Difference between revisions of "NPTN-IT1"
Chunlei Yu (talk | contribs) (Created page with "==Annotated Information== ===Approved Symbol=== NPTN-IT1 ===Approved Name=== NPTN intronic transcript 1 ===Previous Symbols=== _ ===Synonyms=== lncRNA-LET ===Chromosome=== 15q...") |
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| + | ''NPTN-IT1'', NPTN intronic transcript 1 plays a tumor-suppressive role in several types of cancer. | ||
==Annotated Information== | ==Annotated Information== | ||
| + | [[File:lncRNA-LET is downregulated in tumors compared to paired adjacent noncancerous tissues.png|right|thumb|400px|'''NPTN-IT1 is downregulated in tumors compared to paired adjacent noncancerous tissues in (A) human HCC, (B) squamous cell lung carcinoma, and (C) colorectal cancer.'''<ref name="ref1" />]] | ||
| + | [[File: lncRNA-LET shRNA Increases the Invasion of Hepatocellular Carcinoma Cells.png|right|thumb|400px|'''NPTN-IT1 shRNA Increases the Invasion of Hepatocellular Carcinoma Cells.'''<ref name="ref1" />]] | ||
===Approved Symbol=== | ===Approved Symbol=== | ||
| − | NPTN-IT1 | + | NPTN-IT1 (NPTN intronic transcript 1) |
| − | + | ||
| − | NPTN intronic transcript 1 | ||
| − | |||
| − | |||
===Synonyms=== | ===Synonyms=== | ||
| − | lncRNA-LET | + | lncRNA-LET: long non-coding RNA, low expression in tumor [https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:45091 (HGNC:45091)] |
| − | |||
| − | |||
===RefSeq ID=== | ===RefSeq ID=== | ||
NR_103844 | NR_103844 | ||
| Line 16: | Line 14: | ||
===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000281183 | ENSG00000281183 | ||
| − | === | + | |
| − | + | ===Characteristics=== | |
| + | ''NPTN-IT1'' is a recently identified lncRNA located at chromosome 15q24.1. <ref name="ref2" /> | ||
| + | |||
| + | ===Function=== | ||
| + | NPTN-IT1 inhibits the metastasis of HCC and colorectal cancer cells in vivo.<ref name="ref1" /> | ||
| + | NPTN-IT1 downregulation increase lung colonization, hepatic invasion, and abdominal metastases.<ref name="ref1" /> | ||
| + | The association between NPTN-IT1 and NF90 enhance the degradation of NF90, thereby affecting HIF-1α mRNA accumulation and stability under hypoxic conditions without altering HIF-1α promoter transcriptional activity.<ref name="ref1" /> | ||
| + | NPTN-IT1 expression can decrease the CDC42 and increase the DUSP1 protein levels under normoxic conditions.<ref name="ref1" /> | ||
| + | |||
| + | ===Regulation=== | ||
