCTCAGGAGCAGAAGGAAGCCCGGTGCCAGCCAGCCTTCCTGAAAGACCAAGCCCGCGCCATCCGGCTTCCTCCAGTGGACGCCTGCAGGACCCAGGAATGTTTTTCTTGAAGGCATCCAGCATCTCCAGTTAGCAGTACTGATTTTTTTTCCCCCCAACAAAGGAACACTACATCAACACTGTTGGCGGGGACCTGGACACAGAAGACTCCTGTTTCAAGAAAATACAATCATCTCTCAAAGGCTGTAATTTATATGCATTTTAAAACTCTAGGCATTGAAAACCACCCAAGTGTCCCAAATAGAAGGGTAATATATAATCAATCACTCAGTGTAATATTATACATCCTTTAAAAATGTTATTGGGAAATGTTTTATGATCTGTAAGTCCAAGGAATCCTCTCCCACCATTTCTTTCCCCCCGCTGTTCCCCCATACCCACACTTCTTTGTTCCAATTGGCATGTAAATTTGGTTTTCCCGCCAAATGAGTCAGTCATGATGGGAACCTCAACTGATTTGAACAGATGTGTGTCAATGTTACTTGGAAAACTAGATGTCAATAACCAGGGTCACAGAAAAAGGCAGTGGTCACAACTCTGTAAAAATGTATGCATGCACACAGACAAGAACTAAAGTGGAACCCCACACAGG</dnaseq>|
 
}}
 
}}
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[[Category:Intergenic]][[Category:ENSG00000223749.3]][[Category:lnc-PLAC1-1]][[Category:Transcripts]]
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[[Category:Intergenic]][[Category:ENSG00000223749.3]][[Category:lnc-PLAC1-1]][[Category:Transcripts]][[Category:Transcripts]]

Latest revision as of 02:31, 21 November 2018

MIR503HG, a lncRNA which is likely originated at least 370 Myr ago in the tetrapod ancestor, may functions like H19 by promoting miRNA transcription, preferentially in the placenta and in an imprinted manner.

Annotated Information

Name

MIR503HG: MIR503 host gene (HGNC:28258)

Alias

"H19 X-linked co-expressed lncRNA", H19X [1] MGC16121 (HGNC:28258)

Characteristics

Expression pattern for an X-linked H19 co-expressed lncRNA (H19X, identified as ENSG00000223749 in the Ensembl database), in five tetrapod species.[1]

MIG503HG could potentially promote the transcription of between 2 and 7 miRNAs in different species, such as Human,mouse,Opossum,platyous,xenopus,. This lncRNA (that we name H19X, for H19 X-linked co-expressed lncRNA) is ikely originated at least 370 Myr ago, in the tetrapod ancestor[1].

Fuction

H19X is a neighbour of Rsx, the lncRNA that drives imprinted X-inactivation in marsupials, suggesting that H19X may itself be imprinted. These results suggest that H19X may function like H19, by promoting miRNA transcription, preferentially in the placenta and in an imprinted manner[1].

Expression

Expression pattern appears to have dramatically shifted during evolution, from an ancestral testes-predominant pattern to preferential expression in the chorioallantoic placenta of eutherians[1].

Disease

Choriocarcinoma [1]

Evolution

Expression pattern appears to have dramatically shifted during evolution, from an ancestral testes-predominant pattern to preferential expression in the chorioallantoic placenta of eutherians[1].

Labs working on this lncRNA

  • Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland[1].

Sequence

>gi|84848|ref|NR_024607.1| Homo sapiens MIR503 host gene (MIR503HG), long non-coding RNA

