Difference between revisions of "NONHSAT129019"
| Line 6: | Line 6: | ||
===Characteristics=== | ===Characteristics=== | ||
| − | PRNCR1(prostate cancer non-coding RNA 1) , ∼13 kb intron-less long non-coding RNA (ncRNA) ,was transcribed in centromeric region | + | PRNCR1(prostate cancer non-coding RNA 1) , ∼13 kb intron-less long non-coding RNA (ncRNA) ,was transcribed in centromeric region of human chromosome 8q24.21 hat, a large “gene-desert”, whose region is susceptibility to prostate cancer <ref name="ref1" />. |
===Function=== | ===Function=== | ||
| Line 23: | Line 23: | ||
{|class='wikitable' style="text-align:center" | {|class='wikitable' style="text-align:center" | ||
|- | |- | ||
| − | ! | | + | ! | Experiment |
! | Forward | ! | Forward | ||
! | Reverse | ! | Reverse | ||
|- | |- | ||
| − | | | | + | | | Real Time PCR |
| | 5'-CCAGGG-GGAAACACACAG-3' | | | 5'-CCAGGG-GGAAACACACAG-3' | ||
| | 5'-AAATGGCAGTTTCCTTCAATG-3'<ref name="ref1" /> | | | 5'-AAATGGCAGTTTCCTTCAATG-3'<ref name="ref1" /> | ||
|- | |- | ||
| − | | | | + | | | RT-PCR |
| − | | | | + | | | 5′-ATTGTTCCCAGTTCTCTGGAC-3′ |
| − | | | | + | | | 5′-GGAGGAAGTGGAGTAGGTATAAGAG-3′<ref name="ref1" /> |
|} | |} | ||
| Line 51: | Line 51: | ||
| | 5'-GAAGCAGCACGACUUCUUC-3'<ref name="ref1" /> | | | 5'-GAAGCAGCACGACUUCUUC-3'<ref name="ref1" /> | ||
|} | |} | ||
| − | |||
===Allelic Information and Variation=== | ===Allelic Information and Variation=== | ||
| Line 70: | Line 69: | ||
</references> | </references> | ||
| − | + | ===Sequence=== | |
| − | + | >gi|101867536|ref|NR_109833.1| Homo sapiens prostate cancer associated non-coding RNA 1 (PRNCR1), long non-coding RNA | |
| − | + | <dnaseq>AAATCTCAGCCTCCCACTCCCATATTTACAGTTTGATTAGGGAGGCACATTTAGATATGCAGTGATAATT | |
| − | + | GCTTTGCTTAGAGAAATTCAAGGTGATAGAATGCATGGTGACACCTAACCCAGACTGGTAGAGAAAGGGA | |
| − | + | ATTCTTCCACTGGGAATGACATGATTATCTAAATAAGTAGGCTCAATCAGGTCAGGAAAGGGCCTGAAAG | |
| − | + | ACTATTTCAAGCAGAGGGAAGGTATTTGCCAAGGCCAGGGTGTGTAGTGGAGAGAATGGGCAGTGGCAGA | |
| − | + | GAATTATGAAGTGTTCCAATGACTAAAAGTAAAGTAACAAGTTCCTTGTCCAAGAGCTTGGATTGTATCC | |
| − | + | TAACTGAAATGAGTATACACTAAGTGTTTGAAGAAGAGGGATGAAATGGTCAAGTTTTCATTACACAAAA | |
| − | + | ATAACCTGTTCCTTTCATTTTATGTTTATTTATTTTTTTAATTTTCTGACTGCTCCTTTCTGGAAATCTC | |
| − | + | AAATTTATATTTGCCAAATATTGTCACATTTTCGATGGAGAATACAAACTAAGAATGGGTTAGGGAACTG | |
| − | + | AGTCAGAAAGTCCCTGTTGTACAATTCAATCATGTTTTTCTAAGGATGTGCTTTTGGACATTATGGAAAC | |
| − | + | TATCTTAGGCTCTCACTTGGATCCTAGAAAAGAAGGCACCTGTTAAAAGGAATGTCCAGCCCCACCTAAT | |
| − | + | TTGGCAGCTGCCCCTCCAAGCTAATGACATTAGGGATGTAGTGGATTCAAGAGGCTGATGATGCCATCTG | |
| − | + | GTCAACTCATGTGACTATTTCTATCAGCTTTATTTCTGCAACATCCTGTGCCCACAGAGGGGACACAAAA | |
| − | + | TCGCTTTATAATTCCTTCACCATGTGAAGATACAGATACACCCAGAACCTTAAAGGCAAGAATATGATTG | |
| + | AAATGTCAAATGGGGACTTGGTGATCTAAATTATGTCCCCCAAAAGCCAATGTCTTGCCACCACCAGTGC | ||
| + | CCTATGGGTGGAGTTTCTAAACAGATTACTCAAAACACAAACTTTCAAAAAGGGAAAGTCATAACCCTCT | ||
| + | AGTCATCAGGGCAATTACGGAATAACATTGCTGGAGTAAGGTTTTCTCAATGCCCAAGAGATGAGCTGGC | ||
| + | AATGCCACAACAATGTCCAATTCTTAGTGGGTCCAAGACCATGTGTTACATTTCCCTCCCATGATTACTC | ||
| + | ACAGCTTCACAGTTCTGCTGTCCTCTTCGCCTCTCTGCCACCTCTTAACTGCACCTTTGACCTCCTACCC | ||
| + | CTAAGATTCAACCCTGTGAGATTACTTGTCTTTTCATCTACACTCTGGTCACTCTGACCCCCATTCTTTA | ||
| + | GATTCAGGATTTTCTCTTTTCCTGGCTTACTCTCCAGCACAAGTAGAAAAATATTGTGCTTCATTGGAAA | ||
| + | ATGCATGTTGTTTGAATCACACTCTTTCAGATTATACAATTGTAGTCTTTCATTATCTTTGAGCCATTTT | ||
| + | ATAATGCTGTAAACTAATATTAATGCATATAATTCTTGTCTATAGACATGTAAATTGTGTCCAGGGGTGA | ||
| + | TTTAATTGACTTTTCTTCCCCATTGTGGAAAAGGCTAGTAGTTTTGCCTCCATTTGCCCATTTATTTCTA | ||
| + | TATTCCTGATCTGTAAATGCATTTCTGGGTTTTCCCTTGGACTCATTCTAACATCTCTTCTTTTTCCTCA | ||
| + | TTAATTAATTAAATTAAATCTTTAACACCTCTTCATATTTTTGTCAGTATGAGAGTATAAAAAAAAATCT | ||
| + | TTTTTTGAAAATTATCTTTTAATAGGTGACAAAAAGAATAAACACTGAACAAGAAGTCCTGAGCTCCTAC | ||
| + | TACAATCCAAAGTGAACTAGTTGCAGTGCCATAGGATGATGTTTCTCCTGAGACTTCTTTACTAGGATCA | ||
| + | TTTAGACTGTTATAAATGCAGATTCCTGGGCCTCTCCTTAGACCCACTGAATCAGACACTCTAAGAGGAG | ||
| + | GGTCAGAAATCTCCATCTTAGCAAGTTAATGTCCAGGAGAGTTAGAGACTCACTATGACGTATGATAAAA | ||
| + | AGTAGAAGGAAGGACTTTCCAGCACCTTAAACTACTTGGAAAGATAGATTAATGTCTAGATGAAACTTGA | ||
| + | TGAGACTTTAGACTAATATGTTACATATACATCAGGAGATGCATGTATAAACCAAATCCAAATAACCCAA | ||
| + | AGCAAAATTTCTTTTAGAAATAGTGATAAATAAATGAGTGAGGAGTTTGTCACTCACATCCCCCAGGTAA | ||
| + | AACATACCTTTTTAGCCTAAATAAATGCTATAGTTTGAATGTGTTCCCTCCAAAATTCAGGTACTGATAG | ||
| + | TTAACAGCAGCCGATATGATGGTATTACACAAAATAGTAGGTTCTTTAGGAGGTTGTTAGGCCATGAGTG | ||
| + | CCTCCCCCAAGAATGGGATGAAGGACCTCATAAAAGAGGCTTCTCACAGCATTGTGACCTCTAGCCCTCC | ||
| + | CACCTTCCATAAGTGAGGACACAGTGTTCCTCCCCTCTGGAGGATGCAGCAACAAAGTGTCATCTTGGAA | ||
| + | GCAGAGGAGCCATCACCAGACAACAGAACCAGCCAACAGCTTGATCCTGGACATCTCATTTTCTCCAGAA | ||
| + | CTGGGATAAAATAAATTCCTGTTTTTTAATAAATTTCCCAATTTCAGGTATTTTGTGATAGCAGCAAAAA | ||
| + | CAGACTAAGACAACTAGTATGAAAATATACATTAACAAATAAAATTAATCATAATATATGTTTGCTTTTA | ||
| + | AAAGAAAATAAATAAGCCAATATGCTTTCTGTTGATTGATTGATTTACTAAACATTGATTGGCCATCTCC | ||
| + | ACTGGGGATATGGCATTTAAGAGATCTCTTTGATCTTAGTACTTTTACTGCTTTTTAAATAGGATCAAAT | ||
| + | ACACCCAAGGTAAAAAATAGAACACACTATACGTTACATTTTGGAACTGTTAGAAATTCCTTTGAAGCTA | ||
| + | AAATTACTGCTATCATTTGACAACTTTTACCCCTAAAATAATGTGGTGCTCACCAGCTTGCTTAAGTTAC | ||
| + | AGCACTTGCTGTCTTCTCAGATACAATATCAGAAACTTATAATCCAAGAAAAATCTAAATGGCAAGTGTG | ||
| + | AGTTAATGGAAGCCTCATAAAGCAAGAGGTGTTTTGGAAGTGTATGGAAGACATCAATAAATGATATGTA | ||
| + | TAACATCAAGTGCAAAAGTGTGTGCTAGGAAAGTTCAAAAAAGAAAAAAAATATGGTAAGGTAAGACCAG | ||
| + | AGATTGGGGAGTATATAGCTTTTGGGAATTCAGGAAATGCTAACGTCTATGGAGAATTTGCATAGGTGAA | ||
| + | AGATCAGATTGGAAGCCTTTCTCTGTGGAAGCATTGTGGATCTAAGTCCAGAAGTGATCCTGAGCCACCT | ||
| + | ACTATGGAAAGGTGTCAGTGAGCAAGAGACTGTCTGACAAAGGTGGAAGCTGAGCAGACTTCTACTGCGC | ||
| + | ATCGCCTATGTACAGGCCAGATTCCAAGGGCTGATATTACACTGCTAGTTTGATCTTTCTCAGATAGCTG | ||
| + | GGTAGAGAGGGAAAAGTTTCACCCCAAATACCAGATGCCTCCAAACATCTAGATGCTTGGTGTTATGTAT | ||
| + | TTCAAACAGCAGGTTTGATAAAGCTGTTTTTACTCTCCAGTTGGATGTTGGTTGTCAAGGCTGTCATTAA | ||
| + | CTTCTGGGAGTTCCCAAATCCTCAGAGAGAGAGAAATAAGCAGTTCTGCCTGCAATCAGAAGCTGGCTTT | ||
| + | GAGCCCCACATGGCAACATGCCTGTATTTAATTAGAAGTGGCTTAGTTCTTGGGATTTACTGTGGATTGA | ||
| + | GTCTACGAAGCTGGAAGGTTTTATCCTGAGTATTCCACTGTCTCCTCATGTGGATTTTATCAAATTTCTC | ||
| + | CTTTAACCATATAAGCGCTTTCAAAGTTGACATATCACACTTAGTTATGAGGGGAACCTAGAAGTATGAT | ||
| + | TGTGACGTGCATTGTTGAGAGACCATGCTTTGTAAGTGTTAATAATTAAAATTATTTTGAACACTAATTA | ||
| + | TGCTGAAGACTGGATTTTCTACTCCTTCAGATGTTTTCCAGTGGACATATTTTGCCCTTTTAATAAATTG | ||