| + | Under hypoxic conditions,the downregulation of NPTN-IT1 expression is mediated by hypoxia-induced HDAC3.<ref name="ref1" /> | ||
| + | |||
| + | ===Expression=== | ||
| + | Compared with the normal primary tissue specimens that were collected from patients with HCC (n = 93), squamous-cell lung carcinoma (n = 10), and colon carcinoma (n = 22), the NPTN-IT1 transcripts were expressed at lower levels in the tumor tissues.<ref name="ref1" /> | ||
| + | |||
| + | ===Diseases=== | ||
| + | * Cervical cancer <ref name="ref3" /> | ||
| + | * Colorectal cancer <ref name="ref1" /> | ||
| + | * Gallbladder cancer <ref name="ref1" /> | ||
| + | * Hepatocelluar carcinoma <ref name="ref1" /> | ||
| + | * Nasopharyngeal carcinoma <ref name="ref4" /> | ||
| + | * Squamous-cell lung carcinomas <ref name="ref1" /> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | * Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China. <ref name="ref1" /> | ||
| + | * Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China | ||
| + | |||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, Wang F, Sun SH. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. | ||
| + | </ref>(1) | ||
| + | <ref name="ref2"> Liu B, Pan C-F, He Z-C, Wang J, Wang P-L, Ma T et al. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma[J]. BioMed research international. 2016, 2016:4693471-4693471.</ref>(2) | ||
| + | <ref name="ref3"> Jiang S, Wang H-L & Yang J. Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer[J]. International journal of clinical and experimental pathology. 2015, 8(1):806-811.</ref>(3) | ||
| + | <ref name="ref4"> Sun Q, Liu H, Li L, Zhang S, Liu K, Liu Y et al. Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell[J]. Medical Oncology. 2015, 32(9):226.</ref>(4) | ||
| + | </references> | ||
| + | |||
===Sequence=== | ===Sequence=== | ||
>gi|523498743|ref|NR_103844.1| Homo sapiens NPTN intronic transcript 1 (NPTN-IT1), long non-coding RNA | >gi|523498743|ref|NR_103844.1| Homo sapiens NPTN intronic transcript 1 (NPTN-IT1), long non-coding RNA | ||
<dnaseq>CTCACAGACAAAGGAGAGTCTGATGTATCCACCCATCTAGTGTAAGACAGAGATAGCAAAGGCGGAACAAATGGAGTCCATGCCCCGAGGCTGTGCCCTCAAGCTGGCCTAGGGTCAGAGAAGGGAGGAGATGGTAGCAGCAGAACCACAGCACACCACTGAGCACTGGAAAGAGCAAGAGCTGAAATCTTAGGTTATTGGATATGCCTAGAGTCAGAAAAGCCTTGGGAAATTTTTGGTGATCGATTTTTCCTGTGAAGGGGGAAGCTGCTGATGGAGACTTGTATCTGCAGTACTTCAGGTTCCCAGCTGGCTCCCCATCCCCACCCTATAACATGACCGGCGTACAGAAATTAATTGGCCGACTGTTACCACCACTAGTCTGTCCCTGGCTAGACTAGACAGATGGGTGTGCCCCTGGGCTCAGTGGTAGCCTACCCGGGGTGATGGTGGGGTTGCCAGCTGTAGTCCAGCTGTTCTGGGGCCTGTGTTTGTGCACCTGTGGTGCTGTATCCTGCCCCACAGAGCTGGCTGTCCAGTGGAGAATACAAAGTGACATCTGGTGCTCCCTCAGAAAGAATGTGGCCCCAGAGGCATGCCAGTGGCTTTAGACTCTCTGGGAGGACATGTTTGAGAGCAACAGCCCCTTCCCCATCTTTTCCTTTCTTCTCAGCAGTTATAAATCTCTCTGCCTGCAGTAAGTAGAGTGAGTGGCTGGTGAGGAGGTTTGTTGATGACACTGACAATATCTGGTGACTCCCTCCAGATGTGCACTCAGCAGTGAGCTGGGCAGAGGCGTGGGAAGGACGTTGGCTGGGAGCAGACGGCCTCTGCAAATGAATCTCTAGTTTCCTGCAACCTGGGAGTGTCCCCATGAGTTTTACTTTCCTACTTTATGAAGTGAACCTGCTTTCTTTGGGATTTCATGTACTCCTAATGCTTTTTCTCTCCAGGTATTTCTTTCCTGCTACATATTAGGACTCCCAAGGCAAGAGTGCACCTTTATTTAGACCTGGGAGTAAAGGGAAAGAGTTGCCTGTCTTTCGTGTGTTTTCAGCTTTGGCTCTGTGGGATCAGTTATGCCTCATTCCTGAAAAGGGCCTTTTTATCCCCCCAGAATGCTTTTGCTTTGCCAATACCACCTTCCTCAGCCTGCCTTTTGGAAAGGTTGAGAAGCTAAAAAGTCAGGTAAGAGAAGGCAGAGATGGACTTCAGAACCTGATTTTTAAATTTTAAGGCAAGGCTGGCTGCCACTGGTGAGAGTGATGCAGCAGCCTAGCGTGTTCCCAGCAGAGGTCTAGTCTTTGCCCTAAGAAGTCACCGCGCTTATGAGGTTGCTATCACAGTGCATGTGGTAGGTTAGATTTGAGAAATGGTTAGGATTGTTCTGTTGGATAAGTGCAGACACCTGCCCAGGGAAGCAGCTCTTTTTTTGTAAGAGTTTTCTTGGTTACTGAAATCAAATGGGGGACCAGTTTGTTATAGGAGACATCTGTGGCCAGCAAATCTGAACAGCTTCCTAGAGGGAAAGTACCTCTTTTAAACTAAGTTATTATAGACAGTGAATGAATCCTACCCTTAAAAGAGATGACGGCAGGGTAAGTGCAAAGTAAAACCTCCTTGCTCTAGTCTCTTGGGAGAGTATTGTAATGAAAGCAGCGTTTACTTCGTTGTTGTTGCATTGGGGTGAAAAATCTGAGATGCTGGAATGATGGCAATGTTTGCCTTCTCTCCTTCCCTTCCTGACAGCCAGTGTGGGCCAGGCTCCACTCTCCATCTTCACACCCTGCCCTTGCTCCAGTATTTCCATTCTGTTTTTCTCCTCTGTCTCTTTCTGTCTTTCTCTCAAACTCCATCCTGCTTCCACCCCTGCCCGCTTTTCTTCTCCTTTCCTGGAAGTAATCATTAAACAAAAGAAAAAGTTGAATGTTCTTTGGTGAGTTTCCTTCTTCTCTGCCTTTTCCTTCTTTAGCCAGTTCCCCTCAACCCCTGTGCACTCCATAGGAAGGACAAACTTACCTGTCTGCTTCCTTCCCATGTGCTTCTCCCCAAATTTTCATATAGATATATACGTACACTCCTTTTGGAATAAACGAAGAGGTACATTATATTTGACACAAACTTGGGAGTGTTAAGAGGTCATAAGTGTTTACCTATCAGATAACCATCTGTGGCTCTGTGTTGGATTTTTTTTATACCATTAGGAAAATGGGAATTTTTTTATAGGCCTGCCATACTTCTACTTTGCCAAATAGCACTTTATTATCAAGATACACCCATGGCTCATTTCAGACTCACTGAACTTTTTTTATATGAATGCACAGTCGTCATATTTTGGGCAGTCTGTGAGTTCTTGGTAACTCATCCCCTTACTACAAAAGCACTAAGTGAACAATACAAAAGTATAAAAGCACAAATTTGAACTTACATAGTTTAGTTTAAGTATGTTTCACTAGAAAATCAAATATTTAGATTTCTCACATTGAAAATGCTTAGGATTGAGGTTTAGCTGCTTCCTTTAAAAAAAAAAAAAAAAAAAAAGCCCCATGTCTTTTTTCTTTACCTACTGGAGTATTCTCAGACCATTTCCTACATGAAAACACCCA</dnaseq> | <dnaseq>CTCACAGACAAAGGAGAGTCTGATGTATCCACCCATCTAGTGTAAGACAGAGATAGCAAAGGCGGAACAAATGGAGTCCATGCCCCGAGGCTGTGCCCTCAAGCTGGCCTAGGGTCAGAGAAGGGAGGAGATGGTAGCAGCAGAACCACAGCACACCACTGAGCACTGGAAAGAGCAAGAGCTGAAATCTTAGGTTATTGGATATGCCTAGAGTCAGAAAAGCCTTGGGAAATTTTTGGTGATCGATTTTTCCTGTGAAGGGGGAAGCTGCTGATGGAGACTTGTATCTGCAGTACTTCAGGTTCCCAGCTGGCTCCCCATCCCCACCCTATAACATGACCGGCGTACAGAAATTAATTGGCCGACTGTTACCACCACTAGTCTGTCCCTGGCTAGACTAGACAGATGGGTGTGCCCCTGGGCTCAGTGGTAGCCTACCCGGGGTGATGGTGGGGTTGCCAGCTGTAGTCCAGCTGTTCTGGGGCCTGTGTTTGTGCACCTGTGGTGCTGTATCCTGCCCCACAGAGCTGGCTGTCCAGTGGAGAATACAAAGTGACATCTGGTGCTCCCTCAGAAAGAATGTGGCCCCAGAGGCATGCCAGTGGCTTTAGACTCTCTGGGAGGACATGTTTGAGAGCAACAGCCCCTTCCCCATCTTTTCCTTTCTTCTCAGCAGTTATAAATCTCTCTGCCTGCAGTAAGTAGAGTGAGTGGCTGGTGAGGAGGTTTGTTGATGACACTGACAATATCTGGTGACTCCCTCCAGATGTGCACTCAGCAGTGAGCTGGGCAGAGGCGTGGGAAGGACGTTGGCTGGGAGCAGACGGCCTCTGCAAATGAATCTCTAGTTTCCTGCAACCTGGGAGTGTCCCCATGAGTTTTACTTTCCTACTTTATGAAGTGAACCTGCTTTCTTTGGGATTTCATGTACTCCTAATGCTTTTTCTCTCCAGGTATTTCTTTCCTGCTACATATTAGGACTCCCAAGGCAAGAGTGCACCTTTATTTAGACCTGGGAGTAAAGGGAAAGAGTTGCCTGTCTTTCGTGTGTTTTCAGCTTTGGCTCTGTGGGATCAGTTATGCCTCATTCCTGAAAAGGGCCTTTTTATCCCCCCAGAATGCTTTTGCTTTGCCAATACCACCTTCCTCAGCCTGCCTTTTGGAAAGGTTGAGAAGCTAAAAAGTCAGGTAAGAGAAGGCAGAGATGGACTTCAGAACCTGATTTTTAAATTTTAAGGCAAGGCTGGCTGCCACTGGTGAGAGTGATGCAGCAGCCTAGCGTGTTCCCAGCAGAGGTCTAGTCTTTGCCCTAAGAAGTCACCGCGCTTATGAGGTTGCTATCACAGTGCATGTGGTAGGTTAGATTTGAGAAATGGTTAGGATTGTTCTGTTGGATAAGTGCAGACACCTGCCCAGGGAAGCAGCTCTTTTTTTGTAAGAGTTTTCTTGGTTACTGAAATCAAATGGGGGACCAGTTTGTTATAGGAGACATCTGTGGCCAGCAAATCTGAACAGCTTCCTAGAGGGAAAGTACCTCTTTTAAACTAAGTTATTATAGACAGTGAATGAATCCTACCCTTAAAAGAGATGACGGCAGGGTAAGTGCAAAGTAAAACCTCCTTGCTCTAGTCTCTTGGGAGAGTATTGTAATGAAAGCAGCGTTTACTTCGTTGTTGTTGCATTGGGGTGAAAAATCTGAGATGCTGGAATGATGGCAATGTTTGCCTTCTCTCCTTCCCTTCCTGACAGCCAGTGTGGGCCAGGCTCCACTCTCCATCTTCACACCCTGCCCTTGCTCCAGTATTTCCATTCTGTTTTTCTCCTCTGTCTCTTTCTGTCTTTCTCTCAAACTCCATCCTGCTTCCACCCCTGCCCGCTTTTCTTCTCCTTTCCTGGAAGTAATCATTAAACAAAAGAAAAAGTTGAATGTTCTTTGGTGAGTTTCCTTCTTCTCTGCCTTTTCCTTCTTTAGCCAGTTCCCCTCAACCCCTGTGCACTCCATAGGAAGGACAAACTTACCTGTCTGCTTCCTTCCCATGTGCTTCTCCCCAAATTTTCATATAGATATATACGTACACTCCTTTTGGAATAAACGAAGAGGTACATTATATTTGACACAAACTTGGGAGTGTTAAGAGGTCATAAGTGTTTACCTATCAGATAACCATCTGTGGCTCTGTGTTGGATTTTTTTTATACCATTAGGAAAATGGGAATTTTTTTATAGGCCTGCCATACTTCTACTTTGCCAAATAGCACTTTATTATCAAGATACACCCATGGCTCATTTCAGACTCACTGAACTTTTTTTATATGAATGCACAGTCGTCATATTTTGGGCAGTCTGTGAGTTCTTGGTAACTCATCCCCTTACTACAAAAGCACTAAGTGAACAATACAAAAGTATAAAAGCACAAATTTGAACTTACATAGTTTAGTTTAAGTATGTTTCACTAGAAAATCAAATATTTAGATTTCTCACATTGAAAATGCTTAGGATTGAGGTTTAGCTGCTTCCTTTAAAAAAAAAAAAAAAAAAAAAGCCCCATGTCTTTTTTCTTTACCTACTGGAGTATTCTCAGACCATTTCCTACATGAAAACACCCA</dnaseq> | ||
Latest revision as of 08:36, 21 November 2018
NPTN-IT1, NPTN intronic transcript 1 plays a tumor-suppressive role in several types of cancer.
