Difference between revisions of "NIPBL-AS1"

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===Disease===
 
===Disease===
 
autism spectrum disorders
 
autism spectrum disorders
===pubmed IDs===
 
24007600
 
 
===Sequence===
 
===Sequence===
 
>gi|374532768|ref|NR_046262.1| Homo sapiens NIPBL antisense RNA 1 (head to head) (NIPBL-AS1), long non-coding RNA
 
>gi|374532768|ref|NR_046262.1| Homo sapiens NIPBL antisense RNA 1 (head to head) (NIPBL-AS1), long non-coding RNA

Revision as of 05:17, 10 August 2019

Annotated Information

Approved Symbol

NIPBL-AS1

Approved Name

NIPBL antisense RNA 1 (head to head)

Characteristic

NIPBL-AS1 is a long non-coding RNA transcribed upstream and antisense to NIPBL[1]

Function

lncRNA NIPBL-AS1 has no role for NIPBL expression, but its transcription reduces the expression of the NIPBL gene and vice versa, thus revealing an mechanism for the fine-tuning of expression levels.[1]

Synonyms

NIPBL-AS

Chromosome

5p13.2

RefSeq ID

NR_046262

Disease

autism spectrum disorders

Sequence

>gi|374532768|ref|NR_046262.1| Homo sapiens NIPBL antisense RNA 1 (head to head) (NIPBL-AS1), long non-coding RNA