| + | ATTGCGAACTTATCTTCATTTCACCTTTATGATGTTATACCTTTTCATTTTTGTCTTCTCATAGCTAGGG | ||
| + | TCTCCTGGTCCCCAAATGTAGACACACATCTTACACCAATCCCAGAGCCATTTTGTATAAGAGCCACCAT | ||
| + | GGATTTAACCAGCTTTAGCTCCAGTATTTGAACATAATGTTCAGCATCATCACCTGGCCACCAAATCAAA | ||
| + | ACTGAGCACCCTTTAATCCATCAACAAGTTCTCTGCAGCCATGCAAGGTTATGAAATGGGCACAGACATC | ||
| + | AATATACAGTCTTTGTGTTTAAGAGGTTCATGGTCTACCTGAGAAATGCATCTTTAAACCTAAAGTAGAC | ||
| + | GCTCTGTTTATTCCATAAATGATTTTTAAGCATCAATGGTATATCAAGCACTGTACTGGCTTCTGGGCTA | ||
| + | TAATAAATATATAAAGACCACAAGTTTGAATTTCATGACATTGAACTATAATGTTTAAATGTTATAATAA | ||
| + | TCATAGTAAATGTCCTTGAGGAGCTACGGAAGATTCCTGCATGAAGCAGAAACAAGAAGCTGAAGAAAAA | ||
| + | ACAACTGGCTTTGGGGGCTATATAAATATAACCCTCAAATTAAAAACTCAATAGTTTGATTGATTACCAA | ||
| + | ATCAATACAGCCAGAAAATAAATGTATTACCCCAAAAGCTTGAGTGAAGAAAGACTTCTGTAAGTTACTA | ||
| + | GAAAGCGCTAAGGAAGAAATAAAAGAATGATATTCCTGAGAGCCAGGTGCTTTCTGTAGGACACACAGAT | ||
| + | ACAGAATGAGGGAAAACAGAAAATTCTATGGTTGTGGATTCAAAATAGAGGCATCACCATGTCTATCTCA | ||
| + | TCAGGGTTTAACCAGAGGAAACCAAACCAGTAAGATATCTGTATTAAGAGATTTCTTGCAAAGAATTGAC | ||
| + | CTATGTGATTGTGGGCACTGGCTAGGTAAATCCTAAGTCCACAGAGCAGGCAGGAAGAAAACAGGCTGGG | ||
| + | ACTTGTAGGCACAGGATGAAGCTGCAATACTCATGTGGATGCTGCTCTTCTTCAGGGAAGACTTGGCTCT | ||
| + | GCTCTCAAGGACTTTCAGGTGATTAAATCAGGCCCACTCACATTATCTAAAATAATCTCCCTTACTCAAA | ||
| + | ACCAAGTGATTATGGACTTTAATCACATCTATAAAATATCATTATAGTAACACCTAAATTAGTGTTTGAA | ||
| + | TAACTGAGAGTTGTAACTGATATGGTTTGGCTATGTCCCCACCCAAATCTCATCTTGAATTATAGTTCTT | ||
| + | ATAATCCCCATGTGTTGTGGGAGGAACCAGGTGGAGATAATTGAATCATAGGGGCAGTTTCTCCCATTCT | ||
| + | GTTCTCATGATAGTGAGTTAGTTCTCAGGAGATCTCATGGTTTTATAAAGGGCTTCCCTCTTTGCTCCAC | ||
| + | TTTCATTCTCCTTCTTCCTGCTGCCATGTGAAGAAGGACATGTTTGCTTCCCCTTCTGCCATGATTGTAA | ||
| + | GTTTCCTGCGGCCTCCCCAGCCACGCTGAACTGTGAGTCAATTAAATCTCTTTTCTGTATAAATTACCCA | ||
| + | GTCTTGGGCAGTTCTTTATAGCAGCATGAGAATGGACTAATACAGTAACTTTACCAAGTGGACACATAAA | ||
| + | ACTGATCATTACAATGTACAGTGAATATTTGGTGAGTTAATAGATATATTCATAACTGAATGAAAGAGGA | ||
| + | TGGTGATTCCTACTTCAGGGTGGTATTATGAGAGTTAAAAGGGTTAGCATAGATAGAACACTTTTCTATG | ||
| + | ATTGATCTAAGGTTGGCTTTTAGGGACTACATTATACATATGGGTTTTGTCTTCATGTTTTTGCTTGCAT | ||
| + | TTCTCTCTCTGCCCACTCTTGGGGCTATTTGGATGTCACCTCTTCTTCTTCTGAGCTCCAGTCTATGTAT | ||
| + | TCCCTGTTCCATCATCACAACCACTGAAGTCTACACTCCTCATTAGATTCAGGGAACCCAGATGCCAGCC | ||
| + | AAAGACATCCCTTTCCCTCATGACCCAGTTGAAAAAATTCTCCACCCTTCTGTTAATTCTAGAATATTTA | ||
| + | GGAGTAAAGATCTTTTCCCTCAGATATCTGTCAATTCCCGGCCTTATATCTCAAAGCCCCTTTTCATCCA | ||
| + | GGTTTCCTAGATCATTTCTTGTCGTCCCTGTGCTATAACTCATTAACCCAGGCATAAAACTCATCAGCTA | ||
| + | CTAATGTCCTCTTCCATCCCAGACTCCCCTCACACCAATAATTCTTGAATAGAGCAACCCAAATTGAGAA | ||
| + | TTTTAAGTAAAATTGAAGGTAAATTTAATTGCAGGAGGACATACAACATTAACCTTTAAATAGAGATCCT | ||
| + | AATTCTTAAAAAAAAAAGTCCTCATTGATCTCGGGGCCGTTTCACGCAGGTGCTTTTCTAAATCATCAAG | ||
| + | GTTATCTTCAGCTTCACTTTCAGTCTCCTTCTTCGGCTCTGGCGCTGCCACTGGCTCTTCCTGTGCTAAT | ||
| + | GTGGTTGTGGCAGCTGCAATGGCTGCAGGGGTCACAGCAGCTGCAGCAGCTGCAGCCACAGCCTTTTCCT | ||
| + | TCTTGTGTTTTTTGTGCTTCTTGTGCTTCTTATCCTTTTTGTGTTTCCTGTCCTTCTTTTTCTTCTTTTT | ||
| + | CTTTCCATCTCCTTCTTGATCTGAATTTCTTGGCAGTGATGGGCTCGGTGTTGGGCTTTTGGCCTTTTTG | ||
| + | ACCGGTACAGCTGGTGACCAGTTTGTAGACGGTGACTGAGACTGGATGGGGGATGGAGATGCTGGGGGCT | ||
| + | TTTTAGCTGCTGGCTCAGGAGACCCAGAGACAGATCGGGAGGATGAGACCCTCCTTACAGACTGTGGGCT | ||
| + | TGGGGAAGCAGCCTTTTTTTATCTTTTTAGGTTCCGGAGTCCTGGAGACTCTCCTAATGGGCCTAGTACT | ||
| + | TGGAGACGGGGACTGCCTTCTTTGGGGTGATGACGACGCTCCTCTTCGAACGGGTGGAGGACTTGAGGTC | ||
| + | TGAGGAGCTCGAGGCCGTGATGAGGGCGAATGCCATTTGTTTGGATGCGGTGATCGGGCCTCCCGGGTAG | ||
| + | AGCGGCTTGGGGAAGACCCTTTCCTATGCTTGGATGATAGTGAAGGTGAACGTCTCTTGGTGACTGGGGA | ||
| + | GCTTCTTTGGAAGGTGGAGAATGGGAGACCCGCCGCTTTGGTGGTGGAAATGGTGATGCTCTTCGTTTAG | ||
| + | GAGGGGGAGGAGGTGAAGCCGTTCTTCTCTTTGGAGGTGGAGAAGGAGAGTATCTCCTCTGTATTGGAGG | ||
| + | AGAGTATCTTCTAGGAGAAGGTGAGCGCCGACGTAGGGGAGGAGAAGGAGTCCTTCGTCGTGGTGGTGGT | ||
| + | GGTGTGGGAGTCCTGAGCCGTCGAGGATGAGGGGCGGGAGAAGGAGACCGTCGCCTTCTGGTGGGTGGTG | ||
| + | GGGATGGACTTCTCCTCCGTCTACCATGAGGGGAAGTCTCTTTTTGGTGCTTTCGTGGTGATGGAGAAGC | ||
| + | ACTCCGGGAAGGGGAATGTCTCCGCCGCTTGCCAACCTCACCATTCTTCACATGGGATCTCTTGGGTCGT | ||
| + | TCATCTTCTGAGGAGAAGGAGGAACCAGAGTCAGATGAAGACTGCTGGTTTTGTCGTCTGTATTGGCGTC | ||
| + | TCTGCTGAGATCAATGAGGAAGGCCCAAGTGTCCCCACAGTCTTAGGGGGAAATGTTTGTTATGATGTAA | ||
| + | ATTTTATTTGGTTTGTACGCAGTTCAATTTCAAAATTGCTAAAATGTGTTTGAGCTTTAGACTATAACAT | ||
| + | TTGTTGTAATAATTGCTAGGTTGAAGTTCAACATGTAAAAAAAGGGGGCATGGATTTACATTGCAAAAGG | ||
| + | TGTCCACAGTGTATTAGTGACATTCTTTCATTGACAGCTGACATAATTCATTGAGTGAAATATTTTAAGC | ||
| + | CAAAAAAAATTCCCTTTTTAAAAAAGGGGGTTTAAATACTGTTGACACTTTTATGGTTCCTTTAAATGCT | ||
| + | CTGGCTATTCCCAGAGGGGTTTTTTTGTTTGTTTTTTTGGTTTTGATTTGCTTTTTGTTTTTCTTTCTTC | ||
| + | TTCTTACATTTTTTTCCATTTGAGTCTTAGCTCCCATTTAAGTTATGCTTCTGACCTTGTATGGTCTGTA | ||
| + | AGCTTGCCCAGAAATAAGACCACTGTTTTGAACTACCACAAAAGTATAAATGAATATTTTAATGCCACAG | ||
| + | TCTTTCCTGTTGCCTGTGGAGTCTCTGCTGAAATGAATCAGGATTCGAGCTCTAGGATAAGACAGAAAAT | ||
| + | GAAAGCATGTTGTTTGCCAGGACACTGTGGGTTTATATTGATGTGTAACAACTTGATTTGGAACACTGGA | ||
| + | CTCTCATTCTGTTCTTCTGGTTTTGTTTTTTTGTTTTGTTTTTTTCTTTTGTAAAGGCCATGAACTAGTC | ||
| + | CCAGAAAGGATTCCTTCAGTTACATACAATTTGTTTAATGAAATGTCATGGCTCTGTTCATATTTTTGTC | ||
| + | TTGTTCTTCCAATTGGTGTATACAACTTTCAGAGCCTCTTGTATTTGGAAGGCTGGAAGGGCCCAGACTT | ||
| + | TGGAATAGTGTCTCGGTTTCACTGTTTTTGTTTTGATTTTTTTTTTTTATTTTTTTTAAACTAAAGCTAT | ||
| + | ATAAAGCTTGTGGATTAAACAGAATAAATTTCTAAATTTAAAAATTTAAAAAAAAAAAAGTCTATTGTCT | ||
| + | TCCCTCCCCTACCCTAAGCAATATGCAATAGTGGCTCTTCAATAGTCCCAGACTCTTCTTCTCTTCCTGG | ||
| + | ACTGCCCATCTCCTGATCAACCCTTAATTTCTCTTCCTTCTCTCACCCTTCTTTTCAGGATTGAATTAAT | ||
| + | GAATCCTTTCTTCTCACTCATGCAGAGTAAGTTTCTGCCTCCCTGGGTCTTTCTGTTTACTGACCGCAAC | ||
| + | AACTTCAGATTATACCTCTTCTACTCCAAGTGCTTTCAAAGAAAGTCCTCTGCCAAGACAAATTCATTAC | ||
| + | GTTTTTTCCCTCTACCTGTTTGCCTTTATTCTCTTTTGTATTTCATCTTCTCATCTAGATTGAATAATCT | ||
| + | TTGAGAGCACAGATGTTTATTTATATTTTTCCTTTCCATTTCTACTCAGCATGAGGTGTCCATTGAACAA | ||
| + | ACTTGATGAATTTTTATTGCTTAATATCTTGCTAGAGGTGGGGAGAGAGGTTGGGGGCGGTTAAGGAACT | ||
| + | ATCAGCTAGCCTAGGAGATATTAGAGCTGCAGAGATTTGGCTATCTTGTTCAACGTTATATCCCTAGGGA | ||
| + | TTAGTACATAGGCTTGCAAATAGCAGGTATGAATAAAAAATTATTGAATGAGTAAATGAATTTAAAATAT | ||
| + | AAGTTACTTAGGCGGTATCTTCAGGCATATCTGTGTTTATGTGGTATTCAATGGCCCACAAATGTCTACA | ||
| + | TCCTAATTCCTAAGATCTGTAAACATTAATTTGCATGACAAAAGAGACTTTACAGATGTGATTAAATGAA | ||
| + | AGGATTTTGACATGCAGATAATATCCTGTATTCTTCATGTGGAACCAATGTATTTACAAGGGTCCTTATA | ||
| + | AGTAAAACAGAGAAGCAGGAAAATGAGGGTCGCAAAAAAAAAAAAAAAAACAAACATGAAGACAGAGAAG | ||
