Difference between revisions of "LINC01671"
Qianpeng Li (talk | contribs) |
|||
| Line 2: | Line 2: | ||
==Annotated Information== | ==Annotated Information== | ||
===Name=== | ===Name=== | ||
| − | LINC01671:long intergenic non-protein coding RNA 1671 | + | Approved symbol: LINC01671:long intergenic non-protein coding RNA 1671 |
| − | BC041455 <ref name="ref1" /> | + | Alias symbols : BC041455 <ref name="ref1" />, AP001626.1<ref name="ref2" /> |
| + | |||
| + | HGNC ID : HGNC:52459 | ||
| + | |||
| + | LncBook transcript ID: HSALNT0289350 | ||
===Cellular Localization=== | ===Cellular Localization=== | ||
BC041455 is located in cytoplasm <ref name="ref1" />. | BC041455 is located in cytoplasm <ref name="ref1" />. | ||
| Line 11: | Line 15: | ||
[[File:BC041455.fcgi.jpg|right|thumb|400px|'''Overexpression of the oestrogen-repressed lncRNA BC041455 inhibits breast cancer cell proliferation and viability as well as a growth factor signalling pathway, while knockdown of the same lncRNA enhances breast cancer cell proliferation and viability''' <ref name="ref1" />.]] | [[File:BC041455.fcgi.jpg|right|thumb|400px|'''Overexpression of the oestrogen-repressed lncRNA BC041455 inhibits breast cancer cell proliferation and viability as well as a growth factor signalling pathway, while knockdown of the same lncRNA enhances breast cancer cell proliferation and viability''' <ref name="ref1" />.]] | ||
BC041455 regulates proliferation and viability of human breast cancer cells <ref name="ref1" />. Overexpression of the oestrogen-repressed lncRNA BC041455 inhibits breast cancer cell proliferation and viability as well as a growth factor signalling pathway <ref name="ref1" />. | BC041455 regulates proliferation and viability of human breast cancer cells <ref name="ref1" />. Overexpression of the oestrogen-repressed lncRNA BC041455 inhibits breast cancer cell proliferation and viability as well as a growth factor signalling pathway <ref name="ref1" />. | ||
| + | |||
| + | AP001626.1 is reported to have an important role in the carcinogenesis of gastric cancer by an informatic analysis<ref name="ref2" />. | ||
===Expression=== | ===Expression=== | ||
BC041455 is down-regulated following E2 treatment in breast cancer cells <ref name="ref1" />. | BC041455 is down-regulated following E2 treatment in breast cancer cells <ref name="ref1" />. | ||
| + | |||
| + | AP001626.1 is up-regulated in gastric cancer<ref name="ref2" />. | ||
| + | {| class='wikitable' style="text-align:center" | ||
| + | |- | ||
| + | ! | Experiment | ||
| + | ! | Forward primer | ||
| + | ! | Reverse primer | ||
| + | |- | ||
| + | | rowspan="1"|Quantitative real-time PCR | ||