000001 ACTCCACTTC CGCCACCGCC GCAGCCGCCG CTGCCGCCAC TTGGGCTCGC GTCCTCGGCC GCGCCGCGCG GCACCCGGGC 000080
000081 CCAGCAGCCG GGAGGCGGCA GCTCTCCTCT ACGCCCGTCC CCTCAGGGCG GCTGTGGATG TTGCCAGTAT TGTCGATGCT 000160
000161 TCAGAGCGAC GTTTGCCCTG CGACACAGGC GGGCCGGCTC TCCTCTGTCT TTATTTTCCT GGAGGCCGAC AGGAGCGGGG 000240
000241 CCCGAGTTCG GTGGTGGTCG TGAGCGTGGG GGGCACTCAG GCCCGGACGG GCTCTCAGGT CGCCGACGGC GGCGGCTGGA 000320
000321 GGCCGCGCTG GCTGTCCCAG GTCGTCGTTA GCTTTAGGGA GCCGATCTCC GGGCGGCCCC ACAGAGGACG CCCGCGATTC 000400
000401 GATGGCGATG ATGCCCGTTT TAAATGGTGT CCCTGCAGCC GGGTGGATGG ATGGATCGTA CACCTTGCCT TTTGAGAGCC 000480
000481 GGGACCTTAC GCCCGACTGC GTGTTATTTC TGCGAATAAG AACGCAACCT TTGGAGGTGA AGACGACTGT CGGCTGGATT 000560
000561 GAATTGGAAT CGTGTTTGTG ATGATGCGTT TATTTCTGGA AATACGCGGT CTCCGCTGCT TTTGCTTTTT GTCGGCAGAG 000640
000641 GTTTGGGTTC TTCTCTAACG GTCAGGATAA AGGCCTGTAG GCGACGCTGC GCGAGCGAGA AGCTCGCCCG CGGCTGCCCG 000720
000721 GGCGCCCCCC TCTAGGTGTG GGTGGAGCCG AGCGCGCGGG GAGAACCGCC GGCCCCGACT CAGCCACCGG TGACTGCGGG 000800
000801 CGACCCGCGG GCCTGCGGCC AGCTGATTTC AAACATCGTT TTCCTCTTTA GGTTCGGAAA ACTGAGGCGC TGGACAAGGC 000880
000881 TGGAATACAA TATGTGATTA TACGTACAGT ACTATGGTTG TTGTAGTTTT TAAATTGTAA AACAAGAAGT AACCATTGTT 000960
000961 CCACCGTTCT CTATTAAGTT TGTGTAAATT AAAAAGGGGC TATTTTCGGT AAAAAGTGCA GTAGGTAAGC GGAATTTTAC 001040
001041 TCAACCGGGA CGAAATTCGT GTTATATGAA TTGTATTGTG TATTTGTGTG TGTACCAGTG CGCTAAAAGT AAGTAGGAAA 001120
001121 ACTTGCTTAG ATTATTCCTT TTGCCTCAGG CCACTCAGGG GGCCAAGATC CTGTCACTCC TTTTCTCTAG GCCCTGCGAA 001200
001201 TGGCTTCCCG TCTTGAGGGG AGTGAGCCAA AGCCTTGACT GCGGCAGAAG TCCCCGCGCG CCGTTGAGGG TGGGGGCGGG 001280
001281 CCTGCCCTGG CATCCTTGCG AGTAGGACTC TTCCCTGAGC GTCGTCCACA GGGCTTGCTC CTTCACCTTC AGGATTTTGC 001360
001361 TCGTGTCACT CGGTGCTTCC GCGGCTACTT TTAAACTGAA AGTTCCCTAG CCCCCTTCTC ATTTTATCCT TTGGACAGTC 001440
001441 TACATATCCA TACTTGTTTA TCTTCTTATC TCTCCTTCCC CAGTGCAATG TAAGCTCTAA GAGGACAAGA GGTTGTGTTT 001520
001521 TTCTGCACTG GTGTTACGGC CCCCGCCTAG AATGCCACAC AGTAGATGCG TAGTATGTGG TTAAGGAATG AATGCGATTA 001600
001601 TAAGGGCCTT GATGCTCCCC CATTTCTGTC TTTAATATGT ACTTATATGC TACAGAGAGC TTTATAAAAG ATTTAAAACA 001680
001681 CGTTTATTAC AGAATTCTAT AAAAATATAT TGCTTCTAAA CATTGGAAAG CCCTCCACAA CACCAGAAAC CCACAAATGA 001760
001761 GGGATAAAAT TTGTTTTTAG GCTTCTGTAA ATGAGCATGC CCGAGGACAG TGCATCAAAT GATCATATCC ATACTGGGCC 001840
001841 GATTATGTTT GCTCTTCTGA GTCTCAAACT GCATTCTTCA TCTTGTCGTC CTCTGTCTTT CAAAATACAT TAAAAGTGAG 001920