| + | AGGTTAGAGTGATGTTGGCTTTAGAGATGGAAGGAGTCACAAGCTGTCTTAAAGGAATAAGACAAGCTGT | ||
| + | CTTAAAGGAATTGTTATAAAGGAATAGCTGAAGCTGGGTAATTTATTTTAAAAAGGTTTATTTTGCTCAC | ||
| + | TATTCTCATGTCTGGAAAAGTTTAATATTGGGTAGCTGCATCTGGCAAGGGCCTCAGGCTGTTTCCACTC | ||
| + | ATGTCAGAACGTAAAGGGGAGCTGGTGTGTTTAGAGATCACGTGGGGAGAGAGGAAGCAAGAGAGAGGGA | ||
| + | GGAGGGGCCAGGCTTTTTTTAAACAACCAGCTCTTTTTTTAAAAAAAAATTATACTTTAAGTTCTGGTAT | ||
| + | ACATGTGCAGAATGTGCAGGTTTGCTACATAGGAATACACATGCCATAGTGGTTTGCTGCACCCATTAAC | ||
| + | CTGTCTTCTACATTAGGTATTTCTCCTAATGCTATCCCTTCCTTAACCCCCAAACCCTGACAGGCCCTGG | ||
| + | TGTGTGATGTTCCCCTCCCTGTGTCCATGTGTTGTCATTGTTCATCTCCCACTTATGAATGATAACATGC | ||
| + | AGTGTTGGGTTTTCTGTCCTTGTGATAGTTTGCTGAGAATGATGATTTCCAGCTTCATCCATGTCCCTGC | ||
| + | AAAGGACATGAACTTATCCTTTTTATGGTTGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTTA | ||
| + | TCCACTCTATCATTGATGGGCATTTGGGTTGGTTCCAAGTCTTTGCTATTATGAACAGTGCTGCAGTAAA | ||
| + | CATACGTGTGCATGTGTCTTTGTAGTACAGTGATTTATAATCCTTTGGGTATATACACAGTAATGGAATT | ||
| + | GCTGAGTCAAATGGTATTTCTGGTTCTAGATCCTTGAGGAATTGCAACATTGTCTTCCACAATGGAACAA | ||
| + | CCAGTTCTCTTAAGAATAAAAGTGAGAACTCACTTCCCTGGCCCCAGAGAGAGCAAAAGCAATTCATCCC | ||
| + | CATCACCCAAACACCTCCCATTAGGCCCTACCTCCAACATTGGGATCAAATTTCAACATGAGGTTTTTAG | ||
| + | GGGACAAACATCCAAACTATGTCACAAGACAATTCATGTAAGCAGCCTCTAAAAGATGGAAGAGGCAAGG | ||
| + | AAACAGATTCTCCCCTAAAGCCCACAGAAGGAAAGCAGCCCTGCCAACTTCTTGATTTTAACCCAGTAAG | ||
| + | ACCCGTTTTGGACTTTGGACACCAAGAGCTATAAGATGATTATGTTGTTTTAAGCCATTAAGCTTGAGGC | ||
| + | AATTTGTTACAGCAGCAATTGGAAACTAATACAGATCACATTCTAATTCAATTAGTATTGTTCCCAGTTC | ||
| + | TCTGGACCTCAGATTTCTTTCCTGAAAAACATTAAAAATAATACCTGAAAGTTTTGCACACGAGTGCAGA | ||
| + | GTGCCTATTTACTAGAGAGATCAGCATTTGTTTAGGCTCTGAATAGATTTGAGGATGAAATTAAATAGCA | ||
| + | TAAATAAAGTTCCTAGTGATGCTTCTGATAAAAAAATATCTCCTTCAAAATGCCAGAGGCAGGTCCTAAA | ||
| + | AACCCACAAAGCAGGTGAACTGGCAAAAGACTGTAAAAAGCAAAGTAGAGGTTCCTCTTCAAAGACTTTC | ||
| + | CTCTCCATCTAATTAGGAATAAATAGTAACTTATCTTAGAAACAAAATTTATTCAAAGACCTGTGCTAAC | ||
| + | ATTCTGAAATATCTGCTAGCCGTAATAAATAAATCGATGTACTTTATGTTCTTAGCTCCCACAATTTAAC | ||
| + | CTAAATATTTGCCCTGGCATGCTTATACTGGTCCAAGCAAGCATTAGGTCATAGCCTGTTCCTCTTCTTT | ||
| + | ATTTTAAGGTGTTTTTACCTTTGTCAGCATGCCACAAGTTACTTCCTCCTTCCTTTGTTCTCCTCTGCCT | ||
| + | TTGACTCTTTTAAAGAGTCCTAAGTTGCTAGCCAATCAGGACAAATACAGAATGTGAGGTCCCGTTTCAG | ||
| + | CCAATGGAAAGTGGACACAGCAGGAAGGTGGATGGGTCAGGTTATAAATGACCCTGTCTCCTTTGTTCGG | ||
| + | TGTACTCTTGTGGCAAAACTGCTGGCAAGTGTACCCTTTCTGCAATAGGTAAAAACTGCCTTGCTGAGGA | ||
| + | AATTAAATTTATGTTCAAGTGCTATTTCTTTATGGCACCGGGGAACAAGCATTTCTAACAAGACTATGTA | ||
| + | ATTTAATTTCAGGAACCTAAAAAAGTGGGATGAAGAACTGAGGTTGCTAATAAATCTATACAACTTATAA | ||
| + | GTAAATATTTAATTTACTAACATATAATAATAAAGACATCATTGTAAGACAATGTTAAAACATTTTACAC | ||
| + | ATTTTAAATGTGCAATAGTAAATCCTTCACTATTCAGGGATTATTTGGAATCCCTTGTCACCAGAAGCTC | ||
| + | TTAAGGAAATAACTTCTACTTCGTTGCAAATATGTTCTTGGCTTAGTTGAGGTAATGCAAATACTAGAAT | ||
| + | ACTTGTTTGTTTAACAGCTTATTCTTCCCTGAAGCTGTTCCTCCAGTCCCTGCCAGTGGGATCTTATGTC | ||
| + | TCCAGGAGTACTTAACACCCCTAATAGCCCCATCTTTTAAGCCTCCCTGGGACCTGCCCTCGCAGTACCT | ||
| + | CTTATACCTACTCCACTTCCTCCTCATGGCCTCCTGCAGAATGCCATTCTAAAATTAGGTTCTATTTTCC | ||
| + | TCGCCCGCATTCTCTTTTGCAAAGCCTCCAAAAAATTTACTTTGCTTCTCTGCGCCTGCTTTATCTCTAT | ||
| + | TTTCTACACTCGCTCCTTCTTTTTCTAATTATCTATAATAGGCGTCACAAAATTTGCATTTGTTGGAACC | ||
| + | AAAATTTCCATGGTTGCCTCAAAATATACAGATGTAAATTTGCATATAATTAAATTTTGCATAAGGGAAA | ||
| + | CTCTCATTTGGGGAGATATGCAATGCCCAATAAATGGCAGTTTCCTTCAATGTCCCCAGGCCAGCCTCCC | ||
| + | AGTCTGTGTGTTTCCCCCTGGCTGCAGCTACCAGGACTCTGCTCTGGGGATTTACGGACAAGGGTATCAA | ||
| + | GTTTTAATTAAACTAACCCTCTCAAACTGAATGAGTGGCTTAAAATCTTCCTGTAAAGAAACCGCAAAAT | ||
| + | AATAATGCTGGCATTGAGAAGTAAGAAAAGAGCGAGCCAGCACCCCCACCCC</dnaseq> | ||
Revision as of 08:23, 23 November 2018
PRNCR1(PCNCR1), is pervasively transcribed from the 8q24 “gene desert” region in strong association with susceptibility of prostate cancer.
Contents
Annotated Information
Name
PRNCR1: Prostate cancer associated non-coding RNA 1 (HGNC nomenclature)
Characteristics
PRNCR1(prostate cancer non-coding RNA 1) , ∼13 kb intron-less long non-coding RNA (ncRNA) ,was transcribed in centromeric region of human chromosome 8q24.21 hat, a large “gene-desert”, whose region is susceptibility to prostate cancer [1].
Function
PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells [2]. PRNCR1 overexpression can potentially serve as a required component of castration-resistance in prostatic tumors [2].
the polymorphisms in the lncRNA PRNCR1 may be related to the development of colorcetal cancer (CRC), offering a novel and potential strategy for functional analysis of susceptibility loci to human diseases[3].
Diseases
Expression
PRNCR1 expression was upregulated in some of the PC cells as well as precursor lesion prostatic intraepithelial neoplasia[1].
The primers for real-time quantitative PCR were as follows,
| Experiment | Forward | Reverse |
|---|---|---|
| Real Time PCR | 5'-CCAGGG-GGAAACACACAG-3' | 5'-AAATGGCAGTTTCCTTCAATG-3'[1] |
| RT-PCR | 5′-ATTGTTCCCAGTTCTCTGGAC-3′ | 5′-GGAGGAAGTGGAGTAGGTATAAGAG-3′[1] |
siRNA target sequences of were as follows,:
| Primer | Sequences |
|---|---|
| si1 | 5'-GCUCUUAAGGAAAUAACUU-3'[1] |
| si2 | 5'-GACGGUUCUGUUUAAGUAA-3'[1] |
| siEGFP(as a negative control) | 5'-GAAGCAGCACGACUUCUUC-3'[1] |
Allelic Information and Variation
The transcript is an approximately 13-kb intron-lessnon-coding RNA spanning a region between rs1016342 and rs7463708, and named this novel ncRNA as PRNCR1 (prostate cancer non-coding RNA 1, GenBank Accession no.AB458446) [1].
Labs working on this lncRNA
- Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.[1].
- Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.[2].
- Laboratory of Molecular and Translational Medicine, West China Institute of Women and Children's Health; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P,R, China.[3].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Chung S, Nakagawa H, Uemura M, Piao L, Ashikawa K, Hosono N, et al. Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility[J]. Cancer science. 2011,102(1):245-52.
- ↑ 2.0 2.1 2.2 2.3 Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, et al. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs[J]. Nature. 2013,500(7464):598-602.
- ↑ 3.0 3.1 3.2 Li L, Sun R, Liang Y, Pan X, Li Z, Bai P, et al. Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer[J]. Journal of experimental & clinical cancer research : CR. 2013,32:104.
