Difference between revisions of "LUARIS"

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LUARIS:lncRNA upregulator of antiviral response interferon signaling
 
LUARIS:lncRNA upregulator of antiviral response interferon signaling
  
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lncRNA#32<ref name="ref1" />
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Alias symbols：lncRNA#32<ref name="ref1" />，SCAT6
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LncBook transcript ID: HSALNT0289157
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 +
 
 
===Characteristics===
 
===Characteristics===
 
Human lncRNA#32 (LOC100506895) is located on chromosome 7p13 and overlaps with the antisense strand of the HECW1 coding gene located within introns 21 and 22 and exon 22. And lncRNA#32 transcript is 2,946 nt in length.<ref name="ref1" />
 
Human lncRNA#32 (LOC100506895) is located on chromosome 7p13 and overlaps with the antisense strand of the HECW1 coding gene located within introns 21 and 22 and exon 22. And lncRNA#32 transcript is 2,946 nt in length.<ref name="ref1" />
  
 
===Function===
 
===Function===
 +
[[File:LncRNA-32 func.jpg|right|thumb|400px|'''lncRNA#32 regulates ISG expression'''<ref name="ref1" />.]]
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LncRNA#32 has a critical role in ISG expression. The targeted depletion of lncRNA#32 leads to a reduction in the mRNA levels of several ISGs, including 2′-5′-Oligoadenylate Synthetase Like (OASL), Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2), interferon gamma-induced protein 10 (IP-10), apolipoprotein B mRNA editing enzyme catalytic polypeptide 3A (APOBEC3A), and apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3G), and results in a significant increase in the replication of encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), and HCV, all of which are human pathogens. In contrast, the overexpression of lncRNA#32 increases ISG mRNA levels.<ref name="ref1" />
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The higher expression of all SCATs including SCAT6 is correlated with poor overall survival in KIRC<ref name="ref2" />.
  
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LncRNA#32 has a critical role in ISG expression. The targeted depletion of lncRNA#32 leads to a reduction in the mRNA levels of several ISGs, including 2′-5′-Oligoadenylate Synthetase Like (OASL), Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2), interferon gamma-induced protein 10 (IP-10), apolipoprotein B mRNA editing enzyme catalytic polypeptide 3A (APOBEC3A), and apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3G), and results in a significant increase in the replication of encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), and HCV, all of which are human pathogens. In contrast, the overexpression of lncRNA#32 increases ISG mRNA levels.<ref name="ref1" />
 
 
===Regulation===
 
===Regulation===
−
lncRNA#32 is stabilized by heterogeneous nuclear ribonucleoprotein U (hnRNPU) and functions through interactions with activating transcription factor 2 (ATF2). <ref name="ref1" />
+
LncRNA#32 is stabilized by heterogeneous nuclear ribonucleoprotein U (hnRNPU) and functions through interactions with activating transcription factor 2 (ATF2). <ref name="ref1" />
 
===Expression===
 
===Expression===
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[[
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[[File:LncRNA-32 expression.jpg|right|thumb|400px|'''Expression of lncRNA#32 in human tissues'''<ref name="ref1" />.]]
 
RT-qPCR experiment shows that expression of lncRNA#32 is expressed at variable levels in a wide variety of tissues.<ref name="ref1" />
 
RT-qPCR experiment shows that expression of lncRNA#32 is expressed at variable levels in a wide variety of tissues.<ref name="ref1" />
  
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interferon-stimulated gene expression. Proc Natl Acad Sci U S A. 2016 Sep
 
interferon-stimulated gene expression. Proc Natl Acad Sci U S A. 2016 Sep
 
13;113(37):10388-93.
 
13;113(37):10388-93.
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</ref>
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</ref>(1)
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<ref name="ref2">
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Ali MM, Akhade VS, Kosalai ST, Subhash S, Statello L, Meryet-Figuiere M, Abrahamsson J, Mondal T, Kanduri C. PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers. Nat Commun. 2018 Feb 28;9(1):883. doi: 10.1038/s41467-018-03265-1.
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</ref>(2)
 
</references>
 
</references>

Latest revision as of 13:39, 7 August 2019

Annotated Information

Name

LUARIS:lncRNA upregulator of antiviral response interferon signaling

Alias symbols：lncRNA#32[1]，SCAT6

LncBook transcript ID: HSALNT0289157


Characteristics

Human lncRNA#32 (LOC100506895) is located on chromosome 7p13 and overlaps with the antisense strand of the HECW1 coding gene located within introns 21 and 22 and exon 22. And lncRNA#32 transcript is 2,946 nt in length.[1]

Function

lncRNA#32 regulates ISG expression[1].

LncRNA#32 has a critical role in ISG expression. The targeted depletion of lncRNA#32 leads to a reduction in the mRNA levels of several ISGs, including 2′-5′-Oligoadenylate Synthetase Like (OASL), Radical S-Adenosyl Methionine Domain Containing 2 (RSAD2), interferon gamma-induced protein 10 (IP-10), apolipoprotein B mRNA editing enzyme catalytic polypeptide 3A (APOBEC3A), and apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3G), and results in a significant increase in the replication of encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), and HCV, all of which are human pathogens. In contrast, the overexpression of lncRNA#32 increases ISG mRNA levels.[1]

The higher expression of all SCATs including SCAT6 is correlated with poor overall survival in KIRC[2].