001921 AATTTGGTTG GCTCAGAGCA AATCCAGCAC TATTGGAAAA GTTCATTCAG CAAGTATTTA TTGGGCACAA ATGGGTACCA 002000
002001 GGCACGCTAA TTCAAAAGGT GTGTGTTTCT GAGGCTAGAA GGCCTTACAT AAAGGACCAC ATGTGGCTAC TTTGGTTGCT 002080
002081 ACTCAATTAT GCTGTCAAGC AAAGCAAATG CTAGTGAAAT TTATTTTTAG TTTTCTTCTG AAGAAAAGGT TCAATGAAAG 002160
002161 CTGAGGTCAG GCTTGGTGTG GATATTTTAA TTCACCATTT AGTTTGCTGT TTGCTTACAC TTAGGTTAGC ATTAGATATA 002240
002241 CTTAATCATG ATTTTTGAGT ACTATAAAAC GTGAGAAATC TTATTTCCTA GTGGCTGGAA AAACAGGCTT TTTAAATTAA 002320
002321 AATAAGTAAA TATATCAGTA AGCTAGAAGC TATGCAATAA GGCTTTGGCT ATGGTATTAC AAATTTTCAT ATTTCATGTA 002400
002401 TTGAATTTTT GGACAAGAAA AGACAGCCTT GATAGGTATT TTATAACCAT TAATACAATT AATCAAACAT TGTTTAGTAA 002480
002481 ATCCAATCGT CTATTCATTA TTATTTTTCC CATTAATCTT CAGAACAGCT TTAAGTTAAT ACAGATGACT CAGAATGTGT 002560
002561 TTTTCACTCA GTTTCAAAAT ACCATTATTT CAATTCGCTA ATAGAAGCAC AATTATCTTC TTGTCTGCTT TCTTAAATGT 002640
002641 TACTGGTAAA CTAGTAATTT TGCATGTCCA GGTAACTGCA GCTGCTACAG TCAATCTGCT TTGGAAAGTC TTGGCATTAT 002720
002721 TGTGTCATTT AATTTAAAAT TTTTAAGTTT TTTTAGTTTC TTCCCTTATT GAGGACTTAT TAGGCGCTAA TTAGCTTTAT 002800
002801 GCTAGACATC TCATGCATGG CAGTGAATGA AAACAACACT GCCTTTGAGG GTTTTAACTT GTATATAGTT TATACCATTT 002880
002881 TTTTTCCAGG TTATAGAATC AAAGAAATTG TTTCAATTCA TATCACAGTA TTTCTCTATT AAATCAAATG GTATTTTGCT 002960
002961 TGCATAAATT TAAGTATCCA AGTTGAGATC TTACATAGAA TCTGTTAATC TAATATTAGT GTTTTCTTCA TTTCATTGTC 003040
003041 TTGGGTTTTT TTTTCTTAAT AATTATTTTT CCCAATACCA TCCATTTGTT TTGCTCTTAC ATTTTTAAGT CTTTTATGTT 003120
003121 CCAAATCAGG TGACTTACAT CCTCCACTTG TCCATTGAGG ATAGCCCAGT AAACCTTTAT TCTGACTTTA AATTGCCTCC 003200
003201 TTGCTTCAAG AACTGAGTTG CATGACTCAG TTTTCTTTGC TAGAAATATC CCTGGATAGT CTCGTATGTA TTCTTGATCA 003280
003281 ATGAATTGCA GAAGATTTGA TTAAAAATTT TAAATGGATT TCAGGGATAA ACTATTTGTA TCAAATGTCA TCACCAGGAA 003360
003361 TTTCTACAAC TGAAAAATTT GAATTGTTAT TTTTATTGAA GAATATTTAT CTTTAAGATA AATGCAACTT GCTATAAAAT 003440
003441 GATAGAAATG AAAAATTTTA GAAAATCATT TTCTACTCAC TATTTTATGC CTGCCAGTTA TCCTTTGTTA GTGATAAAAT 003520
003521 TGTCTTTTAT GGGAACGAAT TTGTTAAAGG TAGAAAAAAA ACTGGTAGTG TATGTATGTT TTATAGATTA GACACTACCA 003600
003601 AAATTATTTA ACATTTAGAA TAATTAACTT GCTTTCAGGA TGACAGATGA CTTAAGAAAC TGATGAAGGG TTAATTAAGG 003680
003681 ATATTGATTT TTAGGGCAGA ACTACAAAAT TATCAAATCA CTTAACACTG TAAATATGTT CCTGTTTCAG GTTTTCAAAG 003760
003761 TAAATACCTT AATCAAATTT GGAAATAGTA TTTATGGATT TTATTCAACA TAGATTATCT ATTTTGTTAA AATTATAGAA 003840