Sequence
>gi|101867536|ref|NR_109833.1| Homo sapiens prostate cancer associated non-coding RNA 1 (PRNCR1), long non-coding RNA
000001 AAATCTCAGC CTCCCACTCC CATATTTACA GTTTGATTAG GGAGGCACAT TTAGATATGC AGTGATAATT GCTTTGCTTA 000080
000081 GAGAAATTCA AGGTGATAGA ATGCATGGTG ACACCTAACC CAGACTGGTA GAGAAAGGGA ATTCTTCCAC TGGGAATGAC 000160
000161 ATGATTATCT AAATAAGTAG GCTCAATCAG GTCAGGAAAG GGCCTGAAAG ACTATTTCAA GCAGAGGGAA GGTATTTGCC 000240
000241 AAGGCCAGGG TGTGTAGTGG AGAGAATGGG CAGTGGCAGA GAATTATGAA GTGTTCCAAT GACTAAAAGT AAAGTAACAA 000320
000321 GTTCCTTGTC CAAGAGCTTG GATTGTATCC TAACTGAAAT GAGTATACAC TAAGTGTTTG AAGAAGAGGG ATGAAATGGT 000400
000401 CAAGTTTTCA TTACACAAAA ATAACCTGTT CCTTTCATTT TATGTTTATT TATTTTTTTA ATTTTCTGAC TGCTCCTTTC 000480
000481 TGGAAATCTC AAATTTATAT TTGCCAAATA TTGTCACATT TTCGATGGAG AATACAAACT AAGAATGGGT TAGGGAACTG 000560
000561 AGTCAGAAAG TCCCTGTTGT ACAATTCAAT CATGTTTTTC TAAGGATGTG CTTTTGGACA TTATGGAAAC TATCTTAGGC 000640
000641 TCTCACTTGG ATCCTAGAAA AGAAGGCACC TGTTAAAAGG AATGTCCAGC CCCACCTAAT TTGGCAGCTG CCCCTCCAAG 000720
000721 CTAATGACAT TAGGGATGTA GTGGATTCAA GAGGCTGATG ATGCCATCTG GTCAACTCAT GTGACTATTT CTATCAGCTT 000800
000801 TATTTCTGCA ACATCCTGTG CCCACAGAGG GGACACAAAA TCGCTTTATA ATTCCTTCAC CATGTGAAGA TACAGATACA 000880
000881 CCCAGAACCT TAAAGGCAAG AATATGATTG AAATGTCAAA TGGGGACTTG GTGATCTAAA TTATGTCCCC CAAAAGCCAA 000960
000961 TGTCTTGCCA CCACCAGTGC CCTATGGGTG GAGTTTCTAA ACAGATTACT CAAAACACAA ACTTTCAAAA AGGGAAAGTC 001040
001041 ATAACCCTCT AGTCATCAGG GCAATTACGG AATAACATTG CTGGAGTAAG GTTTTCTCAA TGCCCAAGAG ATGAGCTGGC 001120
001121 AATGCCACAA CAATGTCCAA TTCTTAGTGG GTCCAAGACC ATGTGTTACA TTTCCCTCCC ATGATTACTC ACAGCTTCAC 001200
001201 AGTTCTGCTG TCCTCTTCGC CTCTCTGCCA CCTCTTAACT GCACCTTTGA CCTCCTACCC CTAAGATTCA ACCCTGTGAG 001280
001281 ATTACTTGTC TTTTCATCTA CACTCTGGTC ACTCTGACCC CCATTCTTTA GATTCAGGAT TTTCTCTTTT CCTGGCTTAC 001360
001361 TCTCCAGCAC AAGTAGAAAA ATATTGTGCT TCATTGGAAA ATGCATGTTG TTTGAATCAC ACTCTTTCAG ATTATACAAT 001440
001441 TGTAGTCTTT CATTATCTTT GAGCCATTTT ATAATGCTGT AAACTAATAT TAATGCATAT AATTCTTGTC TATAGACATG 001520
001521 TAAATTGTGT CCAGGGGTGA TTTAATTGAC TTTTCTTCCC CATTGTGGAA AAGGCTAGTA GTTTTGCCTC CATTTGCCCA 001600
001601 TTTATTTCTA TATTCCTGAT CTGTAAATGC ATTTCTGGGT TTTCCCTTGG ACTCATTCTA ACATCTCTTC TTTTTCCTCA 001680
001681 TTAATTAATT AAATTAAATC TTTAACACCT CTTCATATTT TTGTCAGTAT GAGAGTATAA AAAAAAATCT TTTTTTGAAA 001760
001761 ATTATCTTTT AATAGGTGAC AAAAAGAATA AACACTGAAC AAGAAGTCCT GAGCTCCTAC TACAATCCAA AGTGAACTAG 001840
001841 TTGCAGTGCC ATAGGATGAT GTTTCTCCTG AGACTTCTTT ACTAGGATCA TTTAGACTGT TATAAATGCA GATTCCTGGG 001920
001921 CCTCTCCTTA GACCCACTGA ATCAGACACT CTAAGAGGAG GGTCAGAAAT CTCCATCTTA GCAAGTTAAT GTCCAGGAGA 002000
002001 GTTAGAGACT CACTATGACG TATGATAAAA AGTAGAAGGA AGGACTTTCC AGCACCTTAA ACTACTTGGA AAGATAGATT 002080
002081 AATGTCTAGA TGAAACTTGA TGAGACTTTA GACTAATATG TTACATATAC ATCAGGAGAT GCATGTATAA ACCAAATCCA 002160
002161 AATAACCCAA AGCAAAATTT CTTTTAGAAA TAGTGATAAA TAAATGAGTG AGGAGTTTGT CACTCACATC CCCCAGGTAA 002240
002241 AACATACCTT TTTAGCCTAA ATAAATGCTA TAGTTTGAAT GTGTTCCCTC CAAAATTCAG GTACTGATAG TTAACAGCAG 002320
002321 CCGATATGAT GGTATTACAC AAAATAGTAG GTTCTTTAGG AGGTTGTTAG GCCATGAGTG CCTCCCCCAA GAATGGGATG 002400
002401 AAGGACCTCA TAAAAGAGGC TTCTCACAGC ATTGTGACCT CTAGCCCTCC CACCTTCCAT AAGTGAGGAC ACAGTGTTCC 002480
002481 TCCCCTCTGG AGGATGCAGC AACAAAGTGT CATCTTGGAA GCAGAGGAGC CATCACCAGA CAACAGAACC AGCCAACAGC 002560
002561 TTGATCCTGG ACATCTCATT TTCTCCAGAA CTGGGATAAA ATAAATTCCT GTTTTTTAAT AAATTTCCCA ATTTCAGGTA 002640
002641 TTTTGTGATA GCAGCAAAAA CAGACTAAGA CAACTAGTAT GAAAATATAC ATTAACAAAT AAAATTAATC ATAATATATG 002720
002721 TTTGCTTTTA AAAGAAAATA AATAAGCCAA TATGCTTTCT GTTGATTGAT TGATTTACTA AACATTGATT GGCCATCTCC 002800
002801 ACTGGGGATA TGGCATTTAA GAGATCTCTT TGATCTTAGT ACTTTTACTG CTTTTTAAAT AGGATCAAAT ACACCCAAGG 002880
002881 TAAAAAATAG AACACACTAT ACGTTACATT TTGGAACTGT TAGAAATTCC TTTGAAGCTA AAATTACTGC TATCATTTGA 002960
002961 CAACTTTTAC CCCTAAAATA ATGTGGTGCT CACCAGCTTG CTTAAGTTAC AGCACTTGCT GTCTTCTCAG ATACAATATC 003040
003041 AGAAACTTAT AATCCAAGAA AAATCTAAAT GGCAAGTGTG AGTTAATGGA AGCCTCATAA AGCAAGAGGT GTTTTGGAAG 003120
003121 TGTATGGAAG ACATCAATAA ATGATATGTA TAACATCAAG TGCAAAAGTG TGTGCTAGGA AAGTTCAAAA AAGAAAAAAA 003200
003201 ATATGGTAAG GTAAGACCAG AGATTGGGGA GTATATAGCT TTTGGGAATT CAGGAAATGC TAACGTCTAT GGAGAATTTG 003280
003281 CATAGGTGAA AGATCAGATT GGAAGCCTTT CTCTGTGGAA GCATTGTGGA TCTAAGTCCA GAAGTGATCC TGAGCCACCT 003360
003361 ACTATGGAAA GGTGTCAGTG AGCAAGAGAC TGTCTGACAA AGGTGGAAGC TGAGCAGACT TCTACTGCGC ATCGCCTATG 003440
003441 TACAGGCCAG ATTCCAAGGG CTGATATTAC ACTGCTAGTT TGATCTTTCT CAGATAGCTG GGTAGAGAGG GAAAAGTTTC 003520
003521 ACCCCAAATA CCAGATGCCT CCAAACATCT AGATGCTTGG TGTTATGTAT TTCAAACAGC AGGTTTGATA AAGCTGTTTT 003600
003601 TACTCTCCAG TTGGATGTTG GTTGTCAAGG CTGTCATTAA CTTCTGGGAG TTCCCAAATC CTCAGAGAGA GAGAAATAAG 003680
003681 CAGTTCTGCC TGCAATCAGA AGCTGGCTTT GAGCCCCACA TGGCAACATG CCTGTATTTA ATTAGAAGTG GCTTAGTTCT 003760
003761 TGGGATTTAC TGTGGATTGA GTCTACGAAG CTGGAAGGTT TTATCCTGAG TATTCCACTG TCTCCTCATG TGGATTTTAT 003840
003841 CAAATTTCTC CTTTAACCAT ATAAGCGCTT TCAAAGTTGA CATATCACAC TTAGTTATGA GGGGAACCTA GAAGTATGAT 003920
003921 TGTGACGTGC ATTGTTGAGA GACCATGCTT TGTAAGTGTT AATAATTAAA ATTATTTTGA ACACTAATTA TGCTGAAGAC 004000
004001 TGGATTTTCT ACTCCTTCAG ATGTTTTCCA GTGGACATAT TTTGCCCTTT TAATAAATTG ATTGCGAACT TATCTTCATT 004080
004081 TCACCTTTAT GATGTTATAC CTTTTCATTT TTGTCTTCTC ATAGCTAGGG TCTCCTGGTC CCCAAATGTA GACACACATC 004160
004161 TTACACCAAT CCCAGAGCCA TTTTGTATAA GAGCCACCAT GGATTTAACC AGCTTTAGCT CCAGTATTTG AACATAATGT 004240
004241 TCAGCATCAT CACCTGGCCA CCAAATCAAA ACTGAGCACC CTTTAATCCA TCAACAAGTT CTCTGCAGCC ATGCAAGGTT 004320
004321 ATGAAATGGG CACAGACATC AATATACAGT CTTTGTGTTT AAGAGGTTCA TGGTCTACCT GAGAAATGCA TCTTTAAACC 004400
004401 TAAAGTAGAC GCTCTGTTTA TTCCATAAAT GATTTTTAAG CATCAATGGT ATATCAAGCA CTGTACTGGC TTCTGGGCTA 004480
004481 TAATAAATAT ATAAAGACCA CAAGTTTGAA TTTCATGACA TTGAACTATA ATGTTTAAAT GTTATAATAA TCATAGTAAA 004560
004561 TGTCCTTGAG GAGCTACGGA AGATTCCTGC ATGAAGCAGA AACAAGAAGC TGAAGAAAAA ACAACTGGCT TTGGGGGCTA 004640
004641 TATAAATATA ACCCTCAAAT TAAAAACTCA ATAGTTTGAT TGATTACCAA ATCAATACAG CCAGAAAATA AATGTATTAC 004720
004721 CCCAAAAGCT TGAGTGAAGA AAGACTTCTG TAAGTTACTA GAAAGCGCTA AGGAAGAAAT AAAAGAATGA TATTCCTGAG 004800
004801 AGCCAGGTGC TTTCTGTAGG ACACACAGAT ACAGAATGAG GGAAAACAGA AAATTCTATG GTTGTGGATT CAAAATAGAG 004880
004881 GCATCACCAT GTCTATCTCA TCAGGGTTTA ACCAGAGGAA ACCAAACCAG TAAGATATCT GTATTAAGAG ATTTCTTGCA 004960