Contents
Annotated Information
NPTN-IT1 is downregulated in tumors compared to paired adjacent noncancerous tissues in (A) human HCC, (B) squamous cell lung carcinoma, and (C) colorectal cancer.[1]
NPTN-IT1 shRNA Increases the Invasion of Hepatocellular Carcinoma Cells.[1]
Approved Symbol
NPTN-IT1 (NPTN intronic transcript 1)
Synonyms
lncRNA-LET: long non-coding RNA, low expression in tumor (HGNC:45091)
RefSeq ID
NR_103844
OMIM ID
615176
Ensembl ID
ENSG00000281183
Characteristics
NPTN-IT1 is a recently identified lncRNA located at chromosome 15q24.1. [2]
Function
NPTN-IT1 inhibits the metastasis of HCC and colorectal cancer cells in vivo.[1] NPTN-IT1 downregulation increase lung colonization, hepatic invasion, and abdominal metastases.[1] The association between NPTN-IT1 and NF90 enhance the degradation of NF90, thereby affecting HIF-1α mRNA accumulation and stability under hypoxic conditions without altering HIF-1α promoter transcriptional activity.[1] NPTN-IT1 expression can decrease the CDC42 and increase the DUSP1 protein levels under normoxic conditions.[1]
Regulation
Under hypoxic conditions,the downregulation of NPTN-IT1 expression is mediated by hypoxia-induced HDAC3.[1]
Expression
Compared with the normal primary tissue specimens that were collected from patients with HCC (n = 93), squamous-cell lung carcinoma (n = 10), and colon carcinoma (n = 22), the NPTN-IT1 transcripts were expressed at lower levels in the tumor tissues.[1]
Diseases
- Cervical cancer [3]
- Colorectal cancer [1]
- Gallbladder cancer [1]
- Hepatocelluar carcinoma [1]
- Nasopharyngeal carcinoma [4]
- Squamous-cell lung carcinomas [1]
Labs working on this lncRNA
- Department of Medical Genetics, Second Military Medical University, Shanghai, 200433, China. [1]
- Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, Wang F, Sun SH. Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis.
- ↑ Liu B, Pan C-F, He Z-C, Wang J, Wang P-L, Ma T et al. Long Noncoding RNA-LET Suppresses Tumor Growth and EMT in Lung Adenocarcinoma[J]. BioMed research international. 2016, 2016:4693471-4693471.
- ↑ Jiang S, Wang H-L & Yang J. Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer[J]. International journal of clinical and experimental pathology. 2015, 8(1):806-811.
- ↑ Sun Q, Liu H, Li L, Zhang S, Liu K, Liu Y et al. Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell[J]. Medical Oncology. 2015, 32(9):226.
Sequence
>gi|523498743|ref|NR_103844.1| Homo sapiens NPTN intronic transcript 1 (NPTN-IT1), long non-coding RNA
000001 CTCACAGACA AAGGAGAGTC TGATGTATCC ACCCATCTAG TGTAAGACAG AGATAGCAAA GGCGGAACAA ATGGAGTCCA 000080
000081 TGCCCCGAGG CTGTGCCCTC AAGCTGGCCT AGGGTCAGAG AAGGGAGGAG ATGGTAGCAG CAGAACCACA GCACACCACT 000160
000161 GAGCACTGGA AAGAGCAAGA GCTGAAATCT TAGGTTATTG GATATGCCTA GAGTCAGAAA AGCCTTGGGA AATTTTTGGT 000240
000241 GATCGATTTT TCCTGTGAAG GGGGAAGCTG CTGATGGAGA CTTGTATCTG CAGTACTTCA GGTTCCCAGC TGGCTCCCCA 000320
000321 TCCCCACCCT ATAACATGAC CGGCGTACAG AAATTAATTG GCCGACTGTT ACCACCACTA GTCTGTCCCT GGCTAGACTA 000400