| + | | | 5'-AGCTGCACCAAGGAGAATC- 3' | ||
| + | | | 5'-CAAAGCCAAGGTCCACTGTT- 3'<ref name="ref2" /> | ||
| + | |} | ||
| + | |||
===Regulation=== | ===Regulation=== | ||
BC041455 is repressed by oestrogen <ref name="ref1" />. | BC041455 is repressed by oestrogen <ref name="ref1" />. | ||
===Diseases=== | ===Diseases=== | ||
Breast cancer <ref name="ref1" /> | Breast cancer <ref name="ref1" /> | ||
| + | |||
| + | Gastric cancer<ref name="ref2" /> | ||
===Evolution=== | ===Evolution=== | ||
BC041455 is primate-specific as it has primate-specific splice site and primate-specific polyA signal <ref name="ref1" />. | BC041455 is primate-specific as it has primate-specific splice site and primate-specific polyA signal <ref name="ref1" />. | ||
| Line 50: | Line 71: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1">Lin CY, Kleinbrink EL, Dachet F, Cai J, Ju D, Goldstone A, Wood EJ, Liu K, Jia H, Goustin AS, Kosir MA, Thepsuwan P, Lipovich L. Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells. Open Biol. 2016 Dec;6(12).</ref> | + | <ref name="ref1">Lin CY, Kleinbrink EL, Dachet F, Cai J, Ju D, Goldstone A, Wood EJ, Liu K, Jia H, Goustin AS, Kosir MA, Thepsuwan P, Lipovich L. Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells. Open Biol. 2016 Dec;6(12). |
| + | </ref>(1) | ||
| + | <ref name="ref2"> | ||
| + | Wang Y, Zhang J. Identification of differential expression lncRNAs in gastric cancer using transcriptome sequencing and bioinformatics analyses. Mol Med Rep. 2018 Jun;17(6):8189-8195. | ||
| + | </ref>(2) | ||
</references> | </references> | ||
Latest revision as of 04:03, 7 August 2019
Contents
Annotated Information
Name
Approved symbol: LINC01671:long intergenic non-protein coding RNA 1671
Alias symbols : BC041455 [1], AP001626.1[2]
HGNC ID : HGNC:52459
LncBook transcript ID: HSALNT0289350
Cellular Localization
BC041455 is located in cytoplasm [1].
Function
Overexpression of the oestrogen-repressed lncRNA BC041455 inhibits breast cancer cell proliferation and viability as well as a growth factor signalling pathway, while knockdown of the same lncRNA enhances breast cancer cell proliferation and viability [1].
BC041455 regulates proliferation and viability of human breast cancer cells [1]. Overexpression of the oestrogen-repressed lncRNA BC041455 inhibits breast cancer cell proliferation and viability as well as a growth factor signalling pathway [1].
AP001626.1 is reported to have an important role in the carcinogenesis of gastric cancer by an informatic analysis[2].
Expression
BC041455 is down-regulated following E2 treatment in breast cancer cells [1].