004961 AAGAATTGAC CTATGTGATT GTGGGCACTG GCTAGGTAAA TCCTAAGTCC ACAGAGCAGG CAGGAAGAAA ACAGGCTGGG 005040
005041 ACTTGTAGGC ACAGGATGAA GCTGCAATAC TCATGTGGAT GCTGCTCTTC TTCAGGGAAG ACTTGGCTCT GCTCTCAAGG 005120
005121 ACTTTCAGGT GATTAAATCA GGCCCACTCA CATTATCTAA AATAATCTCC CTTACTCAAA ACCAAGTGAT TATGGACTTT 005200
005201 AATCACATCT ATAAAATATC ATTATAGTAA CACCTAAATT AGTGTTTGAA TAACTGAGAG TTGTAACTGA TATGGTTTGG 005280
005281 CTATGTCCCC ACCCAAATCT CATCTTGAAT TATAGTTCTT ATAATCCCCA TGTGTTGTGG GAGGAACCAG GTGGAGATAA 005360
005361 TTGAATCATA GGGGCAGTTT CTCCCATTCT GTTCTCATGA TAGTGAGTTA GTTCTCAGGA GATCTCATGG TTTTATAAAG 005440
005441 GGCTTCCCTC TTTGCTCCAC TTTCATTCTC CTTCTTCCTG CTGCCATGTG AAGAAGGACA TGTTTGCTTC CCCTTCTGCC 005520
005521 ATGATTGTAA GTTTCCTGCG GCCTCCCCAG CCACGCTGAA CTGTGAGTCA ATTAAATCTC TTTTCTGTAT AAATTACCCA 005600
005601 GTCTTGGGCA GTTCTTTATA GCAGCATGAG AATGGACTAA TACAGTAACT TTACCAAGTG GACACATAAA ACTGATCATT 005680
005681 ACAATGTACA GTGAATATTT GGTGAGTTAA TAGATATATT CATAACTGAA TGAAAGAGGA TGGTGATTCC TACTTCAGGG 005760
005761 TGGTATTATG AGAGTTAAAA GGGTTAGCAT AGATAGAACA CTTTTCTATG ATTGATCTAA GGTTGGCTTT TAGGGACTAC 005840
005841 ATTATACATA TGGGTTTTGT CTTCATGTTT TTGCTTGCAT TTCTCTCTCT GCCCACTCTT GGGGCTATTT GGATGTCACC 005920
005921 TCTTCTTCTT CTGAGCTCCA GTCTATGTAT TCCCTGTTCC ATCATCACAA CCACTGAAGT CTACACTCCT CATTAGATTC 006000
006001 AGGGAACCCA GATGCCAGCC AAAGACATCC CTTTCCCTCA TGACCCAGTT GAAAAAATTC TCCACCCTTC TGTTAATTCT 006080
006081 AGAATATTTA GGAGTAAAGA TCTTTTCCCT CAGATATCTG TCAATTCCCG GCCTTATATC TCAAAGCCCC TTTTCATCCA 006160
006161 GGTTTCCTAG ATCATTTCTT GTCGTCCCTG TGCTATAACT CATTAACCCA GGCATAAAAC TCATCAGCTA CTAATGTCCT 006240
006241 CTTCCATCCC AGACTCCCCT CACACCAATA ATTCTTGAAT AGAGCAACCC AAATTGAGAA TTTTAAGTAA AATTGAAGGT 006320
006321 AAATTTAATT GCAGGAGGAC ATACAACATT AACCTTTAAA TAGAGATCCT AATTCTTAAA AAAAAAAGTC CTCATTGATC 006400
006401 TCGGGGCCGT TTCACGCAGG TGCTTTTCTA AATCATCAAG GTTATCTTCA GCTTCACTTT CAGTCTCCTT CTTCGGCTCT 006480
006481 GGCGCTGCCA CTGGCTCTTC CTGTGCTAAT GTGGTTGTGG CAGCTGCAAT GGCTGCAGGG GTCACAGCAG CTGCAGCAGC 006560
006561 TGCAGCCACA GCCTTTTCCT TCTTGTGTTT TTTGTGCTTC TTGTGCTTCT TATCCTTTTT GTGTTTCCTG TCCTTCTTTT 006640
006641 TCTTCTTTTT CTTTCCATCT CCTTCTTGAT CTGAATTTCT TGGCAGTGAT GGGCTCGGTG TTGGGCTTTT GGCCTTTTTG 006720
006721 ACCGGTACAG CTGGTGACCA GTTTGTAGAC GGTGACTGAG ACTGGATGGG GGATGGAGAT GCTGGGGGCT TTTTAGCTGC 006800
006801 TGGCTCAGGA GACCCAGAGA CAGATCGGGA GGATGAGACC CTCCTTACAG ACTGTGGGCT TGGGGAAGCA GCCTTTTTTT 006880
006881 ATCTTTTTAG GTTCCGGAGT CCTGGAGACT CTCCTAATGG GCCTAGTACT TGGAGACGGG GACTGCCTTC TTTGGGGTGA 006960
006961 TGACGACGCT CCTCTTCGAA CGGGTGGAGG ACTTGAGGTC TGAGGAGCTC GAGGCCGTGA TGAGGGCGAA TGCCATTTGT 007040
007041 TTGGATGCGG TGATCGGGCC TCCCGGGTAG AGCGGCTTGG GGAAGACCCT TTCCTATGCT TGGATGATAG TGAAGGTGAA 007120
007121 CGTCTCTTGG TGACTGGGGA GCTTCTTTGG AAGGTGGAGA ATGGGAGACC CGCCGCTTTG GTGGTGGAAA TGGTGATGCT 007200
007201 CTTCGTTTAG GAGGGGGAGG AGGTGAAGCC GTTCTTCTCT TTGGAGGTGG AGAAGGAGAG TATCTCCTCT GTATTGGAGG 007280
007281 AGAGTATCTT CTAGGAGAAG GTGAGCGCCG ACGTAGGGGA GGAGAAGGAG TCCTTCGTCG TGGTGGTGGT GGTGTGGGAG 007360
007361 TCCTGAGCCG TCGAGGATGA GGGGCGGGAG AAGGAGACCG TCGCCTTCTG GTGGGTGGTG GGGATGGACT TCTCCTCCGT 007440
007441 CTACCATGAG GGGAAGTCTC TTTTTGGTGC TTTCGTGGTG ATGGAGAAGC ACTCCGGGAA GGGGAATGTC TCCGCCGCTT 007520
007521 GCCAACCTCA CCATTCTTCA CATGGGATCT CTTGGGTCGT TCATCTTCTG AGGAGAAGGA GGAACCAGAG TCAGATGAAG 007600
007601 ACTGCTGGTT TTGTCGTCTG TATTGGCGTC TCTGCTGAGA TCAATGAGGA AGGCCCAAGT GTCCCCACAG TCTTAGGGGG 007680
007681 AAATGTTTGT TATGATGTAA ATTTTATTTG GTTTGTACGC AGTTCAATTT CAAAATTGCT AAAATGTGTT TGAGCTTTAG 007760
007761 ACTATAACAT TTGTTGTAAT AATTGCTAGG TTGAAGTTCA ACATGTAAAA AAAGGGGGCA TGGATTTACA TTGCAAAAGG 007840
007841 TGTCCACAGT GTATTAGTGA CATTCTTTCA TTGACAGCTG ACATAATTCA TTGAGTGAAA TATTTTAAGC CAAAAAAAAT 007920
007921 TCCCTTTTTA AAAAAGGGGG TTTAAATACT GTTGACACTT TTATGGTTCC TTTAAATGCT CTGGCTATTC CCAGAGGGGT 008000
008001 TTTTTTGTTT GTTTTTTTGG TTTTGATTTG CTTTTTGTTT TTCTTTCTTC TTCTTACATT TTTTTCCATT TGAGTCTTAG 008080
008081 CTCCCATTTA AGTTATGCTT CTGACCTTGT ATGGTCTGTA AGCTTGCCCA GAAATAAGAC CACTGTTTTG AACTACCACA 008160
008161 AAAGTATAAA TGAATATTTT AATGCCACAG TCTTTCCTGT TGCCTGTGGA GTCTCTGCTG AAATGAATCA GGATTCGAGC 008240
008241 TCTAGGATAA GACAGAAAAT GAAAGCATGT TGTTTGCCAG GACACTGTGG GTTTATATTG ATGTGTAACA ACTTGATTTG 008320
008321 GAACACTGGA CTCTCATTCT GTTCTTCTGG TTTTGTTTTT TTGTTTTGTT TTTTTCTTTT GTAAAGGCCA TGAACTAGTC 008400
008401 CCAGAAAGGA TTCCTTCAGT TACATACAAT TTGTTTAATG AAATGTCATG GCTCTGTTCA TATTTTTGTC TTGTTCTTCC 008480
008481 AATTGGTGTA TACAACTTTC AGAGCCTCTT GTATTTGGAA GGCTGGAAGG GCCCAGACTT TGGAATAGTG TCTCGGTTTC 008560
008561 ACTGTTTTTG TTTTGATTTT TTTTTTTTAT TTTTTTTAAA CTAAAGCTAT ATAAAGCTTG TGGATTAAAC AGAATAAATT 008640
008641 TCTAAATTTA AAAATTTAAA AAAAAAAAAG TCTATTGTCT TCCCTCCCCT ACCCTAAGCA ATATGCAATA GTGGCTCTTC 008720
008721 AATAGTCCCA GACTCTTCTT CTCTTCCTGG ACTGCCCATC TCCTGATCAA CCCTTAATTT CTCTTCCTTC TCTCACCCTT 008800
008801 CTTTTCAGGA TTGAATTAAT GAATCCTTTC TTCTCACTCA TGCAGAGTAA GTTTCTGCCT CCCTGGGTCT TTCTGTTTAC 008880
008881 TGACCGCAAC AACTTCAGAT TATACCTCTT CTACTCCAAG TGCTTTCAAA GAAAGTCCTC TGCCAAGACA AATTCATTAC 008960
008961 GTTTTTTCCC TCTACCTGTT TGCCTTTATT CTCTTTTGTA TTTCATCTTC TCATCTAGAT TGAATAATCT TTGAGAGCAC 009040
009041 AGATGTTTAT TTATATTTTT CCTTTCCATT TCTACTCAGC ATGAGGTGTC CATTGAACAA ACTTGATGAA TTTTTATTGC 009120
009121 TTAATATCTT GCTAGAGGTG GGGAGAGAGG TTGGGGGCGG TTAAGGAACT ATCAGCTAGC CTAGGAGATA TTAGAGCTGC 009200
009201 AGAGATTTGG CTATCTTGTT CAACGTTATA TCCCTAGGGA TTAGTACATA GGCTTGCAAA TAGCAGGTAT GAATAAAAAA 009280
009281 TTATTGAATG AGTAAATGAA TTTAAAATAT AAGTTACTTA GGCGGTATCT TCAGGCATAT CTGTGTTTAT GTGGTATTCA 009360
009361 ATGGCCCACA AATGTCTACA TCCTAATTCC TAAGATCTGT AAACATTAAT TTGCATGACA AAAGAGACTT TACAGATGTG 009440
009441 ATTAAATGAA AGGATTTTGA CATGCAGATA ATATCCTGTA TTCTTCATGT GGAACCAATG TATTTACAAG GGTCCTTATA 009520
009521 AGTAAAACAG AGAAGCAGGA AAATGAGGGT CGCAAAAAAA AAAAAAAAAA CAAACATGAA GACAGAGAAG AGGTTAGAGT 009600
009601 GATGTTGGCT TTAGAGATGG AAGGAGTCAC AAGCTGTCTT AAAGGAATAA GACAAGCTGT CTTAAAGGAA TTGTTATAAA 009680
009681 GGAATAGCTG AAGCTGGGTA ATTTATTTTA AAAAGGTTTA TTTTGCTCAC TATTCTCATG TCTGGAAAAG TTTAATATTG 009760
009761 GGTAGCTGCA TCTGGCAAGG GCCTCAGGCT GTTTCCACTC ATGTCAGAAC GTAAAGGGGA GCTGGTGTGT TTAGAGATCA 009840
009841 CGTGGGGAGA GAGGAAGCAA GAGAGAGGGA GGAGGGGCCA GGCTTTTTTT AAACAACCAG CTCTTTTTTT AAAAAAAAAT 009920
009921 TATACTTTAA GTTCTGGTAT ACATGTGCAG AATGTGCAGG TTTGCTACAT AGGAATACAC ATGCCATAGT GGTTTGCTGC 010000
010001 ACCCATTAAC CTGTCTTCTA CATTAGGTAT TTCTCCTAAT GCTATCCCTT CCTTAACCCC CAAACCCTGA CAGGCCCTGG 010080