000001 GAAGGTAGAA GGTGGGGTCT GCCGGACGCG TGTTCCTGCC ACCAGGTGCC CGCTCCCCGC GAGGCCGGCT CAGGAGCAGA 000080
000081 AGGAAGCCCG GTGCCAGCCA GCCTTCCTGA AAGACCAAGC CCGCGCCATC CGGCTTCCTC CAGTGGACGC CTGCAGGACC 000160
000161 CAGGAATGTT TTTCTTGAAG GCATCCAGCA TCTCCAGTTA GCAGTACTGA TTTTTTTTCC CCCCAACAAA GGAACACTAC 000240
000241 ATCAACACTG TTGGCGGGGA CCTGGACACA GAAGACTCCT GTTTCAAGAA AATACAATCA TCTCTCAAAG GCTGTAATTT 000320
000321 ATATGCATTT TAAAACTCTA GGCATTGAAA ACCACCCAAG TGTCCCAAAT AGAAGGGTAA TATATAATCA ATCACTCAGT 000400
000401 GTAATATTAT ACATCCTTTA AAAATGTTAT TGGGAAATGT TTTATGATCT GTAAGTCCAA GGAATCCTCT CCCACCATTT 000480
000481 CTTTCCCCCC GCTGTTCCCC CATACCCACA CTTCTTTGTT CCAATTGGCA TGTAAATTTG GTTTTCCCGC CAAATGAGTC 000560
000561 AGTCATGATG GGAACCTCAA CTGATTTGAA CAGATGTGTG TCAATGTTAC TTGGAAAACT AGATGTCAAT AACCAGGGTC 000640
000641 ACAGAAAAAG GCAGTGGTCA CAACTCTGTA AAAATGTATG CATGCACACA GACAAGAACT AAAGTGGAAC CCCACACAGG 000720
000721 AAAACAGTGG GCTGTACTCC AGTGCTGGGA CATTGAATGA CTGTATGCTG CTTTTGATTT CCGTTA

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, et al. The evolution of lncRNA repertoires and expression patterns in tetrapods[J]. Nature. 2014,505(7485):635-40.

Basic Information

Transcript ID

ENST00000414769.1

Source

Gencode19

Same with

lnc-PLAC1-1:2, MIG403HG, H19X, MGC16121

Classification

intergenic

Length

720 nt

Genomic location

chrX-:133677473..133680660

Exon number

3

Exons

133677473..133678029,133678744..133678827,133680582..133680660

Genome context

Sequence
000001 GAAGGTAGAA GGTGGGGTCT GCCGGACGCG TGTTCCTGCC ACCAGGTGCC CGCTCCCCGC GAGGCCGGCT CAGGAGCAGA 000080
000081 AGGAAGCCCG GTGCCAGCCA GCCTTCCTGA AAGACCAAGC CCGCGCCATC CGGCTTCCTC CAGTGGACGC CTGCAGGACC 000160
000161 CAGGAATGTT TTTCTTGAAG GCATCCAGCA TCTCCAGTTA GCAGTACTGA TTTTTTTTCC CCCCAACAAA GGAACACTAC 000240
000241 ATCAACACTG TTGGCGGGGA CCTGGACACA GAAGACTCCT GTTTCAAGAA AATACAATCA TCTCTCAAAG GCTGTAATTT 000320
000321 ATATGCATTT TAAAACTCTA GGCATTGAAA ACCACCCAAG TGTCCCAAAT AGAAGGGTAA TATATAATCA ATCACTCAGT 000400
000401 GTAATATTAT ACATCCTTTA AAAATGTTAT TGGGAAATGT TTTATGATCT GTAAGTCCAA GGAATCCTCT CCCACCATTT 000480
000481 CTTTCCCCCC GCTGTTCCCC CATACCCACA CTTCTTTGTT CCAATTGGCA TGTAAATTTG GTTTTCCCGC CAAATGAGTC 000560
000561 AGTCATGATG GGAACCTCAA CTGATTTGAA CAGATGTGTG TCAATGTTAC TTGGAAAACT AGATGTCAAT AACCAGGGTC 000640
000641 ACAGAAAAAG GCAGTGGTCA CAACTCTGTA AAAATGTATG CATGCACACA GACAAGAACT AAAGTGGAAC CCCACACAGG 000720
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Predicted Small Protein

Name ENST00000414769.1_smProtein_443:556
Length 38
Molecular weight 4124.8464
Aromaticity 0.135135135135
Instability index 65.8432432432
Isoelectric point 9.30364990234
Runs 5
Runs residual 0.0446317877511
Runs probability 0.0455043278572
Amino acid sequence MICKSKESSPTISFPPLFPHTHTSLFQLACKFGFPAK
Secondary structure LEELLLLLLLLLLLLLLLLLLLHHHHHHHHHLLLLLL
PRMN -
PiMo -
Name ENST00000414769.1_smProtein_443:556
Length 37
Molecular weight 4124.8464
Aromaticity 0.135135135135
Instability index 65.8432432432
Isoelectric point 9.30364990234
Runs 5
Runs residual 0.0446317877511
Runs probability 0.0455043278572
Amino acid sequence MICKSKESSPTISFPPLFPHTHTSLFQLACKFGFPAK
Secondary structure LEELLLLLLLLLLLLLLLLLLLHHHHHHHHHLLLLLL
PRMN -
PiMo -
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=ENST00000414769.1&oldid=1275433"