AP001626.1 is up-regulated in gastric cancer[2].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Quantitative real-time PCR | 5'-AGCTGCACCAAGGAGAATC- 3' | 5'-CAAAGCCAAGGTCCACTGTT- 3'[2] |
Regulation
BC041455 is repressed by oestrogen [1].
Diseases
Breast cancer [1]
Gastric cancer[2]
Evolution
BC041455 is primate-specific as it has primate-specific splice site and primate-specific polyA signal [1].
Sequence
>NR_131192.1 Homo sapiens long intergenic non-protein coding RNA 1671 (LINC01671), long non-coding RNA
000001 CAGGTCCTGT GACAACAGGT ACGGGCCAGC ATTGGGACAG GCTTTGCCTG TAAGAGGGCT GGTCTGGGGG GACATCTGAA 000080
000081 CCCAATTCAG GAACACCTCA CAGGTCTGCC AGCAGGGCTA GACCCGGGGT GAGATCCAGG GCAACAGGGT CTGCCTGGGA 000160
000161 AGCTCAGCTC CGGCACTGCC TGGGGCGTCT CTGCCTACAC AGGACCATTC CTCTCGCCTG GACTCCTCTT GGAGTTTGCC 000240
000241 AAGGCTGGCC TCTGCAGAAA TAGGAGACTC CTGGAGGAAG ACAGTGGACT TCAGCAAGCT GCACCAAGGA GAATCCACAG 000320
000321 CGGCAGCTGC CCTGCCAGGC GCGGGATCTC GGTCAAGGTG GATCAACACA GCCTCAGGTG TGTGCTCTGC CCCACTGAGA 000400
000401 TGGCAAGTGC ATTCTTTTCT ATTCCTACGA GGAAAGAGCA TCCGAAAGAG CCTGCCTTCA CATAGGATGA ATAACAGTGG 000480
000481 ACCTTGGCTT TGCCTCAGTG TTATGTGCTA ATAAACCATG TATTCTATGC CCTAAGGAAG CCCAGAGAGA ACTGGACAAG 000560
000561 CTGGATATCC CAAAGAGCAT GGCACTGGCC CACCACATTG ATTACATTGC GCTGGCCGGG TGCTAACCAA GAAGCAGCTA 000640
000641 ACACACTGGG AGTCTTGGTA AGATGCCTGA GTGCCTGCAG CTGGCAGACA AATCCTACAA AGATTCTGGG AACTGCCACT 000720
000721 AATAACACTC TTGGTGGGGA GGTCCCATAT CCCATAACCA GGAGCATACT GGGCCTCCTG TCCACAGCAA AGAGCCAATT 000800
000801 ACTGCATCTT GCATCTCCCA TGACCAAGAG AGACAGACAA TGCCAGTACG CCTTCTGGAG GCAGCACGTT CCACACACAT 000880
000881 GAAGACTACT CCAGCCTATG TACCATTGAT AGGAGAAGCT GTCGGCCTTC CCTGAGCCTG CAGCAGGTCG AGGCTGCAGT 000960
000961 GCTGGCAGCC CTGTGACTCA GGCCCTGCAG CTGGTCGGAC CCTGTGTTAT GAGAGGTATC AGACGTGGGA AAGCAATGCT 001040
001041 GTGTGTTTAT GGCAAACCAC TATGCCAGAA TCACAGTGCA GGCCCCTGGG ATTCAGAAAC AAAGCCGTGC CATCTGCGGC 001120
001121 AGAGGATTCT GCGAAAAATT CTGAAAAGTC CCTGTTGATG TGCTCCTGGG GCCTGGGGTG ATGGAATACC TGATTGTGCA 001200
001201 TGTGGAACTG CTCAGATGAG CTGGATTCTG TCTCACCCCT GGGTCATGAG GTTGGGGACT CAGAAATAAC CCATCACAGG 001280
001281 TGGGAGTGTG CGTGTGGCAG CAGCAGAAGC AGGAGCAGGA GGCCAAGCAG CGGCAGCTGC CCAGTACCCC CCCCCACCCT 001360
001361 CCACAGCAGT CCCCACAGCC CCAGTGGAGG AACCTTCTGG TGAACTGAGG AGGGAGGGAC AAGCCCGGCC TCAGTTCATG 001440
001441 GAGGTGTCTG CTCTGCCTGT GGGGCCAGCC CAAATCGCCT GGCTGCCATA CTCCAGTCTC AGCAAGCTGC CCTTTAAAGA 001520
001521 GGGTGATATG GTTTGGCTCT GTGTCCCCAC CCAAATCTCA TCTTGAACTG TAATCCCCAG GTGATGAGGG TGAGACCTGA 001600
001601 TGGGAAGTGA TTGGATCATG GGGGCTGTTT TCCCCATGCT GTTCTCGTGA TAGTGAAGGA GTTCTCATGA GATCTGATGG 001680
001681 TTTTATAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA
000081 CCCAATTCAG GAACACCTCA CAGGTCTGCC AGCAGGGCTA GACCCGGGGT GAGATCCAGG GCAACAGGGT CTGCCTGGGA 000160
000161 AGCTCAGCTC CGGCACTGCC TGGGGCGTCT CTGCCTACAC AGGACCATTC CTCTCGCCTG GACTCCTCTT GGAGTTTGCC 000240
000241 AAGGCTGGCC TCTGCAGAAA TAGGAGACTC CTGGAGGAAG ACAGTGGACT TCAGCAAGCT GCACCAAGGA GAATCCACAG 000320
000321 CGGCAGCTGC CCTGCCAGGC GCGGGATCTC GGTCAAGGTG GATCAACACA GCCTCAGGTG TGTGCTCTGC CCCACTGAGA 000400
000401 TGGCAAGTGC ATTCTTTTCT ATTCCTACGA GGAAAGAGCA TCCGAAAGAG CCTGCCTTCA CATAGGATGA ATAACAGTGG 000480
000481 ACCTTGGCTT TGCCTCAGTG TTATGTGCTA ATAAACCATG TATTCTATGC CCTAAGGAAG CCCAGAGAGA ACTGGACAAG 000560
000561 CTGGATATCC CAAAGAGCAT GGCACTGGCC CACCACATTG ATTACATTGC GCTGGCCGGG TGCTAACCAA GAAGCAGCTA 000640
000641 ACACACTGGG AGTCTTGGTA AGATGCCTGA GTGCCTGCAG CTGGCAGACA AATCCTACAA AGATTCTGGG AACTGCCACT 000720
000721 AATAACACTC TTGGTGGGGA GGTCCCATAT CCCATAACCA GGAGCATACT GGGCCTCCTG TCCACAGCAA AGAGCCAATT 000800
000801 ACTGCATCTT GCATCTCCCA TGACCAAGAG AGACAGACAA TGCCAGTACG CCTTCTGGAG GCAGCACGTT CCACACACAT 000880
000881 GAAGACTACT CCAGCCTATG TACCATTGAT AGGAGAAGCT GTCGGCCTTC CCTGAGCCTG CAGCAGGTCG AGGCTGCAGT 000960
000961 GCTGGCAGCC CTGTGACTCA GGCCCTGCAG CTGGTCGGAC CCTGTGTTAT GAGAGGTATC AGACGTGGGA AAGCAATGCT 001040
001041 GTGTGTTTAT GGCAAACCAC TATGCCAGAA TCACAGTGCA GGCCCCTGGG ATTCAGAAAC AAAGCCGTGC CATCTGCGGC 001120
001121 AGAGGATTCT GCGAAAAATT CTGAAAAGTC CCTGTTGATG TGCTCCTGGG GCCTGGGGTG ATGGAATACC TGATTGTGCA 001200
001201 TGTGGAACTG CTCAGATGAG CTGGATTCTG TCTCACCCCT GGGTCATGAG GTTGGGGACT CAGAAATAAC CCATCACAGG 001280
001281 TGGGAGTGTG CGTGTGGCAG CAGCAGAAGC AGGAGCAGGA GGCCAAGCAG CGGCAGCTGC CCAGTACCCC CCCCCACCCT 001360
001361 CCACAGCAGT CCCCACAGCC CCAGTGGAGG AACCTTCTGG TGAACTGAGG AGGGAGGGAC AAGCCCGGCC TCAGTTCATG 001440
001441 GAGGTGTCTG CTCTGCCTGT GGGGCCAGCC CAAATCGCCT GGCTGCCATA CTCCAGTCTC AGCAAGCTGC CCTTTAAAGA 001520
001521 GGGTGATATG GTTTGGCTCT GTGTCCCCAC CCAAATCTCA TCTTGAACTG TAATCCCCAG GTGATGAGGG TGAGACCTGA 001600
001601 TGGGAAGTGA TTGGATCATG GGGGCTGTTT TCCCCATGCT GTTCTCGTGA TAGTGAAGGA GTTCTCATGA GATCTGATGG 001680
001681 TTTTATAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA
Labs working on this lncRNA
- Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, USA.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Lin CY, Kleinbrink EL, Dachet F, Cai J, Ju D, Goldstone A, Wood EJ, Liu K, Jia H, Goustin AS, Kosir MA, Thepsuwan P, Lipovich L. Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells. Open Biol. 2016 Dec;6(12).
- ↑ 2.0 2.1 2.2 2.3 2.4 Wang Y, Zhang J. Identification of differential expression lncRNAs in gastric cancer using transcriptome sequencing and bioinformatics analyses. Mol Med Rep. 2018 Jun;17(6):8189-8195.