010081 TGTGTGATGT TCCCCTCCCT GTGTCCATGT GTTGTCATTG TTCATCTCCC ACTTATGAAT GATAACATGC AGTGTTGGGT 010160
010161 TTTCTGTCCT TGTGATAGTT TGCTGAGAAT GATGATTTCC AGCTTCATCC ATGTCCCTGC AAAGGACATG AACTTATCCT 010240
010241 TTTTATGGTT GCATAGTATT CCATGGTGTA TATGTGCCAC ATTTTCTTTA TCCACTCTAT CATTGATGGG CATTTGGGTT 010320
010321 GGTTCCAAGT CTTTGCTATT ATGAACAGTG CTGCAGTAAA CATACGTGTG CATGTGTCTT TGTAGTACAG TGATTTATAA 010400
010401 TCCTTTGGGT ATATACACAG TAATGGAATT GCTGAGTCAA ATGGTATTTC TGGTTCTAGA TCCTTGAGGA ATTGCAACAT 010480
010481 TGTCTTCCAC AATGGAACAA CCAGTTCTCT TAAGAATAAA AGTGAGAACT CACTTCCCTG GCCCCAGAGA GAGCAAAAGC 010560
010561 AATTCATCCC CATCACCCAA ACACCTCCCA TTAGGCCCTA CCTCCAACAT TGGGATCAAA TTTCAACATG AGGTTTTTAG 010640
010641 GGGACAAACA TCCAAACTAT GTCACAAGAC AATTCATGTA AGCAGCCTCT AAAAGATGGA AGAGGCAAGG AAACAGATTC 010720
010721 TCCCCTAAAG CCCACAGAAG GAAAGCAGCC CTGCCAACTT CTTGATTTTA ACCCAGTAAG ACCCGTTTTG GACTTTGGAC 010800
010801 ACCAAGAGCT ATAAGATGAT TATGTTGTTT TAAGCCATTA AGCTTGAGGC AATTTGTTAC AGCAGCAATT GGAAACTAAT 010880
010881 ACAGATCACA TTCTAATTCA ATTAGTATTG TTCCCAGTTC TCTGGACCTC AGATTTCTTT CCTGAAAAAC ATTAAAAATA 010960
010961 ATACCTGAAA GTTTTGCACA CGAGTGCAGA GTGCCTATTT ACTAGAGAGA TCAGCATTTG TTTAGGCTCT GAATAGATTT 011040
011041 GAGGATGAAA TTAAATAGCA TAAATAAAGT TCCTAGTGAT GCTTCTGATA AAAAAATATC TCCTTCAAAA TGCCAGAGGC 011120
011121 AGGTCCTAAA AACCCACAAA GCAGGTGAAC TGGCAAAAGA CTGTAAAAAG CAAAGTAGAG GTTCCTCTTC AAAGACTTTC 011200
011201 CTCTCCATCT AATTAGGAAT AAATAGTAAC TTATCTTAGA AACAAAATTT ATTCAAAGAC CTGTGCTAAC ATTCTGAAAT 011280
011281 ATCTGCTAGC CGTAATAAAT AAATCGATGT ACTTTATGTT CTTAGCTCCC ACAATTTAAC CTAAATATTT GCCCTGGCAT 011360
011361 GCTTATACTG GTCCAAGCAA GCATTAGGTC ATAGCCTGTT CCTCTTCTTT ATTTTAAGGT GTTTTTACCT TTGTCAGCAT 011440
011441 GCCACAAGTT ACTTCCTCCT TCCTTTGTTC TCCTCTGCCT TTGACTCTTT TAAAGAGTCC TAAGTTGCTA GCCAATCAGG 011520
011521 ACAAATACAG AATGTGAGGT CCCGTTTCAG CCAATGGAAA GTGGACACAG CAGGAAGGTG GATGGGTCAG GTTATAAATG 011600
011601 ACCCTGTCTC CTTTGTTCGG TGTACTCTTG TGGCAAAACT GCTGGCAAGT GTACCCTTTC TGCAATAGGT AAAAACTGCC 011680
011681 TTGCTGAGGA AATTAAATTT ATGTTCAAGT GCTATTTCTT TATGGCACCG GGGAACAAGC ATTTCTAACA AGACTATGTA 011760
011761 ATTTAATTTC AGGAACCTAA AAAAGTGGGA TGAAGAACTG AGGTTGCTAA TAAATCTATA CAACTTATAA GTAAATATTT 011840
011841 AATTTACTAA CATATAATAA TAAAGACATC ATTGTAAGAC AATGTTAAAA CATTTTACAC ATTTTAAATG TGCAATAGTA 011920
011921 AATCCTTCAC TATTCAGGGA TTATTTGGAA TCCCTTGTCA CCAGAAGCTC TTAAGGAAAT AACTTCTACT TCGTTGCAAA 012000
012001 TATGTTCTTG GCTTAGTTGA GGTAATGCAA ATACTAGAAT ACTTGTTTGT TTAACAGCTT ATTCTTCCCT GAAGCTGTTC 012080
012081 CTCCAGTCCC TGCCAGTGGG ATCTTATGTC TCCAGGAGTA CTTAACACCC CTAATAGCCC CATCTTTTAA GCCTCCCTGG 012160
012161 GACCTGCCCT CGCAGTACCT CTTATACCTA CTCCACTTCC TCCTCATGGC CTCCTGCAGA ATGCCATTCT AAAATTAGGT 012240
012241 TCTATTTTCC TCGCCCGCAT TCTCTTTTGC AAAGCCTCCA AAAAATTTAC TTTGCTTCTC TGCGCCTGCT TTATCTCTAT 012320
012321 TTTCTACACT CGCTCCTTCT TTTTCTAATT ATCTATAATA GGCGTCACAA AATTTGCATT TGTTGGAACC AAAATTTCCA 012400
012401 TGGTTGCCTC AAAATATACA GATGTAAATT TGCATATAAT TAAATTTTGC ATAAGGGAAA CTCTCATTTG GGGAGATATG 012480
012481 CAATGCCCAA TAAATGGCAG TTTCCTTCAA TGTCCCCAGG CCAGCCTCCC AGTCTGTGTG TTTCCCCCTG GCTGCAGCTA 012560
012561 CCAGGACTCT GCTCTGGGGA TTTACGGACA AGGGTATCAA GTTTTAATTA AACTAACCCT CTCAAACTGA ATGAGTGGCT 012640
012641 TAAAATCTTC CTGTAAAGAA ACCGCAAAAT AATAATGCTG GCATTGAGAA GTAAGAAAAG AGCGAGCCAG CACCCCCACC 012720
012721 CC
000081 GAGAAATTCA AGGTGATAGA ATGCATGGTG ACACCTAACC CAGACTGGTA GAGAAAGGGA ATTCTTCCAC TGGGAATGAC 000160
000161 ATGATTATCT AAATAAGTAG GCTCAATCAG GTCAGGAAAG GGCCTGAAAG ACTATTTCAA GCAGAGGGAA GGTATTTGCC 000240
000241 AAGGCCAGGG TGTGTAGTGG AGAGAATGGG CAGTGGCAGA GAATTATGAA GTGTTCCAAT GACTAAAAGT AAAGTAACAA 000320
000321 GTTCCTTGTC CAAGAGCTTG GATTGTATCC TAACTGAAAT GAGTATACAC TAAGTGTTTG AAGAAGAGGG ATGAAATGGT 000400
000401 CAAGTTTTCA TTACACAAAA ATAACCTGTT CCTTTCATTT TATGTTTATT TATTTTTTTA ATTTTCTGAC TGCTCCTTTC 000480
000481 TGGAAATCTC AAATTTATAT TTGCCAAATA TTGTCACATT TTCGATGGAG AATACAAACT AAGAATGGGT TAGGGAACTG 000560
000561 AGTCAGAAAG TCCCTGTTGT ACAATTCAAT CATGTTTTTC TAAGGATGTG CTTTTGGACA TTATGGAAAC TATCTTAGGC 000640
000641 TCTCACTTGG ATCCTAGAAA AGAAGGCACC TGTTAAAAGG AATGTCCAGC CCCACCTAAT TTGGCAGCTG CCCCTCCAAG 000720
000721 CTAATGACAT TAGGGATGTA GTGGATTCAA GAGGCTGATG ATGCCATCTG GTCAACTCAT GTGACTATTT CTATCAGCTT 000800
000801 TATTTCTGCA ACATCCTGTG CCCACAGAGG GGACACAAAA TCGCTTTATA ATTCCTTCAC CATGTGAAGA TACAGATACA 000880
000881 CCCAGAACCT TAAAGGCAAG AATATGATTG AAATGTCAAA TGGGGACTTG GTGATCTAAA TTATGTCCCC CAAAAGCCAA 000960
000961 TGTCTTGCCA CCACCAGTGC CCTATGGGTG GAGTTTCTAA ACAGATTACT CAAAACACAA ACTTTCAAAA AGGGAAAGTC 001040
001041 ATAACCCTCT AGTCATCAGG GCAATTACGG AATAACATTG CTGGAGTAAG GTTTTCTCAA TGCCCAAGAG ATGAGCTGGC 001120
001121 AATGCCACAA CAATGTCCAA TTCTTAGTGG GTCCAAGACC ATGTGTTACA TTTCCCTCCC ATGATTACTC ACAGCTTCAC 001200
001201 AGTTCTGCTG TCCTCTTCGC CTCTCTGCCA CCTCTTAACT GCACCTTTGA CCTCCTACCC CTAAGATTCA ACCCTGTGAG 001280
001281 ATTACTTGTC TTTTCATCTA CACTCTGGTC ACTCTGACCC CCATTCTTTA GATTCAGGAT TTTCTCTTTT CCTGGCTTAC 001360
001361 TCTCCAGCAC AAGTAGAAAA ATATTGTGCT TCATTGGAAA ATGCATGTTG TTTGAATCAC ACTCTTTCAG ATTATACAAT 001440
001441 TGTAGTCTTT CATTATCTTT GAGCCATTTT ATAATGCTGT AAACTAATAT TAATGCATAT AATTCTTGTC TATAGACATG 001520
001521 TAAATTGTGT CCAGGGGTGA TTTAATTGAC TTTTCTTCCC CATTGTGGAA AAGGCTAGTA GTTTTGCCTC CATTTGCCCA 001600
001601 TTTATTTCTA TATTCCTGAT CTGTAAATGC ATTTCTGGGT TTTCCCTTGG ACTCATTCTA ACATCTCTTC TTTTTCCTCA 001680
001681 TTAATTAATT AAATTAAATC TTTAACACCT CTTCATATTT TTGTCAGTAT GAGAGTATAA AAAAAAATCT TTTTTTGAAA 001760
001761 ATTATCTTTT AATAGGTGAC AAAAAGAATA AACACTGAAC AAGAAGTCCT GAGCTCCTAC TACAATCCAA AGTGAACTAG 001840
001841 TTGCAGTGCC ATAGGATGAT GTTTCTCCTG AGACTTCTTT ACTAGGATCA TTTAGACTGT TATAAATGCA GATTCCTGGG 001920
001921 CCTCTCCTTA GACCCACTGA ATCAGACACT CTAAGAGGAG GGTCAGAAAT CTCCATCTTA GCAAGTTAAT GTCCAGGAGA 002000
002001 GTTAGAGACT CACTATGACG TATGATAAAA AGTAGAAGGA AGGACTTTCC AGCACCTTAA ACTACTTGGA AAGATAGATT 002080
002081 AATGTCTAGA TGAAACTTGA TGAGACTTTA GACTAATATG TTACATATAC ATCAGGAGAT GCATGTATAA ACCAAATCCA 002160
002161 AATAACCCAA AGCAAAATTT CTTTTAGAAA TAGTGATAAA TAAATGAGTG AGGAGTTTGT CACTCACATC CCCCAGGTAA 002240
002241 AACATACCTT TTTAGCCTAA ATAAATGCTA TAGTTTGAAT GTGTTCCCTC CAAAATTCAG GTACTGATAG TTAACAGCAG 002320
002321 CCGATATGAT GGTATTACAC AAAATAGTAG GTTCTTTAGG AGGTTGTTAG GCCATGAGTG CCTCCCCCAA GAATGGGATG 002400
002401 AAGGACCTCA TAAAAGAGGC TTCTCACAGC ATTGTGACCT CTAGCCCTCC CACCTTCCAT AAGTGAGGAC ACAGTGTTCC 002480
002481 TCCCCTCTGG AGGATGCAGC AACAAAGTGT CATCTTGGAA GCAGAGGAGC CATCACCAGA CAACAGAACC AGCCAACAGC 002560