Regulation

LncRNA#32 is stabilized by heterogeneous nuclear ribonucleoprotein U (hnRNPU) and functions through interactions with activating transcription factor 2 (ATF2). [1]

Expression

Expression of lncRNA#32 in human tissues[1].

RT-qPCR experiment shows that expression of lncRNA#32 is expressed at variable levels in a wide variety of tissues.[1]

Sequence

>NR_038276.1 Homo sapiens lncRNA upregulator of antiviral response interferon signaling (LUARIS), long non-coding RNA

000001 CAGCCTTCAT GAAGAGCCCA TGGCAACTCT GTGGGAATCC TTCCAGCAGC CCGCTTATGG CTGGAGACAG AGGTGTGGCT 000080
000081 TCTATCTAAG CTTTTCCCTC TGACTCAGTC CAGGAGGCAA CTGTCTTGGG AAGCAAATGA TAACAGCATC TGGGAGATTC 000160
000161 TCTTCTGGAT GGACTAGCAG GGAATCAGGA CATGAACTCA GTGGACTAAC TGCACCGAGA CTCACCTGGT CATTACTTGA 000240
000241 AGGTCATTAC TTAAACCTCC ATGAATCTCC TGATGAACTC CCTCAGAAGG TGGAAGGAGC ACCTGACACC GACCCGAGAT 000320
000321 CAGCAGCAGC TACGCCCACG CTGTGGGCAG TTAAGAGGCA GCCAGTGGTA CCAGTCGTGA GCGATCAGAT TTGAGGACTC 000400
000401 AGGATTCTGG TTTCCTGAGT GTCATGGACC TGCGGGCTGC AGAAATGACA GCGACAGGTC TTCAGGCAGG TGCCACAGCA 000480
000481 CCCACACACT GCCAGCATTT TGTGCAAAAT ACCCAAAGCC ACATCACCAG ATCTGGGCTC TCCTAGCTTC CCTTTGCTAA 000560
000561 AATGCTGGCC AAAGAGCTTA ACGAGCCACT CAGGGGCACA AGATAGGTGA AACCTGCATG TTTTGTTTGT TAAACTATTT 000640
000641 GCCACATGGC ACAAGAAAAT AACAAAAAAT AAACAAAAGG AATAACTGCA GCATCATGGT TTTGTTAAGA TGTCCCAAAG 000720
000721 CTGATCAGGG CTTCCTGTTG AAATCTAAAT GAGACTCTTC CTAGGTGGCT TACATTCAGT CAGCTGTGGC TCTGTGCAAA 000800
000801 GAAAACCAGT TTCCCTTGCT CAGAAATTTG GAGCCACTGA TAAGAGAAGA AAAGTGTGAT TCCACATGGA GGGTCATGAT 000880
000881 ACAATCTGAT CTCTGACCCC GTGGAGGTGA AGGGGCTTGT TCTGCATGCC AGGCTGAGGA CTCTCGGGAC TGAGGCATTC 000960
000961 AGAGTCGCAG CTTTAAATCA TAAGGGTTCC CTGCCCATTT CATCACAAGT CAGCAGCATC CAAAGAGTGG CGTTGAAGAA 001040
001041 AATCTCATCA CCGTGGGCTC AGTTTAGATT GCTAGTCGGC TCAGAAAGCT ACCTGCAATT GCGTTTCCAG GATGCACCAC 001120
001121 AAATACTCTC CACATGAGGG AGAACATCAG TGGATGAAAC TCAGCATGCT TAGTGCGGGG CCAAGTCCTC TAACAAAGGA 001200
001201 CACAGCGGTT AACCTGCATT TCGAGGACAG GCACTGTCAA GCCCTCATCA GGGATCCATC CAGAGAACTT TGGTAATTCT 001280
001281 TGCAAAATCC CTGTATCACA CAATTTCCTT CCTTAATGTG ATGAAGTGTA ACGGACACAT CTATAAAGCT TCTTCAGTCC 001360
001361 TGCAATGCAT AGATGAGCAG AAGGCCACAA AGCCAGGTCA TAGCACTCTC TACCATCAGA ATGGAGCCTG CCTGAATGTG 001440
001441 AGCTCAGTGA GAGGCAGATT CCATTCTTGG GCCCGTCCAC GGTGACTTGT CTGCTCTGCT CCATCATCCA CTTATTCACA 001520
001521 AGTTCTGGGG CAACAAAGGG CACGTTTTGT TTCATCTTGT GCCAAACCCT CGATGTGTAC TCACTCACTC TACCTCATCT 001600
001601 CAAGAACTTC AGGGCTGGGA GTGCATTTGG AGAGAAGGCA TGTGCAATAT CTGGAAGCCT TAGCACAGGT GGGTTATACT 001680
001681 GATGCTCTAT AGCCAAACTA TAGGAACTTG GGTTCTAAGG CCAGCAGGCC CAGGTGTCAC CCCAATGGCT CCCTTCAACA 001760
001761 GCAGCATAAA TAAGTCATGT CAGAAGAACT CACATTAGCC ATCTCCAGGA CTCATTTCCC TCTCAACAGC AGGAGCTCCT 001840
001841 GCAGTCAGAA CA