Difference between revisions of "PCBP2-OT1"

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LncBook ID: [https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0189341 HSALNT0189341]
 
LncBook ID: [https://bigd.big.ac.cn/lncbook/transcript?transid=HSALNT0189341 HSALNT0189341]
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===Chromosome===
 
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12q13.13
 
  
 
===Characteristics ===
 
===Characteristics ===
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[[File:Functional domains of 7SK RNA..png|right|thumb|Functional domains of 7SK RNA([https://www.ncbi.nlm.nih.gov/pubmed/19246988 (Diribarne 2009)])]]
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located in 12q13.13, containing an ultraconserved region.
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~330 nt in vertebrates*. Transcribed by RNAP III, GC-rich sequence forming conserved secondary structures (especially 3' and 5' stem-loop motifs).
 
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The 7SK gene is located on chromosome 6, and chromosome 6 is the sole human chromosome that produces 7SK RNA ([https://www.ncbi.nlm.nih.gov/pubmed/8139910 (Driscoll 1994)])
 
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7SK RNA is capped at its 5' end by BCDIN3, a specific methylase methylphosphate capping enzyme (MePCE) ([http://www.ncbi.nlm.nih.gov/pubmed/17643375 (Jeronimo 2007)]).
 
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RNAP II was recently found to bind near 7SK promoter, as well as many other known Pol III genes, suggesting that RNAP II may also play a role in regulating their transcription ([http://www.ncbi.nlm.nih.gov/pubmed/20139302 (Raha 2010)]).
 
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In invertebrates, 7SK homologs may have different sizes (such as >400 nt and ~130 nt in drosophilids and nematodes, respectively). ([http://www.ncbi.nlm.nih.gov/pubmed/20139302 (Gruber 2008)]) ([http://www.ncbi.nlm.nih.gov/pubmed/18566019 (Marz 2009)])
 
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===Expression===
 
===Expression===
 
Upregulated in HCC([https://www.ncbi.nlm.nih.gov/pubmed/27154519 (Bo C 2016)]).
 
Upregulated in HCC([https://www.ncbi.nlm.nih.gov/pubmed/27154519 (Bo C 2016)]).

Latest revision as of 06:09, 10 August 2019

Annotated Information

Name

Approved symbol: PCBP2-OT1

Approved name: PCBP2 overlapping transcript 1

HGNC ID: HGNC:49150

Previous names: PCBP2 overlapping transcript 1 (non-protein coding)

Alias symbols: TUC338; uc.338; TUC.338

Alias names: transcribed ultra-conserved region 338

RefSeq ID: NR_109828

LncBook ID: HSALNT0189341

Characteristics

located in 12q13.13, containing an ultraconserved region.

Expression

Upregulated in HCC((Bo C 2016)).

Regulation

uc.338 modulated the transcription of CDKN1A((Bo C 2016)).

Function

uc.338 promotes HCC cell proliferation and induces cell cycle progression through association with BMI1((Bo C 2016)). The oncogenic activity of uc.338 is partially due to its repression of p21, it may be a potential target for HCC therapy((Bo C 2016)).

Disease

Hepatocellular carcinoma (HCC)((Bo C 2016)).

Evolution

Please input evolution information here.

Labs working on this lncRNA

  • Department of Oncology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Sequence

>gi|565671810|ref|NR_109828.1| Homo sapiens PCBP2 overlapping transcript 1 (PCBP2-OT1), long non-coding RNA

000001 AGTGGGCTCT GTAGGGGTTC AACTTAATCC CACACTGACC AGGAGCTGGC ATCAGCTCTG TTGCCCCACC CCTTCATTCT 000080
000081 TATTGAAAAT AGCCCAATTG TGCAGTGTGA AATCTGCCAC TAGGTAACTT TTTTTTTTAA TTCACTGATT ACAGCTCGTT 000160
000161 TCAAATTGTG TCTGAGCTCC TTTTTAAAGG AAAAAGGAAA AAAATAAACA ACTTTTTTTG TGTGAATTTC ATGCTGGTGA 000240
000241 CAAGGTGCCG GATTGACAGC CCTGGAGACT GAAATCCTCT ATTTATCCAC AGGACAGGTA CAGCACAGGC AGCGACAGTG 000320
000321 CGAGCTTTCC CCACACCACC CCGTCCATGT GCCTCAACCC TGACCTGGAG GGACCACCTC TAGAGGTGAG AGGGGATGTT 000400
000401 CAGTCTCCAA GGCTCACTCA ATCCTTCCGC CTCAGCCGAG ACTGCCAACA CACGGGGGGC CAGTGGCGCT GGTGATTTTT 000480
000481 GGTGCTGTGG ACACCACCTG TCCACGGGGA CCTGGACTGA CCCCCCCAAC CTCATTTCAC CCAGGCCGCG TAGCCCACCA 000560
000561 GATGGTAACA CCAACTTTTT TTTTTTTTTT
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