003841 ATGAACAGTT CTTTTCCCAT GGATGCCTTT TTTCATCTTG GCCTATTCTG ATCCTTTAAG AACAAGCTTT GTCCTTTCAT 003920
003921 TAATACTTCT CACCTATAAT TACGAATTTT CTCTAAACTT GTAGATTTTA TTATCCATGC CATCTATTTA TAATCCTATG 004000
004001 ACACTCCTAT ATTGTTTATG GTTTTTTTGT TTTTTTTTGT TTTTTTTTTT AGACGAAGTC TTGCTCTGTC ACCCAGGCTG 004080
004081 GAGTGCAGTG GTGCAATCTC GGCTCACTGC AAGCTCCGCC TCCCGGTTCA CGCCATGCTT CTGCCTCAGC CTCCCCAGTA 004160
004161 CCTGGGACTA CAGGCGCCCA CCACCACGCC CGGCTAATTT TTTGTACTTT TAGTAGAGAT GGGGTTTCAC CGTGTTAGCC 004240
004241 AGGATGGTCT CCATCTCCTG ACCTCGTGAT CCCCCGGCCT CGGCCTCCCA AAGTGTTGGG ATTACAGGCG TGAGCCACTG 004320
004321 TGCCTGGCCT TACTGTTTAT GTTTTCATGC ATCTATACCT TATGTTACTA AATCAAAGTG ACCAGTTCCA CATTATACTA 004400
004401 CAAGTTTCAC TGTGTAATGC ATAAGAATTA CACAGAGGGA AGGGCCTCAA AAAATGCACT TCTGAAGTAT TTTAATGTAA 004480
004481 AATTATTTAA GACCATAAAG TTTCATGAAA GCCTAATCTT TCTGGAACCT ACACATACTC TGCATGTGAA CCAGAGTTAA 004560
004561 ACTAGTCAAG TATTTTAATA CTGAACTAAT CTGGAAAAAC ATCATTTAAA AAATTACTGT ATTTATGAAG GAAGAATATA 004640
004641 AAATCTGTTA AAAACTTAAA ACATCTAAAA TAGGTATGAA GAGAGGCTTA TGGTGCTCAT TTTAACAGCA TTCTTGAGTA 004720
004721 GGTTACCTTG CAGTCAAAGC ATCTGCTCCA GACCAGTGTT TTAAACTGTG GATTATGGTA CCACTATGGG TCATGAAATT 004800
004801 AATTTATTGC ATTATGACTA GCATTTTTTA TTTAAAATAG AGAAAAGAAT AGAAAATAAA AGCGTACATC ACAGATGGTA 004880
004881 AGGGTATGTG TTTTTAAGTA AACATTTGTT CATGTGTATA TGTGTTAGAT TACCTTGTAA AACATATTCC TTATTGTGGG 004960
004961 TTACAGGCCA AAAAAAGTGT TTGTTTTTGT TTTTAAAAAT CTACAGTTCA GATTTTCCTT AGAAAATGGG GAAAAAAGGA 005040
005041 ATGTTAGAAA GATCTGACTG CCTATGAACT AGTGAAGGAT TTTAGAGGAA GTACCAGGCT ATTTTAGAGA TCTGATACTG 005120
005121 GTTTCAGAAA GGTAATCTTA AGGCAAAGGG TAGGAAATAA AGTTATGTTG TTAGTAGAAA TGTCAAATAC GGTTAAAGTT 005200
005201 GTGAGGAGGA ATTATTTTCC TAGTGGACCT ACATTTGTTG TGTGTAGATC TGTGACTATT ACTGATCTGT TGTAGCACAT 005280
005281 TTTCCAATCT AAAATGTCCG ATACAGCACA ATAATAAACA TGGGGCAGAA TATAAAAAAA AAAAAA

Labs working on this lncRNA

  • Department of Cell Biology, Erasmus MC, Rotterdam, The Netherlands.

References

  1. 1.0 1.1 Zuin J, Casa V, Pozojevic J, Kolovos P, van den Hout MCGN, van Ijcken WFJ, Parenti I, Braunholz D, Baron Y, Watrin E, Kaiser FJ, Wendt KS. Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element. PLoS Genet. 2017 Dec 20;13(12):e1007137. doi: 10.1371/journal.pgen.1007137. eCollection 2017 Dec. PubMed PMID: 29261648; PubMed Central PMCID: PMC5754091.