Difference between revisions of "LncRNA-MVIH"

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(Created page with " ==Annotation== ===Name=== lncRNA-MVIH ===Alias=== NA ===Disease=== Disease: hepatocellular cancer [http://www.ncbi.nlm.nih.gov/pubmed/24829860 (PMID:24829860)] Dysfunctio...")
 
 
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''MVIH'', lncRNA associated with microvascular invasion in HCC, promotes angiogenesis in hepatocellular carcinoma.<ref name="ref1" />
  
 
==Annotation==
 
==Annotation==
 
===Name===
 
===Name===
lncRNA-MVIH
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lncRNA-MVIH <ref name="ref1" />
  
 
===Alias===
 
===Alias===
 
NA
 
NA
  
===Disease===
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===Characteristics===
Disease: hepatocellular cancer [http://www.ncbi.nlm.nih.gov/pubmed/24829860 (PMID:24829860)]
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MVIH is a lncRNA with no protein‐coding potential. A majority of the MVIH sequence is located within the intron of the RPS24 gene, which encodes a protein belonging to the S24E family of ribosomal proteins. Despite the interrelated location of MVIH within the RPS24 gene, these two genes are independently transcribed. The independent regulation of the two transcripts suggests that MVIH might play a role in biological behaviors independent of RPS24. <ref name="ref1" />
  
Dysfunction type: expression
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===Function===
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MVIH plays a key role in activating angiogenesis. It is associated with tumor growth and metastasis upregulation, and poor recurrence-free survival. <ref name="ref1" /> MVIH can promote tumor inducing angiogenesis through inhibiting the secretion of phosphoglycerate kinase 1 (PGK1). <ref name="ref1" /><ref name="ref2" /> MVIH also promotes cell proliferation and invasion in non-small cell lung cancer. <ref name="ref3" />
  
Description: Yuan et al discovered that the lncRNA MVIH (long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma) was overexpressed in hepatocellular carcinoma.  
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===Regulation===
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Dysregulation of lncRNA promotes tumor growth through angiogenesis. <ref name="ref1" />
  
 +
===Expression===
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lncRNA MVIH (long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma) was overexpressed in hepatocellular carcinoma. MVIH overexpression was associated with frequent microvascular invasion and a higher tumor node metastasis stage as well as decrease in recurrence-free survival. <ref name="ref1" />
  
===Function===
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===Diseases===
Function Mechanism: NA [http://www.ncbi.nlm.nih.gov/pubmed/24829860 (PMID:24829860)]
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Breast cancer <ref name="ref4" />
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Hepatocellular carcinoma <ref name="ref1" />
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Non-small cell lung cancer <ref name="ref3" />
  
Biological Process: pathogenic process
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==Labs working==
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*Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
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*Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
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*Department of Oncology, First Affiliated HospitalNanjing Medical UniversityNanjingPeople’s Republic of China
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*Department of Breast SurgeryHarbin Medical University Cancer HospitalHarbinChina
  
Description: NA
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==References==
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<references>
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<ref name="ref1"> Yuan S-X, Yang F, Yang Y, Tao Q-F, Zhang J, Huang G et al. Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy[J]. Hepatology. 2012, 56(6):2231-2241.</ref>(1)
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<ref name="ref2"> Eades G, Zhang Y-S, Li Q-L, Xia J-X, Yao Y & Zhou Q. Long non-coding RNAs in stem cells and cancer[J]. World journal of clinical oncology. 2014, 5(2):134-141.</ref>(2)
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<ref name="ref3"> Nie F-q, Zhu Q, Xu T-p, Zou Y-f, Xie M, Sun M et al. Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion[J]. Tumor Biol. 2014, 35(8):7587-7594.</ref>(3)
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<ref name="ref4"> Lei B, Xu S-p, Liang X-s, Li Y-w, Zhang J-f, Zhang G-q et al. Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer[J]. Tumor biology. 2016, 37(4):5257-5264.</ref>(4)
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</references>

Latest revision as of 05:47, 21 November 2018

MVIH, lncRNA associated with microvascular invasion in HCC, promotes angiogenesis in hepatocellular carcinoma.[1]

Annotation

Name

lncRNA-MVIH [1]

Alias

NA

Characteristics

MVIH is a lncRNA with no protein‐coding potential. A majority of the MVIH sequence is located within the intron of the RPS24 gene, which encodes a protein belonging to the S24E family of ribosomal proteins. Despite the interrelated location of MVIH within the RPS24 gene, these two genes are independently transcribed. The independent regulation of the two transcripts suggests that MVIH might play a role in biological behaviors independent of RPS24. [1]

Function

MVIH plays a key role in activating angiogenesis. It is associated with tumor growth and metastasis upregulation, and poor recurrence-free survival. [1] MVIH can promote tumor inducing angiogenesis through inhibiting the secretion of phosphoglycerate kinase 1 (PGK1). [1][2] MVIH also promotes cell proliferation and invasion in non-small cell lung cancer. [3]

Regulation

Dysregulation of lncRNA promotes tumor growth through angiogenesis. [1]

Expression

lncRNA MVIH (long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma) was overexpressed in hepatocellular carcinoma. MVIH overexpression was associated with frequent microvascular invasion and a higher tumor node metastasis stage as well as decrease in recurrence-free survival. [1]

Diseases

Breast cancer [4] Hepatocellular carcinoma [1] Non-small cell lung cancer [3]

Labs working

  • Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.
  • Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, United States
  • Department of Oncology, First Affiliated HospitalNanjing Medical UniversityNanjingPeople’s Republic of China
  • Department of Breast SurgeryHarbin Medical University Cancer HospitalHarbinChina

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Yuan S-X, Yang F, Yang Y, Tao Q-F, Zhang J, Huang G et al. Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy[J]. Hepatology. 2012, 56(6):2231-2241.
  2. Eades G, Zhang Y-S, Li Q-L, Xia J-X, Yao Y & Zhou Q. Long non-coding RNAs in stem cells and cancer[J]. World journal of clinical oncology. 2014, 5(2):134-141.
  3. 3.0 3.1 Nie F-q, Zhu Q, Xu T-p, Zou Y-f, Xie M, Sun M et al. Long non-coding RNA MVIH indicates a poor prognosis for non-small cell lung cancer and promotes cell proliferation and invasion[J]. Tumor Biol. 2014, 35(8):7587-7594.
  4. Lei B, Xu S-p, Liang X-s, Li Y-w, Zhang J-f, Zhang G-q et al. Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer[J]. Tumor biology. 2016, 37(4):5257-5264.