Difference between revisions of "CDRT3"

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(Expression)
(Function)
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===Function===
 
===Function===
[[File:LeXis functions as a ceRNA of β-catenin.jpg|right|thumb|LeXis functions as a ceRNA of β-catenin([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)])]]
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Please input evolution information here.
LeXis binds with heterogeneous ribonucleoprotein Raly which contains both an RNA-binding domain and a leucine-zipper coiled domain, to affect the expression of srebf2 gene, resulting to the change of the level of SREBP-2(sterol regulatory element-binding protein), to modulate cholesterol metabolism([https://www.ncbi.nlm.nih.gov/pubmed/27251289 (Sallam T 2016)]).
 
 
 
LeXis positively regulates CTNNB1 expression by functioning as a ceRNA against miR-199a to promote osteosarcoma growth([https://www.ncbi.nlm.nih.gov/pubmed/28744406 (Wang G 2017)]).
 
  
 
===Disease===
 
===Disease===

Revision as of 03:17, 28 July 2019

Annotated Information

Name

Approved symbol: CDRT3

Approved name: CMT1A duplicated region transcript 3

HGNC ID: HGNC:14382

RefSeq ID: NR_146601

Characteristics

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Expression

CDRT3 reveal no expression in adult tissues but obvious expression in fetal tissues.((Inoue K 2001))

Regulation

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Function

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Disease

  • osteosarcoma
  • colon adenocarcinoma [1]

Evolution

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Labs working on this lncRNA

  • No.4 Department of Orthopedics, Cangzhou Central HospitalCangzhou, Hebei Province, China
  • Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, California 90095, USA.

References

  1. Shahriyari L. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma. Brief Bioinform. 2017 Nov 3. doi: 10.1093/bib/bbx153.

Annotation originally sourced from lncRNAdb.