002561 TTGATCCTGG ACATCTCATT TTCTCCAGAA CTGGGATAAA ATAAATTCCT GTTTTTTAAT AAATTTCCCA ATTTCAGGTA 002640
002641 TTTTGTGATA GCAGCAAAAA CAGACTAAGA CAACTAGTAT GAAAATATAC ATTAACAAAT AAAATTAATC ATAATATATG 002720
002721 TTTGCTTTTA AAAGAAAATA AATAAGCCAA TATGCTTTCT GTTGATTGAT TGATTTACTA AACATTGATT GGCCATCTCC 002800
002801 ACTGGGGATA TGGCATTTAA GAGATCTCTT TGATCTTAGT ACTTTTACTG CTTTTTAAAT AGGATCAAAT ACACCCAAGG 002880
002881 TAAAAAATAG AACACACTAT ACGTTACATT TTGGAACTGT TAGAAATTCC TTTGAAGCTA AAATTACTGC TATCATTTGA 002960
002961 CAACTTTTAC CCCTAAAATA ATGTGGTGCT CACCAGCTTG CTTAAGTTAC AGCACTTGCT GTCTTCTCAG ATACAATATC 003040
003041 AGAAACTTAT AATCCAAGAA AAATCTAAAT GGCAAGTGTG AGTTAATGGA AGCCTCATAA AGCAAGAGGT GTTTTGGAAG 003120
003121 TGTATGGAAG ACATCAATAA ATGATATGTA TAACATCAAG TGCAAAAGTG TGTGCTAGGA AAGTTCAAAA AAGAAAAAAA 003200
003201 ATATGGTAAG GTAAGACCAG AGATTGGGGA GTATATAGCT TTTGGGAATT CAGGAAATGC TAACGTCTAT GGAGAATTTG 003280
003281 CATAGGTGAA AGATCAGATT GGAAGCCTTT CTCTGTGGAA GCATTGTGGA TCTAAGTCCA GAAGTGATCC TGAGCCACCT 003360
003361 ACTATGGAAA GGTGTCAGTG AGCAAGAGAC TGTCTGACAA AGGTGGAAGC TGAGCAGACT TCTACTGCGC ATCGCCTATG 003440
003441 TACAGGCCAG ATTCCAAGGG CTGATATTAC ACTGCTAGTT TGATCTTTCT CAGATAGCTG GGTAGAGAGG GAAAAGTTTC 003520
003521 ACCCCAAATA CCAGATGCCT CCAAACATCT AGATGCTTGG TGTTATGTAT TTCAAACAGC AGGTTTGATA AAGCTGTTTT 003600
003601 TACTCTCCAG TTGGATGTTG GTTGTCAAGG CTGTCATTAA CTTCTGGGAG TTCCCAAATC CTCAGAGAGA GAGAAATAAG 003680
003681 CAGTTCTGCC TGCAATCAGA AGCTGGCTTT GAGCCCCACA TGGCAACATG CCTGTATTTA ATTAGAAGTG GCTTAGTTCT 003760
003761 TGGGATTTAC TGTGGATTGA GTCTACGAAG CTGGAAGGTT TTATCCTGAG TATTCCACTG TCTCCTCATG TGGATTTTAT 003840
003841 CAAATTTCTC CTTTAACCAT ATAAGCGCTT TCAAAGTTGA CATATCACAC TTAGTTATGA GGGGAACCTA GAAGTATGAT 003920
003921 TGTGACGTGC ATTGTTGAGA GACCATGCTT TGTAAGTGTT AATAATTAAA ATTATTTTGA ACACTAATTA TGCTGAAGAC 004000
004001 TGGATTTTCT ACTCCTTCAG ATGTTTTCCA GTGGACATAT TTTGCCCTTT TAATAAATTG ATTGCGAACT TATCTTCATT 004080
004081 TCACCTTTAT GATGTTATAC CTTTTCATTT TTGTCTTCTC ATAGCTAGGG TCTCCTGGTC CCCAAATGTA GACACACATC 004160
004161 TTACACCAAT CCCAGAGCCA TTTTGTATAA GAGCCACCAT GGATTTAACC AGCTTTAGCT CCAGTATTTG AACATAATGT 004240
004241 TCAGCATCAT CACCTGGCCA CCAAATCAAA ACTGAGCACC CTTTAATCCA TCAACAAGTT CTCTGCAGCC ATGCAAGGTT 004320
004321 ATGAAATGGG CACAGACATC AATATACAGT CTTTGTGTTT AAGAGGTTCA TGGTCTACCT GAGAAATGCA TCTTTAAACC 004400
004401 TAAAGTAGAC GCTCTGTTTA TTCCATAAAT GATTTTTAAG CATCAATGGT ATATCAAGCA CTGTACTGGC TTCTGGGCTA 004480
004481 TAATAAATAT ATAAAGACCA CAAGTTTGAA TTTCATGACA TTGAACTATA ATGTTTAAAT GTTATAATAA TCATAGTAAA 004560
004561 TGTCCTTGAG GAGCTACGGA AGATTCCTGC ATGAAGCAGA AACAAGAAGC TGAAGAAAAA ACAACTGGCT TTGGGGGCTA 004640
004641 TATAAATATA ACCCTCAAAT TAAAAACTCA ATAGTTTGAT TGATTACCAA ATCAATACAG CCAGAAAATA AATGTATTAC 004720
004721 CCCAAAAGCT TGAGTGAAGA AAGACTTCTG TAAGTTACTA GAAAGCGCTA AGGAAGAAAT AAAAGAATGA TATTCCTGAG 004800
004801 AGCCAGGTGC TTTCTGTAGG ACACACAGAT ACAGAATGAG GGAAAACAGA AAATTCTATG GTTGTGGATT CAAAATAGAG 004880
004881 GCATCACCAT GTCTATCTCA TCAGGGTTTA ACCAGAGGAA ACCAAACCAG TAAGATATCT GTATTAAGAG ATTTCTTGCA 004960
004961 AAGAATTGAC CTATGTGATT GTGGGCACTG GCTAGGTAAA TCCTAAGTCC ACAGAGCAGG CAGGAAGAAA ACAGGCTGGG 005040
005041 ACTTGTAGGC ACAGGATGAA GCTGCAATAC TCATGTGGAT GCTGCTCTTC TTCAGGGAAG ACTTGGCTCT GCTCTCAAGG 005120
005121 ACTTTCAGGT GATTAAATCA GGCCCACTCA CATTATCTAA AATAATCTCC CTTACTCAAA ACCAAGTGAT TATGGACTTT 005200
005201 AATCACATCT ATAAAATATC ATTATAGTAA CACCTAAATT AGTGTTTGAA TAACTGAGAG TTGTAACTGA TATGGTTTGG 005280
005281 CTATGTCCCC ACCCAAATCT CATCTTGAAT TATAGTTCTT ATAATCCCCA TGTGTTGTGG GAGGAACCAG GTGGAGATAA 005360
005361 TTGAATCATA GGGGCAGTTT CTCCCATTCT GTTCTCATGA TAGTGAGTTA GTTCTCAGGA GATCTCATGG TTTTATAAAG 005440
005441 GGCTTCCCTC TTTGCTCCAC TTTCATTCTC CTTCTTCCTG CTGCCATGTG AAGAAGGACA TGTTTGCTTC CCCTTCTGCC 005520
005521 ATGATTGTAA GTTTCCTGCG GCCTCCCCAG CCACGCTGAA CTGTGAGTCA ATTAAATCTC TTTTCTGTAT AAATTACCCA 005600
005601 GTCTTGGGCA GTTCTTTATA GCAGCATGAG AATGGACTAA TACAGTAACT TTACCAAGTG GACACATAAA ACTGATCATT 005680
005681 ACAATGTACA GTGAATATTT GGTGAGTTAA TAGATATATT CATAACTGAA TGAAAGAGGA TGGTGATTCC TACTTCAGGG 005760
005761 TGGTATTATG AGAGTTAAAA GGGTTAGCAT AGATAGAACA CTTTTCTATG ATTGATCTAA GGTTGGCTTT TAGGGACTAC 005840
005841 ATTATACATA TGGGTTTTGT CTTCATGTTT TTGCTTGCAT TTCTCTCTCT GCCCACTCTT GGGGCTATTT GGATGTCACC 005920
005921 TCTTCTTCTT CTGAGCTCCA GTCTATGTAT TCCCTGTTCC ATCATCACAA CCACTGAAGT CTACACTCCT CATTAGATTC 006000
006001 AGGGAACCCA GATGCCAGCC AAAGACATCC CTTTCCCTCA TGACCCAGTT GAAAAAATTC TCCACCCTTC TGTTAATTCT 006080
006081 AGAATATTTA GGAGTAAAGA TCTTTTCCCT CAGATATCTG TCAATTCCCG GCCTTATATC TCAAAGCCCC TTTTCATCCA 006160
006161 GGTTTCCTAG ATCATTTCTT GTCGTCCCTG TGCTATAACT CATTAACCCA GGCATAAAAC TCATCAGCTA CTAATGTCCT 006240
006241 CTTCCATCCC AGACTCCCCT CACACCAATA ATTCTTGAAT AGAGCAACCC AAATTGAGAA TTTTAAGTAA AATTGAAGGT 006320
006321 AAATTTAATT GCAGGAGGAC ATACAACATT AACCTTTAAA TAGAGATCCT AATTCTTAAA AAAAAAAGTC CTCATTGATC 006400
006401 TCGGGGCCGT TTCACGCAGG TGCTTTTCTA AATCATCAAG GTTATCTTCA GCTTCACTTT CAGTCTCCTT CTTCGGCTCT 006480
006481 GGCGCTGCCA CTGGCTCTTC CTGTGCTAAT GTGGTTGTGG CAGCTGCAAT GGCTGCAGGG GTCACAGCAG CTGCAGCAGC 006560
006561 TGCAGCCACA GCCTTTTCCT TCTTGTGTTT TTTGTGCTTC TTGTGCTTCT TATCCTTTTT GTGTTTCCTG TCCTTCTTTT 006640
006641 TCTTCTTTTT CTTTCCATCT CCTTCTTGAT CTGAATTTCT TGGCAGTGAT GGGCTCGGTG TTGGGCTTTT GGCCTTTTTG 006720
006721 ACCGGTACAG CTGGTGACCA GTTTGTAGAC GGTGACTGAG ACTGGATGGG GGATGGAGAT GCTGGGGGCT TTTTAGCTGC 006800
006801 TGGCTCAGGA GACCCAGAGA CAGATCGGGA GGATGAGACC CTCCTTACAG ACTGTGGGCT TGGGGAAGCA GCCTTTTTTT 006880
006881 ATCTTTTTAG GTTCCGGAGT CCTGGAGACT CTCCTAATGG GCCTAGTACT TGGAGACGGG GACTGCCTTC TTTGGGGTGA 006960
006961 TGACGACGCT CCTCTTCGAA CGGGTGGAGG ACTTGAGGTC TGAGGAGCTC GAGGCCGTGA TGAGGGCGAA TGCCATTTGT 007040
007041 TTGGATGCGG TGATCGGGCC TCCCGGGTAG AGCGGCTTGG GGAAGACCCT TTCCTATGCT TGGATGATAG TGAAGGTGAA 007120
007121 CGTCTCTTGG TGACTGGGGA GCTTCTTTGG AAGGTGGAGA ATGGGAGACC CGCCGCTTTG GTGGTGGAAA TGGTGATGCT 007200
007201 CTTCGTTTAG GAGGGGGAGG AGGTGAAGCC GTTCTTCTCT TTGGAGGTGG AGAAGGAGAG TATCTCCTCT GTATTGGAGG 007280
007281 AGAGTATCTT CTAGGAGAAG GTGAGCGCCG ACGTAGGGGA GGAGAAGGAG TCCTTCGTCG TGGTGGTGGT GGTGTGGGAG 007360
007361 TCCTGAGCCG TCGAGGATGA GGGGCGGGAG AAGGAGACCG TCGCCTTCTG GTGGGTGGTG GGGATGGACT TCTCCTCCGT 007440
007441 CTACCATGAG GGGAAGTCTC TTTTTGGTGC TTTCGTGGTG ATGGAGAAGC ACTCCGGGAA GGGGAATGTC TCCGCCGCTT 007520
007521 GCCAACCTCA CCATTCTTCA CATGGGATCT CTTGGGTCGT TCATCTTCTG AGGAGAAGGA GGAACCAGAG TCAGATGAAG 007600