000401 GACAGATGGG TGTGCCCCTG GGCTCAGTGG TAGCCTACCC GGGGTGATGG TGGGGTTGCC AGCTGTAGTC CAGCTGTTCT 000480
000481 GGGGCCTGTG TTTGTGCACC TGTGGTGCTG TATCCTGCCC CACAGAGCTG GCTGTCCAGT GGAGAATACA AAGTGACATC 000560
000561 TGGTGCTCCC TCAGAAAGAA TGTGGCCCCA GAGGCATGCC AGTGGCTTTA GACTCTCTGG GAGGACATGT TTGAGAGCAA 000640
000641 CAGCCCCTTC CCCATCTTTT CCTTTCTTCT CAGCAGTTAT AAATCTCTCT GCCTGCAGTA AGTAGAGTGA GTGGCTGGTG 000720
000721 AGGAGGTTTG TTGATGACAC TGACAATATC TGGTGACTCC CTCCAGATGT GCACTCAGCA GTGAGCTGGG CAGAGGCGTG 000800
000801 GGAAGGACGT TGGCTGGGAG CAGACGGCCT CTGCAAATGA ATCTCTAGTT TCCTGCAACC TGGGAGTGTC CCCATGAGTT 000880
000881 TTACTTTCCT ACTTTATGAA GTGAACCTGC TTTCTTTGGG ATTTCATGTA CTCCTAATGC TTTTTCTCTC CAGGTATTTC 000960
000961 TTTCCTGCTA CATATTAGGA CTCCCAAGGC AAGAGTGCAC CTTTATTTAG ACCTGGGAGT AAAGGGAAAG AGTTGCCTGT 001040
001041 CTTTCGTGTG TTTTCAGCTT TGGCTCTGTG GGATCAGTTA TGCCTCATTC CTGAAAAGGG CCTTTTTATC CCCCCAGAAT 001120
001121 GCTTTTGCTT TGCCAATACC ACCTTCCTCA GCCTGCCTTT TGGAAAGGTT GAGAAGCTAA AAAGTCAGGT AAGAGAAGGC 001200
001201 AGAGATGGAC TTCAGAACCT GATTTTTAAA TTTTAAGGCA AGGCTGGCTG CCACTGGTGA GAGTGATGCA GCAGCCTAGC 001280
001281 GTGTTCCCAG CAGAGGTCTA GTCTTTGCCC TAAGAAGTCA CCGCGCTTAT GAGGTTGCTA TCACAGTGCA TGTGGTAGGT 001360
001361 TAGATTTGAG AAATGGTTAG GATTGTTCTG TTGGATAAG
000081 TGCCCCGAGG CTGTGCCCTC AAGCTGGCCT AGGGTCAGAG AAGGGAGGAG ATGGTAGCAG CAGAACCACA GCACACCACT 000160
000161 GAGCACTGGA AAGAGCAAGA GCTGAAATCT TAGGTTATTG GATATGCCTA GAGTCAGAAA AGCCTTGGGA AATTTTTGGT 000240
000241 GATCGATTTT TCCTGTGAAG GGGGAAGCTG CTGATGGAGA CTTGTATCTG CAGTACTTCA GGTTCCCAGC TGGCTCCCCA 000320
000321 TCCCCACCCT ATAACATGAC CGGCGTACAG AAATTAATTG GCCGACTGTT ACCACCACTA GTCTGTCCCT GGCTAGACTA 000400
000401 GACAGATGGG TGTGCCCCTG GGCTCAGTGG TAGCCTACCC GGGGTGATGG TGGGGTTGCC AGCTGTAGTC CAGCTGTTCT 000480
000481 GGGGCCTGTG TTTGTGCACC TGTGGTGCTG TATCCTGCCC CACAGAGCTG GCTGTCCAGT GGAGAATACA AAGTGACATC 000560
000561 TGGTGCTCCC TCAGAAAGAA TGTGGCCCCA GAGGCATGCC AGTGGCTTTA GACTCTCTGG GAGGACATGT TTGAGAGCAA 000640
000641 CAGCCCCTTC CCCATCTTTT CCTTTCTTCT CAGCAGTTAT AAATCTCTCT GCCTGCAGTA AGTAGAGTGA GTGGCTGGTG 000720
000721 AGGAGGTTTG TTGATGACAC TGACAATATC TGGTGACTCC CTCCAGATGT GCACTCAGCA GTGAGCTGGG CAGAGGCGTG 000800
000801 GGAAGGACGT TGGCTGGGAG CAGACGGCCT CTGCAAATGA ATCTCTAGTT TCCTGCAACC TGGGAGTGTC CCCATGAGTT 000880
000881 TTACTTTCCT ACTTTATGAA GTGAACCTGC TTTCTTTGGG ATTTCATGTA CTCCTAATGC TTTTTCTCTC CAGGTATTTC 000960
000961 TTTCCTGCTA CATATTAGGA CTCCCAAGGC AAGAGTGCAC CTTTATTTAG ACCTGGGAGT AAAGGGAAAG AGTTGCCTGT 001040
001041 CTTTCGTGTG TTTTCAGCTT TGGCTCTGTG GGATCAGTTA TGCCTCATTC CTGAAAAGGG CCTTTTTATC CCCCCAGAAT 001120
001121 GCTTTTGCTT TGCCAATACC ACCTTCCTCA GCCTGCCTTT TGGAAAGGTT GAGAAGCTAA AAAGTCAGGT AAGAGAAGGC 001200
001201 AGAGATGGAC TTCAGAACCT GATTTTTAAA TTTTAAGGCA AGGCTGGCTG CCACTGGTGA GAGTGATGCA GCAGCCTAGC 001280
001281 GTGTTCCCAG CAGAGGTCTA GTCTTTGCCC TAAGAAGTCA CCGCGCTTAT GAGGTTGCTA TCACAGTGCA TGTGGTAGGT 001360
001361 TAGATTTGAG AAATGGTTAG GATTGTTCTG TTGGATAAG