007601 ACTGCTGGTT TTGTCGTCTG TATTGGCGTC TCTGCTGAGA TCAATGAGGA AGGCCCAAGT GTCCCCACAG TCTTAGGGGG 007680
007681 AAATGTTTGT TATGATGTAA ATTTTATTTG GTTTGTACGC AGTTCAATTT CAAAATTGCT AAAATGTGTT TGAGCTTTAG 007760
007761 ACTATAACAT TTGTTGTAAT AATTGCTAGG TTGAAGTTCA ACATGTAAAA AAAGGGGGCA TGGATTTACA TTGCAAAAGG 007840
007841 TGTCCACAGT GTATTAGTGA CATTCTTTCA TTGACAGCTG ACATAATTCA TTGAGTGAAA TATTTTAAGC CAAAAAAAAT 007920
007921 TCCCTTTTTA AAAAAGGGGG TTTAAATACT GTTGACACTT TTATGGTTCC TTTAAATGCT CTGGCTATTC CCAGAGGGGT 008000
008001 TTTTTTGTTT GTTTTTTTGG TTTTGATTTG CTTTTTGTTT TTCTTTCTTC TTCTTACATT TTTTTCCATT TGAGTCTTAG 008080
008081 CTCCCATTTA AGTTATGCTT CTGACCTTGT ATGGTCTGTA AGCTTGCCCA GAAATAAGAC CACTGTTTTG AACTACCACA 008160
008161 AAAGTATAAA TGAATATTTT AATGCCACAG TCTTTCCTGT TGCCTGTGGA GTCTCTGCTG AAATGAATCA GGATTCGAGC 008240
008241 TCTAGGATAA GACAGAAAAT GAAAGCATGT TGTTTGCCAG GACACTGTGG GTTTATATTG ATGTGTAACA ACTTGATTTG 008320
008321 GAACACTGGA CTCTCATTCT GTTCTTCTGG TTTTGTTTTT TTGTTTTGTT TTTTTCTTTT GTAAAGGCCA TGAACTAGTC 008400
008401 CCAGAAAGGA TTCCTTCAGT TACATACAAT TTGTTTAATG AAATGTCATG GCTCTGTTCA TATTTTTGTC TTGTTCTTCC 008480
008481 AATTGGTGTA TACAACTTTC AGAGCCTCTT GTATTTGGAA GGCTGGAAGG GCCCAGACTT TGGAATAGTG TCTCGGTTTC 008560
008561 ACTGTTTTTG TTTTGATTTT TTTTTTTTAT TTTTTTTAAA CTAAAGCTAT ATAAAGCTTG TGGATTAAAC AGAATAAATT 008640
008641 TCTAAATTTA AAAATTTAAA AAAAAAAAAG TCTATTGTCT TCCCTCCCCT ACCCTAAGCA ATATGCAATA GTGGCTCTTC 008720
008721 AATAGTCCCA GACTCTTCTT CTCTTCCTGG ACTGCCCATC TCCTGATCAA CCCTTAATTT CTCTTCCTTC TCTCACCCTT 008800
008801 CTTTTCAGGA TTGAATTAAT GAATCCTTTC TTCTCACTCA TGCAGAGTAA GTTTCTGCCT CCCTGGGTCT TTCTGTTTAC 008880
008881 TGACCGCAAC AACTTCAGAT TATACCTCTT CTACTCCAAG TGCTTTCAAA GAAAGTCCTC TGCCAAGACA AATTCATTAC 008960
008961 GTTTTTTCCC TCTACCTGTT TGCCTTTATT CTCTTTTGTA TTTCATCTTC TCATCTAGAT TGAATAATCT TTGAGAGCAC 009040
009041 AGATGTTTAT TTATATTTTT CCTTTCCATT TCTACTCAGC ATGAGGTGTC CATTGAACAA ACTTGATGAA TTTTTATTGC 009120
009121 TTAATATCTT GCTAGAGGTG GGGAGAGAGG TTGGGGGCGG TTAAGGAACT ATCAGCTAGC CTAGGAGATA TTAGAGCTGC 009200
009201 AGAGATTTGG CTATCTTGTT CAACGTTATA TCCCTAGGGA TTAGTACATA GGCTTGCAAA TAGCAGGTAT GAATAAAAAA 009280
009281 TTATTGAATG AGTAAATGAA TTTAAAATAT AAGTTACTTA GGCGGTATCT TCAGGCATAT CTGTGTTTAT GTGGTATTCA 009360
009361 ATGGCCCACA AATGTCTACA TCCTAATTCC TAAGATCTGT AAACATTAAT TTGCATGACA AAAGAGACTT TACAGATGTG 009440
009441 ATTAAATGAA AGGATTTTGA CATGCAGATA ATATCCTGTA TTCTTCATGT GGAACCAATG TATTTACAAG GGTCCTTATA 009520
009521 AGTAAAACAG AGAAGCAGGA AAATGAGGGT CGCAAAAAAA AAAAAAAAAA CAAACATGAA GACAGAGAAG AGGTTAGAGT 009600
009601 GATGTTGGCT TTAGAGATGG AAGGAGTCAC AAGCTGTCTT AAAGGAATAA GACAAGCTGT CTTAAAGGAA TTGTTATAAA 009680
009681 GGAATAGCTG AAGCTGGGTA ATTTATTTTA AAAAGGTTTA TTTTGCTCAC TATTCTCATG TCTGGAAAAG TTTAATATTG 009760
009761 GGTAGCTGCA TCTGGCAAGG GCCTCAGGCT GTTTCCACTC ATGTCAGAAC GTAAAGGGGA GCTGGTGTGT TTAGAGATCA 009840
009841 CGTGGGGAGA GAGGAAGCAA GAGAGAGGGA GGAGGGGCCA GGCTTTTTTT AAACAACCAG CTCTTTTTTT AAAAAAAAAT 009920
009921 TATACTTTAA GTTCTGGTAT ACATGTGCAG AATGTGCAGG TTTGCTACAT AGGAATACAC ATGCCATAGT GGTTTGCTGC 010000
010001 ACCCATTAAC CTGTCTTCTA CATTAGGTAT TTCTCCTAAT GCTATCCCTT CCTTAACCCC CAAACCCTGA CAGGCCCTGG 010080
010081 TGTGTGATGT TCCCCTCCCT GTGTCCATGT GTTGTCATTG TTCATCTCCC ACTTATGAAT GATAACATGC AGTGTTGGGT 010160
010161 TTTCTGTCCT TGTGATAGTT TGCTGAGAAT GATGATTTCC AGCTTCATCC ATGTCCCTGC AAAGGACATG AACTTATCCT 010240
010241 TTTTATGGTT GCATAGTATT CCATGGTGTA TATGTGCCAC ATTTTCTTTA TCCACTCTAT CATTGATGGG CATTTGGGTT 010320
010321 GGTTCCAAGT CTTTGCTATT ATGAACAGTG CTGCAGTAAA CATACGTGTG CATGTGTCTT TGTAGTACAG TGATTTATAA 010400
010401 TCCTTTGGGT ATATACACAG TAATGGAATT GCTGAGTCAA ATGGTATTTC TGGTTCTAGA TCCTTGAGGA ATTGCAACAT 010480
010481 TGTCTTCCAC AATGGAACAA CCAGTTCTCT TAAGAATAAA AGTGAGAACT CACTTCCCTG GCCCCAGAGA GAGCAAAAGC 010560
010561 AATTCATCCC CATCACCCAA ACACCTCCCA TTAGGCCCTA CCTCCAACAT TGGGATCAAA TTTCAACATG AGGTTTTTAG 010640
010641 GGGACAAACA TCCAAACTAT GTCACAAGAC AATTCATGTA AGCAGCCTCT AAAAGATGGA AGAGGCAAGG AAACAGATTC 010720
010721 TCCCCTAAAG CCCACAGAAG GAAAGCAGCC CTGCCAACTT CTTGATTTTA ACCCAGTAAG ACCCGTTTTG GACTTTGGAC 010800
010801 ACCAAGAGCT ATAAGATGAT TATGTTGTTT TAAGCCATTA AGCTTGAGGC AATTTGTTAC AGCAGCAATT GGAAACTAAT 010880
010881 ACAGATCACA TTCTAATTCA ATTAGTATTG TTCCCAGTTC TCTGGACCTC AGATTTCTTT CCTGAAAAAC ATTAAAAATA 010960
010961 ATACCTGAAA GTTTTGCACA CGAGTGCAGA GTGCCTATTT ACTAGAGAGA TCAGCATTTG TTTAGGCTCT GAATAGATTT 011040
011041 GAGGATGAAA TTAAATAGCA TAAATAAAGT TCCTAGTGAT GCTTCTGATA AAAAAATATC TCCTTCAAAA TGCCAGAGGC 011120
011121 AGGTCCTAAA AACCCACAAA GCAGGTGAAC TGGCAAAAGA CTGTAAAAAG CAAAGTAGAG GTTCCTCTTC AAAGACTTTC 011200
011201 CTCTCCATCT AATTAGGAAT AAATAGTAAC TTATCTTAGA AACAAAATTT ATTCAAAGAC CTGTGCTAAC ATTCTGAAAT 011280
011281 ATCTGCTAGC CGTAATAAAT AAATCGATGT ACTTTATGTT CTTAGCTCCC ACAATTTAAC CTAAATATTT GCCCTGGCAT 011360
011361 GCTTATACTG GTCCAAGCAA GCATTAGGTC ATAGCCTGTT CCTCTTCTTT ATTTTAAGGT GTTTTTACCT TTGTCAGCAT 011440
011441 GCCACAAGTT ACTTCCTCCT TCCTTTGTTC TCCTCTGCCT TTGACTCTTT TAAAGAGTCC TAAGTTGCTA GCCAATCAGG 011520
011521 ACAAATACAG AATGTGAGGT CCCGTTTCAG CCAATGGAAA GTGGACACAG CAGGAAGGTG GATGGGTCAG GTTATAAATG 011600
011601 ACCCTGTCTC CTTTGTTCGG TGTACTCTTG TGGCAAAACT GCTGGCAAGT GTACCCTTTC TGCAATAGGT AAAAACTGCC 011680
011681 TTGCTGAGGA AATTAAATTT ATGTTCAAGT GCTATTTCTT TATGGCACCG GGGAACAAGC ATTTCTAACA AGACTATGTA 011760
011761 ATTTAATTTC AGGAACCTAA AAAAGTGGGA TGAAGAACTG AGGTTGCTAA TAAATCTATA CAACTTATAA GTAAATATTT 011840
011841 AATTTACTAA CATATAATAA TAAAGACATC ATTGTAAGAC AATGTTAAAA CATTTTACAC ATTTTAAATG TGCAATAGTA 011920
011921 AATCCTTCAC TATTCAGGGA TTATTTGGAA TCCCTTGTCA CCAGAAGCTC TTAAGGAAAT AACTTCTACT TCGTTGCAAA 012000
012001 TATGTTCTTG GCTTAGTTGA GGTAATGCAA ATACTAGAAT ACTTGTTTGT TTAACAGCTT ATTCTTCCCT GAAGCTGTTC 012080
012081 CTCCAGTCCC TGCCAGTGGG ATCTTATGTC TCCAGGAGTA CTTAACACCC CTAATAGCCC CATCTTTTAA GCCTCCCTGG 012160
012161 GACCTGCCCT CGCAGTACCT CTTATACCTA CTCCACTTCC TCCTCATGGC CTCCTGCAGA ATGCCATTCT AAAATTAGGT 012240
012241 TCTATTTTCC TCGCCCGCAT TCTCTTTTGC AAAGCCTCCA AAAAATTTAC TTTGCTTCTC TGCGCCTGCT TTATCTCTAT 012320
012321 TTTCTACACT CGCTCCTTCT TTTTCTAATT ATCTATAATA GGCGTCACAA AATTTGCATT TGTTGGAACC AAAATTTCCA 012400
012401 TGGTTGCCTC AAAATATACA GATGTAAATT TGCATATAAT TAAATTTTGC ATAAGGGAAA CTCTCATTTG GGGAGATATG 012480
012481 CAATGCCCAA TAAATGGCAG TTTCCTTCAA TGTCCCCAGG CCAGCCTCCC AGTCTGTGTG TTTCCCCCTG GCTGCAGCTA 012560
012561 CCAGGACTCT GCTCTGGGGA TTTACGGACA AGGGTATCAA GTTTTAATTA AACTAACCCT CTCAAACTGA ATGAGTGGCT 012640
012641 TAAAATCTTC CTGTAAAGAA ACCGCAAAAT AATAATGCTG GCATTGAGAA GTAAGAAAAG AGCGAGCCAG CACCCCCACC 012720
012721 CC
